Stages Of Registration Research Articles

Deformable vector fields warping for modelling of irregular breathing.

Purpose
4D computed tomography (4DCT) is the clinical standard to image organ motion in radiotherapy, although it is limited in imaging breathing variability. We propose a method to transfer breathing motion across longitudinal imaging datasets to include intra-patient variability and verify its performance in lung cancer patients. 
Methods 
Five repeated control 4DCTs for 6 non-small cell lung cancer patients were combined into multi-breath datasets (m4DCT) by merging stages of deformable image registration to isolate respiratory motion. The displacement of the centre of mass of the primary tumour and its volume changes were evaluated to quantify intra-patient differences. Internal target volumes defined on the m4DCT were compared with those conventionally drawn on the 4DCT.
Results 
Motion analysis suggests no discontinuity at the junction between successive breaths, confirming the method's ability to merge repeated imaging into a continuum. Motion (variability) is primarily in superior-inferior direction and goes from 14.4 mm (8.7 mm) down to 0.1 mm (0.6 mm), respectively for tumours located in the lower lobes or most apical ones. On average, up to 65% and 74% of the tumour volume was subject to expansion or contraction in the inhalation and exhalation phases. These variations lead to an enlargement of the ITV up to 8% of its volume in our dataset.
Conclusion 
4DCT can be extended to model variable breathing motion by adding synthetic phases from multiple time-resolved images. The inclusion of this improved knowledge of patients' breathing allows better definition of treatment volumes and their margins for radiation therapy.&#xD.

Analisis Penerapan Prinsip First To File Terhadap Perlindungan Hukum Preventif

This research aims to examine the application of the first-to-file principle as a preventive legal protection in trademark disputes between MS GLOW and PS GLOW. This legal writing falls under the category of normative legal research, utilizing legislative approaches and case approaches. Legal sources used in this research include primary legal materials and secondary legal materials, collected through document studies and analyzed using deductive legal material analysis with syllogism method. The results of this research indicate that the application of the first-to-file principle as a preventive legal protection in trademark disputes between MS GLOW and PS GLOW is not well implemented and effective. This is due to existing weaknesses both in the substance of the trademark law, namely Law Number 20 of 2016, and in the stages of trademark registration, namely in the announcement stage and the substantive examination stage.

Realizing The Principle Of Simple, Fast, And Low Cost In The Examination Of Civil Disputes With The E-Court Application Model

The influence of technological developments on the case examination process is in line with the industrial revolution which requires the application of technology-based performance, which is used in administering cases and implementing procedural law. The online system is a new breakthrough in the administration of justice. The formulation of the problem is how to apply e-court in the examination of cases in the Court, and how the application of the principle of simple, fast, and light costs is connected with e-court in the Court. The purpose of this study is to find out how the application of e-court in the examination of cases in the Court, as well as to find out how the application of the principle of simple, fast, and light costs when connected with e-court in the Court. The method used is empirical juridical. The results of the study, the application of e-court in case examination, namely for online case registration, obtaining online case cost estimates, online payments, electronic summons, and electronic trials. E-court can be accessed by registered users and other users. E-court as a case administration management system is very helpful for the mechanism of proceedings in court because it simplifies and speeds up the stages of registration and examination in court, in addition to the registration, summons, and submission of hearing documents are carried out electronically so as to save costs.

Data processing for administrative systems

Digitization of public services is a necessity for the development of administration, especially in big cities. Many studies show that citizens need fast and transparent public services. The process of digilatization has different degrees of development in different countries. Although progress still need to be made, Romania's administrative digitization has developed in recent years. The concept of big data and artificial intelligence algorithms are part of Romanian digital administrative systems. This paper describes the stages of a taxpayer registration in an electronic administrative system in Romania. A case study is also presented in order to highlight the evolution of the state of digitization in Romania during the Covid-19 pandemic when it was necessary to avoid traveling to administrative offices.

