Initial Stage Research Articles

Nail involvement in connective tissue diseases: an epidemiological, clinical, and dermoscopic study.

The assessment of nail changes in connective tissue diseases (CTD) has been rarely explored in previous studies. The use of dermoscopy to study vascular changes in nailfolds is an interesting diagnostic technique. The aim of the study was to describe the epidemiological, clinical, and dermoscopic features of nail lesions in CTD. A prospective study was performed at the Dermatology Department of Habib Thameur Hospital (Tunis, Tunisia) in collaboration with the Internal Medicine Department over a period of 15 months, from July 2020 to September 2021, including patients diagnosed with systemic sclerosis (SS), systemic lupus erythematosus (SLE) and dermatomyositis (DM). Our study included 48 patients. Nail involvement was found in 44 cases. Dermoscopic nailfold abnormalities were identified in 37 cases. The most common clinical features were ragged cuticle, nailfold erythema, and onycholysis. Additionally, splinter hemorrhage, longitudinal ridging, lunula abnormalities, melanonychia, trachyonychia, leukonychia, increase in transverse curvature, parrot beak nail, half and half nails, and onychorrhexis were described. Nailfold dermoscopy showed a normal pattern in 10 cases, a nonspecific pattern in nine cases (SLE), and a scleroderma pattern in 29 cases (SS and DM). The scleroderma pattern was further categorized into an early pattern (6), an active pattern (14), and a late pattern (9). Normal pattern was observed solely in patients in remission. The late scleroderma pattern was associated with disease duration and systemic involvement. In SLE, disease activity correlated with onycholysis, nailfold erythema, and pathologic pattern in dermoscopy. However, patients with DM displayed a positive correlation between pulmonary involvement and scleroderma pattern. Nail involvement in CTD includes a diverse range of abnormalities. Despite being nonspecific, it can provide crucial clues for establishing a diagnosis. Nailfold dermoscopy serves as a mirror for microangiopathy, enabling the detection of changes at an initial stage, and thus, it becomes a diagnostic and prognostic tool.

Promoting the Sustainable Development of Power Construction Projects through Stakeholder Participant Mechanisms: An Evolutionary Game Analysis

The sustainable development of power construction projects (PCPs) is of great significance in solving the issue of high carbon emissions in the power industry. However, the profit-seeking nature of stakeholders’ strategic choices and other conflicts have seriously hindered this process. This study constructs a tripartite game evolution model for the government, grid companies and the public, and determines the factors and range of values that affect the behavioral and strategic choices of stakeholders based on the literature analysis method and case study method. Numerical simulations are conducted with the help of MATLAB R2021a software to explore the changes in decision-making behavior of stakeholders and system stabilization strategies in different stages of the industry life cycle and the influencing mechanisms. The results show that in the initial stage, the government lays the foundation for the development of PCPs through policy guidance under the government-led mechanism. As PCPs move into the development stage, stakeholders’ benefits increase, creating a collaborative participation situation. As PCPs mature, the role of market guidance comes to the fore, and the interventionist role of government diminishes to a guardian role. In terms of sensitivity analysis of relevant parameters, low government rewards and penalties are not conducive to the adoption of low-carbon sustainable construction programs by power grid companies. The public influences the sustainable behavior of the government and power grid companies through public opinion. In addition, reasonable cost inputs from all stakeholders are critical to effectively promote the steady growth of PCPs. Based on the results, a sustainable development promotion mechanism for PCPs is constructed based on multiple dimensions, with a view to providing decision-making services for stakeholders and thus contributing to the sustainable development of PCPs.

Stress Prediction Model of Super-High Arch Dams during Their Initial Operation Stages

It is of great significance to identify the spatiotemporal stress distribution characteristics to ensure the safety of a super-high arch dam during the initial operation stage. Taking the 285.5 m-high Xiluodu Dam as an example, the spatiotemporal distribution characteristics were analyzed based on the five-year observation data after impoundment. Statistical and boosted-regression-tree-based prediction models for the dam stress were established. The boosted-regression-tree-based prediction model is more accurate than the statistical model. The monitoring indicators for the measuring points of focused locations were determined using the confidence interval estimation method. The results show that the dam was in a compression state, and the arching effect was obvious. The arch direction compressive stress gradually increased and stabilized, and the maximum appeared in the middle of the upstream face of the crown cantilever monolith. For the crown cantilever, the cantilever direction stress at the dam heel was significantly affected by the interior temperature recovery, and the arch direction stress in the middle of the upstream face was significantly affected by the reservoir water level. The measuring points of the focused locations with reliable observation data can be selected as a monitoring index to guide the initial operation.

