Stabilization Strategy Research Articles

Cross-Species Applications of Peptide Substrate Reporters to Quantitative Measurements of Kinase Activity.

Peptide substrate reporters are short chains of amino acids designed to act as substrates for enzymes of interest. Combined with capillary electrophoresis and laser-induced fluorescence detection (CE-LIF), they are powerful molecular tools for quantitative measurements of enzyme activity even at the level of single cells. Although most peptide substrate reporters have been optimized for human or murine cells in health-related applications, their performance in nonmammalian organisms remains largely unexplored. In this study, we evaluated three peptide substrate reporters for protein kinase B (PKB) in two eukaryotic microbes, Dictyostelium discoideum and Tetrahymena thermophila, which are evolutionarily distant from mammals and from each other yet express PKB homologues. All three peptide substrate reporters were phosphorylated in lysates from both organisms but with varying phosphorylation kinetics and stability. To demonstrate reporter utility, we used one to screen for and identify the previously unknown stimulus needed to activate PHK5, the PKB homologue in T. thermophila. In D. discoideum, we employed the highly quantitative nature of these assays using CE-LIF to make precise measurements of PKB activity in response to transient stimulation, drug treatment, and genetic mutation. These results underscore the broad applicability of peptide substrate reporters across diverse species while highlighting the need for further research to determine effective peptide stabilization strategies across different biological contexts.

Evolutionary Game Analysis of Government–Enterprise Collaboration in Coping with Natech Risks

The synergistic interaction between emergency management departments and enterprises constitutes a fundamental mechanism for mitigating the risks of technological accidents caused by natural disasters (Natech). The efficacy of this collaborative approach is impacted by comprehensive risk analyses and the game between government and enterprise. Predicated on these premises, the evolutionary game analysis of government–enterprise collaboration in coping with Natech risk was carried out. Firstly, an evolutionary game model of government–enterprise collaboration in coping with Natech risk was constructed. Secondly, the evolutionary stability strategy (ESS) was developed. Finally, these strategies were substantiated through numerical simulations. The findings revealed that at lower levels of Natech risk, enterprises will choose low investment in coping capacity building, and emergency management departments will choose delayed disposal. Under moderate Natech risk, enterprises will increase their investments if emergency management departments persist with delayed strategies, and emergency management departments will react proactively if enterprises persist with low investment. Under a high Natech risk, a pattern of strategic misalignment emerges between the two entities. This study contributes a theoretical basis for the optimization of government–enterprise collaboration in coping with Natech risks.

Research on stability strategy based on the dynamic evolution game of promoting low-carbon building green building materials market

Research on stability strategy based on the dynamic evolution game of promoting low-carbon building green building materials market

Acidic water oxidation with ultralow 131 mV overpotential over surface-reconstructed RuIr nanoalloy: Chloride-driven high performance

The oxygen evolution reaction (OER) in kinetics is sluggish but a key electrode reaction for various energy storage and conversion devices, such as green hydrogen from water electrolysis, rechargeable metal-air battery, sustainable carbon dioxide electroreduction, synthetic ammonia, etc. However, it still remains a major and cutting-edge challenge to pioneering catalysts with simultaneously ultrahigh activity and stability for OER, even with diverse performance enhancement strategies, such as complex composition designs, surface chemical reconstructions, and multiphase engineering have been implemented to accelerate this key electrochemical process. Herein, we proposed a chloride-triggered activation and stabilization strategy for the branched RuIr alloy coated by thin IrO2 layer to achieve unparalleled high-performance toward OER in acidic water. The ultralow overpotential of the activated catalyst is reduced to about 131 mV at 10 mA cm−2, with 79-fold enhancement of mass-activity than commercial IrO2. Moreover, a modified proton exchange membrane water electrolysis (PEMWE) device was first constructed by introducing NaCl into recyclable electrolyte. It run a stably and low cell potential (1.514 V) for 170 h, having no obvious performance decay at 50 mA cm−2 in 0.5 M H2SO4 with 1.6 M NaCl, which far exceeding traditional IrO2||Pt/C PEMWE. The outstanding performance stems from that Cl- ions enable a faster lattice oxygen evolution mechanism. The novel catalyst activates asymmetric O-Ir-Cl structure induced by Cl- filled oxygen vacancies, which modify the electronic and geometric properties, improving OER activity. Moreover, these adsorbed ions can also efficiently patch and refill the oxygen vacancies that ensure the long-term structure stability. Therefore, tailoring the chloride-activated Ir-based catalysts with simultaneously improved activity and stability may be a valuable guide to achieve surprisingly high-performances for acidic water splitting.

