Standard Disinfection Research Articles

Disinfection with single or double usage of new antiseptic olanexidine gluconate in general surgery: a randomized study.

Olanexidine gluconate is a newly developed solution for skin disinfection that was recently approved in Japan. We aimed to compare single and double application of the solution in preventing surgical site infection (SSI) in patients undergoing general surgery. This randomized study was conducted at the Tottori University Hospital. Patients scheduled to undergo gastrointestinal or hernia surgery were randomly assigned to one of two groups using either one or two Olanedine applicators for skin disinfection. The primary endpoint was the difference in SSI incidence between the two groups. The secondary endpoint was all adverse events related to olanexidine gluconate. A total of 393 patients qualified for the study protocol: 193 received a single application, and 200 received a double application of Olanedine. SSI occurred in 10 patients (2.5%) overall; nine were superficial incisional SSIs, and one patient had a deep incisional SSI. Of the 10 patients who developed SSI, six (3.1%) were in the group receiving a single application, and four (2.0%) were in the group receiving a double application; there was no statistically significant difference between the two groups (P = 0.537). Allergic reactions or skin disorders related to olanexidine gluconate were not observed. There was no difference in the SSI incidence between the use of one or two Olanedine applicators for skin preparation in elective general surgery. Therefore, a single application of Olanedine is sufficient and is recommended for general surgery as a standard disinfection precaution. UMIN000027319; 5/12/2017.

Non-sexual HPV transmission and role of vaccination for a better future (Review).

Human papilloma viruses (HPVs) belong to the Papillomaviridae family and are epitheliotropic infecting squamous epithelia (skin and mucosae). HPV is estimated to be the cause of 99% of cervical cancers (there is no evidence of significant genetic predisposition for cervical cancer), 90% of anal cancer, 65% vaginal cancers, 50% vulvar cancers, and 45-90% oropharyngeal cancers. The route of HPV transmission is primarily through skin-to-skin or skin-to-mucosa contact. Sexual transmission is the most documented, but there have been studies suggesting non-sexual courses. The horizontal transfer of HPV includes fomites, fingers, and mouth, skin contact (other than sexual). Self-inoculation is described in studies as a potential HPV transmission route, as it was certified in female virgins, and in children with genital warts (low-risk HPV) without a personal history of sexual abuse. Vertical transmission from mother to child is another HPV transfer course. Several studies have emphasized the possibility of infection through the amniotic fluid, or the placenta, or via contact with maternal genital mucosa during natural birth. Waterborne transmission of HPV has never been demonstrated; however, HPV DNA has been detected in water environments. Routine hygiene measures are proven to be inefficient in preventing HPV transmission, as the studies which have evaluated samples of HPV on contaminated medical equipment (after standard disinfection) have found them to be still positive. Annual costs associated with the morbidity and mortality of HPV-related diseases are estimated at approximately $4 billion. Once the HPV vaccine program in Australia was launched, many studies reported the initial effects: A decrease in the incidence of high-grade cervical abnormalities, no new genital warts cases in females under 21 years. Promoting greater understanding in the general public about the evident benefits of vaccination can create positive vaccine attitudes and scatter the myths of spurious side effects.

Duodenoscope-related infections and potential role of single-use duodenoscopes.

ERCP has been used for management of pancreaticobiliary diseases since the 1960s. The use of ERCP has continued to increase over the past decade in the United States.1 Over this timeframe, several duodenoscope-related infections have been reported.2 Many of these cases have occurred in the setting of standard high-level disinfection protocols.3 As a result, more novel methods to prevent duodenoscope-related infections have been pursued.

Perioperative Microbial Contamination From Patients on Contact Precaution in Operating Room Environment

