State University Teaching Hospital Ikeja Research Articles

Burden of respiratory morbidity amongst survivors of COVID-19 infection in Lagos, Southwest Nigeria

<b>Background</b>: COVID-19 disease is associated with long-term effects in some survivors. There exists dearth of information about the burden of respiratory morbidity among COVID-19 survivors in Nigeria. This study was designed to identify the common respiratory symptoms of long COVID-19 to educate and increase index of suspicion of healthcare practitioners caring for such patient for optimal care.<br /> <b>Material and methods</b>: This is a cross-sectional survey that took place at the adult pulmonology clinic of Lagos State University Teaching Hospital Ikeja. The individuals who were treated for PCR confirmed COVID-19 infection referred for unresolved symptoms 4 weeks following discharge that consented were recruited. A proforma was used to obtain information on socio-demographic characteristics, medical history, and comorbidities. The degree of dyspnea was assessed using MRC(Medical Research Council) dyspnea scale while the functional capacity of patients was assessed using Six-minute walk test (6mwt). The analysis of the data collected was done using descriptive statistics, and chi-square was used to test for association.<br /> <b>Results</b>: Ninety-four subjects participated. The mean age of participants was 49.48±17.8 years, with male: female ratio of 1:1.1. The median duration of admission due to COVID-19 infection was 10.0 (7.0-15.8) days. The common symptoms were fatigue (85.1%), loss of smell (71.3%), dyspnea 53(56.4%), and Cough (62.8%). Dyspnea was present in 62.8% using the MRC dyspnea scale, while the 6-meter walk test showed inadequate functional capacity in 61.7%, and both showed significant association. (X<sup>2</sup>=18.606, P=0.001*)<br /> <b>Conclusion</b>: Respiratory morbidity remains a significant post covid condition. There is a need to raise awareness amongst healthcare workers, particularly within the primary healthcare setting for early identification and referral of COVID-19 survivors with prolonged respiratory symptoms to pulmonology clinics for optimal care. There is also a need for further research on predictors of post COVID syndrome and treatment modalities.

Hypoglycemia In Diabetics 65 Years And Older Using Ademolus Classification Of Hypoglycemia

Introduction: Aging is one of the well-recognized risk factor of diabetes mellitus recognized worldwide in literature. Aging at the molecular and cellular level is characterized by the occurrence and accumulation of damage in DNA and RNA protein. This research seeks to answer the question what clinical deduction can be derived from the management of diabetics 65 years and above in African when Ademolus Classification of Hypoglycemia (ACH) is used as a tool in this age bracket? Methodology: This is a retrospective study of 182 documented hypoglycemic episodes occurring in 64 diabetics attending the Lagos State University Teaching Hospital Ikeja in Africa between September 2004 and November 2017, a 13 years period. Exclusion criteria include probable hypoglycemia, hypoglycemia occurring in non-diabetics, hypoglycemia in diabetics aged below 65years were also excluded from the study. Hypoglycemia was defined as blood sugar of 70mg/dl or less whether symptomatic or not. Result: In all,182 episodes of hypoglycemia were analyzed. 97 episodes from the 22 in patients involved in this study and 85 hypoglycemic episodes from 42 out patients involved in this study. Discussion: The tendency for elderly diabetic patients 65 years and above to develop hypoglycemia is more with in patient or hospitalized patient management when blood sugar control is intensive compared with outpatient management. Also, from this study, it can be deducted that if diabetics 65 years and older is having life threatening problem with repeated severe hypoglycemia while on insulin or insulin and oral hypoglycemic agents then consider placing them on oral hypoglycemic agents alone Conclusion: The tendency for elderly diabetic patients 65 years and above to develop hypoglycemia is more with in patient or hospitalized patient.

Recurrence and Tooth Mobility Associated with Gingival Enlargements in Patients Attending a Tertiary Hospital in Lagos, Nigeria

