SnCl2 Research Articles

Engineering a hierarchical reduced graphene oxide and lignosulfonate derived carbon framework supported tin dioxide nanocomposite for lithium-ion storage

Tin dioxide (SnO2) is widely recognized as a high-performance anode material for lithium-ion batteries. To simultaneously achieve satisfactory electrochemical performances and lower manufacturing costs, engineering nano-sized SnO2 and further immobilizing SnO2 with supportive carbon frameworks via eco-friendly and cost-effective approaches are challenging tasks. In this work, biomass sodium lignosulfonate (LS-Na), stannous chloride (SnCl2) and a small amount of few-layered graphene oxide (GO) are employed as raw materials to engineer a hierarchical carbon framework supported SnO2 nanocomposite. The spontaneous chelation reaction between LS-Na and SnCl2 under mild hydrothermal condition generates the corresponding SnCl2@LS sample with a uniform distribution of Sn2+ in the LS domains, and the SnCl2@LS sample is further dispersed by GO sheets via a redox coprecipitation reaction. After a thermal treatment, the SnCl2@LS@GO sample is converted to the final SnO2/LSC/RGO sample with an improved microstructure. The SnO2/LSC/RGO nanocomposite exhibits excellent lithium-ion storage performances with a high specific capacity of 938.3 mAh/g after 600 cycles at 1000 mA g−1 in half-cells and 517.1 mAh/g after 50 cycles at 200 mA g−1 in full-cells. This work provides a potential strategy of engineering biomass derived high-performance electrode materials for rechargeable batteries.

In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models

Objective The objective of this study was to develop radiolabeled ibuprofen (99mTc-ibu) for imaging and discrimination of inflammation and infection and compare its biodistribution in two different animal models. Significance The development of radiolabeled ibuprofen as an imaging agent for inflammation and infection may have significant clinical implications for the diagnosis and management of various inflammatory and infectious diseases. This study provides a promising approach to the detection of sterile infections. Methods Ibuprofen was radiolabeled with 99mTc using the stannous chloride method with a yield of 99.05 ± 0.83% (n = 5). The in vivo biological behavior of radiolabeled ibuprofen was determined in Wistar albino rat models of sterile inflammation and bacterial infection with Staphylococcus aureus gram-positive bacteria. Biodistribution studies were carried out at different time points, and the results were compared between the two animal models. Results The uptake of 99mTc-ibu in sterile inflammation sites at all time points was higher than that in the infection sites. This suggests that 99mTc-ibu can be used to discriminate between sterile inflammation and bacterial infection. Conclusions The results of this study suggest that the detection of sterile infections with 99mTc-ibu is possible and highly encouraging.

99mTc-linezolid as a radiotracer for brain abscess: Labeling, in silico docking, and biodistribution studies

Brain abscess is a life-threatening condition that requires a timely and accurate diagnosis. In this study, linezolid, an oxazolidinone antibiotic, was labeled with technetium-99m according to the stannous chloride method. The labeling reaction factors were studied and optimized to achieve a high yield (97.4 ± 2.3%). The 99mTc-linezolid was radio- and physico-chemically characterized to assess its suitability as a radiopharmaceutical for the brain. In-silico docking to target peptidyltransferase showed an optimal binding fit (energy = −66.6 Kcal/mol). The complex was biologically evaluated in-vitro using binding assays in alive and heat-killed bacteria and in-vivo in an MRSA brain infection model. All results suggested that the labeled complex could potentially be a new nuclear imaging agent to diagnose and localize brain abscesses specifically.