Background: The contaminated healthcare environment, including operating rooms (ORs), can serve as an important role in transmission of healthcare-associated pathogens. Studies are very limited regarding the level of contamination of ORs during the surgery of a patient on contact precautions and the risk to the next surgery patient after standard room cleaning and disinfection. Objective: Here, we investigated the microbial burden on the OR environment when patients on contact precautions receive surgery, and we assessed the impact of cleaning and disinfection on the contamination of OR environmental sites. Methods: This investigation was conducted in the ORs of an academic facility during an 8-month period. It involved 10 patients on contact precautions for multidrug-resistant pathogens, including methicillin-resistant Staphylococcus aureus (MRSA; n = 7); carbapenem-resistant Enterobacteriaceae (CRE) plus MRSA (n = 2); and vancomycin-resistant Enterococcus (VRE) plus MRSA (n = 1), who underwent surgery. Environmental sampling was performed at the following time points: (1) immediately before the surgical patient’s arrival in the OR, (2) after surgery but before the OR cleaning and disinfection, and (3) after the OR cleaning and disinfection. In total, 1,520 environmental samples collected from 15 OR sites for 10 surgical patients at 3 time points were analyzed. Relatedness among environmental MRSA isolates was determined by pulsed-field gel electrophoresis. Results: Overall, the mean CFUs of aerobes per Rodac plate (CFU/25 cm2) were 10.1 before patient arrival, 14.7 before cleaning and disinfection, and 6.3 after cleaning and disinfection (P < .0001, after cleaning and disinfection vs before cleaning and disinfection). Moreover, 7 environmental sites (46.7%) after cleaning and disinfection, including bed, arm rest, pyxis counter, floor (near, door side), floor (far, by door), steel counter (small, near bed), and small computer desk, had significantly lower mean counts of aerobes than before patient arrival or before cleaning and disinfection (Fig. 1). The mean CFUs of MRSA per Rodac plate (CFU/25 cm2) were 0.04 before patient arrival, 0.66 before cleaning and disinfection, and 0.08 after cleaning and disinfection (P = .0006, after cleaning and disinfection vs before cleaning and disinfection). Of environmental sites where MRSA was identified, 87.2% were on floors (41 of 47) and 19.1% were after cleaning and disinfection (9 of 47, 8 from floors and 1 from pyxis touchscreen). The A2/B2 MRSA strain was identified on different environmental sites (eg, floor, computer desk, counter) in various rooms (eg, OR2, OR10, and OR16), even after cleaning and disinfection (Fig. 2). Conclusions: Our study has demonstrated that the OR environment was contaminated with aerobic bacteria and MRSA after surgery and that MRSA persisted in the environment even after cleaning and disinfection. Enhanced environmental cleaning in the perioperative environment used for patients on isolation is necessary to prevent transmission of healthcare-associated pathogens in ORs.Funding: NoneDisclosures: Drs. Rutala and Weber are consultants to PDI (Professional Disposable International)

Effects of cold atmospheric pressure plasma and disinfecting agents on Candida albicans in root canals of extracted human teeth.

Reinfection in endodontically treated teeth is linked to the complexity of the root canal system, which is problematic to reach with conventional disinfection methods. As plasma is expected to have the ability to sanitize narrow areas, the aim of this study was to analyze the effect of cold atmospheric pressure plasma (CAP) on Candida albicans in root canals of extracted human teeth. CAP was applied as mono treatment and in combination with standard endodontic disinfectants (sodium hypochlorite, chlorhexidine and octenidine). Disinfection efficiency was evaluated as reduction of the logarithm of colony forming units per milliliter (log10 CFU/mL) supported by scanning electron microscopy as imaging technique. Plasma alone showed the highest reduction of log10 CFU, suggesting the best disinfection properties of all tested agents.

American Association for Bronchology and Interventional Pulmonology (AABIP) Statement on the Use of Bronchoscopy and Respiratory Specimen Collection in Patients With Suspected or Confirmed COVID-19 Infection.

American Association for Bronchology and Interventional Pulmonology (AABIP) Statement on the Use of Bronchoscopy and Respiratory Specimen Collection in Patients With Suspected or Confirmed COVID-19 Infection.

High-level disinfection of re-usable neonatal resuscitation equipment through boiling and steaming

Infection and asphyxia are two major causes of neonatal death globally. Where single-use resuscitation devices or sterilization of re-usable devices are unavailable, there is a need for effective, low-cost methods of high-level disinfection. Laboratory validation examined the efficacy of boiling and enclosed steaming (without pressure) as methods for attaining high-level disinfection of re-usable neonatal resuscitation equipment. The microbial load extracted and measured for each test article met internationally accepted standards for high-level disinfection. Boiling and steaming are low-cost, effective methods for reprocessing re-usable neonatal resuscitation devices in low- and middle-income countries.

