Synthesis of ethyl 2-methyl-4-(diethoxyphosphoryl)4,7-dihydro-5<i>H</i>-thiopyrano[3,4-<i>b</i>]furan-5-carboxylate and its functionalization at the position 3

Abstract

Ethyl 2-methyl-4-(diethoxyphosphoryl)-4,7-dihydro-5 Н -thiopyrano[3,4- b ]furan-5-carboxylate was synthesized. It was shown that at elevated temperatures it is acetylated in presence of tin tetrachloride and chloromethylated with paraformaldehyde-hydrogen chloride system in the presence of zinc dichloride at the positon 3 of heterocyclic system. Reaction of chloromethyl derivative with N -, S - and О -nucleophiles were studied.