We reformulate the quasi-static SDA applicable to a lossy multilayer CPW that also incorporates two-layer model of a conductor thickness and the concept of effective permeability due to magnetic field penetration in an imperfect conductor. The present static SDA formulation accounts for the effect of conductor thickness and low frequency dispersion on computation of quasi-static effective relative permittivity and characteristic impedance. The paper also presents the single layer reduction (SLR) formulation and circuit model to compute frequency dependent line parameters of a lossy multilayer CPW. The accuracy of formulation is comparable to that of HFSS and CST, without using complex and time consuming full-wave methods. The results of CST for εeff, Z0, αd, αc of multilayer CPW, in the frequency range 1–100 GHz, deviate from results of HFSS up to 1.26%, 2.78%, 11.75%, and 18.7%, respectively; whereas corresponding deviations of present formulation are up to 1.56%, 2.4%, 3.04%, and 7%. The results of the present formulation and HFSS are also compared against the available experimental results. © 2013 Wiley Periodicals, Inc. Int J RF and Microwave CAE 24:18–29, 2014.