The article is devoted to a computer modeling method of electrocardiogram rhythm based on a mathematically justified model in the form of a vector of stationary random sequences. The developed computer modeling method allows for generating realizations of vector electrocardiogram rhythm signal (vector components of stationary random sequences) for different types of electrocardiogram signals, both normal and with various types of rhythm pathologies. The modeling of electrocardiogram rhythms was carried out based on the obtained statistical information in the form of estimates of the mathematical expectation and variance of the components of the vector of stationary random sequences. It has been shown that the obtained estimates of statistical characteristics of the modeled vector components (components that describe the electrocardiogram rhythm) are within confidence intervals, which is an indication of the correctness of the experiments conducted using the developed computer simulation method. The accuracy of the computer simulation method for generating realizations of the vector components of stationary random sequences has been investigated, and the error of the computer simulation does not exceed 13% for the investigated vector components.