Eight dentists evaluated 72 proximal surfaces of premolars with respect to all caries lesions and to lesions into dentine in digital images from a storage phosphor plate system. The images were processed in four different ways: (1) the default algorithm of the standard imaging system (DF); (2) an algorithm correcting for attenuation and visual response (AV), and two proprietary caries-specific enhancement algorithms (3) K1, and (4) K2, respectively. The lesions were validated by histological examination. There were no significant differences in the areas under the receiver operating characteristic curves between differently processed radiographs for the categories of all caries lesions and caries into dentine.