Kepemilikan Tanah Eks Eigendom Verponding 1065 Yang Ada Di Negeri Tawiri

Introduction: Land is a very important thing in Customary Law (can be referred to as Customary Land Law). The relationship between humans and land is closely related, namely land as a place for humans to live and continue their lives. Customary land is the property of customary law communities that have been controlled for a long time. Customary land law, known as land rights in Indonesia, such as ulayat lands, private lands, business lands, Gogolan lands, bengkok lands, agrarisch eigendom lands, and others.
 Purposes of the Research: This writing aims to find out the relationship between humans and the soil is very related to the land as a place for humans to live and continue their lives. While eigendom is a right of ownership to a land asset that existed during the Dutch colonial era that is subject to the provisions of Western land law in force for eigendom rights, then with the promulgation of the UUPA, the unification of Indonesian land law with the former Western rights that have not been converted to land rights as stipulated in the UUPA.
 Methods of the Research: legal writing that is juridical normative approach
 Results / Findings / Novelty of the Research: that the arrangement of compensation for the right of ownership of the Land of the former Eigendom Verponding 1065 that has not been converted is still possible to obtain proof of ownership, but not through conversion again but through granting new rights to the Office of the National Land Agency (BPN) with a certificate of ownership issued by the village head of the local area. Procedures and stages of land registration carried out by BPN Ambon on former Land objects eigendom 1065 the process of land rights derived from western rights including eigendom verponding to obtain legal certainty, by implementing the provisions of PP No.24 of 1997 consistently, well and truly will be about the right to land eigendom verponding, which ensures legal protection for holders of rights to the land of the former eigendom verponding. then the bookkeeping is simply done by giving a stamp/stamp on the evidence by writing the type of rights and rights number converted, which is regulated in PP Regulation No.24 of 1997 on land registration

ISSUES OF IMPLEMENTATION OF THE PRINCIPLES OF ELECTORAL LAW IN TERMS OF MODERNIZATION OF KAZAKHSTAN

The article examines some issues of the implementation of the principles of electoral law and modernization of the Kazakh legislation in this area. The purpose of this work is to analyze the problems of the content and implementation of election legislation, as well as to determine effective ways to improve it based on the study of the fundamental principles of the electoral process. The relevance of the topic is justified by the social and political value of the right to vote for society and the country in the light of its recognition as a necessary factor in the development of democracy in the state. The implementation of systematic and statistical methods is relevant to achieve the goal of the work, supporting the reasoning with practical data. The article examines the content of the principles of electoral law and issues of practical implementation, taking into account their features. The compliance of the principles of electoral law enshrined in the Constitution of the Republic of Kazakhstan with international standards and obligations of the state is indisputable. The article raises the problem of their interpretation and observance in the process of election campaigns. Recommendations on improving the electoral process in the state are being considered. In particular, special attention is paid to the stages of registration and implementation of election activities by candidates, as well as the issue of accreditation of observers. In addition, the article says that the possible inequality among the candidates may lead to difficulties in applying the capabilities of the media, namely, an unlimited number of paid speeches. With regard to the activities of political parties in the process under study, the dynamics of the distribution of votes and mandates shows the presence and preservation of multiparty system in the legislative body of the state. It is necessary to improve legislative activities to increase the number of mandates for each political party in order to reduce the monopoly of one political party over the others. The paper analyzes the conduct of elections for various historical periods, including recent ones.

EVALUASI PELAKSANAAN PERATURAN DAERAH NOMOR 4 TAHUN 2016 TENTANG RENCANA PEMBANGUNAN JANGKA MENENGAH DAERAH KABUPATEN PONOROGO TAHUN 2016-2021 DI DESA DAYAKAN KECAMATAN BADEGAN KABUPATEN PONOROGO TAHUN 2019

The results showed an evaluation of the implementation of Non-Cash Food Assistance (BPNT) using William Dunn with six variables, namely effectiveness, efficiency, adequacy, leveling, responsiveness and accuracy, namely: BPNT implementation starts from the stages of registration or account opening, education and socialization. , distribution, and purchase of goods at e-warong and Bank BNI 46. Achievement of BPNT implementation results, seen from BPNT objectives, is still not optimal for all BPNT KPM. The assessment of the implementation of BPNT in Dayakan Village, Badegan District, Ponorogo Regency based on William Dunn's theory is the effectiveness of achieving BPNT goals, efficiency of distribution time and the number of e-warongs or BNI 46 agents who facilitate the purchase of goods, criteria for the leveling of BPNT program recipients, and responsiveness criteria for problem handling not good. Meanwhile, the criteria for the adequacy of the results / benefits of BPNT that are felt by the poor to meet food needs and the criteria for BPNT's accuracy in answering the problems of poverty and hunger faced by the poor are quite good.

