State Of Hemodynamics Research Articles

Effect of different variants of non-invasive ventilation on the course and outcomes in patients with hypoxemic respiratory failure caused by SARS-nCoV-2 ( COVID-19)

Hypoxemic respiratory failure (HRF) or acute respiratory distress syndrome is the most common and severe complication in patients with COVID-19, requiring oxygen and ventilation support. Non-invasive ventilation methods (NIV) allow to maintain adequate oxygenation in patients with HRF, but it remains unclear which NIV regimen is more effective for reducing the need for invasive ventilation and improving outcomes.The aim. To compare the effect of different non-invasive lung ventilation strategies, namely CPAP+PSV and CPAP without PSV on the results of intensive care of patients with HRF caused by SARS-nCoV-2 (COVID-19).Materials and methods. A prospective single-center study of 59 patients with severe SARS-nCoV-2 (COVID-19) with HRF was performed. Depending on the type of NIV, patients were divided into two groups: in patients of group 1 (n=46) respiratory support was performed in CPAP mode without PSV, in patients of group 2 (n=13) - CPAP+PSV. All patients underwent clinical blood tests, biochemical studies aimed at assessing the severity of COVID-19, visualization of lung tissue (chest radiography, ultrasound to determine the profile of B and C), monitoring of gas exchange, echocardiography to assess the state of central hemodynamics. Statistical analysis of the results was performed using the program “Statistica 10”. Estimated mean values, standard deviation. The relative risk (RR) of adverse events was assessed.Results. The use of CPAP without PSV improves the results of intensive care of patients with severe coronavirus disease with the development of HRF.Conclusions. CPAP NIV is a promising method of respiratory support in patients with moderate to severe ARDS caused by SARS-nCoV-2 virus (COVID-19), which needs further study

Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin

Aim.To evaluate the effect ofb-blockers (BB) on myocardial remodeling and endothelial adhesive function in patients with chronic heart failure (CHF) and atrial fibrillation (AF) of ischemic origin.
 Material and methods.The study included 77 patients with functional class IIIII CHF and AF who had previously suffered a large-focalQ-myocardial infarction. Patients were randomized into 2 groups, comparable in clinical and instrumental characteristics and homogeneous in basic therapy of CHF and AF. Group 1 included 40 patients who took carvedilol for 24 weeks as part of the basic therapy of CHF and AF, and group 2 included 37 patients who received metoprolol tartrate. We used clinical and instrumental (echocardiography, 6-minute walking test, clinical assessment scale) and enzyme immunoassay (analysis of the level of soluble molecules of intercellular adhesion sVCAM-1 and sE-selectin) research methods.
 Results.The use of carvedilol a non-cardioselective BB that performsa1,b1andb2-adrenoblockade, andb1-selective, short- acting BB metoprolol tartrate as part of basic therapy improved the clinical condition and physical performance of patients with CHF and AF. It was found that carvedilol more significantly than metoprolol affects the state of intracardiac hemodynamics, slows down the processes of remodeling of the left atrium and left ventricle, increases the contractile function of the myocardium. Carvedilol as part of basic therapy reduces endothelial adhesion and inhibits the overexpression of intercellular adhesion molecules sVCAM-1 and sE-selectin, and when using metoprolol tartrate, there is only a tendency to decrease these indicators.
 Conclusion.Carvedilol as part of the basic therapy of CHF and AF has significant endothelial-protective and clinical-hemodynamic effects, positively affects the adhesive function of the endothelium and the processes of left atrium and left ventricle remodeling.

The application experience of terahertz radiation for osteoarthritis of the knee

The aim of this work was to increase the effectiveness of treatment in patients with osteoarthritis of the knee by including in the treatment complex procedures of electromagnetic radiation of the terahertz range. This study was prospective and randomized. 65 patients were examined and treated. They were divided into 2 groups comparable to sex, age, disease type, and severity. All patients received basic therapy, including drugs and exercise therapy. In addition to the basic treatment, the patients of the main group underwent a course of terahertz therapy using the Emir device with a ceramic coating of the emitter. The study revealed that the procedures of terahertz therapy are well tolerated by patients, do not cause exacerbation and are combined with other methods of treatment of gonarthrosis. Repeated studies at the end of the course of treatment showed that the inclusion of terahertz radiation in the therapeutic complex has a positive effect on the main clinical symptoms of the disease, reducing the intensity of pain in the knee joints and improving their functional state, having a favorable effect on the state of local hemodynamics.

