Tone Stimuli Research Articles

Late ERP correlates of confidence for auditory categorization of complex sounds

Recent research suggests that confidence judgments relate to the quality of early sensory representations and later modality independent processing stages. It is not known whether the nature of this finding might vary based on task and/or stimulus characteristics (e.g., detection vs. categorization). The present study investigated the neural correlates of confidence using electroencephalography (EEG) in an auditory categorization task. This allowed us to examine whether the early event-related potentials (ERPs) related to confidence in detection also apply to a more complex auditory task. Participants listened to frequency-modulated (FM) tonal stimuli going up or down in pitch. The rate of FM tones ranged from slow to fast, making the stimuli harder or easier to categorize. Tone-locked late posterior positivity (LPP) but not N1 or P2 amplitudes were larger for (correct-only) trials rated with high than low confidence. These results replicated for trials presenting stimuli at individually identified threshold levels (rate of change producing ∼71.7% correct performance). This finding suggests that, in this task, neural correlates of confidence do not vary based on difficulty level. We suggest that the LPP is a task general indication of the confidence for an upcoming judgment in a variety of paradigms.

Indexical meaning of Mandarin full tone in the construction of femininity: Evidence from social perceptual data

This paper examines the indexical association between Mandarin full tone and a newly emergent cute feminine style. Prior work has identified full tone as a component of cosmopolitanism in mainland China, but we argue that the influence of Taiwanese pop culture and social media phenomena has resulted in expanded indexical boundaries for this variable. A matched guise task was conducted to examine the connection between Mandarin full tone and social meanings, traits, and other symbolic resources for mainland Chinese listeners. The full tone stimuli were perceived as feminine and youthful, explicitly linked to Taiwan, influencer, and stereotypical “cute-coded” behaviors that typify a stylized femininity. We argue that both speaker traits and the more abstract social meanings are attached to full tone and can be activated during social perception.

Effect of Subsequent Repetitive Tone Stimuli on Time Perception: Replication of Ono and Kitazawa (2010)

Ono and Kitazawa (2010) found that the time interval immediately before a fast auditory flutter was perceived to be shorter than the time interval just before a slow auditory flutter, terming it the subsequent flutter effect. In contrast, conceptual replication studies suggested that this phenomenon is unlikely to replicate. A direct replication of the experiment of Ono and Kitazawa (2010) was performed along with three additional experiments to determine why the subsequent flutter effect was not replicated by the previous conceptual replications. The results indicate that the presence or absence of a control condition in which a flutter is not presented within the same block, as well as the time range within which participants should direct attention, is important for the reproducibility of the subsequent flutter effect.

The influence of foreperiod duration on the preparation and control of sequential aiming movements.

Reaction time (RT) and movement times (MTs) to the first target are typically longer for two-target sequential movements compared to one-target movements. While this one-target advantage has been shown to be dependent on the availability of advance information about the numbers of targets, there has been no systematic investigation of how foreperiod duration (i.e., interval between presentation of the target(s) and stimulus) influences the planning and execution of sequential movements. Two experiments were performed to examine how the one-target advantage is influenced by the availability and timing of advance target information. In Experiment 1, participants performed one- and two-target movements in two separate blocks. In Experiment 2, target conditions were randomised from trial to trial. The interval between target(s) appearing and stimulus tone (i.e., foreperiod) was varied randomly (0, 500, 1,000, 1,500, and 2,000 ms). The results of Experiment 1 revealed that while the one-target advantage in RT was not influenced by foreperiod duration, the one-target advantage in MT increased as foreperiod duration increased. The variability of endpoints at the first target was greater in the two- compared to one-target condition. In Experiment 2, the one-target advantage in both RT and MT increased as the length of the foreperiod increased. However, there was no difference in limb trajectory variability between target conditions. The implication of these findings for theories of motor planning and execution of multiple segment movements is discussed.

Matrix metalloproteinase activity during methamphetamine cued relapse.

