In order to deepen the understanding of the occurrence mechanism and water vapor transport characteristics of the heavy rain process in the extreme arid region of Xinjiang, a rare heavy rain process in the Tarim Basin during the period of 18–22 July 2021 was comprehensively analyzed by using multi-source data. The results show that the upper tropospheric South Asian high was distributed in a “west-high-east-low” pattern during the rainstorm process, and the rainstorm area was located on the right side of the upper jet stream entrance area, while the middle-level Iranian high pressure, Baikal high pressure and Central Asian low pressure formed a “two-highs and one-low” circulation situation. The coupling of the high and low air jets and the strong vertical upward motion provided favorable dynamic conditions. Rainstorm water vapor mainly comes from the Mediterranean Sea, Central Asia and the Indian Ocean, and it enters the basin in four paths: west, east to west, west to east, and southwest and south. The water vapor mainly flows into the middle layer of the western boundary and the southern boundary and the lower layer of the eastern boundary, and it flows out from the middle and upper layer of the eastern boundary. The negative moist potential vorticity region at a low level has a strong indicator significance for the occurrence and development of heavy rain, and the superposition of positive and negative moist potential vorticity regions at vertical height is conducive to the occurrence and development of heavy rain.