Angiogenic growth factors and hemodynamics in the ovaries in women with menstrual dysfunction in the puberty

To date, there is insufficient information in the literature on studies of the regulatory system of angiogenesis represented by vascular growth factors in women with menstrual dysfunction in the pubertal period.The objective: using the clinical material using clinical, laboratory and instrumental methods to study the state of angiogenic growth factors (VEGF and its receptors VEGF-R1, VEGF-R2) and ovarian hemodynamics, as well as expand the understanding of the mechanisms of development of luteal phase deficiency (LPD) in women with menstrual dysfunction in the puberty.Materials and methods. Studies were conducted among women of reproductive age from 19 to 32 years. According to the nature of the violations, the main group of women (n=90) who had a pathology of menstrual function in the puberty period was divided into 3 subgroups (n=30): the first – women with primary oligomenorrhea in the anamnesis, the second – with a late age menarche, the third – with puberty bleeding. The control group included women (n=30) with the correct rhythm of menstruation in puberty. Biochemical and ultrasound markers of angiogenesis were studied. Results. In women with menstrual dysfunction in the puberty, a decrease in the maximum systolytic blood flow velocity (Vmax) in the ovarian artery in the ovary with a preovulatory follicle was found compared with women in the control group (p<0,01). Blood flow in the arteries of the ovarian stroma with a preovulatory follicle was higher than in the arteries of the opposite ovary (p<0,05), but remained lower than in women with the correct rhythm of menstruation in puberty (p<0,05), and the lowest was noted in women with a primary history of oligomenorrhea (p<0,05). In the preovulatory period of the menstrual cycle in the ovarian arteries and arteries of the ovarian stroma, the vascular resistance indices did not significantly differ. During the corpus luteum stage, the vascular resistance indices in the arteries of the ovarian stroma with the corpus luteum are significantly lower than in the opposite ovary, the lowest in women with pubertal bleeding (subgroup 3). In all subjects from the main group, the vascular resistance indices in the arteries along the periphery of the corpus luteum are lower than along the periphery of the preovulatory follicle. A direct correlation between the vascular resistance indices in the arteries of the ovarian stroma with preovulatory follicle and VEGF and the inverse between VEGF-R1 in women with a history of primary oligomenorrhea indicate an improvement in vascularization of the preovulatory follicle due to newly formed and functioning capillaries.Conclusion. Studies have shown that the formation of a full-fledged preovulatory follicle and corpus luteum in the ovary is affected by microcirculation in the ovarian tissue, the state of which depends on the activity of the angiogenic system represented by VEGF and its receptors VEGF-R1 and VEGF-R2. The establishment of a correlation between VEGF and vascular resistance indices indicates the participation of angiogenic growth factors in ovarian hemodynamics during the formation of the preovulatory follicle in women with menstrual dysfunction in the pubertal period.

Estimation of efficiency of shock wave therapy in patients with chronic nonbacterial prostatitis / chronic pelvic pain syndrome

Estimation of efficiency of shock wave therapy in patients with chronic nonbacterial prostatitis / chronic pelvic pain syndrome

MULTIMODAL METHODS IN THE DIAGNOSIS OF CHANGES IN THE ORGAN OF VISION AT ATHEROSCLEROSIS

Background. The study of the parameters of optical coherence tomography with angiography (OCTA) broadens the understanding of the state of hemodynamics for the early detection of vascular disorders of the organ of vision in atherosclerosis (AS). Purpose. To study the parameters of OCTA with changes in the organ of vision against the background of AS. Material and methods. 26 patients (41 eyes) with changes in the organ of vision in AS. The age contingent of patients ranged from 32 to 78 years, the average age was 47.5 ± 2.0 g, of which 10 were women, 16 men. Depending on the damage to target organs, all patients were conditionally divided into 2 groups: group I (19 eyes) included patients without damage, and group II (22 eyes) consisted of patients with target organs damage. Results. The registration of OCTA in patients of group I, a decrease in the density of capillaries of the superficial vascular network was 15% and amounted to 45.21 ± 2.62% (p <0.05), of the deep vascular plexus by 19%, which amounted to 45.89 ± 2 , 71% (p <0.05). In the macular region, the area of the hypoperfused retina was 1.07 ± 0.14 mm2 (p <0.05). In the region of the optic nerve disc, areas of hypoperfusion were noted in the superficial layers in 7 eyes and in the deep layers in 4 eyes. Analysis of OCTA in patients of group II revealed a sharp decrease (by 48%) in the density of capillaries in both the superficial and deep vascular plexuses of the retina, which amounted to 33.91 ± 3.01% (p <0.05); 33.65 ± 2.89% (p <0.05), respectively. In the macular region, the area of the non-perfused retina was 2.19 ± 0.21 mm2 (p <0.05). In the area of the optic nerve disc, areas of nonperfusion were noted both in the surface layers and in the deep layers in 4 eyes. Conclusion. The use of OCTA allows to detect changes in hemoperfusion in all layers of the retina and optic nerve in the early stages of AS development, which will allow early diagnosis and monitoring of the disease. KEY WORDS: optical coherence tomography with angiography, ischemic diseases, organ of vision, atherosclerosis, hemoperfusion, vascular plexuses, retina and optic nerve.