Relapse to drug seeking involves transient synaptic remodelling that occurs in response to drug-associated cues. This remodelling includes activation of matrix metalloproteinases (MMPs) to initiate catalytic signalling in the extracellular matrix in the nucleus accumbens core (NAcore). We hypothesized that MMP activity would be increased in the NAcore during cue-induced methamphetamine (meth) seeking in a rat model of meth use and relapse. Male and female rats had indwelling jugular catheters and bilateral intracranial cannula targeting the NAcore surgically implanted. Following recovery, rats underwent meth or saline self-administration (6h/day for 15 days) in which active lever responding was paired with a light + tone stimulus complex, followed by home cage abstinence. Testing occurred after 7 or 30 days of abstinence. On test day, rats were microinjected with a fluorescein isothiocyanate (FITC)-quenched gelatin substrate that fluoresces following cleavage by MMP-2,9, allowing for the quantification of gelatinase activity during cued-relapse testing. MMP-2,9 activity was significantly increased in the NAcore by meth cues presentation after 7 and 30 days of abstinence, indicating that remodelling by MMPs occurs during presentation of meth associated cues. Surprisingly, although cue-induced seeking increased between Days 7 and 30, MMP-2,9 activity did not increase. These findings indicate that although MMP activation is elicited during meth cue-induced seeking, MMP activation did not parallel the meth seeking that occurs during extended drug abstinence.

Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder

BackgroundAtypical auditory cortical processing is consistently found in scalp electrophysiological and magnetoencephalographic studies of Autism Spectrum Disorder (ASD), and may provide a marker of neuropathological brain development. However, the relationship between atypical cortical processing of auditory information and adaptive behavior in ASD is not yet well understood.MethodsWe sought to test the hypothesis that early (100-175 ms) auditory processing in ASD is related to everyday adaptive behavior through the examination of auditory event-related potentials (AEPs) in response to simple tones and Vineland Adaptive Behavior Scales in a large cohort of children with ASD (N = 84), aged 6–17, and in age- and IQ- matched neurotypically (NT) developing controls (N = 132).ResultsStatistical analyses revealed significant group differences in early AEPs over temporal scalp regions (150-175 ms), and the expected rightward lateralization of the AEP (100-125 ms and 150-175 ms) to tonal stimuli in both groups. Lateralization of the AEP (150-175 ms) was significantly associated with adaptive functioning in the socialization domain.ConclusionsThese results lend support to the hypothesis that atypical processing of sensory information is related to everyday adaptive behavior in autism.

Mismatch negativity as an early biomarker of cognitive impairment in schizophrenia

BackgroundDue to its disturbance in schizophrenic patients, mismatch negativity (MMN) generation is believed to be a potential biomarker for recognizing primary impairments in auditory sensory processing during the course of the disease. However, great controversy exists regarding the type and onset of MMN-related impairments, with the deficits to frequency deviants is more debatable. This cross-sectional, case–control study was conducted to assess the cognitive functions among 33 eligible Egyptian schizophrenics (15 early and 18 chronic), and 30 matched healthy controls by assessing their psychometric tests and correlating them to the coexisting frequency deviant MMN responses (using both tone and speech stimuli).ResultsDeficits in frequency MMN and neuropsychological tests were evident among early and chronic schizophrenics compared to their matched control counterparts, and also between early versus chronic schizophrenia in favor of the later. MMN deficits to speech stimuli were more elicited than tone stimuli among schizophrenics. Moreover, significant correlations were identified between MMN parameters and the results of psychiatric cognitive scales.ConclusionsWe demonstrated that frequency-deviant MMN deficits are evident feature among the enrolled Egyptian schizophrenics. The cognitive functions as indexed by MMN seem affected early, with the striking decrease of MMN amplitude and delay of latency point towards the progression of the illness. The normal lateralization of MMN was absent in chronic schizophrenia. These findings could be helpful in using the MMN as an additional objective tool for confirming cognitive impairments among schizophrenics and to differentiate between early- and chronic-schizophrenic patients for medico-legal purposes and clinical implication for medications.