Surviving on a Shoestring: An In-depth Look into the Financial Realities of Public Junior High School Teachers

Public school teachers in the Philippines play a pivotal role in shaping the nation's future by imparting knowledge and nurturing young minds. However, despite their dedication and commitment, most of them face significant financial hardships, struggling to make ends meet while fulfilling their vital educational responsibilities. Thus, this qualitative phenomenological paper explored the lived experience of financially struggling public-school teachers, gaining an in-depth understanding of their financial realities. The data were gathered from the five (5) participants who were chosen using a purposeful sampling technique and determined using the following inclusion criteria: teachers earning an allowable minimum net pay of five thousand pesos (Php 5,000); engaging in secondary income-generating activities; at least 5 years in the service; and with family dependents. The data were collected utilizing the in-depth, semi-structured interview. Employing a thematic analysis by Moustakas, six (6) major themes emerged that highlighted the financial realities experienced by public junior high school teachers, namely: (1) Financial Struggles and Insufficient Support Systems; (2) The Dual Roles of Educators as Teachers and Earners; (3) The Toll of Financial Stress on Teachers' Well-being and Professional Performance; (4) Debt Trap: The Continuous Cycle of Borrowing and Repayment; (5) Financial Pressures and Sacrifices of Family Obligations; and (6) Boosting Teacher Financial Wellness: Strategies for Stability and Support. Hence, these findings underscore the urgent need for systemic reforms and financial literacy education, offering valuable insights for policymakers to enhance support for educators and improve the quality of education.

Unravelling the potential of prussian blue analogues in oxygen electrocatalysis: A perspective on surface reconstruction

Prussian blue analogues (PBAs) hold promises as catalysts for electrochemical energy conversion, especially in the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER). Their high surface area and porosity combined with a tunable electronic structure featuring abundant metallic centers, make them attractive alternatives to traditional noble metal-based catalysts. Amongst these fascinating properties, the capacity for surface reconstruction to form active layers is one of the most sought-after characteristics of PBAs for enhanced activity. Recent advancements in operando and in situ techniques have further highlighted PBAs' capability for surface reconstruction during the electrocatalysis, particularly in alkaline solutions. State-of-the-art strategies for enhancing activity and stability of PBA-based catalysts, such as metal doping, tuning metal centers, introducing coordination sphere vacancies (VFeCN), and utilizing carbon supports, are closely linked to their ability towards surface reconstruction. However, key aspects warrant further exploration to achieve high electrocatalytic activity, including identifying initiators and pathways for surface reconstruction, establishing structure-property-activity correlations, and strategically manipulating in-situ catalyst surface reconstruction. This perspective focuses on understanding the transformation of PBA-based pre-catalysts to surface active layers on catalysts via surface reconstruction. A recent progress in PBA-catalysts towards advancing the electrochemical energy systems is highlighted. This perspective will guide the new entrants in the field to understand the process of surface transformation for establishing structure-property-activity relationships and thus to develop highly efficient PBA-based electrocatalysts.

Analysis of Shared Parking Game Model under Dynamic Parking Pricing

In recent years, the problem of "parking difficulty" has led to a large number of illegal parking incidents. The shared parking mode has been considered as an effective way to alleviate the conflict between parking supply and demand and urban traffic pressure. To address the issue of illegal parking and promote the development of shared parking, this paper constructs an evolutionary game model with shared platforms and motor vehicle drivers as the main entities. The study investigates the evolutionary stability strategy of the model, conducts sensitivity analysis on model parameters, and further analyzes the impact of highly sensitive parameters on the evolutionary paths of both players in the game. Finally, numerical simulations are performed on dynamic parking pricing standard. The research findings demonstrate that the sensitivity of discounts received by drivers from shared platforms and the additional revenue gained by the shared platform is higher than that of other parameters. Moderately increasing the penalty for illegal parking and the additional revenue of the shared platform can encourage drivers to choose legal parking and promote the development of shared parking. Under given parameterized and periodic parking pricing standard, finally, according to the particle swarm optimization algorithm, a set of relatively optimal parameter values is derived to enable the model to evolve rapidly into a stable state where drivers choose to park legally and the shared platform selects surrounding parking lots. It can effectively reduce the frequency of illegal parking.