Rehabilitation of patients after septoplasty

Background. In recent years, in the general structure of the incidence of ENT organs diseases, the pathology of the nasal cavity and paranasal sinuses has firmly ranked first both in terms of visits to the clinic and in the group of patients undergoing inpatient treatment, which indicates a trend in an increase in the incidence rate. Septoplasty is one of the most commonly performed rhinological surgeries.
 Aim: to analyze the effectiveness of complex treatment on the state of cerebral hemodynamics in patients with septal deviation after septoplasty.
 Methods. Rehabilitation of patients was performed in several stages. Preoperative preparation included low-intensity laser exposure along with drug therapy. In this study, in order to prevent complications and activate reparative processes, patients of the main group (n=40) received additional bipolar-pulse irritative current therapy, while the control group patients (n=10) received only standard drug therapy.
 Results. Patients of the main group showed an increase in treatment efficiency, a significant improvement in the clinical condition and indicators of cerebral hemodynamics compared with the control group.
 Conclusion. To prevent complications and activate reparative processes in modern rehabilitation, it is necessary to integrate therapeutic measures, which can include, in addition to surgical methods, drug therapy (anti-inflammatory drugs, antihistamines, anticholinergics, etc., as well as physical factors (medicinal electrophoresis, ultraphonophoresis, laser therapy, magnetotherapy, etc.).

The Effect of Cytoflavin on the Outcome of Ischemic Stroke in Children

The aim of the study is to assess the impact of cytoflavin inclusion on the dynamics of indicators of arterial ischemic stroke of various etiologies in children. Dynamic monitoring of 47 children with arterial ischemic stroke was carried out, 30 of them received cytoflavin via a slow intravenous drip infusion with 5 ml of the drug per 100 ml of saline for 10 days. Subsequently, after 2, 6 months and one year patients received the tablet form of the drug 2 times a day in the 1st year after the disease in the complex of rehabilitation measures, in the course of 25 days. The control group consisted of 17 patients who received only basic therapy. In addition to the conventional methods of assessment, transcranial ultrasound dopplerography and electroencephalogram were performed; patients were assessed using the pedNIHSS and PSOM-SNE scales. The severity of seizures was evaluated according to the NHS3 scale. The degree of impaired consciousness was evaluated using Glasgow Coma Scale. It was revealed that the inclusion of cytoflavin in neurometabolic correction in patients with arterial ischemic stroke positively affects the state of cerebral hemodynamics, which is confirmed by transcranial ultrasound dopplerography. The clinical effect of the inclusion of the drug in the treatment regimen is manifested by a decrease in sensorimotor and cognitive impairment, a reduced risk of epileptic activity foci forming as a result of a penumbra zone decrease, which ultimately increases the rehabilitation potential of children with ischemic stroke.

State of central hemodynamics and myocardial contractility in vibration disease

The article describes the peculiarities of Central hemodynamics and myocardial contractility in patients with vibration disease, various forms and degrees of severity with the help of echocardiography of the Department of pathology of the regional center of occupational pathology of SBME "Samara mediko-a sanitary part of № 5 of Kirov district". It was found that patients with vibration disease are characterized by the formation of a phase syndrome of myocardial hyperdynamics and a hyperkinetic variant of Central hemodynamics, while hemodynamic changes depend on the form of vibration disease, the severity of the disease, and the length of work in contact with vibration.