Microstructure and elemental analysis of iron-based powder composite materials

This paper studies the kinetics of structure formation of an iron-bronze composite containing solid lubricants. Depending on the compacting pressure and sintering temperature, binary and complex phases are detected in the iron-bronze structure. The presence of solid lubricants in the composition of the composite material significantly reduces interaction of the liquid (bronze) and solid (iron) phases during sintering. Talc and graphite, which are heat–resistant at a sintering temperature of 850 – 1150 °C, were used as solid lubricants. The presence of talc, located on the surface of compressed particles of iron, copper, tin and graphite, significantly reduces the effect of their interaction. At the same time, the micro-talc particles envelop them, and its thermal stability retains this state up to high temperatures (approximately 900 °C). It was established that there is no perlite in the microstructure of iron-bronze sintered at a temperature of 850 °C. This can be explained by the talc adsorbing ability on the surface of iron particles which prevents diffusion of carbon into the iron crystal lattice. An increase in the sintering temperature up to 1000 °C leads to the formation of perlite in the iron-bronze structure, while the amount of perlite predominates over ferrite. This indicates the partial burnout of talc from the surface of iron particles and the opening of diffusion paths to carbon. At a sintering temperature of 1150 °C, perlite and a grid of light inclusions are formed in the microstructure of the iron-bronze samples. According to the results of electron microprobe analysis, the light inclusions are solid solutions of variable compositions such as Fe – Cu – Sn, Cu – Fe – Sn, Cu – Sn – Fe. In order to confirm these assumptions, a phase X-ray diffraction analysis was performed. Diffraction patterns of these samples are represented by reflections of iron and copper crystals. The absence of diffraction effects (characteristic of tin crystals) is conditioned by tin solubility in the copper lattice. This is due to the low melting point of tin (232 °C) and its ionic radius, which allows isomorphically replacing of copper and iron ions with tin ions (their difference is less than 15 %).

Mercury Determination in Fish Using Cold Vapour-Atomic Absorption Spectrometry (CV-AAS) with Sodium Borohydride (NaBH4) as the Reductor

Marine fish can potentially accumulate heavy metal pollutants, such as mercury, from anthropogenic activities that can harm people who consume it. Marine fishes like Bandeng fish (Chanos chanos), Banjar fish (Rastrelliger kanagurta), Bawal Hitam fish (Parastromateus niger), Selar Kuning fish (Atule mate), Tenggiri fish (Scomberomorini), and Tuna fish (Thunnini) are consumed a lot by people in Bandung City. All these fish were analyzed using the CV-AAS method with the United States – Environment Protection Agency (USEPA, 2006), and the reducing agent was replaced by stannous (II) chloride with sodium borohydride. Variations in the sample preparation process include drying the sample using an oven and freeze dryer. SEM-EDX in the frozen-dried samples shows that the fibbers’ morphology is intact, while the fibbers are damaged in the hot-dried samples. During characterization using FTIR, there is a slight shift in wave number. The mercury concentrations obtained from every sample were below 0.5 mg/kg based on the Indonesian National Standard (SNI) 2009 standard for total mercury in fish. Therefore, it can be concluded that the samples are safe to be consumed. Validation methods showed that 0.3% sodium borohydride as the reductor can be used to analyze mercury and replace stannous (II)chloride. However, further studies are needed to determine the optimal concentration of sodium borohydride (NaBH4) in the marine fish samples as a reduction agent.

Anti-erosion effect of an experimental varnish on eroded dentin.

This in vitro study evaluated the effect of an experimental varnish containing 20% nano-hydroxyapatite (nHAP) associated with 5% stannous chloride (SnCl2) against erosive-abrasive wear on bovine dentin. Samples of bovine cervical dentin were pre-eroded (0.3% citric acid, pH 2.6 for 10 minutes) and randomized into 4 groups (n=10): Control group - experimental varnish without active ingredient (CG); experimental varnish containing 20% nHAP (nHG); experimental varnish containing 5% SnCl2 (24.800 ppm Sn2+) (SnG); experimental varnish containing 20% nHAP associated with 5% SnCl2 (18.300 ppm Sn2+) (nHSnG). After applying the materials, the erosive-abrasive challenges were performed for five days. Erosive dentin loss and analysis of the pattern of dentinal obliteration were performed by 3D confocal laser microscopy. A one-way ANOVA/Bonferroni test was performed to analyze the data (α=0.05). The SnG and nHSnG experimental groups presented more effectiveness in preventing erosive wear when compared to the other groups (p<0.05). There was no statistically significant difference between the SnG and nHSnG groups (p = 0.731) in tooth structure dentin loss. Regarding the amount of open dentinal tubules, the highest amount of obstructed dentinal tubules was demonstrated in SnG and nHSnG (p < 0.05) when compared to the others. Between SnG and nHSnG there was no significant difference (p = 0.952) in the amount of closed dentinal tubules in the dentin. Experimental varnishes containing 5% SnCl2 associated or not with 20% nHAP showed to be a promising strategy in preventing erosive-abrasive wear of dentin. In addition, nHSnG was able to obliterate dentinal tubules.

