The aim of the article is a comprehensive analysis of the foreign policy course of U.S. President J. Biden’s administration regarding the war in Gaza. The article examines the formation of principled positions by the American president and his team regarding the war in Gaza in the context of preventing the spread of hostilities to the entire region of the Middle East, the post-war fate of Gaza and the need to implement a two-state solution to the Palestinian-Israeli conflict, prospects for resuming the process of normalization of relations between Israel and Arab countries. Research methods include a set of general and special research methods, including systematic and comparative analysis, methods of critical analysis of sources. The scientific novelty of the study lies in the fact that its author was one of the first in Ukrainian historiography to make a systematic analysis of the foreign policy course of US President J. Biden’s administration regarding the war in Gaza. The study was conducted in the context of war challenges and risks and in view of the next presidential election in the United States in November 2024. Special attention is paid to introducing the latest American, Israeli and Arab sources into scientific circulation. The author concludes that there is a close relationship between the war in Gaza and the Russian aggression against Ukraine, which allowed Biden to combine these two problems into one package of actions. The author of the article also distinguishes two stages in the implementation of the policy of the US President J. Biden’s administration regarding the war in Gaza. The first stage (October – December 2023) is marked by the formation of the main principles and directions of this policy, realizing that the main condition for resolving the long-term Palestinian-Israeli conflict is the creation of an independent Palestinian state. Its second stage (January 2024 – until now) is characterized by working out the ways of radical transformation of Gaza in the post-war period, with the financial help of the Arab monarchies.