Leading edge erosion (LEE) poses greater challenges to the blade design of offshore wind turbines. This paper analyzes the influence of LEE on blade aerodynamic performance and wind turbine load based on high-power offshore wind turbines through the GH-Bladed computing platform. The study found that LEE severely weakens the blade aerodynamic performance, resulting in a lag in the wind turbine reaching its rated power. LEE expands the range of blade surface flow separation, leading to an increase in blade stall risk and a decrease in wind turbine load stability. The promotion of blade aerodynamic performance will cause an increase in blade force, which will strengthen the load level of both the blade and the wind turbine. The optimization of twist angle is an effective method to avoid the loss of power generation of wind turbines under LEE interference, but it is inevitable to cause a decrease in the load stability of wind turbines. Therefore, when the load safety margin of wind turbines is sufficient, adjusting the twist angle is an efficient technique to improve the blade aerodynamic performance and promote the stability of power output, which provides a novel solution for blade design of high-power offshore wind turbines.