Commercial Stage Research Articles

Spiro‐Based Thermally Activated Delayed Fluorescence Emitters for Organic Light‐Emitting Diodes

AbstractSpiro structures, possessing unique π‐electron systems, large steric hindrance, high glass transition temperature, and chemical stability, serve as critical structural building blocks in constructing thermally activated delayed fluorescence (TADF) emitters. The incorporation of various heteroatoms such as oxygen, sulfur, and nitrogen in 9,9′‐spirobifluorene generates diverse spiro structures like spiro[fluorene‐9,9′‐xanthene], spiro[fluorene‐9,9′‐thioxanthene], and spiro[acridine‐9,9′‐fluorene]. Based on the charge transfer characteristics, TADF emitters built upon spiro structures can be classified into various types, including twisted intramolecular charge transfer, through‐space charge transfer, multiresonance, and exciplex‐type TADF emitters. This review systematically highlights the recent progress in the research on TADF emitters comprised of spiro‐structured aromatics. It intricately explores the molecular design strategies, material synthesis methods, understanding of photophysical attributes, and analysis of organic light‐emitting diode performance. Concurrently, it sketches out the challenges faced in the commercial application stage while providing an outlook for potential research trajectories.

A chronicle of titanium niobium oxide materials for high‐performance lithium‐ion batteries: From laboratory to industry

AbstractTitanium niobium oxide (TiNbxO2 + 2.5x) is emerging as a promising electrode material for rechargeable lithium‐ion batteries (LIBs) due to its exceptional safety characteristics, high electrochemical properties (e.g., cycling stability and rate performance), and eco‐friendliness. However, several intrinsic critical drawbacks, such as relatively low electrical conductivity, significantly hinder its practical applications. Developing reliable strategies is crucial to accelerating the practical use of TiNbxO2 + 2.5x‐based materials in LIBs, especially high‐power LIBs. Here, we provide a chronicle review of the research progress on TiNbxO2 + 2.5x‐based anodes from the early 1950s to the present, which is classified into early stage (before 2008), emerging stage (2008–2012), explosive stage (2013–2017), commercialization (2018), steady development (2018–2022), and new breakthrough stage (since 2022). In each stage, the advancements in the fundamental science and application of the TiNbxO2 + 2.5x‐based anodes are reviewed, and the corresponding developing trends of TiNbxO2 + 2.5x‐based anodes are summarized. Moreover, several future research directions to propel the practical use of TiNbxO2 + 2.5x anodes are suggested based on reviewing the history. This review is expected to pave the way for developing the fabrication and application of high‐performance TiNbxO2 + 2.5x‐based anodes for LIBs.

Enhancing new service development effectiveness: the role of customer participation and the moderating effects of empowerment and satisfaction

PurposeThe purpose of this paper is to investigate the role of Customer Participation (CP) in the effectiveness of New Service Development (NSD) by examining the moderating roles of Customer Empowerment (CE) and Customer Satisfaction (CS). The research reduces the risk of failure of the NSD process and/or improves the NSD processes used by companies through the consideration of the results in the practical dimension.Design/methodology/approachThis study investigates the effects of CP at different stages of NSD using a quantitative approach. Data were collected through an online survey questionnaire. Smart PLS was used to analyse the data collected from 509 newsreaders and users of the news agency’s application.FindingsThe model confirmed that CE has an impact on the effectiveness of NSD in the idea generation and commercialization stages, but not in the development stage. Empowerment and customer satisfaction did not influence the three stages of NSD indirectly but directly. The results show that CP, CS and CE do not always have a direct or indirect effect on the development of new services. Therefore, in order to design new service development projects, media news companies need to determine the level of user cooperation.Research limitations/implicationsThe lack of objective data, especially on company performance, forces researchers to use questionnaires to analyse NSD effectiveness. Another limitation is that newspaper users answered the questionnaires, which creates “common method variance.”Practical implicationsResearchers on NSD effectiveness must use questionnaires due to a lack of objective data, especially on company performance. Another limitation is “common method variance” from newspaper users answering questionnaires.Originality/valueThis paper is a response to a perceived need for an examination of how new service development can be successful and effective.