Gel‐Derived Amorphous Precursor Enables Homogeneous Pure‐Phase α‐FAPbI3 Films for Efficient and Stable Perovskite Solar Cells

AbstractPure‐phase α‐formamidinium lead iodide (α‐FAPbI3) perovskite solar cells (PSCs) possess potential high efficiency because of suitable bandgap. However, achieving high‐quality α‐FAPbI3 films during the spin‐coating process is challenging without anti‐solvent extraction, due to the spontaneous formation of the more stable δ‐FAPbI3 phase and the complexity of multi‐component perovskite precursor solutions. Here a gel precursor with an amorphous structure to eliminate the need for anti‐solvent extraction in achieving the homogeneous and highly oriented pure‐phase α‐FAPbI3 is devised films. The incorporation of N,N′‐dimethylpropyleneurea, and alkylammonium chloride results in extended iodoplumbate clusters in the perovskite precursor solution. In situ, spectroscopic analysis reveals that the emergence of the stable amorphous gel precursor during the initial solidification stage ensures a uniform solute distribution. This effectively prevents preferentially oriented growth in the crystal phase precursor, leading to a significant enhancement in film homogeneity. As a result, power conversion efficiencies of 24.17% for the PSC, and 19.3% for the module are achieved, along with superior operational stability, retaining 96.1% of their initial efficiency after 850 h at the maximum power point tracking. These demonstrate the best performance for the reported pure‐phase α‐FAPbI3 PSCs without anti‐solvent extraction, showing great promise for scalable manufacture.

Development of the nursing associate professional identity: A longitudinal qualitative study.

The aim of this study was to understand the factors that contribute to the development of the nursing associate professional identity. A 3-year longitudinal qualitative study of trainee nursing associates. Trainee nursing associates in England were interviewed remotely annually in February 2020, March 2021 and March 2022. They also provided diary entries. Data were anonymised, transcribed and analysed thematically. Nursing associate professional identity was developed through: increased knowledge, skills and responsibility; and self-perceptions of identity alongside responses to the role by colleagues. Tensions arose when the scope of practice expected by organisations differed from that expected by the nursing associates. Frustrations occurred when nursing associates were perceived as substitutes for Registered Nurses in the context of nursing workforce shortages. Nursing associates in this study clearly valued their new knowledge, skills and responsibility, enabling them to provide enhanced patient care. Increased clarity of role boundaries is necessary in enhancing the professional identity of nursing associates and reducing inter-professional tensions arising from role ambiguity within health and social care organisations. National guidance and employers should provide clarity on the boundaries of the nursing associate role which will strengthen their professional identity and mitigate role ambiguity within health and social care organisations. The Consolidated Criteria for Reporting Qualitative Research has been used to guide reporting. A patient and public involvement group was consulted during the initial study design stage. This study aimed to understand the factors which contribute to the development of a nursing associate professional identity. Nursing associate professional identity is developed through increased knowledge, skills and responsibility, and the perceptions of identity by participants themselves and their colleagues. The findings should inform the implementation of initiatives to clarify nursing associate role boundaries and the development of similar roles internationally.

Synthesis and toxicological study of chitosan-pirul (Schinus molle L.) essential oil nanoparticles on Aspergillus flavus.

In recent years, the study of essential oils as antifungal alternatives and their encapsulation to increase their properties for greater effects has been tested. In this work, nanoparticles of chitosan-Schinus molle L. essential oil (CS-PEO-Np) with a size of 260 ± 31.1nm were obtained by ionic gelation and evaluated in some growth phases of Aspergillus flavus, a toxigenic fungus. At a concentration of 250μg/mL of CS-PEO-Np, the A. flavus mycelial growth was inhibited at 97.1% with respect to control, at 96h of incubation; the germination and viability of spores were inhibited at 74.8 and 40%, respectively, after exposure to 500μg/mL of these nanomaterials, at 12h of incubation. The fluorescence images of stained sporeswith DAPI showed the affectations caused by nanoparticles in the cell membrane, vacuoles and vacuolar content, cell wall, and nucleic acids. For both nanoparticles, CS-Np and CS-PEO-Np, no mutagenic effect was observed in Salmonella Typhimurium; also, the phytotoxic assay showed low-to-moderate toxicity toward seeds, which was dependent on the nanoparticle's concentration. The acute toxicity of CS-PEO-Np to A. salina nauplii was considered low in comparison to CS-Np (control), which indicates that the incorporation of Schinus molle essential oil into nanoparticles of chitosan is a strategy to reduce the toxicity commonly associated with nanostructured materials. The nanoparticulated systems of CS-PEO-Np represent an effective and non-toxic alternative for the control of toxigenic fungi such as A. flavus by delaying the initial growth stage.