Biopolymer/tannic acid-based nanocomposites system: Stability enhancement of nobiletin

Based on self-assembly coatings guided by hydrogen bonding interaction, nobiletin (NOB)-loaded nanocomposites could be synthesized by the anti-solvent method. In this work, we fabricated controllable nanoaggregates with desired properties from molecular building blocks governed by tannic acid (TA) and polyethylene glycol (PEG), selected as the wall materials for embedding NOB. From the results, TA/PEG coating was regulated by the pH conditions, temperatures, and the proportion of coating materials, further affecting the stability of the whole nanocomposite system. Eventually, the optimized samples demonstrated stability for at least 30 days, which was characterized as high-loading efficiency and sustained release properties in-vitro digestion experiments. Taken together, this study paves a new facile stabilization strategy for overcoming some bottlenecks in the storage and treatment of hydrophobic substances, which is expected to facilitate the rational design of polyphenol-based systems with potential in biomedical and environmental applications.

Insulator‐transition‐induced Degradation of Pyrochlore Ruthenates in Electrocatalytic Oxygen Evolution and Stabilization through Doping

Ru‐based pyrochlores (e.g., Y2Ru2O7–d) are promised to replace IrO2 in polymer electrolyte membrane (PEM) electrolyzers. It is significant to reveal the cliff attenuation on the oxygen evolution reaction (OER) performance of these pyrochlores. In this work, we monitor the structure changes and electrochemical behavior of Y2Ru2O7–d over the OER process, and it is found that the reason of decisive OER inactivation is derived from an insulator transition occurred within Y2Ru2O7–d due to its inner ²perfecting² lattice induced by continuous atom rearrangement. Therefore, a stabilization strategy of the Ir‐substituted Y2Ru2O7–d is proposed to alleviate this undesirable behavior. The double‐exchange interaction between Ru and Ir in [RuO6] and [IrO6] octahedra leads the charge redistribution with simultaneous spin configuration adjustment. The electronic state in newly formed octahedrons centered with Ru 4d3 (with the state of eg'2­­a1g­1 eg0) and Ir 5d6 (eg'4a1g­2 eg0) relieves the uneven electron distributions in [RuO6] orbital. The attenuated Jahn‐Teller effect alleviates atom rearrangement, represented as the mitigation of insulator transition, surface reconstruction, and metal dissolution. As results, the Ir‐substituted Y2Ru2O7–d presents the greatly improved OER stability and PEM durability. This study unveils the OER degradation mechanism and stabilization strategy for material design of Ru‐based OER catalysts for electrochemical applications.

Imparting Stability to Chiral Helical Gold Nanoparticle Superstructures.

Realizing the promise of chiral inorganic nanomaterials hinges on improving their structural stability under various chemical and environmental conditions. Here, we examine the stability of 1-D gold nanoparticle (Au NP) single helices prepared using the amphiphilic peptide conjugate Cx-(PEPAuM-ox)2 (PEPAuM-ox = AYSSGAPPMoxPPF; x = 16-22). We present a general template-independent strategy of tuning helix stability that relies on controlling the dimensions of constituent NPs. As NP dimensions increase, Au NP single helices become both more thermally stable and more stable in the presence of chemical denaturants and protein digestion agents (e.g., urea and proteinase K, respectively). We use this strategy for imparting helix stability to create colloidal suspensions of thermally robust Au NP single helices which maintain their plasmonic chiroptical activity up to ∼80 °C.

Somatoform Disorders in Primary Care-An Exploratory Mixed-Methods Study on Experiences, Challenges and Coping Strategies of General Practitioners in the Federal Republic of Germany.