Would edible insects become part of our gastronomic quest?

Global food security status has been contested in recent times with claims of efficient food production by the proponents and severe to moderate food insecurity by the opponents. The current population growth prediction of 9.7 billion by 2050 requires additional food production due to the impact of climate change leading to diminished yield rates. Novel food sources such as cellular agriculture utilizing modern biotechnology are at various trial and commercialization stages. Old traditions of insects as a reliable food (entomophagy) source are gaining momentum in recent times. This article explores various aspects of entomophagy. The ecological footprint of entomophagy on its animal counterparts is presented. Since religious factors have a major impact on eating habits that privileges certain elements, perspectives from major religions on entomophagy have been discussed. The regulatory standpoint of Anglo-Saxon, Western and Eastern societies are given. Consumer knowledge and commercialization challenges are also discussed with concluding remarks.

Advancements in genetically modified insect pest-resistant crops in India.

The review offers insights into the current state of research on insect pest-resistant GM crops and the regulations governing the cultivation of GM crops in India. India has a rich crop diversity of more than 160 major and minor crops through its diverse agroclimatic conditions. Insect pests alone cause around USD 36 billion in crop loss annually in India. The last two decades witnessed considerable progress in managing insect pests by adopting innovative techniques including transgenics. In research, significant advancement has been brought in insect pest-resistant transgenics in India since its inception in 2002. However, any events have not been endorsed owing to biosafety impediments, except Bt cotton reaching the commercial release stage. A landmark decision to exempt certain types of gene-edited plants from genetically modified organism (GMO) regulations offers great promise for developing novel insect-resistant crops in India. The article reviews the current research on insect pest-resistant transgenics and its regulations in India.

A Multi-scale Framework for Advancing Battery Safety Through Early Calorimetric Analysis of Materials and Components

Batteries are the cornerstone of the global shift toward electrification, powering applications from passenger transportation, like electric vehicles (EVs), to load shifting of renewable energy generation at the grid level. The demand for batteries is accelerating, and is projected to nearly quadruple by 2030. In response to increasing battery demands, in particular demand for longer range EVs, higher energy density and specific energy alternatives to conventional Li-ion battery technologies are being researched. However, higher energy density directly correlates with an increased potential for higher peak temperatures on failure. In addition, safety evaluation of conventional and new battery technologies generally occurs late in development, often at the commercialization stage when mandated by stakeholders or industry standards. This approach can be costly and challenging as it may require a change to manufacturing processes, a re-design of the battery, and even a change in chemistry to meet safety requirements. This is critical; scale-up efforts alone can take tens to hundreds of millions of dollars and >5 years to achieve. Safety risks discovered after commercialization can significantly exacerbate those figures. Furthermore, safety is still a major risk with already commercialized Li-ion batteries. These risks hinder adoption, slow commercialization, and when they become issues, the outcome may result in recalls, fires, injuries, and even fatalities. Providing additional levers to proactively mitigate safety risk at the materials and components scale (e.g., composite cathode) will lead to considerable time and money savings in the long run.

Somatic Gene Therapy: Ethics and Access.

Manipulation of a patient's genome for therapeutic ends is being attempted through numerous methods, some of which have resulted in disease-modifying interventions. The much anticipated promise of somatic gene therapy is starting to pay off; however, there remain many scientific unknowns, including concerns about safety and durability. A significant ethical concern is that of access to these novel interventions, an issue that is normally framed in terms of the high costs of approved products. I describe how access issues permeate gene therapy long before there is any commercial product and how even upstream decisions-such as choices of indication to pursue, viral vector, and where to site a trial-have significant implications for access to resultant products in both the developmental and commercial stages.

