Stages Of Integration Research Articles

Семантика орнамента свадебных тканых рушников IV–XVIII вв. и их роль в свадебных обрядах

The wedding ceremony is one of the integral stages of a person's life, richly saturated with traditions. A wedding is on a par with such events in a person's life as birth and death. For many centuries, the peculiarities of its conduct, rituals that should be observed, have been formed. Textiles occupied an important place in the wedding tradition. It was not only part of the bride's dowry, but also accompanied the entire procession, being an integral part of it. At the same time, the wedding textiles had to be decorated with a certain ornament bearing a sacred meaning, since pagan beliefs played an important role in the wedding process. With the adoption of Christianity, wedding customs have changed, but the importance of textiles in wedding activities has remained the same. Embroidery and weaving were an ordinary women's needlework and a kind of entertainment, in which the principle of “copying” was preserved, that is, sewing according to the pattern, the canon. When creating a dowry and, in particular, towels, young girls copied the drawing and ornament of an earlier period. That said, Slavic pagan symbols were able to find their place in Orthodoxy and were copied from generation to generation. The original semantic load that the Slavs put into reproducible patterns was eventually forgotten. But the repetition of ancient ornaments continued on wedding textiles, namely on towels. Thus, it was believed that these symbols protect a young family from the evil eye and help to find happiness. An important place in the design of wedding textiles is occupied by such symbols as “orepey” (or “burdock”), “World Tree” (or “Tree of Life”) and “Great Goddess” (or “Great Mother”, “Makosh”), depicted as a female silhouette.

Integrated synthesis and control of heat exchanger networks with dynamic flexibility consideration

• Dynamic flexible aspect is taken into account in early integration stage. • A sequential iterative algorithm for the problem solution is devised. • Stream matches, heat transfer areas and bypass fractions are optimized. • Results indicate considerable cost (−14.95%) and control performances (+61.83%). • Major advantages found for case studies with multiple disturbances. Flexible synthesis and control which can be both used to reduce the influences of disturbances on heat exchanger networks are often considered as two separate issues assisting network development at different stages. A proper integration of these separate yet connected tasks carries the promise of achieving superior designs. Currently, the study of integration of heat exchanger networks is still towards a sequential procedure consisting of initial flexible synthesis based on steady-state economic calculations followed by a controller. To overcome this challenge, based on the stage-wise superstructure, an optimization framework in this work is presented to address dynamic flexible synthesis and advanced control simultaneously for maximizing performance in face of disturbances. The framework is based on a sequential iterative procedure that decomposes the overall problem into two stages. The first stage is performed by the dynamic flexibility analysis where the design variables are chosen. In the second stage, the optimization variables are adjusted during the discrete time intervals on the realizations of the control actions and the variation ranges of outlet stream temperatures. The sequential iterative is to map the temperature regulations to the network configuration retrofits. The application to two case studies indicates that the proposed framework returns solutions which are considerably better all in terms of dynamic flexibility, economics and control performance than those published in literature. Compared to previous literature studies, the optimized solutions feature a total annual cost reduction up to 14.95%, a decrease in control action up to 48.58% and an increase in control performance up to 61.83%. Moreover, the application to two case studies indicates that allows solving a real-world problem with up to 26 hot streams and 29 cold streams (leading to models with a size of 523 binary variables and 1655 equations).

‘놀이 경험’의 교육적 이해

The purpose of this study is to investigate what kind of experience do the participants offer in traditional Korean children's play. Through this, this paper clarified that traditional Korean children's play has Function and Significance of human cultivation. Especially, components of play experience is divided into three element; fun and pleasure, rule and order, commitment and freedom. Then, it is considered how does each element work, centering on cases of traditional Korean children's play. As a result, the following was revealed: the fun and pleasure of play serves as a towing vehicle, that introduce a child to the outside world; the world of play created with unique rules and order become an integrated stage helping interalize new norms and values; freedom to reach through immersion, it means the qualitative rise of child's self. In conclusion, this paper emphasized that the world of traditional Korean children's play become the educational stage cultivating a child humanly.

