Introduction: Stroke knowledge, risk factor awareness, and medication adherence are critical to post-stroke outcomes. Here, we aimed to quantify the impact of a personalized video-based educational platform that facilitates ongoing engagement after discharge. Hypothesis: We hypothesize that a personalized educational platform improves patient satisfaction and stroke knowledge. Methods: In a single-center randomized trial, stroke patients and caregivers were randomized to receive standard stroke education during the hospitalization or access to MyStroke, a personalized educational platform with brief videos about their stroke etiology, risk factors, medications, and post-stroke lifestyle. Satisfaction, quality of life, and stroke knowledge were assessed 90 days after discharge. Results: 120 subjects (96 patients and 24 caregivers) were randomized to receive MyStroke (n=61) or standard education (n=59). Satisfaction with stroke education was higher among those who received MyStroke ( Figure 1 ). Participants who received MyStroke were more likely to correctly identify their stroke etiology, but no effect was observed with respect to risk factor recognition, medication awareness, or quality of life ( Table 1 ). Participants without a college degree experienced a larger educational benefit and improved in quality of life ( Table 1 ). Conclusions: The MyStroke personalized video-based education platform improved stroke knowledge, and then impact was augmented in subjects with less formal education. A multicenter trial is needed to confirm these results, clarify generalizability, and target clinically relevant metrics such as stroke recurrence or adherence.