Comparative evaluation of pre-infusion at caesar section performed under spinal anesthesia. Results of multicenter trial

Abstact. Study of the effect of preinfusion, various infusion solutions on the state of hemodynamics, in patients undergoing a cesarean section performed under spinal anesthesia with 0.5 % solution of Longocain Heavy (0.5 % hyperbaric bupivacaine).Materials and methods. Spinal anesthesia (SAN) was performed in 2 190 women, aged 21 to 39 years, with a gestational age of 39 to 40 weeks. The structure of extragenital pathology was dominated by chronic anemia of varying severity – 1 650 (75.3 %), urinary tract infections – 756 (34.5 %), mild preeclampsia – 245 (11.2 %), chronic nonspecific lung diseases – 125 (5.7 %). 1 786 (81.5 %) patients underwent surgery in a planned manner, according to emergency indications – 404 (18.4 %). A combination of the two pathologies was observed in 852 (38.9 %) women. Indications for surgery were: disease of the operated uterus, insolvency of the scar on the uterus, clinically narrow pelvis, high-grade myopia, secondary labor weakness. The duration of surgery is ranged from 40 to 52 minutes.Results. In group I, the expressed hypotension, requiring sympathomimetic support with mezaton was observed in 192 (34.8 %) patients. In group II, severe hypotension requiring sympathomimetic support with mezaton was observed in 114 (20.8 %) patients. And in group III, hypotension requiring sympathomimetic support with mezaton was observed in 127 (23.2 %) patients. At that time, in patients of group IV severe hypotension, requiring sympathomimetic support with mezaton was observed in only 91 (18 %) cases.Conclusions. Neuraxial anesthesia is accompanied by the development of hypotension, which can be prevented by preinfusion with crystalloid solutions. Aggressive preinfusion of large volumes of isoosmolar crystalloids at a dose of 10–14 ml/kg was associated with an increase in the frequency of hemodynamic instability requiring sympathomimetic support.

PHARMACOLOGICAL FEATURES OF MEDICINAL PRODUCTS WITH MINERALCORTICOID ACTIVITY IN NEPHROLOGICAL PRACTICE

Introduction. Mineralocorticoids mainly affect the exchange of electrolytes, promote retention in the body of sodium, chlorides and water, and accelerate the excretion of potassium, calcium and magnesium. Their synthesis and blood supply are regulated mainly by angiotensin-II, which makes it possible to consider aldosterone as a part of renin-angiotensin-aldosteon system, which ensures the proper state of water-salt metabolism and hemodynamics. 
 The purpose. Consider the relationship of dynamic balance of mineralocorticoids in patients with kidney and adrenal lesions.
 Material and methods. Review of contemporary and foreign literary sources; techniques - description, analysis, abstracting. 
 Results. The pathogenesis of the development and progression of adrenal and kidney damage is closely associated with impaired synthesis, absorption of mineralocorticoids. The glucocorticoid activity of aldosterone roughly corresponds to 1/3 of cortisone. Main target organs of the hormone are salivary glands and kidneys. In the kidneys, aldosterone enhances sodium reabsorption. In pathological cases, the prolonged presence of chlorides and water in the body leads to the development of edema, hypernatremia, hypokalemia, hypervolemia, arterial hypertension, and sometimes, to the development of congestive heart failure. It poses particular danger in patients with impaired renal function. Deoxycorticosterone acetate (DOCSA) is a synthetic analogue of the Mineralocorticoids of the adrenal cortex. The drug is indicated for rapid-flowing adrenal hypofunction (addisonism), for myasthenia (increases muscle tone and performance), shock and trauma, for hypocorticism. Spironolactone is effective in swelling associated with increased aldosterone production, congestive heart failure, liver cirrhosis and nephrotic syndrome. Conclusions. Patients with kidney and adrenal lesions may have a violation of mineralocorticoid homeostasis, for the correction of which synthetic mineralocorticoids and their analogues, mineral and glucocorticoid antagonists, are used.

Состояние артериальной и венозной церебральной гемодинамики у пациентов с различными видами головной боли

Состояние артериальной и венозной церебральной гемодинамики у пациентов с различными видами головной боли

SERUM NATRIURETIC PEPTIDE CONCENTRATION AND PARAMETERS OF CENTRAL HEMODYNAMICS IN FIREFIGHTERS AT THE BEGINNING AND AT THE END OF THE 24-HOURS SHIFT