Background: Gingival enlargements has attracted much review in literature, however sequelae such as recurrence and tooth mobility and associated factors demands more research attention. Objective-This study assessed the prevalence and distribution of recurrence and tooth mobility associated with gingival enlargements and their predisposing factors in Lagos, Nigeria. Methods-This is a retrospective study of 138 patients seen over 5 years at the Dental Centre of the Lagos state University Teaching Hospital Ikeja, Lagos, Nigeria. Records were accessed from the Oral Pathology and medical records department of the same institution. SPSS 21 was used for data analysis; descriptive statistics was carried out for both continuous and categorical variables. Chi square and fisher’s exact were carried out as appropriate and logistic regression was used to test the covariates. Significance was determined at p≤0.05. Results- Prevalence of recurrence and tooth mobility was 26.8% and 39.1% respectively. Tooth mobility was highest among the 31-40-year-oldswhile recurrence was commonest in the 21–40-year-olds. Maxillary anterior sextant and the buccal/labial location were commonest sites for recurrence and tooth mobility. Pyogenic granuloma has the highest prevalence of tooth mobility (50%) and recurrence (67.6%). There is significant relationship between the dependent variables and tooth malpositioning and oral hygiene(p<0.05).Logistic regression reveals significant relationship between tooth mobility and recurrence, poor oral hygiene, tooth malpositioning, age and medications (p<0.05). Recurrence has statistical significance with educational level, poor oral hygiene, tooth mobility and malpositioning (p<0.05). Conclusion- Poor oral hygiene and tooth malpositioning werefactors significantly associated with both recurrence and tooth mobility recorded with gingival enlargements in this study. Thisemphasizes the need for improvement in oral hygiene and early institution of orthodontic interception to correct malposed teeth in preventing these sequelae in patients that develops gingival enlargement.

Antioxidant Status of Breast, Cervical and Ovarian Cancer Patients at Various Menopausal Stages in Lagos State, Nigeria

Cancer is a collection of diseases which involves the abnormal growth of cells with the potential to invade or spread to other parts of the body. The aim of this study is to access the antioxidant status of women with female predominant cancer (breast, cervical and ovarian) in relationship with their menopausal stages. Blood samples were collected from 180 freshly diagnosed female patients of breast, cervical and ovarian cancer at Lagos State University Teaching Hospital, Idi- Araba, Mushin, Lagos and Lagos State University Teaching Hospital Ikeja, Lagos and 60 relatively healthy subjects at different menopausal stages. Serum catalase (CAT), Superoxide dismutase (SOD) activites, Reduced Glutathione (GSH), Vitamin C and E concentrations were evaluated in subject’s blood sample using standard established methods. The results obtained were subjected to statistical analysis (p<0.05). However, the results of the female cancer patients at each menopausal stage were compared to premenopausal, menopausal and postmenopausal control groups, while the results obtained from the menopausal and postmenopausal control subjects were compared to the premenopausal control subjects. There was significant decrease (p<0.05) in the activities of CAT, SOD and in the concentrations of GSH, Vitamins C and E in all the menopausal stages when compared to the control groups. However, MDA concentrations showed significant increase (p<0.05) in all the menopausal stages in comparison to the corresponding control groups. These findings suggest that cancer patients might be at risk from oxidative cell damage. Therefore, further research is required in this field with a view of improving the management of cancers predominant in females.

Impact of Self-monitoring of Blood Glucose on Glycaemic Control in Type 2 Diabetic Nigerians who Reside in Lagos

Background: Self-Monitoring of Blood Glucose (SMBG) is a vital constituent of diabetes care. The aim of this study was to document the practice, determinants and effects of SMBG in our setting. Methods: A cross-sectional study was carried out on 249 adult type 2 diabetic subjects who attended the diabetes clinic of the Lagos State University Teaching Hospital Ikeja. The statistical analysis was done with independent t-test and logistic regression. A P-value of less than 0.05 was taken as significant. Results: The age of the study subjects ranged from 28 years to 87 years. The mean + S.D age is 62 + 11 years. The mean + S.D BMI of the study subjects is 27.79 + 4.73 Kgm2. 159 (64%) of the patients practised SMBG while 90 (36%) patients did not. Twenty-two (14%) of the patients have been practising SMBG for less than 12 months, 71 (46%) patients for 12 - 36 months, while 60 (39%) of them for more than 36 months. 36 (23%) of the patients did SMBG daily, 58 (37%) patients twice weekly, 48 (30%) patients weekly, 11 (7%) patients monthly, 5 (3%) patients did it for unspecified time period while 1 (1%) patient was unable to report the time period. SMBG practice was associated with better short term glycemic control P= < 0.001, OR= 0.399 and 95% CI 0.229-0.693. Predictors of SMBG were male sex, higher socioeconomic status and insulin therapy. More male patients (72.7%) practice SMBG compared to female patients (59.9%) p-value 0.051. The detection of chronic complications of DM was comparable between those who practice SMBG and those who do not. Conclusion: SMBG practice is significantly associated with better short term glycaemic control.