Optimizing Sweet Cherry Attributes through Magnesium and Potassium Fertilization

Plant nutrition through fertilizer application plays a crucial role in enhancing crop quality and yield, necessitating a balanced fertilization approach. Sweet cherry, esteemed as one of the most prized crops worldwide, was the focus of this three-year study spanning from 2019 to 2021, involving the sweet cherry cultivar Burlat. This study investigated the foliar application of magnesium (Mg) and potassium (K) to enhance fruit quality parameters. Different doses of Mg (250 g hL−1 and 125 g hL−1) and K (100 g hL−1 and 50 g hL−1) and a control treatment were administered to sweet cherry trees to assess their impact on fruit quality. At the commercial ripening stage, fruits from each treatment were harvested for comprehensive evaluation, including biometric and chromatic parameters, fruit firmness, routine parameters, sensory profile, and nutrient content analysis. Results from the study revealed notable enhancements in fruit weight and dimensions, particularly in the control treatment in 2020. Furthermore, Mg125 and Mg250 treatments exhibited improved color development and accelerated maturity by increasing the total soluble solids content while decreasing titratable acidity. Sensorial profiling indicated that Mg125 and Mg250 treatments intensified color intensity and sweet taste while mitigating sour taste perceptions. Conversely, potassium fertilization, especially the K50 treatment, led to increased fruit firmness and nutrient content. These findings offer valuable insights into optimizing sweet cherry production practices globally.

Growth Configuration of Invention-based Entrepreneurial Start-up

This research studies an important question of configurational change of entrepreneurial growth. More precisely, it explores the question of post-start-up configurations in invention-based ventures and aims to improve our understanding of how and why aspects of start-ups transition from one stage to another. A case study method enables us to see what happens when a start-up tries to move from product invention to its commercialization stage, why specific actions occur, and how they impact the venture. Our findings show the importance of enabling the organizational emergence process through two complementary mechanisms, changes in entrepreneurs’ sense- and decision-making logic and using temporal or similar pressure as a motivational tool.

Artificial intelligence and innovation management: Charting the evolving landscape

The excitement surrounding Artificial Intelligence (AI) is palpable. It is rapidly gaining prevalence in academia, business, and personal use. In particular, the emergence of generative AI, exemplified by large language models such as ChatGPT, has been marked by substantial media attention, discourse, and hype. Like most, if not all, aspects of business, innovation processes have been impacted. However, little is known about the degree of impact or the benefits that might be gained. To cut through the hype and understand the use of AI in innovation processes in businesses today, a large-scale survey amongst innovation managers in the USA was conducted, followed by interviews. The findings indicate that the use of AI in innovation processes is high and widespread, with AI being used for more than half of the surveyed firms' innovation projects. Furthermore, AI is used more in the development stage of the innovation process than in the idea or commercialization stages, which counters much of the existing discourse, which focuses on the idea stage. We uncover interesting differences by comparing the use and impact of generative AI with that of more traditional AI. Among these is a significant difference in expected benefits in making employees’ jobs more fulfilling — managers believe generative AI is more likely to confer this benefit than traditional AI. This paper offers two valuable contributions. First, it enriches the evolving dialogue at the intersection of AI and innovation management by offering much-needed empirical evidence about practical applications. Second, it provides timely managerial implications by examining relationships between the use of AI and innovation performance and understanding the benefits that AI can confer in the innovation process.

Seizing the Hidden Assassin: Current Detection Strategies for Staphylococcus aureus and Methicillin-Resistant S. aureus.

Staphylococcus aureus (S. aureus) is a kind of pathogenic bacteria which can lead to food poisoning, hospital, and community infections. S. aureus and methicillin-resistant S. aureus (MRSA) have become headaches for public health worldwide. Therefore, strengthening the detection of S. aureus and MRSA is a critical step to prevent and control its spread and infection. This review summarized multiple detection methods (electrochemical, optical, and other biosensors) for sensitive and efficient detection of nonresistant and resistant S. aureus. First, we have introduced the principle and methods of detection platform for S. aureus and MRSA. We also contrasted various detection strategies. Finally, the current situation and prospect of S. aureus and MRSA detection in the future are explored in depth, and its development direction of detection methods is also predicted. In this review, we found that although biosensors have shown tremendous brilliance in the field of monitoring, they are currently in the experimental stage. It can be certain that we are very close to entering the commercialization stage. The point-of care testing available to nonprofessionals will become a new direction. We firmly believe that the monitoring system will be more perfect and stable and public life will be healthier and safer.