Temporal profiles of neuronal responses to repeated tone stimuli in the mouse primary auditory cortex

How the auditory system processes temporal information of sound has been investigated extensively using repeated stimuli. Recent studies on how the response of neurons in the primary auditory cortex (A1) changes with the progression of stimulus repetition, have reported response temporal profiles of two categories: “adaptation”, i.e., gradual decrease, and “facilitation”, i.e., gradual increase. To explore the existence of profiles of other categories and to examine the tone-frequency-dependence of the profile category in single neurons, here we studied the response of mouse A1 neurons to four or five tone-trains; each train comprised 10 identical tone pips, with 0.5-s inter-tone-intervals, and the four or five trains differed only in tone frequency. The response to each tone in a train was evaluated using the peak of the ON response, and how the peak response changed with the tone number in the train, i.e., the response temporal profile, was examined. We confirmed the existence of profiles of both “adaptation” and “facilitation” categories; “adaptation” could be further subcategorized into “slow adaptation” and “fast adaptation” profiles, with the latter being encountered more frequently. Moreover, two new categories of non-monotonic profiles were identified: an “adaptation with recovery” profile and a “facilitation followed by adaptation” profile. Examination of single neurons with trains of different tone frequencies revealed that some A1 neurons exhibited profiles of the same category to tone trains of different tone frequencies, whereas others exhibited profiles of different categories, depending on the tone frequency. These results demonstrate the variety in the response temporal profiles of mouse A1 neurons, which may benefit the encoding of individual tones in a train.

Broad nonlinearity in reticular lamina vibrations requires compliant organ of Corti structures

In the mammalian cochlea, each longitudinal position of the basilar membrane (BM) has a nonlinear vibratory response in a limited frequency range around the location-dependent frequency of maximum response, known as the best frequency (BF). This nonlinear response arises from the electromechanical feedback from outer hair cells (OHCs). However, recent in vivo measurements have demonstrated that the mechanical response of other organ of Corti (OoC) structures, such as the reticular lamina (RL), and the electrical response of OHCs (measured in the local cochlear microphonic [LCM]) are nonlinear even at frequencies significantly below BF. In this work, a physiologically motivated model of the gerbil cochlea is used to demonstrate that the source of this discrepancy between the frequency range of the BM, RL, and LCM nonlinearities is greater compliance in the structures at the top of the OHCs. The predicted responses of the BM, RL, and LCM to pure tone and two-tone stimuli are shown to be in line with experimental evidence. Simulations then demonstrate that the sub-BF nonlinearity in the RL requires the structures at the top of the OHCs to be significantly more compliant than the BM. This same condition is also necessary for “optimal” gain near BF, i.e., high amplification that is in line with the experiment. This demonstrates that the conditions for OHCs to operate optimally at BF inevitably yield nonlinearity of the RL response over a broad frequency range.

Tactile perception of auditory roughness.

Auditory roughness resulting from fast temporal beatings is often studied by summing two pure tones with close frequencies. Interestingly, the tactile counterpart of auditory roughness can be provided through touch with vibrotactile actuators. However, whether auditory roughness could also be perceived through touch and whether it exhibits similar characteristics are unclear. Here, auditory roughness perception and its tactile counterpart were evaluated using pairs of pure tone stimuli. Results revealed similar roughness curves in both modalities, suggesting similar sensory processing. This study attests to the relevance of such a paradigm for investigating auditory and tactile roughness in a multisensory fashion.

A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties.

Recent long-term measurements of neuronal activity have revealed that, despite stability in large-scale topographic maps, the tuning properties of individual cortical neurons can undergo substantial reformatting over days. To shed light on this apparent contradiction, we captured the sound response dynamics of auditory cortical neurons using repeated 2-photon calcium imaging in awake mice. We measured sound-evoked responses to a set of pure tone and complex sound stimuli in more than 20,000 auditory cortex neurons over several days. We found that a substantial fraction of neurons dropped in and out of the population response. We modeled these dynamics as a simple discrete-time Markov chain, capturing the continuous changes in responsiveness observed during stable behavioral and environmental conditions. Although only a minority of neurons were driven by the sound stimuli at a given time point, the model predicts that most cells would at least transiently become responsive within 100days. We observe that, despite single-neuron volatility, the population-level representation of sound frequency was stably maintained, demonstrating the dynamic equilibrium underlying the tonotopic map. Our results show that sensory maps are maintained by shifting subpopulations of neurons "sharing" the job of creating a sensory representation.

Wideband absorbance for the assessment of pressure equalizing tubes patency in children.

