You have accessJournal of UrologyCME1 May 2022MP15-20 SURVIVAL AFTER RADICAL PROSTATECTOMY VS. RADIATION THERAPY IN DUCTAL CARCINOMA OF THE PROSTATE Francesco Chierigo, Christoph Würnschimmel, Rocco Simone Flammia, Benedikt Horlemann, Gabriele Sorce, Benedikt Hoeh, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Francesco Montorsi, Felix K.H. Chun, Shahrokh F. Shariat, Guglielmo Mantica, Maro Borghesi, Nazareno Suardi, Carlo Terrone, and Pierre I. Karakiewicz Francesco ChierigoFrancesco Chierigo More articles by this author , Christoph WürnschimmelChristoph Würnschimmel More articles by this author , Rocco Simone FlammiaRocco Simone Flammia More articles by this author , Benedikt HorlemannBenedikt Horlemann More articles by this author , Gabriele SorceGabriele Sorce More articles by this author , Benedikt HoehBenedikt Hoeh More articles by this author , Zhe TianZhe Tian More articles by this author , Fred SaadFred Saad More articles by this author , Markus GraefenMarkus Graefen More articles by this author , Michele GallucciMichele Gallucci More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Felix K.H. ChunFelix K.H. Chun More articles by this author , Shahrokh F. ShariatShahrokh F. Shariat More articles by this author , Guglielmo ManticaGuglielmo Mantica More articles by this author , Maro BorghesiMaro Borghesi More articles by this author , Nazareno SuardiNazareno Suardi More articles by this author , Carlo TerroneCarlo Terrone More articles by this author , and Pierre I. KarakiewiczPierre I. Karakiewicz More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002544.20AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To compare cancer specific mortality (CSM) rates between radical prostatectomy (RP) vs. external beam radiotherapy (RT) in patients with ductal carcinoma (DC) of the prostate. METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004-2016), we identified 369 DC patients, of whom 303 (82%) vs 66 (18%) were treated with RP vs RT, respectively. Kaplan-Meier plots and uni- and stepwise multivariate Cox regression models addressed CSM in the unmatched population. After propensity score matching (PSM) and inverse probability of treatment weighting (IPTW), Kaplan-Meier curve and Cox regression models tested the effect of RP vs RT on CSM. RESULTS: Overall, RT patients were older, harbored higher PSA values, higher clinical T and higher Gleason grade groups. 5-year CSM rates were respectively 4.2 vs 10% for RP vs RT (HR 0.40, 95% CI 0.16-0.99, p=0.048, favoring RP). At step-by-step multivariate Cox regression, after adding possible confounders, the central tendency of the HR for RP vs RT approached 1. PSM resulted into 124 vs 53 patients treated respectively with RP vs RT. After PSM, as well as after IPTW, the protective effect of RP was no longer present (HR 1.16, 95% CI 0.23-5.73, p=0.9 and 0.97, 95% CI 0.35-2.66, p=0.9, respectively). CONCLUSIONS: Although CSM rate of ductal carcinoma RP patients is lower of that of RT patients, this apparent benefit disappears after statistical adjustment for population differences. Source of Funding: no funding © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e250 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Francesco Chierigo More articles by this author Christoph Würnschimmel More articles by this author Rocco Simone Flammia More articles by this author Benedikt Horlemann More articles by this author Gabriele Sorce More articles by this author Benedikt Hoeh More articles by this author Zhe Tian More articles by this author Fred Saad More articles by this author Markus Graefen More articles by this author Michele Gallucci More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Felix K.H. Chun More articles by this author Shahrokh F. Shariat More articles by this author Guglielmo Mantica More articles by this author Maro Borghesi More articles by this author Nazareno Suardi More articles by this author Carlo Terrone More articles by this author Pierre I. Karakiewicz More articles by this author Expand All Advertisement PDF DownloadLoading ...