‘Imitate the Motions of Those that are Infected’: Shakespeare’s Love’s Labour’s Lost in Margaret Cavendish’s The Convent of Pleasure

Abstract Despite a Restoration vogue for adapted—or ‘improved’—productions of Shakespeare’s plays, Love’s Labour’s Lost (c.1594) fell out of the theatrical repertoire after 1660. The play’s immediate afterlife exists solely in Margaret Cavendish’s inversion of the play in her closet drama The Convent of Pleasure (1668). This essay argues that both plays respond to the virulent plague outbreaks which immediately preceded them in their depiction of single-sex cloistering, and engage with contemporaneous debates around the efficacy of household quarantine as a public health response. Love’s Labour’s Lost offers a complicated defence of public theatre in the face of quarantine restrictions which saw the playhouses forcibly closed for 11 months. Convent repurposes Shakespeare’s portrayal of infection risk in a public theatre for the closet environment. But transferring a play predicated upon the fear of contagious bodies from the commercial stage to the ‘Stage of Imagination’ has potentially dangerous consequences for its readers. Cavendish’s vitalist materialism renders the recreation of the public stage within the mind an act of potential self-harm. Yet Cavendish’s adaptation of a Shakespearean play preoccupied with plague allows her to think through her own theory of imitation as the driving force behind both contagion and sympathetic inclination.

Understanding no fault found event risk in military aircraft MRO planning: A step towards robust bidding and contract finalization

No fault found (NFF) is a reported fault for which the root cause cannot be found. An NFF event not only reduces the availability of the equipment to customers but also results in financial losses to the manufacturer. To date, risk due to NFF events is not considered separately in aircraft Maintenance, Repair, and Overhaul (MRO) planning. In this paper, we have studied the NFF event risk identification, distribution, and optimization in an aircraft MRO process based on data collected over three decades of aircraft maintenance. For framework development and formulating the critical NFF risk drivers, this paper applies soft system methodology with detailed semi-structured interviews of industry experts. For NFF risk distribution and optimization, we have used agent-based simulation modeling. The quantitative assessment of more than 5000 NFF cases in an aircraft MRO organization shows that NFF events are significantly non-deterministic during the life cycle of an aircraft. The three identified critical NFF risk drivers in the research are the MRO process stage, aircraft life cycle stage, and human working skills. The MRO process stage is the time of the NFF event during repair activity. The life cycle stage represents the timeline of the NFF event in useful aircraft life. Human working skill represents the role of manpower in the NFF event solution. Further theoretical elaborations of the research lead to the optimized NFF risk break-up at the contract preparation stage and risk driver's sensitivity analysis by the aircraft assembler, operator, and sub-contractor at the commercial bid submission stage.

A Perennial Green Revolution to address 21st‐century food insecurity and malnutrition

AbstractFarming practices of the past century have dramatically increased annual crop yields to unprecedented levels but have consequentially created increasing ecological and public health concerns, posing a long‐term threat to global food security. Soil tillage and chemical inputs perpetuate soil erosion, biodiversity loss, wetlands eutrophication, carbon emissions, and other farming stressors. Concomitantly, accompanying poor dietary patterns and malnutrition increase the risk for chronic diseases, such as cardiovascular diseases, obesity, type 2 diabetes, and cancer, which account for greater than 70% of global mortality per annum. Altogether, such annual monocropping systems exacerbate food insecurity, necessitating action across the fields of public health, agriculture, nutrition, medicine, and environmental ecology, that is, a transdisciplinary approach. Herein, we argue that the perennialization of crops creates an opportunity to address the challenges of environmental sustainability and nutritional adequacy economically. Unlike annuals, perennial crops have deeper roots for increased drought tolerance and reduced needs for fertilization and irrigation. Adopting perenniality can result in greater drought tolerance and improved soil health while reducing erosion, farming labor, and seed purchasing. Furthermore, perennializing novel staple crops may offer a superior and diverse dietary profile of phytochemicals, fiber, and macronutrients compared to conventional annuals. Instead of traditional perennial tree crops, we focus on intermediate wheatgrass Kernza® (Thinopyrum intermedium) and sunflowers (Helianthus tuberosus, H. maximiliani, and Silphium integrifolium) as exemplars of perennial staple food crops for grain and oil, respectively, at different stages of perennial crop commercialization. Ultimately, we discuss how integrating perenniality has the potential to revolutionize global agriculture and address food security concerns for the remainder of the 21st century.

