The author emphasizes the need to revise the concept of regional industrial policy during the transition period to the innovative stage of economic development. Analyzing the different scientific approaches to the theoretical foundation of this policy demonstrated its value in ajudent combination of innovative ideas with effective management decisions, and in injecting a reasonable degree of conservatism into the process of change. The article examines the essence of industrial policy and suggests interpreting it through the lens of harmonious interaction between economic entities at all levels of the socio-economic system, from the macro to the nano level. The emphasis on regional policy is on consistency, strategic focus, selective approach to determining content and selection of policy instruments, as well as the unification of industrial, innovation, investment and social policies. A strong emphasis is being placed on maintaining a balance between the interests of the state and other parties involved in the political process, while also providing systematic monitoring of the processes and results of the implementation of regional policy.