To analyze the feasibility of using wideband absorbance to verify the patency of pressure equalizing tubes (PETs) in clinical practice and to present the response pattern of this measure for ears with patent PET. This observational case-control type study evaluated 48 ears of 30 children with severe or profound hearing loss, aged 10-44 months, of both sexes. The subjects were subdivided into two groups: 24 ears with Sheppard type PET (experimental group - EG) and 24 ears with normal middle ear (control group - CG), paired with the EG, according to age, sex, and ear evaluated. To obtain the wideband absorbance, a Middle-Ear Power Analyzer, version 5.0 (Mimosa Acoustics), was used, and absorbance values for pure tone and chirp stimuli were analyzed. There was no influence of ear (right or left) on the measurements obtained. The EG showed higher absorbance values at low frequencies. Although the two stimuli made it possible to identify the difference in acoustic transfer function between the groups studied, compared to pure tone, the chirp stimulus allowed identification of differences in a higher number of frequencies. Ears with a patent PET present an acoustic transfer pattern that differs from that obtained for normal middle ears, with a higher absorbance at low frequencies. Both pure tone and chirp stimuli can be used to identify such differences, nevertheless, the use of chirp stimulus is recommended, since it allows differentiation over a wider frequency range.

Audiovisual Mandarin Lexical Tone Perception in Quiet and Noisy Contexts: The Influence of Visual Cues and Speech Rate.

Armed with the theory of embodied cognition proposing tight interactions between perception, motor, and cognition, this study aimed to test the hypothesis that speech rate-altered Mandarin lexical tone perception in quiet and noisy environments could be affected by the bodily dynamic cross-modal information. Fifty-three adult listeners completed a Mandarin tone perception task with 720 tone stimuli in auditory-only (AO), auditory-facial (AF), and auditory-facial-plus-gestural (AFG) modalities, at fast, normal, and slow speech rates under quiet and noisy conditions. In AF and AFG modalities, both congruent and incongruent audiovisual information were designed and presented. Generalized linear mixed-effects models were constructed to analyze the accuracy of tone perception across different conditions. In Mandarin tone perception, the magnitude of enhancement of AF and AFG cues across three speech rates was significantly higher than that of the AO cue in the adverse context of noise, yet additional metaphoric gestures did not show significant differences from the facial information. Furthermore, the performance of auditory tone perception at the fast speech rate was significantly better than that at the normal speech rate when the inputs were incongruent between auditory and visual channels in quiet. This study provided compelling evidence showing that integrated audiovisual information plays a vital role not only in improving lexical tone perception in noise but also in modulating the effects of speech rate on Mandarin tone perception in quiet for native listeners. Our findings, supporting the theory of embodied cognition, are implicational for speech and hearing rehabilitation among both young and old clinical populations.

Optimizing distortion product otoacoustic emission recordings in normal-hearing ears by adopting cochlear place-specific stimuli.

Distortion product otoacoustic emissions (DPOAEs) provide a window into active cochlear processes and have become a popular clinical and research tool. DPOAEs are commonly recorded using stimulus with fixed presentation levels and frequency ratio irrespective of the test frequency. However, this is inconsistent with the changing mechanical properties of the cochlear partition from the base to the apex that lend specific frequency-dependent spatial properties to the cochlear traveling wave. Therefore, the frequency and level characteristics between the stimulus tones should also need to be adjusted as a function of frequency to maintain optimal interaction between them. The goal of this investigation was to establish a frequency-specific measurement protocol guided by local cochlear mechanics. A broad stimulus parameter space extending up to 20 kHz was explored in a group of normal-hearing individuals. The stimulus frequency ratio yielding the largest 2f1-f2 DPOAE level changed as a function of frequency and stimulus level. Specifically, for a constant stimulus level, the frequency ratio producing the largest DPOAE level decreased with increasing frequency. Similarly, at a given f2 frequency, the stimulus frequency ratio producing the largest DPOAE level became wider as stimulus level increased. These results confirm and strengthen our current understanding of DPOAE generation in the normally functioning cochlea and expand our understanding to previously unexamined higher frequencies. These data support the use of frequency- and level-specific stimulus frequency ratios to maximize DPOAE generation.

The P300 Auditory Evoked Potential in Cochlear Implant Users: A Scoping Review.