Soluble MICA in endometriosis pathophysiology: Impairs NK cell degranulation and effector functions.

Endometriosis exhibits several immune dysfunctions, including deficient natural killer (NK) cell cytotoxicity. MICA (MHC class I chain-related molecule A) is induced by biological stress and soluble MICA (sMICA) negatively modulates the expression of the activating receptor, NKG2D, reducing NK cells activities. We investigated the involvement of soluble MICA in NK cell-deficient activity in endometriosis. sMICA levels (serum and peritoneal fluid-PF) were evaluated by ELISA. Circulating NK cell subsets quantification and its NKG2D receptor expression, NK cell cytotoxicity and CD107a, IFN-γ and IL-10 expressions by NK cells stimulated with K562 cells were determined by flow cytometry. We found higher sMICA levels (serum and PF) in endometriosis, especially in advanced and deep endometriosis. Endometriosis presented lower percentages of CD56dim CD16+ cytotoxic cells and impaired NK cell responses upon stimulation, resulting in lower CD107a and IFN-γ expressions, and deficient NK cell cytotoxicity. NK cell stimulation in the MICA-blocked condition (mimicking the effect of sMICA) showed decreased cytotoxicity in initial endometriosis stages and the emergence of a negative correlation between CD107a expression and sMICA levels. We suggest that soluble MICA is a potential player in endometriosis pathophysiology with involvement in disease progression and severity, contributing to NK cell impaired IFN-γ response and degranulation. NK cell compartment exhibits multiple perturbations, including quantitative deficiency and impaired cytotoxicity, contributing to inadequate elimination of ectopic endometrial tissue.

Dust growth and pebble formation in the initial stages of protoplanetary disk evolution

Aims. The initial stages of planet formation may start concurrently with the formation of a gas-dust protoplanetary disk. This makes the study of the earliest stages of protoplanetary disk formation crucially important. Here we focus on dust growth and pebble formation in a protoplanetary disk that is still accreting from a parental cloud core. Methods. We have developed an original three-dimensional numerical hydrodynamics code, which computes the collapse of rotating clouds and disk formation on nested meshes using a novel hybrid Coarray Fortran-OpenMP approach for distributed and shared memory parallelization. Dust dynamics and growth are also included in the simulations. Results. We found that the dust growth from ~1 µm to 1–10 mm already occurs in the initial few thousand years of disk evolution but the Stokes number hardly exceeds 0.1 because of higher disk densities and temperatures compared to the minimum mass Solar nebular. The ratio of the dust-to-gas vertical scale heights remains rather modest, 0.2–0.5, which may be explained by the perturbing action of spiral arms that develop in the disk soon after its formation. The dust-to-gas mass ratio in the disk midplane is highly nonhomogeneous throughout the disk extent and is in general enhanced by a factor of several compared to the fiducial 1:100 value. Low St hinders strong dust accumulation in the spiral arms compared to the rest of the disk and the nonsteady nature of the spirals is also an obstacle. The spatial distribution of pebbles in the disk midplane exhibits a highly nonhomogeneous and patchy character. The total mass of pebbles in the disk increases with time and reaches a few tens of Earth masses after a few tens of thousand years of disk evolution. Conclusions. We found that protoplanetary disks with an age ≤20 kyr can possess notable amounts of pebbles and feature dust-togas density enhancements in the disk midplane. Hence, these young disks can already be ripe for the planet formation process to start. Multidimensional numerical models of disk formation that consider the coevolution of gas and dust including dust growth are important to improve our understanding of planet formation.