THEORETICAL FOUNDATIONS OF STEM EDUCATION OF STUDENTS

STEM education is a series of sequentially arranged learning programs for students with the purpose of preparing them for productive activities and education by forming levels of competences sufficient for productive activities. It covers natural sciences, technologies, technical creativity, mathematics and is aimed at training specialists (bio and nanotechnology, programmers, IT specialists, engineers, etc.) to ensure industry development. The introduction of STEM education and the development in the individual of abilities and aptitudes for research and analytical work, experimentation and critical thinking in the conditions of the use of the latest technologies will allow to increase the GDP of Ukraine by creating the basis for the formation of high added value in the labor product.
 One of the key tasks of STEM education is to ensure that the student's personality reaches a new level of development thanks to the formation of qualities and values for the purposeful realization of personal and socially significant goals. The realization of creative potential, abilities and aptitudes in this process contributes to the formation of a multifaceted psychological and socio-professional experience.
 As a result of the student's psychological activity, proposed in the process of STEM-education, competencies should be harmonized according to the components of the psychological sphere: cognitive (knowledge); operational and technological (activity); motivational (emotional); ethical; social; behavioral This will enable students at the stages of adaptation, individualization and integration to reach a self-sufficient level of autonomy and competitiveness due to the proposed algorithm of key activities.

The Measurement of the Urban–Rural Integration Level of Resource-Exhausted Cities—A Case Study of Zaozhuang City, China

Urban–rural integration is an inevitable course for the transformation and development of resource-exhausted cities, and it is also an internal requirement to achieve sustainable development goals. Taking Zaozhuang city as a case study, this paper constructed an “Economic–Spatial–Social” (ESS) evaluation index system of urban–rural integration according to the connotations. We used the TOPSIS and obstacle degree (OD) models to measure the urban–rural integration level, from 2009 to 2019, and diagnosed the obstacles. The results show that: (1) The overall level of urban–rural integration in Zaozhuang improves year by year and presents two stages: in the initial stage of integration from 2009 to 2012, the total integration degree slowly increases, but the internal indicators fluctuated. The period ranging from the years 2012 to 2019 was stable for integrated development, with the overall urban–rural integration level significantly increasing and the internal indicators steadily improving year by year. (2) The urban–rural economic integration degree of Zaozhuang has a good foundation, and the degree of economic integration presents the characteristics of decreasing at first and then increasing, attaining the lowest value in 2012 and then slowly increasing; the foundation of urban–rural social integration is weak, but the social integration degree growth rate is the highest. The degree of urban–rural spatial integration has rapidly increased year by year, and urban and rural area exchanges and interactions have been strengthened. (3) According to the diagnosis results of the obstacle degrees, the main obstacles that affect urban–rural integration in Zaozhuang are concentrated at the economic level. Finally, the suggestions are put forward to coordinate urban–rural integration and sustainable development for resource-exhausted cities.

Blood-brain barrier: peculiarities of structural and functional organization in patients with glioblastoma

The research of the blood-brain barrier began at the turn of the 18th19th centuries. To date due to the large number of studies conducted, it is obvious that this system has an impossibly complex structure at the organ, tissue and molecular genetic levels. Scientific interest in the changes in the blood-brain barrier that occur during pathological neoplastic processes is increasing. As it turned out, the restructuring of this system is an important and integral stage in the pathogenesis of glioblastoma, a tumor of the central nervous system with the most unfavorable prognosis. Heterogeneous structure with the formation of areas of altered cellular composition, uneven and uncontrolled permeability, provided by a large number of transport vesicles and the destruction of tight contacts between endotheliocytes, active outflow of molecules from the parenchyma due to the continuous synthesis of new portions of ABC-carrier proteins, the creation of an immature vascular network under the influence of high expression of VEGF by tumor cells the main characteristics of the hematopoietic barrier, formed in glioblastoma and supporting its survival. The further research of the features of the structure and mechanisms of functioning of the blood-brain barrier in glioblastoma is a new and promising task in modern neurooncology, the solution of which will not only expand the understanding of the biology of the most common and malignant brain tumor but will also improve the effectiveness of treatment of patients and improve the prognosis.

