A Staggered Truss System (STS) is a brand-new idea in the construction of high-rise buildings. It is an effective design technique to improve efficiency in building construction. It was initially created in the 1960s at the Massachusetts Institute of Technology. By providing STS we can increase the strength and ductility of the building. It helps to cut down the number of interior columns and thereby reduce the cost of the building construction. This project involved using the ETAB software to undertake an analytical investigation into the seismic behaviour of a 16-storey steel staggered-truss system. The structural shape of the trusses was varied, and their influences on the seismic behaviours of the system were studied. The seismic performance of STS structures by varying the Vierendeel panel width was also evaluated. Time history analysis was used to analyse the models. From the analysis result maximum storey displacement, maximum storey drift and base shear are extracted. From the result, it was found that the model with warren trusses showed the highest strength and stiffness to the corresponding earthquake but all other truss shapes also achieved the target performance level and also the model with less Vierendeel panel width shows higher base shear and lower inter storey drift and displacement.