Antioxidant Profile, Amino Acids Composition, and Physicochemical Characteristics of Cherry Tomatoes Are Associated with Their Color.

This study was conducted to characterize different colored lines of cherry tomatoes and derive information regarding their metabolite accumulation. Different colored cherry tomato cultivars, namely 'Jocheong', 'BN Satnolang', 'Gold Chance', 'Black Q', and 'Snacktom', were assessed for their firmness, taste characteristics, and nutritional metabolites at the commercial ripening stage. The cultivars demonstrated firmness to withstand impacts during harvesting and postharvest operations. The significant variations in the Brix to acid ratio (BAR) and the contents of phenylalanine, glutamic acid, and aspartic acid highlight the distinct taste characteristics among the cultivars, and the nutritional metabolites are associated with the color of the cultivars. The cultivar choices would be the black-colored 'Black Q' for chlorophylls, β-carotene, total flavonoids, and anthocyanins; the red-colored 'Snacktom' for lycopene; the orange-colored 'Gold Chance' for total phenolics; and the green-colored 'Jocheong' for chlorophylls, vitamin C, GABA, glutamic acid, essential amino acids, and total free amino acids. The antioxidant capacity varied among the cultivars, with 'Gold Chance' consistently exhibiting the highest activity across the four assays, followed by 'Snacktom'. This study emphasizes the importance of screening cultivars to support breeding programs for improving the nutritional content and encourages the inclusion of a diverse mix of different colored cherry tomatoes in packaging to obtain the cumulative or synergistic effects of secondary metabolites.

Data Envelopment Analysis-Based Approach to Improving of the Budget Allocation System for Decarbonization Targets

Energy innovation plays an important role in the transition to a zero-carbon economy. Governments in IEA member countries are investing in the R&D, demonstration, and deployment of new energy technologies as part of their energy and climate policies. However, government subsidies for energy innovation are not always efficient in achieving climate policy goals. This paper proposes a two-stage Data Envelopment Analysis model with shared inputs to determine the optimal allocation of public funds for the energy innovation process. The innovation process is divided into two stages: the R&D stage and the commercialization stage. The inputs to the model (budget expenditures for energy innovations) are distributed between the first and second stages. As intermediate products, we use the number of patents in clean energy and hydrocarbon energy. The outputs of the model are the changes in carbon intensity and energy efficiency. This model can be used to assess the effectiveness of government spending on energy innovation. The results show that some IEA member countries should allocate a large part of the fossil fuel technology budget (more than 70%) to the research and development phase. The proposed model can support decision making at the international level to increase the effectiveness of public policies in achieving decarbonization and energy efficiency goals.

Designing and evaluation of a mixed reality system for crime scene investigation training: a hybrid approach

Police investigation in real-life crime scenes is an essential aspect of forensic science education. However, the practicality of bringing young investigators to actual crime scenes is often hindered by the costs and challenges involved. In order to overcome these obstacles, new technologies such as mixed reality (MR) are being explored as potential solutions. MR technology offers an interactive and cost-effective way to simulate real-life crime scenes, providing a valuable training experience for young investigators. This paper presents a novel design of a MR system using Microsoft HoloLens 2.0, which is tailored to work in a spatial 3D scanned and reconstructed crime scene using FARO point cloud 3D scanner X130 blended with photogrammetry techniques. The system was developed through the lens of Experiential Learning Theory and designed using a participatory approach, providing a cost-effective solution to help trained Kuwaiti police officers enhance their investigative skills. In order to evaluate the system’s user experience and user interaction, the Questionnaire of User Interaction Satisfaction and User Experience Questionnaire were utilised. Forty-four young police officers evaluated the system. Police students showed positive levels of satisfaction with user interaction and overall user experience with minimal negative feedback. Female students showed higher satisfaction with the overall impression compared to male students. Based on the positive feedback regarding the system expansion, the system will be taken into the commercialisation stage in the future to be provided as an essential tool for crime scene education and investigation practices.