Microorganism detection and contamination rate of donor eyes in Japan

To evaluate the microorganism detection and contamination rate of donor eyes. Retrospective study. In this retrospective study, we reviewed all donor cornea data collected from Kyoto Prefectural University of Medicine (KPUM) Eye Bank, Kyoto, Japan from April 2015 to June 2018, including microbiologic data obtained from conjunctival swabs and preservation medium and findings of postoperative infection from the medical records. During the study period, 77 eyes from 44 deceased individuals (mean age at time of death: 75 ± 17.3years [range, 30-102years]) were donated to the KPUM Eye Bank after being harvested using standard safety precautions and disinfection procedures. In 49 of the 77 eyes (63.6%), the conjunctival-swab culture revealed microorganisms, with the 3 most commonly detected being methicillin-resistant Staphylococcus epidermidis (MRSE), methicillin-sensitive S aureus (MSSA), and methicillin-resistant S aureus (MRSA). The data revealed positive microorganism detection in only 4 (5.2%) of the 77 donor-cornea storage-medium cultures. Positive microorganism detection was found in all the age groups, with no statistical difference between the groups (P > .05). In the eyes enucleated ≥ 2.5h postmortem, a higher positive microorganism detection occurred (P = .03). During the postoperative follow-up period, there was no record of corneal infection. The preenucleation conjunctival-swab-culture findings revealed that the rate of positive microorganism detection was similar for advanced-age and younger-age donors and that a shorter elapsed time from donor death to postmortem enucleation resulted in less donor-microorganism contamination.

Measuring the Impact of Continuous Disinfection Strategies on Environmental Burden in Outpatient Settings: A Prospective Randomized Controlled Trial

Abstract Background Our primary objective was to determine the effectiveness of 2 enhanced disinfection strategies compared with standard disinfection: “near-UV” light (Arm 1) and a persistent organosilane quaternary ammonium disinfectant (Arm 2) using a triple-blind study design. Our secondary objective was to characterize environmental contamination of outpatient clinics. Methods This trial was conducted at 2 clinics: the wound and pulmonary outpatient clinics at Duke University Health System in Durham, North Carolina. In Arm 1, room overhead lights were replaced with 405-nm near-UV visible light bulbs. In Arm 2, the organosilane quaternary ammonium disinfectant was applied to all room surfaces. The control arm received no intervention. All arms received routine disinfection. Room contamination was measured twice daily (before and after clinic) over 25 clinic days. Results The primary outcome was the change in total contamination, measured in colony forming units (CFUs), on environmental surfaces at the end of the clinic day compared with the beginning of the clinic day. Results from each intervention arm were compared against results from the control arm. The median delta total CFU for Arm 1 was 2092 CFUs (interquartile range [IQR], −1815 to 8566); the median delta for Arm 2 was 2016 CFUs (IQR, −1443 to 7430). Compared with the control arm (median delta = 1987 [IQR, −1611 to 15 857]), neither intervention led to a significant decrease in daily room contamination change (P for Arm 1 = 0.78 and P for Arm 2 = 0.71). Conclusions Neither near-UV lights or a persistent organosilane quaternary ammonium disinfectant reduced environmental contamination in 2 outpatient clinics compared with control rooms but did reduce the number of clinically important pathogens recovered.

Field investigations of multidrug-resistant Salmonella Infantis epidemic strain incursions into broiler flocks in England and Wales

ABSTRACT Salmonella Infantis is a major public health concern and has become established in the broiler sector in some European countries, as well as globally, and is frequently multidrug resistant (MDR). Three broiler farms in England and Wales, which had incursions of MDR S. Infantis between 2013 and 2017, were investigated longitudinally. The company feed mill and two associated hatcheries were intensively sampled. Following each visit, advice on cleaning, disinfection and other control measures for Salmonella was given to help eliminate S. Infantis from the premises. Four samples collected from inside the broiler houses after cleaning and disinfection were Salmonella-positive, indicating cleaning and disinfection within houses was generally effective. However, the exterior of persistently infected houses remained substantially contaminated and feeding systems could not be sampled. Clearance of S. Infantis from affected houses requires additional attention to decontamination of these aspects. Sixty S. Infantis isolates were tested for antimicrobial susceptibility by disk diffusion tests. All isolates were MDR, with resistance to at least nalidixic acid (Na), tetracycline (T), compound sulphonamide (Su), streptomycin (S) and furazolidone. This is a similar resistance pattern to the previously identified MDR (NaSSuT) clone in some European countries. The study shows that to remove S. Infantis from premises effectively, a combined approach to poultry houses and the surrounding farm environment is necessary. A revised cleaning and disinfection programme was developed that was associated with the clearance of MDR S. Infantis from persistently infected and newly infected broiler flocks, and UK livestock remains free of MDR S. Infantis. RESEARCH HIGHLIGHTS Standard cleaning and disinfection protocols did not completely eliminate infection. A revised cleaning and disinfection programme was developed. Disinfecting feeder lines and external areas was key to eliminating S. Infantis. Identified similar antimicrobial resistance pattern to MDR epidemic S. Infantis.

