PurposeIn developing countries such as India, start-ups play an essential role in “industrial output,” “Gross Domestic Product ” and “employment creation.” Evidence suggests that pandemics have risen over the last century due to rising global travel and assimilation, urbanization, alterations in land use, and significantly larger exploitation of the natural environment. These trends are likely to continue and intensify. These pandemic episodes affect businesses, especially start-ups. Supplier selection is among the vital critical elements that start-ups must include in start-ups' strategy procedures during the pandemic episodes. This study's focus is to “identify,” “analyze,” and “categorize” the factors affecting supplier selection in start-ups during frequent pandemic episodes like coronavirus disease 2019 (COVID-19).Design/methodology/approachThrough “literature review” and “experts' opinion” from various start-ups in India, ten affecting factors were identified. Total Interpretative Structural Modeling (TISM) and Cross-Impact Matrix Multiplication Applied to Classification (MICMAC) were employed to analyze the interrelationship among the factors affecting the supplier selection on start-ups during frequent pandemic episodes, and these factors were ranked as “autonomous,” “independent,” “linkage,” and “dependent” factors.FindingsThe findings show that “performance history,” “service levels,” “technical capability,” and “financial stability” are the most critical factors affecting the supplier selection on start-ups during frequent pandemic episodes. The next importance should be safety and environmental concern” and “quality.”Research limitations/implicationsThe factors affecting supplier selection on start-ups during frequent pandemic episodes are the current focus of this study. This study is mainly performed on Indian start-ups and can be extended to other countries.Practical implicationsThe start-ups can rely on this study to clearly understand the factors affecting the supplier selection on start-ups during frequent pandemic episodes.Originality/valueThere is no research regarding factors affecting supplier selection on start-ups during the COVID-19 emergencies. This research gap is filled by analyzing aspects linked to supplier selection in start-ups. This gap inspired the present study, which employs the “Total Interpretive Structural Modeling (TISM)” technique to uncover supplier selection determinants and investigate hierarchical interconnections among factors influencing/affecting supplier selection in start-ups during frequent pandemic episodes.