Complications Following Prostate Biopsy: A Single Centre Five Year Review

Background: Though prostate biopsy is generally a safe procedure, it can be associated with complications. It is important to document the complication rates and identify potential risk factors for these complications. The aim of this study was therefore to investigate the complication rates following prostate biopsy at the Lagos State University Teaching Hospital Ikeja Lagos Nigeria over a 5 year period from January 2012 to December 2016. Patients and Methods: This was a retrospective study in which the clinical records of all the patients who had prostate biopsy at the Lagos State University Teaching Hospital Ikeja, Lagos Nigeria over a 5 year period between January 2012 and December 2016 were retrieved and analyzed. Results: The clinical records of a total of 258 patients were available for review. The mean age was 68.2years (range 45 to 81years). The mean and median PSA values were 560ng/ml and 57ng/ml respectively (range 2.05 to 15,400ng/ml). The prostate biopsy was transrectal and digitally guided in all cases. All the patients had empirical intravenous prophylactic antibiotics with intravenous ciprofloxacin 500mg stat and were discharged on oral ciprofloxacin 500mg bd and oral metronidazole 400mg tds for one week. All the patients had a caudal block. One hundred and seventeen (45.3%) had a comorbidity. The mean prostate size was 109gms (range 16 – 146gms). The size of the trucut needle used was size 16 in 121 patients (46.9%) and size 18 in 125 patients (48.4%). The mean number of biopsy cores taken was 10 (range 4 to 15). The histological diagnosis was carcinoma of the prostate in 154 patients (59.7%) and benign prostatic hyperplasia in 100 patients (38.8%). Twenty four patients (9.3%) had complications. The complications were sepsis (3.1%), rectal bleeding (2.3%), haematuria (2.3%) and acute urinary retention (1.6%). Thirteen patients needed hospitalization (5%). There was no mortality. The incidence of sepsis was statistically significantly higher with increasing the number of cores taken (p=0.000), but there was no significant difference in the incidence of sepsis with the size of the trucut needle used (p= 0.299) or the presence of morbidity (p = 0.503). Conclusion: Though the complication rates following prostate biopsy remain low, increasing number of prostate cores taken is a risk factor for adverse events. We therefore recommend reducing the number of prostate cores taken in patients with advanced prostate cancer with high tumour volume in order to further reduce the risk of prostate biopsy complications in our environment.

Sex Differences in Alcohol-Related Problems Among a Sample of HIV-Positive Nigerians

Although alcohol use is common among persons living with HIV/AIDS (PLWHA), and heavy drinking is more common worldwide in males than females, studies of sex differences in risk for development of symptoms of alcohol dependence have yielded mixed results. In Nigeria, there is a paucity of data on sex differences in alcohol-related problems among PLWHA. This has hindered our ability to tailor treatment to best meet the needs of PLWHA. To address this gap, the present study examined alcohol use patterns and Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV)-related symptoms in a sample of 331 HIV and AIDS patients (64.4% female; Mage = 38.1 years, SD = 9.1 years) recruited from Lagos State University Teaching Hospital Ikeja. The World Health Organization Composite International Diagnostic Interview (WHO-CIDI), Version 7.0, was administered to assess alcohol use and DSM-IV-related symptoms. Based on responses to the interview, patients were classified as having or not having complication(s) or symptom(s). Logistic regressions adjusting for age and marital status revealed that women were at lower risk than men for alcohol-related problems. Symptoms of craving and tolerance did not differ across sex. Study findings support the need for policy to be geared toward sex-specific prevention and harm-reduction approaches among HIV-positive individuals.

Sequence analysis of genes mediating extended-spectrum beta-lactamase (ESBL) production in isolates of Enterobacteriaceae in a Lagos Teaching Hospital, Nigeria.