Strategic environmental assessment in spatial planning

The prerequisite for the development of a strategic environmental assessment (SEA) is the problem of accumulation related to the environment. From this point of view, the measures and methods of countering threats of a planetary scale are analyzed: global warming and climate change; water pollution and ocean acidification; loss of biodiversity. SEA is considered as a tool for balanced development of the territory, as a tool for verifying management and planning decisions, with the help of which it is possible to reveal risks and alternatives in the process of their implementation, to convey conflict situations regarding the use of the territory. The development of the SEA is interpreted as one of the key tools for the post-war reconstruction of Ukraine. The conditions for developing and ensuring the transparency of the SEO of urban planning documentation in spatial planning, it’s content, legislative support for this process and the degree of its European integration are highlighted. The purpose of the study is to show how the procedure of strategic environmental assessment allows optimizing management and planning decisions regarding the development of territories of territorial communities in the process of spatial planning. The legal aspects of SEA regarding general plans of settlements, complex plans for the development of the territory, zoning plans and detailed plans, stages of integration of SEA in urban planning documentation are analyzed. It is proposed to highlight individual stages of the SEO development process. For this, a graphic research method is used. The expediency of implementing into domestic practice the positive foreign experience of implementing SEO, in particular, regarding: construction projects, for example the formulation of projects and evaluation of green construction, sanitary and other facilities, determination of the ecological life cycle of construction products; determining the effectiveness of SEO by whether its benefits are worth it, presenting it through the prism of knowledge and learning, as well as contextual, pluralistic, substantive, normative, and trans active dimensions; delivery of online registers of all SEO documents; promoting an open and proactive attitude to SEO among planners through the SEO Forum. The proposal to include indicators of the ecological capacity of the territory in the SEO (in the existing state and according to the project): coefficients of ecological stability, ecological danger and anthropogenic load are argued. For this, the tabular and normative method of calculation is used. The scientific and practical significance of the article lies in the introduction of the basic indicators of the ecological capacity of the territory (before and after the project of the Comprehensive Development Plan of the territory of the territorial community) into the SEO, which allows to compare the existing and project state of the territory and the environment in terms of the coefficients of ecological stability, ecological danger and anthropogenic load. The ability of the SEO to comprehensively analyze the possible impact of the planned activity on the environment is demonstrated. Keywords: SEO, spatial planning, urban planning documentation, report, territorial community, public discussion, ecological capacity of the territory.

A technical assistance program approach for pharmacist clinical services integration in primary care organizations

BackgroundLittle is known about the use of technical assistance (TA) programs to facilitate the integration of pharmacist clinical services in primary care settings. ObjectiveDesign, implement, and evaluate a TA program to advance pharmacist integration and clinical services in primary care. Practice descriptionStructured TA program for developing new or enhancing current integrated pharmacist services was utilized in 4 primary care organizations (i.e., federally qualified health center, accountable care organization, and an academic and regional health system). Practice innovationHolistic TA program with a logic model, organizational stages of pharmacist integration, project prioritization, and implementation plans. Evaluation methodsA mixed-methods contextual inquiry approach for integration of pharmacist clinical services. Quantitative analysis was used for TA program activities, time spent, pilot project data, and a web-based survey for post-TA program assessment. Coincidence analysis was used to assess organizational commitment to TA services. Qualitative analysis was used for data collected through semi-structured key informant interviews and team meeting activity reports. ResultsTA program team spent 1872 hours over 11 months on program development, logistics, implementation, and project oversight. TA services included 88 onsite and virtual meetings, 11 onsite pharmacist coaching sessions, 6 workflow mapping sessions, and updating online learning resources. Primary care organizations that had already hired a pharmacist were more likely to uptake TA services. Most useful TA methods were webinar meetings (89%) and on-site pharmacist coaching (88%). TA project results were used for strategic planning (73%), pharmacist value/impact assessment (72%), pharmacist capacity modeling (68%), and workflow design (65%). A key learning from the TA program was the importance of a qualified pharmacist with clinical service experience in primary care settings and population health teams. ConclusionTA program for the pharmacist clinical service integration has broad application to primary care organizations with diverse organizational structures, payer mixes, and practice settings.

Information system for studying vertebrates: an example of development and application

The article describes the structure and methods of filling and using the information system created to accumulate data from long-term surveys of small mammals at the Gomselga Biological Research Station of the Institute of Biology KarRC RAS. The data obtained in the period from 1994 to 2022 total 5404 records on individual animals and 668 records on sampling lines. The relational database on small mammals is linked to the GIS which maps of the spatial distribution of animal habitats and the locations of sampling lines. The information system permits storing different types of data in separate interlinked tables which make the source material more visual and easily verifiable. Data are shared between different program environments using the simple csv format. The database and GIS tables are linked via a composite key field facilitating accurate matching of objects (individuals) to unique samples (lines). To acquire a certain subset the user makes a multistage query which is both easily editable and enables control at each stage of data selection and integration. The proposed structure of the information system is universal in nature and applicable whenever series of samples are collected simultaneously in a given locality. The system can be used in the MS Excel, Access, LO Calc, Base, R, and QGIS program environments. The formats of data presentation in tables and links between tables and GIS layers are discussed; the structure and types of queries are presented. Sample queries for acquiring data for subsequent processing by quantitative methods and for illustrations are provided.