Somatoform symptoms are widely spread in outpatient care. For treating physicians, it can be challenging to establish a relationship that is conducive to compliance and to take stabilising action when dealing with affected patients. As primary care providers, GPs are usually the first point of contact for patients with somatoform disorders; they set the course for stabilisation and further care. To date, there is a lack of studies that focus on how GPs respond to such patients. In particular, strategies for establishing a stable doctor-patient relationship have hardly been explored. Consequently, this study investigated how GPs recognise the symptoms of somatoform disorders, what significance they attach to them and how they handle patients. The primary focus is on experienced patient properties, assumed causes of somatoform disorders, obstacles and complexities in consultation, care and stabilisation strategies, as well as diagnostic forms of support. A total of 2797 GPs in the German federal states of Hesse, Rhineland-Palatinate and Baden-Württemberg were surveyed anonymously by means of a written questionnaire between January and August 2023. A t-test was performed with independent samples to determine significant differences between two groups. In addition, 64 GPs were interviewed between March and April by means of qualitative semi-standardised interviews. The respondents make use of a wide range of communication and stabilisation strategies when treating somatoform physical complaints. The GPs combine the establishment of a tangential doctor-patient relationship with measures to consistently exclude physical causes and to enable the best possible assessment of patients, as well as to gently introduce them to the clinical picture of somatoform disorders. Most physicians are not familiar with current clinical guidelines. Cooperation with specialists and therapists is widely described as complicated. GPs have access to a wide range of communication and stabilisation strategies for the management of somatoform physical complaints. Yet, they experience interaction with this patient group as difficult in daily practice. GPs articulate a clear need for more external support. Apart from increasing therapeutic care capacities and interdisciplinary structures, it seems advisable to extend low-threshold therapy and support services.

Administrative regulation-informed analysis of the developmental path of national volume-based procurement to improve drug accessibility in China.

The procurement of medicines via China's national volume-based procurement (NVBP) necessitates collaboration among various entities. This paper highlights the legal significance of the engagement of pharmaceutical companies, hospitals, and the National Healthcare Security Administration (NHSA) in improving drug accessibility. We conducted a numerical simulation using MATLAB to develop an evolutionary game model involving these three participants in NVBP. Our findings indicate that the final evolutionary stabilization strategies are pharmaceutical companies actively participating, hospitals using bid-winning medicines, and the NHSA implementing a low-intensity intervention. The study reveals that the evolutionary outcomes for hospitals and pharmaceutical companies are significantly affected by factors such as NHSA's subsidy level and pharmaceutical companies' level of participation. However, NHSA's decision-making process is less influenced by these factors. From a legal perspective, the successful implementation of NVBP, ensuring fairness and legality, requires adherence to relevant policies and regulations. The NHSA should employ statutory incentives and regulatory methods in formulating and adjusting NVBP policy to enable pharmaceutical companies, hospitals, and the NHSA to exercise their rights rationally within the legal framework of the game process.

Effect of Exchange Rate on Foreign Direct Investment in Nigeria

This study investigates the relationship between exchange rates and Foreign Direct Investment (FDI) in Nigeria from 1981 to 2021. Employing a Fully Modified Ordinary Least Squares (FMOLS) regression analysis, the study reveals a significant positive correlation between exchange rates and FDI. Conversely, the study finds a positive but statistically insignificant association between trade openness and FDI. Finding on interest rates (INTR coefficient: -0.104) indicates a negative relationship with FDI, lacking statistical significance. Similarly, inflation rates (INFR coefficient: 0.012) exhibit a positive yet statistically insignificant link with FDI. Notably, the study highlights a substantial and statistically significant negative relationship between human capital (HC coefficient: -77.787) and FDI, signifying the importance of human capital development in attracting foreign investment. In summary, the research findings indicate a substantial impact of exchange rates on FDI in Nigeria. It suggests that policymakers should proceed with caution to avert possible depreciation of the exchange rate, which could deter foreign investors. Furthermore, adopting a comprehensive strategy for macroeconomic stability could foster a more conducive atmosphere for foreign investment.