The influence of pretend play on the cognitive and emotional development of children 3-4 years old

Introduction. Play is the leading activity of preschool age, and play with an imaginary situation (pretend play) is considered as the most significant type of play for children’s mental development, which allows this type of play to be used in the educational process as a means of teaching and developing preschool children. The purpose of this article was to assess the impact of pretend play on the cognitive and emotional development of children 3-4 years old. We assumed that (1) the play can influence the development of executive functions, imagination and understanding of emotions in children 3-4 years old, (2) the influence of the play can be different depending on which developmental mechanisms it contains more involved. Materials and methods. To test the hypotheses, a training controlled experiment design was developed. As an experimental intervention series of play sessions with an adult were conducted. Before and after the experimental intervention, the level of development of executive functions, imagination and understanding of emotions was assessed. 39 children aged 3-4 years took part in the play sessions. Play sessions were video recorded for later analysis. Results. The data obtained were analyzed in two stages. First, the results of the pre- and post-test in the experimental and control groups were compared. At the second stage, the analysis of video recordings was carried out in order to control the influence of the child's ability to stay in the play context. Thus, the test results of the same children before and after participating in the experiment (Student's paired t-test) were compared. Significant differences were identified in the indicator “Understanding the external causes of emotions” of the Test of Emotion Comprehension and the “Elaboration” of the test for imagination. Analysis of variance with control of the level of development of hot self-regulation in children at the time of participation in the experiment confirmed that the type of experimental exposure is a significant factor affecting the development of the ability to understand the external causes of emotions (F(1.36) = 3.87, p = 0.030, n2 = 0.035). Analysis of video recordings showed that children in both playing conditions to a large extent were involved in the playing and, as expected, in their play there was an emphasis on the meanings of human activity, the relationship between the characters and their feelings. The results of the conducted training experiment as a whole showed a low effectiveness of the pretend play impact even in conditions with active participation of the adult. Conclusion. The age of 3-4 years is the initial stage of the formation of both the pretend play itself, and such mental functions as imagination, self-regulation and understanding of emotions. The results of the training experiment generally showed the low effectiveness of the play influence even in conditions of active participation of the experimenter in the play. We can conclude that when planning to use the play for developmental purposes, it is important to take into account the age and individual zone of proximal development available to the child. This will allow to understand what format of pretend play with and what adult’s interventions will be most effective.

Economic and Mathematical Model of the Development of the Digital Ecosystem of the Regional Economy (Using the Example of the Kursk Region)

Relevance. To form a system of measures for the digitalization of individual regions and the country as a whole, as well as for their effective implementation, it is necessary to develop an economic and mathematical model that allows assessing the current state of the digital ecosystem of the regional economy (DEED). The purpose is development and testing of an economic and mathematical model for the development of the digital ecosystem of the regional economy (using the example of the Kursk region). Objective: systematization of factors and indicators by categories characterizing the development of the digital ecosystem of the regional economy; calculation of indicators for each set of "Factor ‒ Indicator" for the Kursk region for the period from 2016 to 2021; conducting correlation and regression analysis for the categories "Science", "Innovation", "Human Resources", "Education", "Healthcare", "Households", "Business", "Regional Authorities". Methodology. The methodological basis of the study was: the method of statistical processing of information; methods of regression and correlation analysis. Results: factors and indicators are systematized into categories that characterize the development of the digital ecosystem of the regional economy; indicators were calculated for each set of "Factor ‒ Indicator" for the Kursk region for the period from 2016 to 2021; a correlation and regression analysis was carried out for the categories "Science", "Innovation", "Human Resources", "Education", "Healthcare", "Households", "Business", "Regional Authorities". Conclusions. Practical testing of the developed economic and mathematical model using the example of the Kursk region for some processes gave ambiguous results: a low value of the coefficient of determination, as well as non-compliance with the normative values of the Fisher f-criterion, t-criteria for the factor and the free term, which does not means the economic and mathematical model we have developed is incorrect. These results can be explained by the fact that in the region the processes under study, expressed in a certain relationship between the factor and the indicator, are at the initial stage of their formation or have not been formed. The developed economic and mathematical model for the development of the digital ecosystem of the regional economy allows us to assess the current state of the DEER, identify factors that constrain and stimulate its development, determine areas requiring financing, as well as the expected effect of the resources spent.