Analisis Kejahatan Transnasional melalui Aktivitas Money Laundering dalam Illegal Wildlife Trade di India

This article aims to describe the relation between Money Laundering and illegal wildlife trade, with the case study focused on India. Money laundering operations in this article are part of a transnational crime act to disguise the illegal profits of Illegal Wildlife Trade (IWT) and are carried out through the stages of placement, layering, and integration. The findings of this paper are (1) identify the scope of the spread of money laundering within global, national, and regional levels and the impacts; (2) acknowledge the implementation of the model of cooperation which has succeeded in identifying the political conditions in India which are identified as weak states in applying the law & also the model of operation that used the Strategic/Risk Management Model as the TOC entity strategy to minimize the legal risk; and (3) finding methods to address and policy recommendations at various levels with the role of the Financial Action Task Force (FATF) at the global level, Anti-Money Laundering (AML) at the regional level in the South Asian region, and the Prevention of Money Laundering Act (PMLA) which was established in 2012 as a preventive measure for India to eradicate money laundering at the national level. Keywords: Money Laundering; Illegal Wildlife Trade; Transnational Organized Crime

Interaction of network and rehabilitation therapy parameters in defining recovery after stroke in a Bilateral Neural Network

BackgroundRestoring movement after hemiparesis caused by stroke is an ongoing challenge in the field of rehabilitation. With several therapies in use, there is no definitive prescription that optimally maps parameters of rehabilitation with patient condition. Recovery gets further complicated once patients enter chronic phase. In this paper, we propose a rehabilitation framework based on computational modeling, capable of mapping patient characteristics to parameters of rehabilitation therapy.MethodTo build such a system, we used a simple convolutional neural network capable of performing bilateral reaching movements in 3D space using stereovision. The network was designed to have bilateral symmetry to reflect the bilaterality of the cerebral hemispheres with the two halves joined by cross-connections. This network was then modified according to 3 chosen patient characteristics—lesion size, stage of recovery (acute or chronic) and structural integrity of cross-connections (analogous to Corpus Callosum). Similarly, 3 parameters were used to define rehabilitation paradigms—movement complexity (Exploratory vs Stereotypic), hand selection mode (move only affected arm, CIMT vs move both arms, BMT), and extent of plasticity (local vs global). For each stroke condition, performance under each setting of the rehabilitation parameters was measured and results were analyzed to find the corresponding optimal rehabilitation protocol.ResultsUpon analysis, we found that regardless of patient characteristics network showed better recovery when high complexity movements were used and no significant difference was found between the two hand selection modes. Contrary to these two parameters, optimal extent of plasticity was influenced by patient characteristics. For acute stroke, global plasticity is preferred only for larger lesions. However, for chronic, plasticity varies with structural integrity of cross-connections. Under high integrity, chronic prefers global plasticity regardless of lesion size, but with low integrity local plasticity is preferred.ConclusionClinically translating the results obtained, optimal recovery may be observed when paretic arm explores the available workspace irrespective of the hand selection mode adopted. However, the extent of plasticity to be used depends on characteristics of the patient mainly stage of stroke and structural integrity. By using systems as developed in this study and modifying rehabilitation paradigms accordingly it is expected post-stroke recovery can be maximized.

The Study of Feminism Based on Peaky Blinders

This paper makes an in-depth analysis of the "Peaky Blinders" from the aspects of role setting and plot arrangement from the standpoint of feminism, and tries to explain the breakthrough of the play in reshaping the female image and constructing the main body of female mainstream ideology. In the "Peaky Blinders", we can see the development process of feminist creative ideas from "the initial stage of essentialism tendency" to "the transitional stage of collision and integration of different feminist ideas" to "the experimental stage of trying a variety of feminist expressions" and then to "the personality stage of giving up ideas and free expression" which reflects women's recovery of initiative, women are the core and master their own emotional life. Through the analysis of the origin and development of feminism and the creation of female characters in the "Peaky Blinders", this paper reveals the great significance of female characters and tries to provide ideas for the process of creating them in film and television works for the long-term production. European and American female TV dramas can be regarded as an early and systematic bold practice of "she culture" in the field of film and television popular culture, providing rich content and various types of image texts. The image world in European and American female TV dramas corresponds to the real life under "her culture". It can be seen that European and American female TV dramas are new cultural products, which are closely related to the culture of the times and echo each other, which are its advantages. However, how to develop and improve in the future, how to develop new ideas and enrich the meaning of the text, and maintain fresh vitality and keen cultural insight are what European and American female TV dramas should think and adjust at this stage.

