Material handling tasks often lead to skeletal injury of workers. The whole-body static biomechanical modeling method based on virtual humans is the theoretical basis for analyzing the human factor index in the lifting process. This paper focuses on the study of humans' body static biomechanical model for virtual human ergonomics analysis: First, the whole-body static biomechanical model is constructed, which calculates the biomechanical data such as force and moment, average strength, and maximum hand load at human joints. Secondly, the prototype model test system is developed, and the real experiment environment is set up with the inertial motion capture system. Finally, the model reliability verification experiment and application simulation experiment are designed. The comparison results with the industrial ergonomic software show that the model is consistent with the output of the industrial ergonomic software, which proves the reliability of the model. The simulation results show that under the same load, the maximum joint load and the maximum hand load are strongly related to the working posture, and the working posture should be adjusted to adapt to the load. Upright or bent legs have less influence on the maximum load capacity of the hand. Lower hand load capacity is due to forearm extension, and the upper arm extension greatly reduces the load capacity of the hand. Compared with a one-handed load, the two-handed load has a greater load capacity.