Aim: to study associations between concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) and indices of central hemodynamics in firefighters at the beginning and at the end of the 24-hours shirt. Methods: Altogether, 240 firefighters (aged 25-47 years) in the Tver region participated in the study. They were divided into three groups: 1-6, 7-15, 16-25 yearsof experience. Serum NT-proBNP level was measured using EIA assay. Several central hemodynamic parameters were assessed by tetrapolar thoracic rheography at the beginning and end of the 24-hours shift. Independent-samples ANOVA with Bonferroni post-hoc tests were applied for numeric variables. Before-after comparisons were performed using paired t-tests. Associations between the studied variables were assessed by Pearson's correlation coefficients. Results: The average concentration of NT-proBNP increased from 2.23 ± 0.11 at the beginning to 2.95 ± 0.10 f / mol / ml (p = 0.037) at the end of the shift in the first group. In the second and in the third groups an increase was from 4.11 ± 0.09 to 5.81 ± 0.18 f / mol / ml (p = 0.009) and from 3.41 ± 0.10 to 4.59 ± 0.17 f / mol / ml (p = 0.020). The correlation coefficients for the associations between NT-proBNP and volume of blood circulation changed from r = -0.46 (-0.65; -0.37) to r = 0.73 (0.69; 0.77), shock index from r = -0.42 (-0.62; -0.22) to r = 0.71 (0.65; 0.77) and cardiac index with r = -0.32 (-0.55; -0.19 ) to r = 0.82 (0.81; 0.83). Conclusion: NT-proBNP concentration in firefighters reflects the state of central hemodynamics and its change before and after extreme loads.

Clinicopathogenetic features of cardiovascular system affection in influenza patients with hypertensive reaction revealed for the first time

Aim. To study the state of central hemodynamics, oxygen metabolism and tissue blood flow in patients with influenza who suffered from hypertensive reaction detected for the first time, in dynamics of infectious process.
 Materials and methods. At Perm Regional Clinical Infectious Hospital, 65 patients with influenza underwent a deepened study of cardiovascular system: central hemodynamics and local blood flow.
 Results. While studying the central hemodynamics, there was detected the increased general peripheric vascular resistance without normalization during the follow-up period. Investigation of gas exchange showed decrease in tissue oxygenation, vasodilatation and tissue blood flow.
 Conclusions. Among patients with influenza, the oxygen transport system functions in a tense regime. In dynamics of infectious process and after the disease, the following is observed: development of tissue hypoxia, decrease in local blood flow tempo and elevation of general peripheric vascular resistance.

Influence of operative treatment of variсocele on the development of arterial hypertension

Purpose of the research. To assess the incidence of arterial hypertension in men with varicocele and to identify the relationship between increased blood pressure and surgical treatment of varicocele.
 Material and methods. A survey of 412 men receiving treatment for arterial hypertension, 482 men previously operated on for varicocele and 68 patients with varicocele who had no surgical treatment was conducted.
 Results. Varicose veins of the spermatic cord in patients with arterial hypertension were detected in 44.6% of cases, which exceeds the incidence of varicocele occurrence in men of a comparable age category by 1.52 times. Surgical treatment of the left spermatic cord varicocele is combined with the development of arterial hypertension in 51.2% of patients, which is three times higher than the incidence of hypertension in men who didnt undergo surgical treatment for varicocele and twice the frequency of hypertension in the general population of men of comparable age. The more frequent occurrence of renal arterial hypertension in patients who underwent surgical treatment for varicocele may indicate an adverse effect of occlusion of the internal spermatic vein on the state of renal venous hemodynamics.
 Conclusion. Varicocele should be considered as a compensatory process for renal venous hypertension due to obstruction of blood flow through the renal vein, and elimination of compensatory blood flow can lead to renal venous hypertension, hypoxia and the development of arterial hypertension.

Heart rate variability and systemic hemodynamic state in adults with a first time, non-traumatic epileptic seizure during an orthoclinostatic stress test

The aimof the study was to investigate vegetative maintenance of the activity and state of systemic hemodynamics in patients with a first time, non-traumatic epileptic seizure during a tilt table test (TTT).Materials and methods. TTT was performed in 42 patients with absence of seizures and 78 patients having experienced unprovoked seizures. A control group included 70 patients with non-epileptic seizures with transient loss of consciousness (TLC), defined as syncope. The control group included 38 people without episodes of loss of consciousness in their medical history. The parameters of hemodynamics and heart rate variability (HRV) were investigated at all stages of the test.Results. In patients with absence of seizures, initial sympathicotonia was recorded along with a decrease in ergotropic activation in orthostasis. In patients with unprovoked seizures, a hypersympathicotonic response to the orthostatic test was detected in combination with impaired vagal overshoot in the clinostatic phase of the test. In patients with TLC, evidence of vegetative insufficiency in the vertical position was identified, with the indicators going back to the background values in the horizontal position.Conclusion. The revealed features of vegetative regulation in patients with absence of seizures and unprovoked seizures will allow to differentiate the mechanism of the first-time epileptic seizure more accurately.