Analytical approach for a better control of environmental contamination

Abstract Background The environment of hospital rooms plays a role on Hospital Acquired Infections. Objects may be repository of germs and have a role on cross contamination, mainly in high-touch surfaces. Proper sanitation and disinfection procedures are needed. Aims i) to highlight the different probabilities of microbial contaminations in Hospital, ii) to assess whether the use of a UVC device (UVC-D), after standard disinfection procedures, improves the level of hygiene. Methods Between November 2019 and February 2020 a cross sectional study in a real clinical context was conducted. Investigations were carried out in double rehabilitation rooms with patients admitted for at least 48h. 16 preliminary Petri dishes (PD) were used in one rehabilitation room and bathroom, to assess the contamination level after deep disinfection procedures (T0). Matched comparisons were made after the use of UVC-D, 3 points/room and 1 point/bathroom, 3 minutes each(T1). At T0 we estimated the probability of contamination to select the following sampling. Six rooms and bathrooms were investigated using randomized spots. PD were incubated at 36 °C and colony forming unit (CFU) counted at 48h. Descriptive statistic and Wilcoxon test were performed to assess the levels of contamination between (T0) and (T1). Results At T0 we have a mean of 5.83 CFU/PD (CI 3.79-7.86) and a median of 1.0 CFU/PD (min 0 - max 118); at T1 mean is 0.28 CFU/PD (CI 0.15-0.40) and median of 0 CFU/PD (min 0-max 5). Significant reduction of contamination was achieved between T0 and T1 (p < 0.001). 83,33% of the contamination sites had 0 CFU/PD after using UVC-D. Conclusions The probability approach has driven the selection of the highest contaminations spots. Standard disinfection, followed by using UVC-D, significantly reduces contamination assuring a lower probability of cross contamination and risk of infection. Key messages Analytical approach to assess the contamination level of room to address with greater precision the points with higher risk of cross contamination. The UVC technology assures better results when associated with standard sanitation procedure decreasing the risk of hospital acquired infections.

Light-based technologies for management of COVID-19 pandemic crisis

The global dissemination of the novel coronavirus disease (COVID-19) has accelerated the need for the implementation of effective antimicrobial strategies to target the causative agent SARS-CoV-2. Light-based technologies have a demonstrable broad range of activity over standard chemotherapeutic antimicrobials and conventional disinfectants, negligible emergence of resistance, and the capability to modulate the host immune response. This perspective article identifies the benefits, challenges, and pitfalls of repurposing light-based strategies to combat the emergence of COVID-19 pandemic.

Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila.

Legionella pneumophila is an environmental bacterium, an opportunistic premise plumbing pathogen that causes the Legionnaires’ disease. L. pneumophila presents a serious health hazard in building water systems, due to its high resistance to standard water disinfection methods. Our aim was to study the use of photodynamic inactivation (PDI) against Legionella. We investigated and compared the photobactericidal potential of five cationic dyes. We tested toluidine blue (TBO) and methylene blue (MB), and three 3-N-methylpyridylporphyrins, one tetra-cationic and two tri-cationic, one with a short (CH3) and the other with a long (C17H35) alkyl chain, against L. pneumophila in tap water and after irradiation with violet light. All tested dyes demonstrated a certain dark toxicity against L. pneumophila; porphyrins with lower minimal effective concentration (MEC) values than TBO and MB. Nanomolar MEC values, significantly lower than with TBO and MB, were obtained with all three porphyrins in PDI experiments, with amphiphilic porphyrin demonstrating the highest PDI activity. All tested dyes showed increasing PDI with longer irradiation (0–108 J/cm2), especially the two hydrophilic porphyrins. All three porphyrins caused significant changes in cell membrane permeability after irradiation and L. pneumophila, co-cultivated with Acanthamoeba castellanii after treatment with all three porphyrins and irradiation, did not recover in amoeba. We believe our results indicate the considerable potential of cationic porphyrins as effective anti-Legionella agents.