Individual features of the temporal dynamics of inhibitory processes in visual short-term memory depending on the content of stimuli and memorization training

Introduction. Age-related changes in cognitive functions are caused by various processes: degrading inhibitory control, decrease in the volume of working memory, or a slowdown in the speed of thought processes. However, there is no unanimous opinion on the dynamics of these processes and their interactions yet. Based on this, our research goal became finding the temporal dynamics and individual relationship of the effects of proactive interference (Retrival-Induced Forgeting (RIF)) and learning to remember (Retrieval-Based Learning (RBL)) depending on the content of the presented stimuli as well as the age-related specifics of memorization when training the short-term visual memory. Materials and methods. Memory training was carried out in a mode independently organized by the study participants using a computerized memorization program in a proactive interference model, including five sessions of visual presentation of stimuli. University students participated in the first part of the study, aimed at clarifying the meaning of the content of two different sets of stimuli, (220 people, 20.4 ± 1.9 years old), whereas second part aimed to determine the age-related characteristics of visual short-term memory training in a group of students, (70 subjects, 21.7±2.5 years) and a group of elderly women (25 subjects, 64.4±6.3 years). Research results. The results of the memory trace retrieval analysis showed that the RIF effect dominates over the RBL effect regardless of the content of the stimuli, but at different rates of its development depending on the set of stimuli used. With significant individual diversity in the combination of memory strategies, the RIF effect dominated at the initial stage of stimulus presentation (67.6% of cases) and gradually replaced by RBL (56.2% in the fifth run of the experiment). Analysis of age-related characteristics of the effectiveness of short-term visual memory training showed that when it is independently organized, maintaining activity is observed in 32% of university students and 50% in the elderly group. Along with this. Only average of ten approaches to complete this task accompanied by a further decrease in the number of training participants. Comparison of the results of the first three training sessions revealed a significant increase in the memory index in both groups compared to the initial value and the presence of a RIF effect with a further more rapid increase in the efficiency of memorization in students. Conclusion. Proactive interference while memorization of visual stimuli repeatedly presented in five sessions, appears regardless of their content, age of the subjects and memorization training. The efficiency of memorization due to training grows faster in the group of students and accompanied by the combination of the RIF and RBL effects that is characterized by individual diversity without a significant effect on the final result of the memory retrieval.

In situ single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates of monomeric α-synuclein.

α-Synuclein aggregation is a common trait in synucleinopathies, including Parkinson's disease. Being an unstructured protein, α-synuclein exists in several distinct conformational intermediates, contributing to both its function and pathogenesis. However, the regulation of these monomer conformations by biochemical factors and potential drugs has remained elusive. In this study, we devised an in situ single-molecule manipulation approach to pinpoint kinetically stable conformational intermediates of monomeric α-synuclein and explore the effects of various biochemical factors and drugs. We uncovered a partially folded conformation located in the non-amyloid-β component (NAC) region of monomeric α-synuclein, which is regulated by a preNAC region. This conformational intermediate is sensitive to biochemical perturbations and small-molecule drugs that influencing α-synuclein's aggregation tendency. Our findings reveal that this partially folded intermediate may play a role in α-synuclein aggregation, offering fresh perspectives for potential treatments aimed at the initial stage of higher-order α-synuclein aggregation. The single-molecule approach developed here can be broadly applied to the study of disease-related intrinsically disordered proteins.

The evolution of second harmonic waves in oblique transition

The evolution of second harmonic waves in oblique transition

Fat digestion and absorption: Normal physiology and pathophysiology of malabsorption, including diagnostic testing.

Fat digestion and absorption play crucial roles in maintaining energy homeostasis and supporting essential physiological functions. The initial stage of fat digestion occurs in the stomach, where gastric lipase begins the hydrolysis of triglycerides. However, most fat digestion takes place in the small intestine via pancreatic enzymes and bile salts. Emulsification of fat by bile acids facilitates enzymatic action, breaking down triglycerides into free fatty acids and monoglycerides, which are then able to be absorbed by enterocytes. Fat malabsorption can result from various underlying conditions, such as exocrine pancreatic insufficiency, bile acid disorders, or intestinal diseases. The clinical manifestations of fat malabsorption include steatorrhea, malnutrition, and deficiencies of fat-soluble vitamins. Diagnostic approaches involve assessing fecal fat levels, imaging studies, and various functional tests to identify the specific etiology. This review article will describe the normal physiologic process of fat digestion and absorption and discuss various pathophysiology that can lead to fat malabsorption within the gastrointestinal tract as well as their respective diagnostic testing modalities. Effective digestion of fat is essential for overall health, because it allows for absorption of many essential nutrients, plays an integral role in cellular and structural function, and supplies energy to the body. When this is dysfunctional, disorders of malabsorption can occur. This article will give a brief overview of the physiologic process of fat digestion and absorption in healthy individuals as well as review important pathophysiology that can lead to fat malabsorption within the gastrointestinal tract and current diagnostic testing modalities.