An exact algorithm for simultaneous pickup and delivery problem with split demand and time windows

This study introduces a new variant of the vehicle routing problem (VRP) called the simultaneous pickup and delivery problem with split demand and time windows (SPDP-SDTW). The motivation behind this study stems from real-life urban and rural delivery scenarios, encompassing features such as split demand, simultaneous pickup and delivery, many-to-many pickup and delivery, and time windows. The study thoroughly investigates the properties of the optimal solution for the SPDP-SDTW. Based on these properties, an arc flow model is developed for the SPDP-SDTW. Dantzig Wolfe (DW) decomposition techniques are employed to obtain the master problem and the pricing subproblem. In order to effectively address the SPDP-SDTW, an improved branch and price (I-BP) algorithm is proposed, incorporating a tailored column generation (CG) algorithm, branching strategies, and dual stabilization strategies. The proposed CG algorithm provides a framework that combines the improved adaptive degree heuristic (I-AGH) algorithm and the solver Gurobi. This integration substantially mitigates the computational burden involved in solving the subproblem. Extensive computational experiments conducted on datasets of varying sizes, including small, medium, and large instances, consistently demonstrate that the I-BP algorithm performs the best in both solution quality and computational efficiency when compared to existing exact and heuristic algorithms.

Exploring the Relationship between Resilience (Personal Strength), Emotional Stability, Emotional Self-Control, Attachment, and Personal Fear of COVID-19

The research examines correlational and predictive relationships between resilience (personal strength), emotional stability, strategies of emotional self-regulation, the style of attachment, and personal fear of Covid-19. At this study took part 130 adults (91 women and 39 men), the average age being 39 years old. The results indicated statistically significant medium and high levels of correlation among most of the analysed variables, the greatest correlation being obtained between emotional stability and emotional regulation strategies. Another significant result is the predictive relationship between emotional stability, attachment style and self-perception (subdimension of personal strength), which in turn proved to be a predictor for personal fear of Covid-19.

Collaborative Innovation in Construction Supply Chain under Digital Construction: Evolutionary Game Analysis Based on Prospect Theory

In the context of Digital Construction (DC), collaborative innovation in the construction supply chain (CSC) is crucial for long-term competitiveness. However, transparent information flows and fickle market circumstances hinder enterprises from actively participating in collaborative innovation, making it challenging to establish effective incentive mechanisms. To achieve sustained and stable collaborative innovation, an evolutionary game model of collaborative innovation between core enterprises and member enterprises in the CSC under DC based on Prospect Theory is constructed. Five equilibrium scenarios and evolutionary stability strategies are analyzed, and the corresponding stability conditions are obtained. Finally, the impact of different parameters on strategy selection are analyzed by numerical simulation. The results indicate that the balance between knowledge sharing and knowledge leakage is the premise of the positive impact of DC technology on collaborative innovation. Moreover, the adjustment of gain sensitivity and loss sensitivity is the key to enhancing managerial enthusiasm for collaborative innovation. Furthermore, the design of income distribution and innovation incentives must adhere to the reciprocity principle, while subsidies from owners demonstrate a prominent positive impact on collaborative innovation. This paper systematically expounds the dynamic influence of DC technology application, knowledge spillover effects, and managerial cognitive structures while confirming the intrinsic effect of innovation incentive mechanisms. It provides substantial theoretical reference and management enlightenment for promoting the development of collaborative innovation in the CSC under DC.

Lead stabilization and remediation strategy with soil amendment in situ immobilization in contaminated range lands

In situ immobilization is a potential approach that can be used to remediate low-to-medium levels of heavy-metal in contaminated-soil. There is little known about how modifications to soil characteristics may affect Pb’s release from soil. The four different amendments, triple-superphosphate and attapulgite were combined in Ad-1; zeolite and triple-superphosphate were in Ad-2; hydroxyapatite and humus were in Ad-3; and nano-carbon. These amendments are mostly made of phyllosilicate minerals, humus, base minerals, and nano-carbon, respectively. Results revealed that the test amendments’ maximal Pb-adsorption capacity varied from 7.47 to 17.67 mg g−1. Surface precipitation and ion-exchange were found to be the main mechanisms for Pb-adsorption by Ad-1 and Ad-2, while Ad-3 and Ad-4 were promising among the all, according to analysis of the modifications both before and after Pb loading. When the pH dropped (7-1) or the ion-strength rose (0–0.2 M), there was a discernible rise in the Pb-desorption percentages from the amendments. It was determined that Ad-3 and Ad-4 were more effective in situ immobilizing lead in contaminated-soils because of their high adsorption capacities (12.82 and 17.67 mg g−1) and low-desorption percentages (4.46–6.23%) at ion-strengths of 0.01–0.1 mol L−1 and pH levels ranging from 5 to 7.