Introduction The P300 auditory evoked potential is a long-latency cortical potential evoked with auditory stimulation, which provides information on neural mechanisms underlying the central auditory processing. Objectives To identify and gather scientific evidence regarding the P300 in adult cochlear implant (CI) users. Data Synthesis A total of 87 articles, 20 of which were selected for this study, were identified and exported to the Rayyan search software. Those 20 articles did not propose a homogeneous methodology, which made comparison more difficult. Most articles (60%) in this review compare CI users with typical hearing people, showing prolonged P300 latency in CI users. Among the studies, 35% show that CI users present a smaller P300 amplitude. Another variable is the influence of the kind of stimulus used to elicit P300, which was prolonged in 30% of the studies that used pure tone stimuli, 10% of the studies that used pure tone and speech stimuli, and 60% of the studies that used speech stimuli. Conclusion This review has contributed with evidence that shows the importance of applying a controlled P300 protocol to diagnose and monitor CI users. Regardless of the stimuli used to elicit P300, we noticed a pattern in the increase in latency and decrease in amplitude in CI users. The user's experience with the CI speech processor over time and the speech test results seem to be related to the P300 latency and amplitude measurements.

Developmental changes of ABR wave 5 latency to click and tonal stimulation at different intensities in infants

Background The ABR is useful for estimation of hearing thresholds and is considered an objective test since cooperation of the infant is not required. However, wave 5 identification and threshold determination are often based on the audiologist's subjective judgement. The aim of the present study is to describe the developmental changes in ABR wave 5 latency to different stimuli and intensities in infants of different ages. Materials and methods Data from the files of 294 normal hearing infants were used in a retrospective analysis. The latency of wave 5 brainstem component of the ABR to click and tonal stimuli at different intensities down to threshold were measured. Results The wave 5 latency to click was shorter than for tonal stimuli. Furthermore, the rate at which latency of wave 5 decreased as a function of stimulus intensity was more pronounced over the higher intensities. The shortening of wave 5 latency was also more rapid over the first few months in response to the higher frequencies. Discussion and conclusions Latency values obtained were similar to those described in the literature; wave 5 latency for different frequencies followed the tono-topic organization of the cochlea and the decrease in latency followed neural maturation. Further investigation is needed to determine if the latency values at threshold in infants with hearing loss are similar.

Acoustic change complex using short duration stimuli in normal hearing children: temporal resolution and frequency discrimination

Objective Acoustic Change Complex (ACC) is a cortical auditory evoked potential elicited in response to a change in an ongoing sound. Since it is supposed to reflect auditory discrimination at the cortical level, recording of this potential has recently gained much attention. From a technical standpoint, the stimulus used should be long enough to accommodate the needed change. This research addresses the development and standardization of short duration tonal stimuli which can be implemented in most of the Evoked Potential (EP) equipment used in regular Audiology clinics. Methods Short duration tonal stimuli (500 msec.) were generated and edited using Audacity software. Temporal change was done using gap-in-tones stimuli (6, 10, 30 and 50 msec. in 1000 Hz tone). Frequency change was represented by frequency pairs (2%, 4%, 10% and 25% change from 1000 Hz base frequency). The developed stimuli were then used to generate ACC potential in 41 normal hearing children ranging in age from 2 to 10 years. A comparison was held between ACC response recorded using the different stimuli in reference to percent identifiability, morphology, latency and amplitude measures. Results Gap-in-tones at 10 msec. and 4% frequency change could elicit ACC response in 100% of subjects. ACC had the same morphology of the onset response in the majority of subjects, with longer latency and smaller amplitude. ACC amplitude was consistently affected by magnitude of change. Conclusion ACC was successfully recorded in 100% of normal hearing children using the developed short duration tonal stimuli for temporal change (10 msec.) and frequency change (4%). These stimuli can be uploaded in clinical EP equipment. ACC amplitude could be a better indicator of cortical discrimination compared to latency.

Association of Two Opposing Responses Results in the Emergence of a Novel Conditioned Response.

Recent studies examining association of opposing responses, contrasting emotional valences, or counter motivational states have begun to elucidate how learning and memory processes can translate to clinical therapies for trauma or addiction. In the current study, association of opposing responses is tested in C. elegans. Due to its relatively simple and well-described nervous system, it was hypothesized that association of two oppositional stimuli presented in a delayed conditioning protocol would strengthen the behavioral response to the first stimulus (alpha conditioning). To test this, C. elegans were exposed to a tone vibration stimulus (to activate a mechanosensory-driven locomotor reversal response) paired with a blue light (to activate a forward locomotor response) at a 2-s delay. After five pairings, behavior was measured following a tone-alone stimulus. Worms that received stimulus pairing did not show an enhanced response to the first presented stimulus (tone vibration) but rather showed a marked increase in time spent in pause (cessation of movement), a new behavioral response (beta conditioning). This increase in pause behavior was accompanied by changes in measures of both backward and forward locomotion. Understanding the dynamics of conditioned behavior resulting from pairing of oppositional responses could provide further insight into how learning processes occur and may be applied.