Biosafety Measures at the Dental Office After the Appearance of COVID-19: A Systematic Review

The purpose of this research was to determine biosecurity measures at the dental office after the appearance of coronavirus disease 2019 (COVID-19). A search was conducted in the main databases of the scientific literature using the words "COVID-19, coronavirus, SARS-Cov2, biosecurity, disinfection and dentistry." We analyzed biosecurity and disinfection standards at the dental office and dental health personnel to date, and their adaptation to the needs and way of working of each. As a result, according to the information collected the following procedure was identified: a telephone appointment must be made and a questionnaire should be given before dental care; at arrival to the appointment, the temperature of the patient should be taken and proper cleaning and disinfection of the waiting room should be maintained. Panoramic radiography and CBCT are the auxiliary methods of choice. Absolute isolation and atraumatic restorative therapy techniques are a good alternative to decrease fluid exposure. The removal of protective clothing and accessories must follow a specific order and washing hands before and after is essential. In conclusion, the efficient biosecurity for dentists and patients in all dental care processes before, during, and immediately after the appointment reduces the risk of COVID-19 infection and allows healthy dental care environments.

ENT endoscopic procedures and aerosolization during COVID-19 pandemic: a review of concepts and guidelines

<p class="abstract">Otolaryngologists are more prone for exposure to aerosols during routine ENT examination and endoscopic procedures. ENT endoscopy procedures are considered as most aerosol-generating procedures and preferably routine procedures are avoided and deferred, if at all not necessary or urgent at this time of COVID-19 pandemic. The small particle size and extended travel of airborne aerosols mandate the use of specific personal protective equipment (PPE) and barriers by the health care workers to protect against transmission of COVID-19. Studies have recommended ENT endoscopy in awake patients with adequate topical preparation for local anaesthesia. Use of sprays should be avoided, instead, carefully placed pledgets should be used to provide adequate decongestion and anesthesia. Well ventilated endoscopy room with negative pressure (preferably), wearing a N95 mask with face shield or full PPE, thorough cleaning of entire endoscope after removal by standard disinfectants, decontamination of endoscopy room after each procedure and proper disposal of contaminated waste products are some common guidelines advised by health authorities globally till date.</p>

641 The cutaneous response to solar UV radiation is attenuated by chlorination stress originating from swimming pool disinfectants

Hypochlorous acid (HOCl) is the active oxidizing principle released by standard swimming pool disinfectants used on a global scale, but the cutaneous consequences of human exposure to HOCl remain largely unknown, posing a major public health concern relevant to populations around the world. Here, for the first time, we have profiled the HOCl-induced cutaneous stress response in reconstructed human epidermis and SKH1 hairless mouse skin. In addition, we have investigated the molecular consequences of co-exposure to solar simulated ultraviolet (UV) radiation and HOCl, a procedure mimicking environmental exposure experienced by recreational swimmers.

Tu1114 HIGH LEVEL DISINFECTION DUODENOSCOPE PROCESSING MIGHT BE ASSOCIATED WITH HIGHER RATE OF INFECTIOUS COMPLICATION FOLLOWING LAPAROSCOPY ASSISTED ERCP, A MULTICENTER STUDY