Sol-gel synthesis of Tin oxide nanoparticles and their characterizations

Nanotechnology has gained great attention, because nanoparticles have tremendous properties like large surface to volume ratio, quantum confinement effects, and large reactivity. Metal oxides nanoparticles are one of the classes of nanomaterials which are of great interest in previous decades. This paper presents the synthesis and characterization of Tin oxide nanoparticles by wet chemical route method. For the preparation of Tin oxide nanoparticles, Tin tetrachloride pentahydrate and ethylene glycol were used as starting precursor materials. The synthesized powder was calcined at 600 °C to get the crystalline phase. X-ray diffraction studies revealed that SnO2 nanoparticles possessed tetragonal rutile-type crystalline phase with space group P4/2mnm with no traces of secondary phases as confirmed by Rietveld refinement technique. FTIR spectrum showed hydroxyl group (–OH) located at 3226 cm−1 and high frequency bend at 623 cm−1 belonging to Sn-O-Sn, thereby confirming the formation of SnO2 nanoparticles. Raman spectroscopy measurements are carried out to determine the structure of the synthesized nanoparticles which confirms the tetragonal phase formation of SnO2 nanoparticles. Morphological studies were carried out using field emission scanning electron microscope (FESEM), which confirms the nanocrystalline nature of the particles.

SnCl4/γ-Al2O3 nanoparticles: A reusable and green heterogeneous catalyst for the one-pot synthesis of tetrahydropyridines

Nano-SnCl4/γ-Al2O3 as a reusable and green heterogeneous catalyst was prepared by the reaction of tin tetrachloride with γ-alumina. This solid acid catalyst was characterized by fourier transform-infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), thermal gravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) analyses. Tetrahydropyridines were synthesized via the one-pot reaction of 4-substitutd anilines, ethylacetoacetate and 4-substituted aldehydes in the presence of optimized amount (0.06 g) of nano-SnCl4/γ-Al2O3 under thermal conditions (70 °C) in ethanol as a green solvent. The process had short reaction times (5–8 h), good to excellent yields (80–93%), simple work-up and easy purification technique (recrystallization through the hot ethanol). It was found that the catalyst could be reused for three times without any considerable loss of its activity.

Radiolabeled gemcitabine hydrochloride as an imaging agent for lung cancer: Radiolabeling, quality control and cell incorporation studies

The development of new drugs that can specifically screen tumors is a global need. When it comes to lung cancer, which is the second main cause of cancer-related deaths, early detection of lung tumors using appropriate imaging is very important. In this study, gemcitabine hydrochloride (GCH) was radiolabeled with [99mTc]Tc under different conditions (changing reducing agent, antioxidant agent, incubation time, pH, [99mTc]Tc activity) and radiolabeling activity (quality control) using Radio Thin Layer Chromatography and paper electrophoresis. The results showed that the most stable complex ([99mTc]Tc-GCH) was prepared using 0.015 mg of stannous chloride as a reducing agent, 0.01 mg of ascorbic acid as an antioxidant and 37 MBq activity at pH 7.4 after 15 min of incubation time. The complex remained stable for 6 h. Cell incorporation studies showed a six-fold higher uptake of [99mTc]Tc-GCH in cancer (A-549) cells (38.42 ± 1.53) than healthy (L-929) cells (6.11 ± 0.17) have shown that it can. In addition, the different behaviors of R/H-[99mTc]Tc confirmed the specificity of this newly developed radiopharmaceutical. Although these studies are preliminary, it has been concluded that [99mTc]Tc-GCH may be a candidate drug for use in nuclear medicine, particularly in the diagnosis of lung cancer.

Spark Discharge Synthesis and Characterization of Ge/Sn Janus Nanoparticles.

Germanium-tin nanoparticles are promising materials for near- and mid-infrared photonics thanks to their tunable optical properties and compatibility with silicon technology. This work proposes modifying the spark discharge method to produce Ge/Sn aerosol nanoparticles during the simultaneous erosion of germanium and tin electrodes. Since tin and germanium have a significant difference in the potential for electrical erosion, an electrical circuit damped for one period was developed to ensure the synthesis of Ge/Sn nanoparticles consisting of independent germanium and tin crystals of different sizes, with the ratio of the atomic fraction of tin to germanium varying from 0.08 ± 0.03 to 0.24 ± 0.07. We investigated the elemental and phase composition, size, morphology, and Raman and absorbance spectra of the nanoparticles synthesized under different inter-electrode gap voltages and the presence of additional thermal treatment directly in a gas flow at 750 °C. The research shows that the in-flow thermal treatment of aerosol-agglomerated nanoparticles produced special individual bicrystalline Janus Ge/Sn nanoparticles with an average size of 27 nm and a decreasing absorption function with a changing slope at 700 nm.