Experimental and numerical investigation on the dynamic response and damage of large-scale multi-box structure under internal blast loading

Internal blast is different from external or air blast for the reason of internal blast load is much more complicated and more destructive to target structures. The present work presents a large-scale experiment on multiple steel box structure under confined blast loading. A multi-box structure specimen with a dimension of 7.5 m × 2.9 m × 2.2 m was designed and field blast test with 1.782 kg TNT detonated inside this model was carried out. The damage features and dynamic response of the specimen were analyzed. The plates near the explosive suffer from strong impact and result in some fragments with high velocity which are destructive to other structural members. Meanwhile, the dynamic response processes were recorded by using the high-speed photography system. The response process of the whole model can be divided into two different stages, namely, localized damage response stage and integral vibration stage. In addition, numerical model considering both double-sided and single-sided fillet welding of this large-scale experiment were built, the dynamic response and the propagation of internal blast wave were analyzed. The numerical studies show that, to achieve a good consistency with the experiment, the failure strain for double-sided and single-sided fillet welding should be set to 0.1 and 0.08 respectively for such large-scale structure under explosive load. Finally, several suggestions for the design of multi-box structure are put forward based on the experimental and numerical investigations.

Analysis of the key factors for successful international expansion based on the case of Weichai Power's acquisition of the Germany KION Group

The internationalization of companies is now a major direction and trend in the further development of companies, and the motivations and effects of internationalization are more widely studied. The successful realization of the internationalization process is not easy. Based on the case of Weichai Power's acquisition of the Germany KION Group, this paper analyses the motivations and risks of enterprises internationalization, and concludes that the key factors for successful international expansion are: understanding own needs in the early stages and taking countermeasures in the later stages of integration to match the target. However, after internationalization, the high overseas cost leads to low net profit contributed by overseas revenue is still a huge problem. How to make overseas sales contribute more profit is a topic to be discussed continuously.

The Role of the Psychotherapist in the Application of the Five Steps of Individual Psychosomatic Psychotherapy in the Context of the Three Integration Stages

The process of psychotherapy of psychosomatic disorders requires key intervention skills from the psychotherapist. The transition through the five steps of therapy occurs against the background of the three integration stages in the communication on the axis “client-therapist” and respectively “therapist-client”. It is possible for the process of going through the five steps to be repeated for each of the three integration stages, and it is also permissible for it to go smoothly in parallel with the client reaching “separation” from the therapeutic environment. The psychotherapist’s ability to observe these mental phenomena that occur during therapy gives the client security. The goal is to “eradicate” the cause of the symptom, not just cure it.

Impacts of the integral development of agriculture and tourism on agricultural eco-efficiency: a case study of two river basins in China

The integral development of agriculture and tourism heavily depends on natural resources, especially agricultural resources, and it also may contribute to the sustainability of agriculture. The sustainability of agriculture is usually measured by the agricultural eco-efficiency. The main objective of this paper is to demonstrate the impact of the agriculture and tourism integration on agricultural eco-efficiency, so as to reflect the role of the agriculture and tourism integration on promoting agricultural sustainability. Applying panel data of 19 provinces in Yangtze River Basin and Yellow River Basin in China from 2008 to 2019, this paper uses a PSTR model to demonstrate the impact of agriculture and tourism integration on agricultural eco-efficiency and its mechanisms. It is found that in the study area, the integration of agriculture and tourism can contribute to improvements in agricultural eco-efficiency, and when levels of integration are high, the promotional effect is enhanced. However, impacts vary among different regions to some extent. In terms of influencing mechanisms, inputs of agricultural labor, sown crop area, effective irrigation area and other factors decrease with continuous improvements of integration. The input of pesticides, fertilizers and other factors does not decrease in the initial stage of integration but undergoes a rapid decrease after crossing a threshold value. And it demonstrates that the integration of agriculture and tourism is beneficial for improving the agricultural eco-efficiency, so that it will contribute to agricultural sustainability. Meanwhile, this paper offers a new research perspective for discovering effects of agriculture and tourism integration, providing implications for formulating regional policies for the integration.

Development of an Integrated Scheduling System Prototype at the Department of Electrical Engineering Education, Makassar State University

This study aims to produce a prototype of an integrated scheduling system that manages all activities related to scheduling within the Department of Electrical Engineering Education, Makassar State University. An integrated scheduling information system was developed using the Research and Development (R&D) research method by collecting data from observation and interviews. The prototype development model is carried out in various integrated stages so that a web-based scheduling system design is obtained with the aim of providing optimal services to lecturers and students so that lecture activities can run well and effectively..