Laparoscopy-assisted (LA) ERCP is highly successful procedure in patients with roux-en-y gastric bypass (RYGB) anatomy. Yet, it carries a significant change to the usual gastroenterology practice as the scope is entering through a sterile, surgically made orifice. This poses the question of the need for Ethylene Oxide (ETO) gas sterilization for duodenoscope reprocessing as compared the standard high-level disinfection (HLD) that is commonly used for regular ERCP. Our aim was to evaluate the rate of infectious complication following LA-ERCP according to the scope reprocessing method. This is an IRB approved, retrospective study that included adult patients with RYGB undergoing LA-ERCP in 25 centers in the United States, 1 in Canada, and 1 in Brazil. A standardized data entry form was distributed across all the centers to collect information about demographics, indications, operative details, success rate, scope reprocessing method, and complications. Rates of infectious complications were compared according to duodenoscope reprocessing method using Fisher's Exact Test. We included 457 patients with median age of 52 (+/- 12) years and 86% females. Indication for lap-assist ERCP was biliary in 92% (stones 50%) and pancreatic in 8% (acute pancreatitis 94%). Success in reaching the papilla was achieved in 99%, cannulating the desired duct in 99%, and performing the desired intervention in 98%. Scope processing was with HDL and periodic cultures in 381 cases (83%) whereas it was with ETO gas sterilization (proceeded by HDL) in 76 cases (17%). Overall rate of infectious complication was 6.9%. Port site or surgical wound infections reported 3.7%. Whereas post ERCP cholangitis reported in 1.3% of the cases. There was a trend towards less infectious complications among ETO gas sterilization cases with a rate of overall infectious complication of 3.9% versus 7.5% (p=0.196), site or surgical wound infections 2.6% versus 3.9% (p=0.671) as compared to HLD cases. On the other hand, there was significantly less perioperative antibiotics used with ETO gas sterilization as compared to HLD cases (75% versus 90%, p <0.001) group, Table 1. Our large multicenter study indicates that ETO gas sterilization might be associated with less infectious complication following LA-ERCP as compared to HLD. Lack of statistical significance is attributed to low power due to the rarity of the infectious outcomes. However, ETO gas sterilization was associated with statistically significant less use of peri-procedure prophylactic antibiotics and yet showed a clinically relevant trend toward lower infectious rates. Although the optimal duodenoscope processing prior to LA-ERCP remains to be determined, it appears sensible to perfume ETO gas sterilization and administer pre-procedure antibiotic prophylaxis to lower the chance of infectious complications.

Concise Review: SARS-CoV-2 Persistence in the Environment and Its Sensitivity to Biocides

Abstract The novel coronavirus SARS-CoV-2 has caused a global health threat. This review summarizes comprehensive research findings about the SARS-CoV-2 persistence in inanimate surfaces and opportunities for applying biocides to limit spread of COVID-19. SARS-CoV2 is highly stable at 4°C but sensitive to heat and extremely stable in a wide range of pH values at room temperature. Coronaviruses also well survive in suspension. Desiccation has a more severe effect. SARS-CoV-2 can survive in the air for hours and on surfaces for days. Hospitals are significant epicenters for the human-to-human transmission of the SARS-CoV-2 for healthcare workers. The most contaminated SARS-CoV-2 zones and objects in isolation wards, in intensive care unit specialized for novel coronavirus pneumonia, are under discussion. SARS-CoV2 is sensitive to standard disinfection methods. Studies revealed that 62-71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite inactivated SARS-CoV2 in 1 minute exposition; while 0.05-0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate were less effective. Both ethanol and isopropanol were able to reduce viral titers after 30-seconds exposure. It was found for reusing personal protective equipment vaporized hydrogen peroxide treatment exhibits the best combination of rapid inactivation of SARS-CoV-2 and preservation of N95 respirator integrity under the experimental conditions. Overall, SARS-CoV-2 can be highly stable in a favourable environment, but it is also susceptible to standard disinfection methods. Environmental infection control of the air and especially for surfaces is considered as a mandatory step in addition to limiting person-to-person contact.

Food safety risk during the pandemic

Food safety risk during the pandemic

Application and thinking of health standards related to public health in prevention and control of coronavirus disease 2019

Objective: To systematically analyze the basic characteristics and contents of the current health standards for infectious disease, environmental health, school health and disinfection in the context of COVID-19 prevention and control, and provide support for the further optimization of epidemic prevention and control guidelines and reference for the revision and improvement of related health standards. Methods: Public health standards used in COVID-19 prevention and control were selected for a systematic comparison with "The Plan of COVID19 Prevention and Control (the 6(t)h Edition)" and other epidemic prevention and control guidelines from the perspectives of application scope and technical elements. Results: The current standards of public health are with scientificity, timeliness and feasibility. The application scope and technical elements of the current public health standards basically meet the needs of the prevention and control of COVID-19 epidemic, but the public health standardization system still needs improvement, and some public health standards need to be revised. Conclusions: The implementation of current public health standards can provide strong technical support for the prevention and control of COVID-19 epidemic. The experience obtained from COVID-19 epidemic prevention and control might promote the further improvement of the health standardization system.