A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines

Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a vaccine focusing antibody responses on the highly conserved but metastable S2 subunit, which folds as a spring-loaded fusion machinery. We describe a strategy for prefusion-stabilization and high yield recombinant production of SARS-CoV-2 S2 trimers with native structure and antigenicity. We demonstrate that our design strategy is broadly generalizable to sarbecoviruses, as exemplified with the SARS-CoV-1 (clade 1a) and PRD-0038 (clade 3) S2 subunits. Immunization of mice with a prefusion-stabilized SARS-CoV-2 S2 trimer elicits broadly reactive sarbecovirus antibodies and neutralizing antibody titers of comparable magnitude against Wuhan-Hu-1 and the immune evasive XBB.1.5 variant. Vaccinated mice were protected from weight loss and disease upon challenge with XBB.1.5, providing proof-of-principle for fusion machinery sarbecovirus vaccines.

Enhancing stability via coordinated control of generators, wind farms, and energy storage: Optimizing system parameters

This study delves into the intricacies of power system stability, specifically addressing the challenges posed by integrating renewable energy sources, primarily focusing on wind power. The intricate dynamic interactions between Synchronous Generators (SGs), Doubly Fed Induction Generators (DFIGs), and Battery Energy Storage Systems (BESS) under varying operating conditions necessitate advanced control strategies for effective stabilization. Conventional control methods, such as Power System Stabilizers (PSS) and damping controllers, are scrutinized for their inherent sensitivity to system changes and limitations in mitigating the dynamic complexities arising from integrating Wind Farms (WFs) and BESS. This research accentuates the critical need for synchronized control mechanisms to preempt dynamic instability in power systems, considering factors like wind speed fluctuations, WF integration intricacies, and responses to severe disturbances. The introduction of DFIG-based WFs is particularly examined for its impact on altering system inertia, leading to Low-Frequency Oscillations (LFOs) and diminished damping, thereby heightening stability concerns. The proposed control strategies encompass the integration of BESS, PSS, and coordinated damping controllers meticulously tailored to counteract systemic instability. Recognizing the potential inadequacy of individual control methods during severe disturbances, the study underscores the imperative of synchronized operation between PSS and BESS damping controllers. Furthermore, the investigation sheds light on the pivotal role of uncertainties in power system stability, advocating for a paradigm shift from deterministic methods to more nuanced probabilistic approaches. The proposed coordinated probabilistic control designs, leveraging participation factors for SGs, DFIGs, and BESS, offer a sophisticated solution to mitigate uncertainties and fortify system stability across diverse conditions. A rigorous evaluation employing Real-Time Digital Simulator (RTDS) simulations on the IEEE 9-bus test system substantiates the practical efficacy of the proposed coordinated control approach. The discerned outcomes underscore discernible enhancements in both small signal and transient stability, affirming the practical viability and reliability of the advanced control strategies delineated in this study.

Ternary stabilization strategies for succinonitrile-based in situ polymerized electrolyte enabling high-performance solid lithium metal batteries

Solid-state lithium metal batteries with high energy density and safety have gained increasing attention due to their potential applications. However, the practical use of solid electrolytes is hindered by several challenges. These include poor compatibility at the electrode–electrolyte interface, low ionic conductivity at room temperature, and fast capacity degradation. To address these issues, here we propose ternary strategies by in-situ cross-linked plastic crystal electrolyte (in-situ PCE) based on succinonitrile (SN). Through the in-situ polymerization of SN with polyacrylonitrile/poly(vinylidene difluoride) (PAN/PVDF) nanofibers separator, excellent mechanical strength and compatibility at the electrode–electrolyte interface are achieved. The cross-linked structure of thermally polymerized ethoxylated trimethylolpropane triacrylate (ETPTA) immobilizes the SN molecule, preventing its contact with the lithium metal and inhibiting irreversible side reactions. Additionally, a LiF-rich passivation layer is employed to further protect the SN at the electrolyte-lithium metal interface. The dual protection from ETPTA and LiF offers excellent stability to lithium. Hence, the in-situ PCE exhibits high ionic conductivity (0.79 mS cm−1 at 30 °C) and wide electrochemical window (4.56 V, vs Li+/Li). The cells exhibit excellent cycling stability and high-rate performance. LiFePO4//Li cells retain 96.6 % capacity after 1000 cycles at 10C rate. This study provides valuable insights into the development of high-performance solid-state electrolytes.