Effects of lipoperoxidation and mitochondrial state on milk yield of dairy cows under technological stress

Evaluation of the physiological state of cattle is crucial in creating healthy, high-performing dairy cattle herds. Technological stress is one of the most critical factors determining the biological potential of higher-yielding cows. This work aimed to assess the effect of technological stress on various oxidative parameters and mitochondrial states in dairy cows' blood, milk yield and milk composition. The study was conducted on the black-and-white breed of healthy herds. Regrouping, changing service personnel, and carrying out veterinary and sanitary manipulations were considered technological stress factors. The concentration of cortisol in the blood serum was studied by the immunological method. The concentrations of malonic dialdehyde (MDA), diene conjugates (D.C.), Schiff bases (S.B.), reduced glutathione and catalase activity were measured spectrophotometrically. The mitochondrial state was estimated by laser interference microscopy. While the milk yield, protein and lipid composition of cow milk were studied using an ultrasound analyzer. The researched indicators were analyzed before and for 30 days after the effect of technological stress. Results of the study suggested that technological stress caused an increase in oxidative processes, along with a reduction of antioxidant activity of blood and milk at the initial stages of registration (1-7 days). The concentration of glutathione remained reduced for 30 days after technological stress. A decrease in mitochondrial refractoriness and disintegration accompanied these processes. The milk yield indicator decreased was not restored to the values of intact animals by 30 days after technological stress. Further, the protein and lipid composition also reduced. Thus, a decrease in the quantity and quality of milk under technological stress may be mediated by the development of oxidative stress, which the refractoriness and disintegration of mitochondria might trigger.

Fast mosaicing method based on image resizing pre-processing

In recent years, mosaic images have found great success thanks to the increasing development in the field of imaging as well as the technological evolution of computer systems (camera, mobile, etc.). Mosaic images are obtained by merging several images of the same scene. The process incorporates several steps, each of which requires resources and execution time depending on the size, quality and resolution of the images used. In this paper, we propose a new image mosaic method that significantly reduces the execution time. The idea is to apply the stages of registration and search for the best inliers, necessary for the calculation of the geometric transformation, to the miniature of images. This allows the minimization of the overall processing time without altering the quality of the results. The experiment, on a database of images, shows that the proposed algorithm provides rapid results compared to similar methods. Also, we have extended our method to generate 360° panoramic images.

Aplikasi Sistem Penerimaan Siswa Baru SMK Taruna Bakti Cikarang Selatan Berbasis Web dengan Metode Rapid Application Develoment (RAD)

New student enrollment is a process that exists in government educational institutions such as schools to help screen prospective students and incoming students who are selected as students according to criteria set by the school. In general, the admission process for new students goes through the stages of registration, selection test, admission of students and students. In this study, the application to SMK Taruna Bakti Cikarang Selatan was done manually or by computer, but because Microsoft Office Excel was used, there was a lot of missing data and manual calculation of the test results could lead to errors. there is. The formulation of this research problem is how to create an information system for admission of new students in SMK Taruna Bakti Cikarang Selatan. The research methodologies used are Rapid Application Development (RAD), Observation, Analysis, Design, Testing, and Implementation. This new information system for student enrollment is written in the PHP programming language and uses a MySQL database as the database server. The outcome of this research is her web-based her first-year information that makes it easy for a prospective student and her first-year parent to obtain all information about her first-year and complete online registration system.

Multi-atlas segmentation and quantification of muscle, bone and subcutaneous adipose tissue in the lower leg using peripheral quantitative computed tomography.

Accurate and reproducible tissue identification is essential for understanding structural and functional changes that may occur naturally with aging, or because of a chronic disease, or in response to intervention therapies. Peripheral quantitative computed tomography (pQCT) is regularly employed for body composition studies, especially for the structural and material properties of the bone. Furthermore, pQCT acquisition requires low radiation dose and the scanner is compact and portable. However, pQCT scans have limited spatial resolution and moderate SNR. pQCT image quality is frequently degraded by involuntary subject movement during image acquisition. These limitations may often compromise the accuracy of tissue quantification, and emphasize the need for automated and robust quantification methods. We propose a tissue identification and quantification methodology that addresses image quality limitations and artifacts, with increased interest in subject movement. We introduce a multi-atlas image segmentation (MAIS) framework for semantic segmentation of hard and soft tissues in pQCT scans at multiple levels of the lower leg. We describe the stages of statistical atlas generation, deformable registration and multi-tissue classifier fusion. We evaluated the performance of our methodology using multiple deformable registration approaches against reference tissue masks. We also evaluated the performance of conventional model-based segmentation against the same reference data to facilitate comparisons. We studied the effect of subject movement on tissue segmentation quality. We also applied the top performing method to a larger out-of-sample dataset and report the quantification results. The results show that multi-atlas image segmentation with diffeomorphic deformation and probabilistic label fusion produces very good quality over all tissues, even for scans with significant quality degradation. The application of our technique to the larger dataset reveals trends of age-related body composition changes that are consistent with the literature. Because of its robustness to subject motion artifacts, our MAIS methodology enables analysis of larger number of scans than conventional state-of-the-art methods. Automated analysis of both soft and hard tissues in pQCT is another contribution of this work.