Voltammetric determination of phosphates using ion-selective electrode based on organotin ionophore

This work describes the development of an amperometric phosphate-selective electrode with a plasticized membrane that includes bis(2-ethylhexyl)tin (IV) dichloride as an ionophore. The potentiometric response of the plasticized membrane was investigated, in addition to its selectivity for hydrophilic anions. The membrane provided a linear potential response with respect to HPO42- ions in the concentration range from 4·10-5 to 3·10-2 mol/L with a Nernst slope of 29 ± 2 mV·decade-1 activity. By using cyclic voltammetry, we characterized the ionophore-facilitated transfer of mono- and dihydro phosphate ions at the water/PVC-2-nitrophenyl octyl ether phase interface. An interphase distribution coefficient, a galvanic potential, a half-wave potential, the Gibbs energy of facilitated interphase transfer, as well as the Gibbs energy of facilitated interphase transfer were determined. Alternating current voltammetry was used to quantify phosphate ions in aqueous solutions. The linear response was observed in the range of phosphate concentrations from 2 to 10-6 to 1·10-4 mol/L and the detection limit was 8·10-7 mol/L under these conditions. This AISE has demonstrated high selectivity for phosphate ions in comparison to the most common anions in aqueous solutions. It has been used to determine the amount of phosphates in two fertilizers.

Radiolabeling, Quality Control, and Cell Binding Studies of New 99mTc-Labeled Bisphosphonates: 99mTc-Ibandronate Sodium.

Early detection of bone cancer is critical for treating symptoms, minimizing pain, and increasing overall quality of life. It is critical to develop novel radiopharmaceuticals with high labeling efficiency and stability for the diagnosis of bone cancer. This research aims to design a novel radiopharmaceutical that may be used to diagnose bone cancer. In this study, ibandronate sodium (IBD), a bisphosphonate analog, was radiolabeled with technetium-99m [99mTc] and quality control tests on the newly developed radiopharmaceutical ([99mTc]Tc-IBD) were performed using radioactive thin layer chromatography. After that, the incorporation of [99mTc]Tc-IBD into hydroxyapatite (HA) crystals and a human bone osteosarcoma cell line (U2OS) was tested. According to the results obtained, optimal radiolabeling procedure was obtained for [99mTc]Tc-IBD with 200 μg.mL-1 IBD, 20 μg stannous chloride, and 99mTc with 37 MBq radioactivity. The reaction mixture was adjusted to pH 5.5 and incubated at room temperature for 15 min. The radiochemical purity of [99mTc]Tc-IBD was found to be greater than 95% at room temperature for up to 6 h. Additionally, chromatography analysis showed >95% [99mTc]Tc-IBD complex formation with promising stability for up to 24 h in saline and up to 2 h in cell medium. The percentage binding of IBD to HA was 83.70 ± 3.67 and the logP of [99mTc]Tc-IBD was -1.1014. The radiolabeled complex exhibited a higher rate of cell incorporation to U2OS cells compared to Reduced/Hydrolyzed 99mTcO4 -. The newly produced radiopharmaceutical is very promising according to the results of in vitro cell culture, HA binding, and quality studies, and will be a step forward for further studies in nuclear medicine for bone cancer diagnostics.

Natural Dye from Nerium Oleander L. and Dyeing of Cotton Fabrics Using Different Mordants with Evaluation of Colour Fastness, Strength and Antifungal Properties

Globally, there is growing demand in natural colourants from plants in the food, cosmeceutical and pharmaceutical fields. Generally, among the various categories of secondary metabolites, carotenoids, anthocyanins, and phenols are significant plant-based pigments. Coloured pigments possess remarkable anthocyanin related to anti-oxidant, anti-inflammatory and anti-metastatic features. The major objective of this work was to elucidate the coloured pigments from Nerium oleander L. ornamental flowering shrub and its dying properties in cotton fabrics. Natural dye from flower methanolic extract of Nerium oleander was extracted. Dying experiment on bleached (H2O2) cotton fabric with density of 140 g / square meter was used. Pre, simultaneous and post -mordanting action of cotton fabric samples were carried out using 1-3 % of various metallic salts such as ferrous sulphate, potassium dichromate, stannous chloride, potassium aluminium sulfate. Color strength of the dyed samples for different dyeing condition was assessed by means of K/S value. Best color strength was yielded for the samples dyed with N. oleander which were mordanted with Potassium aluminium sulfate and FeSO4. Color fastness of the selected dyed samples to water, washing, perspiration and rubbing were also ideal. In all cases mordanted samples with Potassium aluminium sulfate and FeSO4 exhibited best results with simultaneous or post mordanting respectively. This results justifies designing a sustainable technology for mobilizing the usage of N. oleander for coloration of cotton fabrics. Fungicidal potential against A. flavus, A. niger, F. moniliforme and wash analysis also yielded significant results. The exquisite assessment of all tested properties of colored samples evolves this technology can be commercially implemented by considering large scale trails.