Key influencing factors of vertical integration of electronic health records in medical consortiums

BackgroundSimilar to other countries around the world, China has incorporated the recording of electronic health data into its national strategy. After the completion of the decentralized construction phase, the construction of electronic health records in China has reached the stages of integration, sharing, and utilization. “Vertical integration” is the premise and foundation of “shared utilization” of electronic health records within the medical consortium, but it is also a bottleneck in realizing this goal. ObjectiveThe main purpose of this paper is to find out the key factors affecting the vertical integration of electronic health records in the medical consortiums, and to clarify the impact mechanism of these key factors, so as to provide reference for improving relevant policies. MethodsIn this study, an index system of influencing factors is established for cross-institutional vertical integration of electronic health records within a medical consortium, identifying key influencing factors using the combined fuzzy-DEMATEL-ASIM method and revealing the influence relationship and action mechanism among the key influencing factors using a multi-layer hierarchical influence structure model. ResultsThere are 32 factors influencing the vertical integration of electronic health records in the medical consortium, 17 of which are key factors. According to the hierarchical structure of key influencing factors, they can be divided into three categories: surface-level factors, middle-level factors and deep-level factors. ConclusionsIn practice, these key factors should be prioritized for improvement and optimization to promote integration projects. In the future, we should focus on key influencing factors to precisely implement policies, such as introducing special promotion policies, unifying development planning, changing health insurance payment methods, establishing sharing standards, and raising public awareness.

Cloud cavitation and flow field characteristics in sudden change channel

AbstractIn this paper, the Delayed Detached‐Eddy Simulation (DDES) model is used to simulate the cloud cavitation process and the flow field distribution characteristics in the three‐dimensional cavitating chamber with a sudden change channel. The effect of cavitation evolution on the flow field is investigated by the change of vacuole volume fraction and the distribution of physical quantities in the flow field. And the Q criterion is introduced to identify the vortex structure and its variation. The results show that the evolution of cavitation presents periodic characteristics, but in a period, the flow field distribution, vortex structure, and vortex intensity under different cavitation states are different. In the stage of bubble growth, falling off, bubble cluster breaking, and separation, the vortex size is large and the vortex intensity is high, making the flow field show drastic fluctuations. However, in the stage of bubble mass integration, the flow field fluctuation is relatively weak, and the pressure fluctuation law is consistent with the bubble shedding frequency. In addition, the Q criterion indicates that the high‐strength vortices are mainly concentrated in the throat, as the degree of cavitation increases, vortex breakage is intensified and vortices are not obvious in the flow field.

Histopathological and Immunohistochemical Features of Small to Big Satellite Nevus Uncover the Nevogenesis of Large/Giant Congenital Melanocytic Nevus.

The nevogenesis of large/giant congenital melanocytic nevus (lgCMN) is a complex biological process including several integral prenatal stages. Limited by ethical concerns, the debate of whether lgCMN develops from the epidermis to the dermis or in the opposite direction remains controversial. With the present study of the accompanying satellite nevi, we tend to support that lgCMN develops from epidermis to dermis. The satellite nevi were divided into 3 groups: big (diameter >10 mm), medium (>5 mm but ≤10 mm), and small (≤5 mm). Hematoxylin and eosin and immunohistochemical staining (SOX10, Ki67, and p16) were performed to compare the nevocyte infiltration depth as well as the positively stained rates among these satellite nevi. Compared to big satellite nevi, less deeply the nevocytes infiltrated the dermis, as well as more cells expressed SOX10 and Ki67 in the epidermis and fewer cells expressed p16 in the dermis of small satellite nevi. Additionally, two specimens were obtained from each of 4 patients who underwent serial resections of lgCMN at an average interval of 1.75 years to examine the histopathological changes. In the present study, satellite nevi of different sizes represent different stages of lgCMN from early to late, deepening our comprehension of the sequential stages of lgCMN nevogenesis. Initially, abnormal nevocytes seeded, proliferated, and spread along the epidermis. At rete ridges that protrude from the papillary dermis within the epidermis, some nevocytes formed nests and gradually penetrated into the dermis. Eventually, the nevocytes infiltrated the dermis and entered a homeostatic state. This study provides new evidence supporting the theory of epidermal-to-dermal nevogenesis in lgCMN.