Audiovisual high variability phonetic training promotes second language lexical tone learning: An event-related potential study

This study investigated the efficacy of a modified high variability phonetic training (HVPT) protocol in second language learning. The target Mandarin lexical tones in the training stimuli were acoustically exaggerated at four levels in terms of duration, pitch range, and pitch contour. Seven audiovisual perceptual training sessions were designed to deliver the training stimuli adaptively based on the listener's identification score. Pre- and post-tests used behavioral identification and discrimination tasks with natural speech, synthetic speech, and non-speech control stimuli. ERP experiments were also conducted with synthetic speech stimuli in a passive listening oddball paradigm. A total of 24 adult monolingual American English speakers were randomly assigned to the training group and control group. Behavioral data showed significant improvement in identifying the four lexical tones in the trainees but not in the controls. There was also training-induced enhancement of categorical perception of the lexical tones for the synthetic speech stimuli. Posttest versus pretest comparison in the trainees showed an increased mismatch negativity (MMN) response with decreased MMN peak latency for the across-category lexical tone stimuli. Collectively, the results demonstrate fundamental neural sensitivity changes at the pre-attentive level underlying training-induced behavioral identification and discrimination changes in second language learners.

Cortical Auditory Evoked Potentials Recorded Directly Through the Cochlear Implant in Cochlear Implant Recipients: a Feasibility Study.

The use of objective measures in cochlear implant (CI) mapping, has greatly contributed to the refinement of the setting of audible and comfortable stimulation levels, which serve as the basis of the mapping process, especially in cases of infants and young children. In addition, objective measures can also confirm the integrity of the CI system. Current CI objective measures mainly reflect neural activity from the auditory nerve and brainstem site. An objective cortical CI measure that reflects directly central auditory activity is greatly needed, especially since it is closely related to CI outcomes in both children and adults. Recording the brain activity currently requires an external evoked potential (EP) system including scalp electrodes, rendering it impractical for widespread clinical use. This study aimed to assess the feasibility of recording cortical auditory evoked potentials (CAEPs) directly and solely through the cochlear implant in response to external acoustic stimulation in the non-implanted ear. A total of nine CI users (four females and five males) participated, including seven post-lingual adults (23 to 72 years), and two pediatric cases, one teenager (15 years), and one child (8 years)-both pre-lingual. All participants had a residual hearing in the ear contralateral to the ear with CI. CAEPs were recorded in the implanted ear in response to acoustic stimulation of the non-implanted ear, consisting of a brief tonal stimulus at comfortable listening levels. Recordings used an intracranial montage consisting of an intracochlear apical electrode (active) and one of the two ( case and ring ) extra-cochlear implanted electrodes serving as reference electrodes. The CI CAEPs were compared with a single-channel conventional CAEP recording obtained simultaneously via scalp electrodes (Fz-mastoid) using a standard EP system and an external trigger from the CI system. Statistical comparisons were made between the CI and the scalp recorded CAEPs and for differences between the CI CAEP measures acquired using the ring and the case as the reference electrode. CAEPs recorded directly and solely through the CI were equivalent to the standard scalp recorded CAEP responses. CAEP responses acquired using the case electrode as the reference were highly correlated in terms of morphology, latencies, and amplitudes of the CAEP components. The CI CAEP latencies of the two pediatric cases were consistent with their normal developed age group and delayed relative to adult CAEP latencies, as expected. This study demonstrated the feasibility of recording long latency CAEPs directly and solely through CI in adults with residual hearing, in response to acoustic stimulation of the non-implanted ear. The CI CAEPs closely resembled the CAEPs recorded simultaneously by an external EP system and via scalp electrodes. The ability to record directly from the implant, without the need of an external recording system, presents an innovative method with many clinical and research implications.