BackgroundExtended-spectrum β-lactamases (ESBLs) in Gram-negative organisms is now a major concern in Enterobacteriaceae worldwide. This study determined a point-prevalence and genetic profiles of ESBL-producing isolates among members of the family Enterobacteriaceae in Lagos State University Teaching Hospital Ikeja, Nigeria.MethodsConsecutive non-repetitive invasive multidrug-resistant isolates of the family Enterobacteriaceae obtained over a period of 1 month (October 2011) were studied. The isolates were identified using VITEK-2/VITEK MS Systems. Susceptibility testing was performed using E test technique; results were interpreted according to the criteria recommended by the Clinical and Laboratory Standards Institute (CLSI, 2012). ESBL production was detected by E test ESBL method and confirmed by polymerase chain reaction (PCR).ResultsDuring the one-month study period, 38 isolates with ESBL phenotypic characteristics were identified and confirmed by PCR. Of these, 21 (55.3 %) were E. coli, 12 (31.6 %) K. pneumoniae, 3 (7.9 %) Proteus spp., 1 (2.6 %) each M. morganii and C. freundii. Thirty (79 %) harbored blaCTX-M genes. Sequence analysis revealed that they were all blaCTX-M-15 genes. Twenty-nine (96.7 %) of these, also harbored blaTEM genes simultaneously. All the CTX-M-15-producing isolates carried insertion sequence blaISEcP1 upstream of blaCTX-M-15 genes. The E. coli isolates were genetically heterogeneous, while the K. pneumoniae had 98 % homology.ConclusionsOur point-prevalence surveillance study revealed a high prevalence of Enterobacteriaceae isolates harboring blaCTX-M-15 in the Hospital. Urgent implementation of antibiotic stewardship and other preventive strategies are necessary at this time in our hospital.

Penile Injuries In Lagos State University Teaching Hospital Ikeja: A 7-year Experience

Background : Injuries to the penis are not frequent events and usually not life threatening. However, they may be associated with significant long term psychological and functional impairment. This study elucidates the clinical spectrum of penile injuries in the Lagos State University Teaching Hospital and how they were managed. Methods: This was a 7-year retzrospective study of all cases of penile injury managed in the Urology unit of a teaching hospital in South West Nigeria; between February 2006 and January 2012. Results : There were 50 cases of penile injury, with the age range between 4 weeks to 49 years and an average age of 12.1 years. Circumcision and sex-related causes accounted for 76% and 18% of the injuries respectively, while occupation and ritual-related causes accounted for 2% each. Urethro-cutaneous fistula (n=22, 44%), penile fracture (n=9, 18%) and penile amputation (n=5,10%) were the commonest injury types. All the cases were managed operatively. Coculusion: Circumcision was the leading cause of penile injury in this study. Mass education of all categories of circumcisers on safe circumcision practices would be desirable.

Haematological values in homozygous sickle cell disease in steady state and haemoglobin phenotypes AA controls in Lagos, Nigeria.

BackgroundSickle cell disease is a genetic abnormality involving the haemoglobin. Although, it is primarily a red cell disorders, the white blood cells and platelets are also affected by the mutation. The consequent haemoglobin S causes polymerization of haemoglobin resulting in haemolysis and anaemia. This study aims to provide baseline haematological values in sickle cell disease patients in steady state and compare the deviation from haemoglobin phenotype AA control values.MethodsA case–control study was conducted amongst homozygous sickle cell patients attending the sickle cell clinics of Lagos State University Teaching Hospital Ikeja and haemoglobin phenotype AA controls. About 4.5mls of blood sample was collected from each participant for full blood count analysis. All blood samples were screened for HIV and haemoglobin phenotypes confirmed using cellulose acetate haemoglobin electrophoresis at pH 8.6.ResultsA total of 103 cases and 98 controls were enrolled. The overall mean haemoglobin concentration for cases was 7.93 ± 1.47 g/dl, packed cell volume 24.44 ± 4.68%, mean cell volume 81.52 ± 7.89 fl, and mean cell haemoglobin 26.50 ± 3.20 pg. While for controls, mean haemoglobin concentration was 13.83 ± 1.32 g/dl, packed cell volume 43.07 ± 3.95%, mean cell volume 86.90 ± 4.69 fl, and mean cell haemoglobin 28.50 ± 1.34 pg. The overall mean white blood cell counts for the cases was 10.27 ± 3.94 *103/μl and platelet counts of 412.71 ± 145.09*103/μl. While white blood cell count for the controls was 5.67 ± 1.59*103/μl and platelet counts of 222.82 ± 57.62*103/μl.ConclusionHomozygous sickle cell disease patients have lower values of red cell parameters, but higher values of white cell and platelets counts compared to haemoglobin phenotype AA controls.