ОБҐРУНТУВАННЯ ДОЦІЛЬНОСТІ ПЕРЕДАЧІ БІЗНЕС-ПРОЦЕСУ УПРАВЛІННЯ ПЕРСОНАЛОМ ПІДПРИЄМСТВА НА HR-АУТСОРСИНГ ЯК ІННОВАЦІЙНОЇ ПЕРСОНАЛ-ТЕХНОЛОГІЇ

To increase the efficiency of management at the enterprise it is necessary to introduce modern methods of organizing the processes of production and economic activity. The use of outsourcing gives the company the opportunity to increase competitive advantage, to ensure the organization of continuous work at all levels, to focus the company's main resources on the most promising areas of business, to abandon uncompetitive work.
 The presence of different types and types of HR-outsourcing indicates the availability of options for companies to choose the method of registration of relations with the employee and the company-provider, as well as the involvement of the necessary specialists due to the constant needs of this employee. The use of HR-outsourcing opportunities in the economic activity of the enterprise allows to save time in the process of "recruitment-selection-hiring" of staff.
 HR-outsourcing is a new and powerful tool for enterprise management, but without proper support it can negatively affect the company's activities. Therefore, to ensure the effectiveness of its application, it is necessary to conduct in-depth analytical and organizational work, objectively assess not only the expected current results, but also the long-term consequences of the transfer of certain functions to third-party specialized performers. 
 The article examines the use of modern personnel technologies in enterprise management. The essence of the concept of HR-outsourcing, the main directions of services provided in the varieties of its forms at the enterprise are determined. Depending on the specifics of the work to be performed, and taking into account the order of registration, the following types of HR-outsourcing are characterized: leasing (rent) of personnel; temporary staff and outstaffing. The advantages and disadvantages of HR-outsourcing for the company are given. The main stages of registration of relations with HR-outsourcing at the enterprise are presented. The achievement of the goals of change and organizational development through HR-outsourcing at the enterprise is reflected. The economic effect of the transfer of the business process of personnel management to HR-outsourcing as an innovative personnel technology is calculated. The effectiveness of HR-outsourcing to perform selected types of work at the enterprise is proved, as the use of outsourcing schemes leads to lower costs.
 Thus, the study of the world experience of such radical innovative solutions testifies to the effectiveness of this model of business organization. And Ukraine with its highly skilled and cheap labor force has all the opportunities to benefit during the boom of this service - HR-outsourcing.

STATE REGISTRATION OF RELIGIOUS ORGANIZATIONS IN UKRAINE

The article considers the issue of the creation and registration of religious organizations and the acquisition of the status of a legal entity. The main problems faced by religious organizations in the process of state recognition are considered. The methods of state registration of religious organizations depending on their type are described, the powers of regional and central executive bodies regarding the legal recognition of religious organizations are outlined. Proposals have been made to amend the current legislation to create a transparent process for registering religious organizations. The article defines religious organizations in Ukraine such as religious communities, centers, administrations, monasteries, church unions, missions, theological educational institutions, organizations, and associations. As the registration procedure of religious organizations has two stages of registration in Ukraine, the article describes in detail each of the stages of state registration of religious organizations. The article describes the state benefits that religious organizations in Ukraine can receive after obtaining the status of a legal entity.

Proposing a security system for the VPN through design and implementation of a scheme for android and IOS mobiles based on two-factor authentication

A virtual private network (VPN) is a network, but a virtual network means that it creates a virtual bridge between the user and the server located somewhere across the world, and this network is private because to connect the connection with it you must have an account and password. The idea of VPN arose to protect its communications from industrial espionage, because there are very easy ways to penetrate a network and steal the information circulating in it. Data transmission encryption protocols and tunneling systems are used in order to secure the transfer of information between two points back and forth, so their data is encrypted and protected. Hacking the VPN is a very dangerous thing because of the importance and privacy of the data. Therefore, special systems must be provided for the VPN to suit the network's work scenarios with high security. In our work, we proposed a private authentication system for the VPN network that provides high security with fast execution and reliability based on two factors authentications: Using the varieties of authentications method, robust VPNs screen everybody who will tries to sign in. An authentication system was designed based on a special user interface that provides an easy environment for choosing two passwords in two different stages of registration and authentication. The proposed system was implemented on Android and iOS devices. The proposed system was evaluated through experiments with 720 participants with 3600 system entry processes, then the proposed system was tested in terms of its ability to break and resistance to different types of attacks. Where it was tested by 1900 attacks at different times with participants who were randomly selected from the main sample of participants during the implementation period of 30 days through using the modern types of mobile devices.