Commercialization Process for Developing Agritourism: The Use of Commodity Chain Analysis

ABSTRACT Agritourism, a combination of agriculture and tourism, entails a complex process of commercializing agricultural resources into tourist products. This study utilizes the commodity chain model to outline the stages of commercialization for rural resources and shed light on critical challenges and prospects in agritourism development in Taiwan. The research reveals that agritourism commercialization unfolds across seven distinct phases: planning experiential products, designing service delivery, positioning commodities in the market, marketing and promotion, establishing sales channels, ensuring on-site delivery and quality control, and consumption by visitors within the Production-Exchange-Consumption (PEC) framework. By analyzing the commodity chain of agritourism, we gain comprehensive insights into each stage of resource commercialization and its intricate implications for the roles and influences of various stakeholders. This study contributes to academic discourse on agritourism commercialization and offers recommendations to foster sustainable agritourism experiences.

SITUACIÓN ACTUAL, DESAFÍOS Y PERSPECTIVAS DE LA FUSIÓN NUCLEAR CONTROLADA: LA TECNOLOGÍA

This article objectively discusses the potential of development of nuclear fusion as a profitable energy source for the society of the future. After a brief exposition treating the physical foundations on which nuclear fusion is based – that are known for a century -, attention is drawn to the formidable difficulties that have been encountered when trying its practical implementation in a controlled device, and to the different proposals for reactors which have been conceived with the aim of overcoming them and demonstrate its scientific-technical feasibility. Information is provided regarding the most relevant (public and private) projects that are currently being developed in this field, which exhibits a situation characterized by the strong irruption of private initiative in recent years, and by diversification in terms of concepts and reactor designs, without it being clear at the moment which solution will prevail in the commercial stage, or whether the path to that goal will be completed by several models that will coexist. It is estimated that, in the most optimistic case and thanks to the impetus given by private initiative, the first commercial fusion energy plants could be available in the 2040s, making it plausible that public-private collaboration mechanisms will proliferate. The enormous advantages that this resource would bring to society are pointed, taking account of its virtues as a clean, safe, almost unlimited and cheap energy. This article will be continued by another devoted to exploring the economic viability of fusion technology, assuming the high level of uncertainty associated with both the vagueness of the details in the design and operation of the plants, as well as the lack of knowledge in the energy environment, economic and social in the coming years. Keywords: energy sources, energy prospective, energy technology, controlled nuclear fusion, energy economics, decarbonization.

Non-destructive optical indices to estimate isoprenoids with nutritional value in packed rocket and spinach

The quantification of phytochemicals with nutritional benefits relies on accuracy yet time-consuming, expensive and destructive methodologies. In contrast, optical indices widely employed in disciplines such as ecology can serve as fast, low-cost, and non-destructive tools for tracking pigment changes. However, their potential application in postharvest phases and commercialization (i.e., supermarkets) remains underexplored. In this context, this work aimed to investigate the feasibility of using the normalized difference vegetation index (NDVI), the chlorophyll content index (CCI) and the photochemical reflectance index (PRI) to estimate phytochemicals of nutraceutical interest (chlorophylls, carotenoids and tocopherols). A fully factorial and randomized experimental design (combining different illumination, packaging, and collecting time) was conducted in two green leafy packaged vegetables (rocket and spinach). With this design that induced differences in physiological parameters a database with variable content of isoprenoids (carotenoids, chlorophylls, and tocopherols) based on treatments was created. By establishing correlations and models between isoprenoids and optical indices, the NDVI was revealed as a valuable tool to estimate chlorophyll content in both species, while the PRI tracked both tocopherol and carotenoid (except for β-carotene) content. Taking this approach, estimation of the sum of total carotenoids and tocopherols was achieved using the PRI. This study confirms the possibility of extending the use of the NDVI and PRI to real-time nutritional monitoring in different stages of production and commercialization. A future application envisions integrating this technology into refrigerators for enhanced consumer access to nutritional information.