Seroprevalence of hepatitis B e antigen (HBe antigen) and B core antibodies (IgG anti-HBcore and IgM anti-HBcore) among hepatitis B surface antigen positive blood donors at a Tertiary Centre in Nigeria

BackgroundHepatitis B virus (HBV) is a common cause of liver disease throughout the world. HBV is transmitted through blood and other body fluids, including semen and saliva. Chronic replication of HBV virons is characterized by persistence circulation of HBsAg, HBeAg and HBV DNA; usually with anti-HBc and occasionally with anti-HBs. Aim: To determine the prevalence of HBeAg, IgG anti-HBcore and IgM anti-HBcore amongst HBsAg positive blood donors. These parameters are reflective of transmissibility and active hepatitis B infection. A cross sectional study was carried out at the blood donor clinics of Lagos State University Teaching Hospital Ikeja and Lagos University Teaching Hospital Idiaraba. A total of 267 donors were recruited to determine HBe antigen, IgG and IgM anti-HBcore antibodies amongst hepatitis BsAg positive donors. Five milliliters of blood was collected from those who tested positive to HBsAg screen during donation. The sera were subjected to enzyme linked immunosorbent assay (ELISA). Pearson chi-squared test was used for the analytical assessment.FindingsA total number of 267 HBsAg positive blood donors were studied. A seroprevalence of 8.2% (22 of 267) HBeAg was obtained, 4 of 267 (1.5%) were indeterminate while 241 (90.3%) tested negative. Only 27 out of 267 donors (10.1%) tested positive to IgM anti-HBcore, 234(87.6%) tested negative, while 6(2.2%) were indeterminate. A higher percentage of 60.7% (162 of 267) tested positive to IgG anti-HBcore, while 39.3% (105 of 267) tested negative.ConclusionThere is a low seroprevalence rate of HBeAg-positive chronic hepatitis and relatively high IgG anti-HBcore and IgM anti-HBcore rates in South West Nigeria.

Seroprevalence of Toxoplasma gondii antibodies amongst pregnant women at Lagos State University Teaching Hospital

Background: Toxoplasma gondii (T.gondii), an obligate intracellular parasite found in many species throughout the world, causes a variety of clinical syndromes in humans and animals. It is also associated with morbidity and mortality in pregnancy. Hence the need to determine the seroprevalence of antibody to toxoplasmosis gondii amongst pregnant women. Methods: A cross-sectional study was carried out using patients attending the ante-natal clinic of Lagos State University Teaching Hospital Ikeja. All consenting newly registered antenatal patients were recruited consecutively into the study within a time frame of six weeks during which a total of 179 pregnant participants were obtained. Participants filled self administered questionnaires. Five milliliters of blood was collected from each participant after obtaining patient's consent. Sera were assayed for antitoxoplasmosis IgG antibody by enzyme linked immunosorbent assay. (ELISA.) Results: A total of 179 pregnant women were studied. An assessment of patients’ status to anti-toxoplasmosis IgG showed 40.8% were positive while 59.2% were negative. Conclusion: It appears that seroprevalence of toxoplasmosis IgG antibody amongst the pregnant women in this study population is high. Therefore, it is valuable to follow up the IgM–antibody status of their off springs which indicates recent exposure. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive

Comparing the specificity and sensitivity of nitrate and leucocyte tests on multistick in screening for urinary tract infections amongst pregnant woment at Lagos State University Teaching Hospital Ikeja, Nigeria

This study was carried out to determine a very reliable and rapid screening test using multistick (or multistix), microscopy, and culture methods for urinary tract infections (UTI) in pregnant women attending the antenatal booking clinic (ANC) of the Department of Obstetrics and Gynaecology of Lagos State University Teaching Hospital, Ikeja, Nigeria. A group of 352 pregnant women were randomly selected at the antenatal booking clinic and evaluated for urinary tract infections (UTI) using the above mentioned screening test methods. The ages of patients ranged from 20 to 40 years, with the 31-35 age range accounting for over 42% of the study population, and two-thirds of them being multigravidae. Positive urine culture with significant bacteriuria was found in 163 patients which was 46.3%. One hundred and thirty three (133) of this number did not present with urinary symptoms at all, although pair urine culture was positive with significant bacteriuria. Also, eleven patients of the study population has urinary symptoms but their urine culture did not yield any significant growth, after 48 hours of incubation. It was found in this study that leucocyte dipstick test has excellent specificity (90.5%) but not a very good sensitivity (28.8%), when compared with nitrite dipstick which has a specificity of 78.8% and sensitivity of 56.4%.