ОСОБЕННОСТИ ЗАБОЛЕВАЕМОСТИ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ (ПО ДАННЫМ ВИТЕБСКОГО ОБЛАСТНОГО КЛИНИЧЕСКОГО ОНКОЛОГИЧЕСКОГО ДИСПАНСЕРА)

The results of statistical processing of data on the diagnostics of breast cancer in patients of the Vitebsk Regional Clinical Oncological Dispensary for 2019-2020 are presented in this article. Extracts from medical records of 1061 patients (617 - 2019; 444 - 2020) aged 20 to 99 years were analyzed. In particular, methods for diagnosing the disease, the stages of registration of breast cancer were studied, the circumstances of the detection of the disease, the ratio of lesions of different parts of the mammary gland according to ICD-10, the results of the analysis of the occurrence of the disease depending on age, the features of the occurrence of relapses and metastases, the mortality of patients of different age groups, the ratio of patients from urban and rural areas. In 91.99 % of cases, the histological method was used to diagnose the disease. Echoscopic (0.75 % of cases) and X-ray (0.28 % of cases) diagnostic methods have found the least use. In the majority (45.80 % of cases) the disease was detected at stage II, in 7.71 % of cases breast cancer was registered at stage IV. In more than half of the cases (50.51 %), the disease affected the upper outer quadrant of the breast, which corresponds to the ICD-10 code C50.4 (Malignant neoplasm of the upper outer quadrant of the breast). There was an increase in the risk of breast cancer with increasing age of patients (approximation - 0.9577) with an average age of patients - 62 years. Relapses and metastases were found in 13.57 % of patients with breast cancer, and in 36.81 % of cases - at stage IV of the disease. Among patients, the largest number of relapses and metastases (22 cases each) was found in the age groups 55-59 and 60-64 years. Mortality for 2019-2020 was 7.92 % (84 patients died, among which relapses and metastases were detected in 38 people). Most of all patients (77.57 %) with diagnosed breast cancer live in urban areas, 22.43 % are patients from rural areas.

PENGEMBANGAN POTENSI PRODUKSI USAHA MIKRO, KECIL, DAN MENENGAH DI PONDOK PESANTREN MELALUI PENDAMPINGAN HAK KEKAYAAN INTELEKTUAL

Islamic boarding schools as one of the educational facilities are currently starting to develop their potential in the economic field by establishing business centers. Most of the businesses owned by pesantren are micro, small and medium scale enterprises (MSMEs). MSMEs are considered to play an important role in Indonesia's economic activities because most businesses in Indonesia are small businesses that absorb a lot of labor. However, significant developments in terms of quantity have not been accompanied by developments in terms of quality. The purpose of this study is to analyze the mapping of potential business products from Islamic boarding schools in Malang, analyze the obstacles faced by MSMEs in Islamic boarding schools in product innovation about ntellectual Property Rights. for MSMEs to increase production potential. This study employs Juridical Empirical research. The focus of this research is the protection of IPR for MSMEs in Islamic boarding schools in Malang. Based on the results of the study, it can be concluded that the potential of MSME products owned by Islamic boarding schools in Malang City is currently quite diverse, ranging from supermarkets which are not only limited to internal boarding schools but also for the surrounding community. This activity also opens up opportunities for opening up job opportunities for many people as well as providing entrepreneurial education for students. Given the enormous benefits, this potential needs to be continuously supported and developed from various aspects, one of which is in terms of guaranteeing legal protection for MSME products of Islamic boarding schools through IPR assistance. Constraints faced by MSMEs in Islamic boarding schools in product innovation in relation to Intellectual Property Rights include: lack of detailed understanding of legal protection for MSME actors; stages of trademark registration that are considered difficult. Management is considered to only be able to be done directly and cannot use an online mechanism so that it will require quite a lot of costs; and product exclusivity is not the main thing, business competition is not too tight. IPR protection for MSME products is needed to prevent ideas that are owned and then stolen and used by other parties. Some forms of IPR protection that can be given to MSME products in Islamic boarding schools are through copyright management, brand rights, and having trade secrets.