The GRPR Antagonist [99mTc]Tc-maSSS-PEG2-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity.

Gastrin-releasing peptide receptors (GRPRs) are overexpressed in the majority of primary prostate tumors and in prostatic lymph node and bone metastases. Several GRPR antagonists were developed for SPECT and PET imaging of prostate cancer. We previously reported a preclinical evaluation of the GRPR antagonist [99mTc]Tc-maSSS-PEG2-RM26 (based on [D-Phe6, Sta13, Leu14-NH2]BBN(6-14)) which bound to GRPR with high affinity and had a favorable biodistribution profile in tumor-bearing animal models. In this study, we aimed to prepare and test kits for prospective use in an early-phase clinical study. The kits were prepared to allow for a one-pot single-step radiolabeling with technetium-99m pertechnetate. The kit vials were tested for sterility and labeling efficacy. The radiolabeled by using the kit GRPR antagonist was evaluated in vitro for binding specificity to GRPR on PC-3 cells (GRPR-positive). In vivo, the toxicity of the kit constituents was evaluated in rats. The labeling efficacy of the kits stored at 4 °C was monitored for 18 months. The biological properties of [99mTc]Tc-maSSS-PEG2-RM26, which were obtained after this period, were examined both in vitro and in vivo. The one-pot (gluconic acid, ethylenediaminetetraacetic acid, stannous chloride, and maSSS-PEG2-RM26) single-step radiolabeling with technetium-99m was successful with high radiochemical yields (>97%) and high molar activities (16-24 MBq/nmol). The radiolabeled peptide maintained its binding properties to GRPR. The kit constituents were sterile and non-toxic when tested in living subjects. In conclusion, the prepared kit is considered safe in animal models and can be further evaluated for use in clinics.

Elaboration by spin coating and characterization of CZTS films

Thin films of Cu2ZnSnS4 (CZTS) were deposited by the sol-gel spin coating method from a non-aqueous solution containing different molarities of precursors, cupric chloride CuCl2 (2H2O) (2M), zinc chloride ZnCl2 (1M), stannic chloride SnCl2 (2H2O) (1M) and thiourea SC(NH2)2 (8M) dissolved in different volumes of solvents, methanol CH3OH and deionized water. A light-yellow solution was formed by thermal centrifugation at adjustable speeds for several minutes. Characterizations were carried out after deposition, drying and thermal annealing of these films. XRD spectra showed the formation of several peaks with one peak corresponding to the (112) directions illustrating the presence of kesterite. The gap energy was deduced 1.87 eV from the transmittance obtained by UV-Visible-NIR. The percentages of the different CZTS constituents by SEM were recorded. The thicknesses of the films obtained by profilometer are between 0.6 μm and 2 μm. The theoretical study and the results of the characterization can contribute to the realization of a CZTS active layer of a photovoltaic cell.

Synthesis of ethyl 2-methyl-4-(diethoxyphosphoryl)4,7-dihydro-5&lt;i&gt;H&lt;/i&gt;-thiopyrano[3,4-&lt;i&gt;b&lt;/i&gt;]furan-5-carboxylate and its functionalization at the position 3

Ethyl 2-methyl-4-(diethoxyphosphoryl)-4,7-dihydro-5 Н -thiopyrano[3,4- b ]furan-5-carboxylate was synthesized. It was shown that at elevated temperatures it is acetylated in presence of tin tetrachloride and chloromethylated with paraformaldehyde-hydrogen chloride system in the presence of zinc dichloride at the positon 3 of heterocyclic system. Reaction of chloromethyl derivative with N -, S - and О -nucleophiles were studied.

Stannous Chloride Redefined: A Mild and an Efficient Catalyst System for Poly(butylene succinate) (PBS) Synthesis

AbstractThe efficiency of stannous chloride as a mild and efficient catalyst system towards PBS synthesis is described in detail. A plausible mechanism has also been proposed for the synthesis of medium to high molecular weight PBS.