Adult Haematooncology Cases: A Six Year Review At Lagos State University Teaching Hospital Ikeja

BACKGROUND: Heamato-oncology is a malignant neoplasia of the blood and blood forming organs, such as the bone marrow, blood cells, and lymphoid tissues. The overall goal of the study was to determine the frequency distribution of Hematooncological cases seen at the Lagos State University Teaching Hospital IkejaMATERIALS & METHODS: This was a retrospective review of Hemato-oncological cases seen at the Lagos State University Teaching Hospital Ikeja over a period of six years from 1st January 2001 to 31st December 2006, who presented at Lagos State University Teaching Hospital Ikeja. All case notes of patients seen at the clinic and those admitted through the medical emergency were retrieved and relevant data were extracted to a standard. form.RESULTS: A total of eighty-one case notes were seen consisting of 23{28%} each. of Chronic Myeloid Leukemia and Chronic Lymphocytic Leukemia.. Twelve cases {14.6%} of Non-Hodgkin’s lymphoma, ten cases {12.2%} of Multiple Myeloma, seven {8.5%} of Acute Lymphoblastic Leukemia, five {6.1%} of Hodgkin’s lymphoma, and one {1.2%} of Acute Myeloid Leukemia.CONCLUSION: Acute Lymphoblastic Leukemia was noted to be commoner than Acute Myelogenous Leukemia in adult contrary to Literature findings, Chronic Lymphocytic leukemia and Multiple Myeloma were diagnosed mainly in the elderly in keeping with other previous studies and Non-Hodgkin’s lymphoma is also commoner than Hodgkin’s lymphoma in this environment.

Adult Haematooncology Cases: A Six Year Review At Lagos State University Teaching Hospital Ikeja

BACKGROUND: Heamato-oncology is a malignant neoplasia of the blood and blood forming organs, such as the bone marrow, blood cells, and lymphoid tissues. The overall goal of the study was to determine the frequency distribution of Hematooncological cases seen at the Lagos State University Teaching Hospital IkejaMATERIALS & METHODS: This was a retrospective review of Hemato-oncological cases seen at the Lagos State University Teaching Hospital Ikeja over a period of six years from 1st January 2001 to 31st December 2006, who presented at Lagos State University Teaching Hospital Ikeja. All case notes of patients seen at the clinic and those admitted through the medical emergency were retrieved and relevant data were extracted to a standard. form.RESULTS: A total of eighty-one case notes were seen consisting of 23{28%} each. of Chronic Myeloid Leukemia and Chronic Lymphocytic Leukemia.. Twelve cases {14.6%} of Non-Hodgkin’s lymphoma, ten cases {12.2%} of Multiple Myeloma, seven {8.5%} of Acute Lymphoblastic Leukemia, five {6.1%} of Hodgkin’s lymphoma, and one {1.2%} of Acute Myeloid Leukemia.CONCLUSION: Acute Lymphoblastic Leukemia was noted to be commoner than Acute Myelogenous Leukemia in adult contrary to Literature findings, Chronic Lymphocytic leukemia and Multiple Myeloma were diagnosed mainly in the elderly in keeping with other previous studies and Non-Hodgkin’s lymphoma is also commoner than Hodgkin’s lymphoma in this environment.

Seroprevalence of Toxoplasma gondii antibodies amongst pregnant women at the Lagos State University Teaching Hospital, Nigeria

Toxoplasma gondii (T.gondii), an obligate intracellular parasite found in many species throughout the world, causes a variety of clinical syndromes in humans and animals. It is also associated with morbidity and mortality in pregnancy. Hence the need to determine the seroprevalence of antibody to toxoplasmosis gondii amongst pregnant women. A cross- sectional study was carried out using patients attending the ante-natal clinic of Lagos State University Teaching Hospital Ikeja. All consenting newly registered ante-natal patients were recruited consecutively into the study within a time frame of six weeks during which a total of 179 pregnant participants were recruited. Literate participants filled self administered questionnaires whilst the non-literate participants were interviewed by research assistants. Five milliliters of blood was collected from each participant after obtaining patient's consent. Sera were assayed for antitoxoplasmosis IgG antibody by enzyme linked immunosorbent assay. (ELISA.) A total of 179 pregnant women were studied. Almost 50.8% were between the ages of 25-30 years, 70.8% of the patients studied, had tertiary education. An assessment of the patients' status to anti-toxoplasmosis IgG showed 40.8% were positive while 59.2% were negative. Pet-keeping was a practice amongst only 6.1% of patients whilst 90.5% did not keep pets. Out of those who kept pets, 63.6% were positive while 39.5% were negative. Amongst those who did not keep pets, 39.5% were positive while 60.5% were negative. This difference was not statistically significant. (P=0.261) It appears that seroprevalence of toxoplasmosis IgG antibody amongst the pregnant women in this study population is high. Therefore, it is valuable to follow up the IgMantibody status of their off springs as its presence indicates recent exposure.