Experimental study of flame extension lengths and fire pattern lengths induced by the turbulent jet fire impinging on inclined wooden boards

The safety of producing and transporting flammable gas may be compromised by the occurrence of jet fires resulting from pipeline leakage. During such incidents, combustible obstacles can impede the development of vertical jet fires, leading to impingement. Wood, a typical building material, was chosen as a combustible solid for the experiment due to its ability to produce regular fire patterns on its surface when heated, making it useful for fire investigation. A series of experiments were conducted to examine the flame extension length and fire pattern length resulting from a jet fire impinging on inclined wooden boards with different nozzle diameters, inclination angles, and heat release rates. This work showed that, unlike non-combustible boards, the rate of increase in flame extension length beneath a wooden board continues to rise as the heat release rate increases. Additionally, the boards' ability to absorb heat during the initial stages of combustion affects the flame extension length at low heat release rates. This work introduces a new correlation that can predict the length of flame extension under wooden boards, addressing a gap in research on jet fire impingement on combustible ceilings. For the regular fire patterns left by jet fires impinging on wooden boards, a new correlation of fire pattern length with flame extension length for different inclination angles of wooden boards is proposed. Considering the characteristics of turbulence, a novel model for fire pattern length is introduced, incorporating the Karlovitz flame stretch factor, nozzle inner diameter, and fire source-wooden board spacing.

Effect of severe wildfire on soil phosphorus fractions and adsorption in a cold temperate coniferous forest after 5 years

AbstractForest fires are a primary driver of biogeochemical processes in ecosystems and affect the soil nutrient balance by altering the distribution of organic matter and associated nutrients as well as the composition and availability of elemental nutrients. We investigated the changes in soils’ phosphorus (P) fractions and the adsorption characteristics of potassium dihydrogen orthophosphate (orthoP) and myo‐inositol hexakisphosphate (IHP) at two depths (0–5 and 5–10 cm) in soils from two sites differing in fire severity: long‐unburned and heavily burned. Five years after the fire, there were increases in the total P and extractable inorganic P (H2O‐P, NaHCO3‐Pi, NaOH‐Pi, D.HCl‐Pi and C.HCl‐Pi) contents. Conversely, there was a decrease in organic P (NaHCO3‐Po, NaOH‐Po and C.HCl‐Po). The adsorption of soil for orthoP at a depth of 0–5 cm was dependent on the amount of P supplied by the soil; at low concentrations, heavily burned soil showed a lower adsorption than long‐unburned soil. However, at high concentrations, the adsorption of heavily burned soil was significantly larger than that of long‐unburned soil. With respect to IHP, the adsorption of long‐unburned soil was also more significant at depths of 0–5 cm. The adsorption of both orthoP and IHP of heavily burned soil was significantly higher than that of long‐unburned soil at a depth of 5–10 cm. Fire also decreased the binding degree (k1) of soil‐P and the solid phase at depths of 0–5 and 5–10 cm. The increase in P adsorption capacity outweighed the addition of P from ash, resulting in less leaching in heavily burned areas and minimizing P loss. Overall, forest fires significantly affect the adsorption characteristics and P fractions of soil, specifically orthoP and IHP, during the initial stage of postfire recovery. These effects are closely related to the direct influences of iron oxide, soil organic matter and aluminium oxide in the soil and may even produce relatively long‐term effects on the P recycling process of the entire ecosystem.

Auditory prediction errors in sound frequency and duration generated different cortical activation patterns in the human brain: an ECoG study.

Sound frequency and duration are essential auditory components. The brain perceives deviations from the preceding sound context as prediction errors, allowing efficient reactions to the environment. Additionally, prediction error response to duration change is reduced in the initial stages of psychotic disorders. To compare the spatiotemporal profiles of responses to prediction errors, we conducted a human electrocorticography study with special attention to high gamma power in 13 participants who completed both frequency and duration oddball tasks. Remarkable activation in the bilateral superior temporal gyri in both the frequency and duration oddball tasks were observed, suggesting their association with prediction errors. However, the response to deviant stimuli in duration oddball task exhibited a second peak, which resulted in a bimodal response. Furthermore, deviant stimuli in frequency oddball task elicited a significant response in the inferior frontal gyrus that was not observed in duration oddball task. These spatiotemporal differences within the Parasylvian cortical network could account for our efficient reactions to changes in sound properties. The findings of this study may contribute to unveiling auditory processing and elucidating the pathophysiology of psychiatric disorders.