FEATURES OF CEREBRAL CIRCULATORY DYNAMICS AND CEREBRAL BIOELECTRIC ACTIVITY IN CHILDREN WITH CRANIOCEREBRAL INJURY

In order to study the state of cerebral hemodynamics and to investigate the electroencephalographic characteristics in children with closed traumatic brain injury, 114 patients were examined. The children were examined in 6.1±0.8 months after a traumatic brain injury. To determine cerebral hemodynamics, transcranial dopplerography was performed, the functional state of brain was evaluated according to electroencephalography. In the course of the study, it was noted that a disordered cerebral hemodynamics in children with moderate and severe brain contusion and its foci presence was accompanied by a rise in a linear velocity of blood flow, while its decrease was found at the same contusion, but that was severe and with the presence of subdural, subarachnoid and epidural hemorrhage. Signs of diffuse changes in bioelectrical activity of the brain were represented by a significant increase in an amplitude of the alpha rhythm in children with closed traumatic brain injury of moderate and serious severities compared to mild one. Key words: children, craniocerebral injury, electroencephalography, transcranial Doppler sonography, paroxysmal activity.

The state of cerebral venous hemodynamics in patients with hypertensive encephalopathy

The state of cerebral venous hemodynamics in patients with hypertensive encephalopathy

Показатели центральной гемодинамики по данным ЭхоКГ у больных хронической болезнью почек на фоне хронического пиелонефрита

Aim. To study the state of central hemodynamics measured with echocardiography in patients with chronic renal disease on the background of chronic pyelonephritis caused by nephrolithiasis and dysmetabolic nephropathy in the phase of incomplete remission and combined with arterial hypertension. Materials and methods. 81 patients with chronic renal disease on the background of chronic pyelonephritis associated with nephrolithiasis in the phase of incomplete clinical and laboratory remission were investigated. Age varied from 25 to 60 years, average age was 46 ± 9.0 years. The study wasperformed at “Tyumen RZHD – hospital” and “Tyumen SMU – multidisciplinary clinic”. Results. Patients with chronic renal disease on the background of chronic pyelonephritis and arterial hypertension had impaired left ventricular diastolic function, characterized by a significant increase in such indicators as the rate of early and late LV filling and the time of isovolumetric relaxation, a decrease in the E/A ratio, with preserved systolic function of left ventricular. Conclusion. Patients with chronic renal disease on the background of chronic pyelonephritis due to nephrolithiasis, combined with arterial hypertension in the absence of severe left ventricular hypertrophy, have diastolic function disorders, preserved left ventricular systolic function, which may contribute to the chronic heart failure.

ВОЗРАСТНЫЕ ОСОБЕННОСТИ РЕОЭНЦЕФАЛОГРАФИИ, СВЯЗАННЫЕ С ФАЗАМИ ДЫХАНИЯ

The article presents the results of a study on the cerebral hemodynamics of residents of the Volgograd region (165 respondents: 18–35 years old; 50–55 years; 56–60 years and over 61 years), making it possible to identify the parameters that are the most informative for assessing of blood supply disorders of the brain. Objective: to study the age features of cerebral blood circulation connected with breath phases. Evaluation of the functional state of the cerebral hemodynamics was carried out on the basis of comprehensive studies of blood supply to the brain (rest and against the background of respiratory test) using the method of reoencephalography. The reoencephalographic examination was performed in 4 leads (FM, OM left hemisphere; FM, OM right hemisphere). Indicators were registered: integral index of pulse filling, amplitude-frequency index, rheographic index, time of propagation of the rheographic wave, average vessel filling rate, venous outflow, dicrotic index, diastolic index. Decrease in total pulse blood filling of the brain at respondents of 50–55 years is revealed. In the dynamics of respiratory test myogenic reactions of vasoconstriction of resistive arteries of the brain in people of older age (50–55 years and older) are slightly expressed. The limit of vasoconstrictor reactions caused by the aging of the body is the cause of deterioration of the conditions of regional blood outflow. The inconsistency of the ratio of regional blood flow to its outflow is a marker of the reduction of adaptive reactions of the circulatory system of people over 50 years of age with an increase in venous pressure in the upper vena cava system. The information value, efficiency and safety of the reographic study at rest and against the background of respiratory test allows it to be recommended for inclusion in the plan of dispensary observations, especially those over 50 years of age.