Legal Regulation of Contractual Relations in the Field of Venture Investment

The article analyzes the features of legal regulation of venture investment contracts. Topical legislative problems of the functioning of the venture industry in the Russian Federation are highlighted. The forms of venture investment transactions are considered: an increase in the authorized capital, the provision of a convertible loan and the sale of the company’s treasury share. Particular attention is paid to the nature of the relationship between the parties and the stages of registration of a venture transaction. As a recommendation for the development of venture business in the Russian Federation, the need to adopt a special federal law on venture investment is substantiated. This law will eliminate the problem of haphazard legislation in this area and will make it possible to determine a clear legal structure of the venture investment agreement. In addition, the law will allow the introduction of a new, convenient and effective organizational and legal form of venture investment. It will contribute to a more equitable distribution of risks between investors, flexibility of interaction between participants in transactions, prompt adoption of management decisions on investment.

Safety of epidural analgesia in an orthotopic liver transplantation

In the literature devoted to the problems of liver transplantation, there is no clearly indicated attitude of the authors to intraoperative epidural blocks, although theoretically the benefits of a sympathetic block are considered. Some sources recommend prophylactic sodium bicarbonate infusion to alleviate post-reperfusion syndrome, but its effectiveness is questionable.Purpose: to present the physiological, biochemical and hematological characteristics of recipients at the stages of orthotopic liver transplantation with an assessment of the feasibility of using sodium bicarbonate for the prevention of reperfusion complications.Materials and methods. An observational study, contains an analysis of data from 39 participants operated on in 2020 in the volume of: hepatectomy, an orthotopic liver transplantation, with an initial assessment on the Child- Turcott- Pugh scale of 11 points. All participants were operated on under general inhalation anesthesia with sevoflurane and thoracic epidural three- component anesthesia according to the Breivik- Niemi method. There are 3 stages of data registration: the beginning of the anhepatic stage; the beginning of the neohepatic stage; the end of the operation.Results and discussion. Significant fluctuations in hemodynamics, violations of the acid-base state and energy metabolism were not revealed; a decrease in hepatic protein synthesis, a shift of the P50 point to the left, and moderate metabolic acidosis did not exceed the levels described in the literature. The dynamics of acidosis, РСО2 and natremia did not depend on the infusion of soda. There was no close correlation between arterial blood pH and lactate concentration.Conclusion. The benefits and safety of epidural anesthesia in orthotopic liver transplants are obvious and make it possible to recommend this component as a routine element of anesthesia during these operations. The indications for sodium bicarbonate infusion should be narrowed and consensus is needed to determine the critical pH value for sodium bicarbonate infusion.

Hierarchical registration of brain images based on B-splines and Laplacian commutators

It is highly desirable that the complementary information of computed tomography (CT) for dose planning and magnetic resonance imaging (MRI) for accurate organ delineation should be merged in oncology. In this paper, we propose a hierarchical method based on B-splines and Laplacian commutators for registration between MR and CT brain images. Firstly, we apply histogram equalization on the CT image for intensifying its local details. Then, the principal component analysis (PCA) is adopted to align MR and CT images roughly. We use PCA to find the centroid and orientation of these two images to initialize the translation and rotation. Next, registration is refined via a free-form deformation which is based on B-splines for describing local deformations. Here we adopt Laplacian commutators as a similarity metric in both stages of registration, and the limited memory Broyden-Fletcher-Goldfarb-Shannon (L-BFGS) optimization method has been applied for optimization process. Experimental results have shown that the performances of the obtained images are improved by comparing with the state-of-the-art methods, demonstrating potentials of the proposed method to be applied for brain tumor radiation therapy.

Registration of Medicines in the Soviet Control and Licensing System on the Example of the Cardiological Drug Trinitrolong

The article presents the history of the study and registration in the USSR of the buccal form of nitroglycerin (trinitrolong) in the 1970s and 1980s, based on a number of author's publications, documentary evidence and oral stories of participants in clinical trials. The specifics of the passage of the main stages of registration of a new pharmacological agent in the Soviet control and authorization system from the author's idea to the introduction of the drug into clinical practice are described. Some reasons for the lag of the USSR from the countries of the capitalist West in the development and introduction of new cardiac drugs are analyzed.