Comprehensive Review on Drug-target Interaction Prediction - Latest Developments and Overview.

Drug-target interactions (DTIs) are an important part of the drug development process. When the drug (a chemical molecule) binds to a target (proteins or nucleic acids), it modulates the biological behavior/function of the target, returning it to its normal state. Predicting DTIs plays a vital role in the drug discovery (DD) process as it has the potential to enhance efficiency and reduce costs. However, DTI prediction poses significant challenges and expenses due to the time-consuming and costly nature of experimental assays. As a result, researchers have increased their efforts to identify the association between medications and targets in the hopes of speeding up drug development and shortening the time to market. This paper provides a detailed discussion of the initial stage in drug discovery, namely drug-target interactions. It focuses on exploring the application of machine learning methods within this step. Additionally, we aim to conduct a comprehensive review of relevant papers and databases utilized in this field. Drug target interaction prediction covers a wide range of applications: drug discovery, prediction of adverse effects and drug repositioning. The prediction of drugtarget interactions can be categorized into three main computational methods: docking simulation approaches, ligand-based methods, and machine-learning techniques.

Sorghum Response to Supplementary Irrigation at Different Growth Stage in Rain-Fed Agriculture for Increasing Yield and Water Productivity at Raya Valley

In arid and semi-arid ecosystems, the efficient use of water becomes increasingly important because water is a crucial limiting factor for increased food and fibre production to supply an ever-growing number of people. A field experiment was conducted in three consecutive seasons three year in Mekhoni Agricultural Research Centre, Raya valley, to investigate with the objective of to evaluate the influence of supplemental irrigation applied at different growth stages on the yield, to prevent sorghum failure caused by less rain water and to maximize the water productivity of the sorghum. The experiment was laid out in a random complete block design (RCBD) consisting of eleven supplemental irrigation treatments (one supplemental irrigation during initial stage, one supplemental during development stage, one supplemental during mid-stage, one supplemental during Late stage, one supplemental during initial and development stage, one supplemental during initial and mid stage, one supplemental during initial and late stage, one supplemental during development and late stage, one supplemental during development and late stage and rain-fed (with no SI) as a control treatment with three replications. The result was showed a significant difference on plant height, panicle length, grain, biomass yield and water productivity sorghum. The highest grain yield was obtained from the treatment supplement one SI at development and mid stage and followed by one SI at mid stage and at late stage. Whereas, the lowest grain yield of sorghum was observed from treatment with rainfed (non-supplementary). It is concluded that in the study area the rain fed amount were very inadequate and supplementary irrigation will help to increase crop productivity, minimize crop failure due to the low rainfed. The experiment showed that supplementary irrigation offers a great potential for improving crop production in Raya valley.

Need Analysis for Development (E-Module) of Analytical Chemistry Integrated with Environmental Analysis Research Results

The current condition is still limited to analytical chemistry teaching materials that are integrated with research results, only using Analytical Chemistry textbooks as teaching materials or in the form of e-books. This is one of the causes of the lack of student interest in participating in the teaching and learning process. The purpose of this research is to produce innovative teaching materials in analytical chemistry based on research results, aiming to enhance students' interest in learning.This research is the initial stage as a basis for developing analytical chemistry e-modules integrated with research results. The development model used is ADDIE which consists of five stages, namely Analysis, Design, Development, Implementation and Evaluation. This research is limited to the needs analysis stage which includes RPS analysis, analysis of problems and needs of lecturers and problems and needs of students. Data collection instruments used interviews and questionnaires. The subjects of this study consisted of 6 Analytical Chemistry lecturers and 59 students from Riau Province, Riau Islands, North Sumatra, and West Java. The research results of this preliminary analysis include RPS analysis where there are 10 topics of study material and based on the needs questionnaire the topic of quantitative analysis is the topic with the highest percentage to be developed into an e-module. Then also obtained the results that there are still some shortcomings with the teaching materials used today, so that 98% of lecturers and students stated that they need the development of teaching materials, especially those that are digital-based and can be integrated with research results which are evidence of the implementation of analytical chemistry learning theory.