Synthesis and characterization of heterobinuclear Schiff base nickel(II) complexes involving nitrogen and oxygen donor ligand

This study reports the synthesis of five novel Schiff base heterobinuclear nickel(II) and tin(II) complexes. The heterobinuclear complexes were synthesized by the interaction of N,N′-ethylenebis(2-hydroxyacetophenoniminato) nickel(II) with tin(II) salts of 2,4,6-trinitrophenol, 1-nitroso-2-naphthol, o-nitrophenol, 8-hydroxyquinoline and 2,4-dinitrophenol. Characterization of these complexes was carried by physico-chemical techniques such as elemental analyses, conductivity measurements, magnetic measurements, infrared spectra and electronic spectral studies. The molar conductance data reveals that the complexes are non-electrolytic in nature. The magnetic susceptibility data and the spectral studies propose square planar geometry of the complexes around nickel(II) and coordination to the metal centre via azomethine nitrogen and deprotonated phenolic oxygen atoms.

99mTc-Labeled, Colistin Encapsulated, Theranostic Liposomes for Pseudomonas aeruginosa Infection

Infectious diseases are still the major issue not only due to antibiotic resistance but also causing deaths if not diagnosed at early-stages. Different approaches including nanosized drug delivery systems and theranostics are researched to overcome antibiotic resistance, decrease the side effects of antibiotics, improve the treatment response, and early diagnose. Therefore, in the present study, nanosized, radiolabeled with 99mTc, colistin encapsulated, neutral and cationic liposome formulations were prepared as the theranostic agent for Pseudomonas aeruginosa infections. Liposomes exhibited appropriate physicochemical properties thanks to their nano-particle size (between 173 and 217nm), neutral zeta potential value (about - 6.5 and 2.8mV), as well as encapsulation efficiency of about 75%. All liposome formulations were radiolabeled with over 90% efficiency, and the concentration of stannous chloride was found as 1mg.mL-1 to obtain maximum radiolabeling efficiency. In alamar blue analysis, neutral liposome formulations were found more biocompatible compared with the cationic formulations. Neutral colistin encapsulated liposomes were found to be more effective against P. aeruginosa strain according to their time-dependent antibacterial effect, in addition to their highest bacterial binding capacity. As conclusion, theranostic, nanosized, colistin encapsulated, neutral liposome formulations were found as promising agents for the imaging and treating of P. aeruginosa infections.

Enhanced activation of H2O2 by bimetallic Cu2SnS3: A new insight for Cu (II)/Cu (I) redox cycle promotion

HypothesisDespite that the development of Cu2SnS3 (CTS) catalyst has attracted increasing interests, few study has reported to investigate its heterogeneous catalytic degradation of organic pollutants in a Fenton-like process. Furthermore, the influence of Sn components towards Cu (II)/Cu (I) redox cycling in CTS catalytic systems remains a fascinating research. ExperimentsIn this work, a series of CTS catalysts with controlled crystalline phases were prepared via a microwave-assisted pathway and applied in the H2O2 activation for phenol degradation. The efficiency of phenol degradation in CTS-1/H2O2 system (CTS-1: the molar ratio of Sn (copper acetate) and Cu (tin dichloride) is determined to be Sn:Cu = 1:1) was systematically investigated by controlling various reaction parameters including H2O2 dosage, initial pH and reaction temperature. We discovered that Cu2SnS3 exhibited superior catalytic activity to the contrast monometallic Cu or Sn sulfides and Cu (I) acted as the dominant active sites. The higher Cu (I) proportions conduce to the higher catalytic activities of CTS catalysts. Quenching experiments and electron paramagnetic resonance (EPR) further proved that the activation of H2O2 by CTS catalyst produces reactive oxygen species (ROS) and subsequently leads to degradation of the contaminants. A reasonable mechanism of enhanced H2O2 activation in Fenton-like reaction of CTS/H2O2 system was proposed for phenol degradation by investigating the roles of copper, tin and sulfur species. FindingsThe developed CTS acted as a promising catalyst in Fenton-like oxidation progress for phenol degradation. Importantly, the copper and tin species contribute to a synergetic effect for the promotion of Cu (II)/Cu (I) redox cycle, which thus enhanced the activation of H2O2. Our work may offer new insight on the facilitation of Cu (II)/Cu (I) redox cycle in Cu-based Fenton-like catalytic systems.