1st Phase Research Articles

Pengaruh Counterpressure Dan Tehnik Relaksasi Nafas Dalam Terhadap Nyeri Melahirkan Pada Ibu Bersalin Kala 1 Fase Aktif di Rumah Sakit Dr Hafiz Cianjur Tahun 2023

Childbirth is a natural process that every pregnant woman will experience. Most mothers start to feel pain or labor pains during the first active phase. In this phase, most mothers feel severe pain because the uterus begins to become active. In this phase, contractions become stronger and more frequent. One of the duties of a nurse is to assess the condition of pain including the cause of pain, quality of pain, location of pain, how much it interferes with life and the time or duration of pain as well as determining diagnosis, planning, implementation and evaluation. The aim of this study was to determine the effect of counterpreasure techniques and deep breathing relaxation techniques on labor pain in women giving birth during the first active phase at Dr. Hospital. Hafiz Cianjur. This research method uses a pre-experimental research design with a one group pretest-posttest design approach. The sampling technique used was a purposive sampling technique, with a sample of 20 respondents in this study. Data analysis for this study used the Wilcoxon test. The results of the research show that there is an influence of Counterpressure and Deep Breathing Relaxation Techniques before and after on the pain of childbirth, seen from the p-value of 0.000, which means <0.005, so it can be concluded that there is an influence or difference in the level of pain in childbirth in mothers giving birth during the 1st active phase in the delivery room. Dr. Hafiz Cianjur in 2023. The conclusion of this research is that there is an influence of counterpressure and deep breathing relaxation techniques on childbirth pain in women giving birth during the first active phase at Dr Hafiz Cianjur Hospital in 2023.

A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues

Vesicular release of neurotransmitters and hormones relies on the dynamic assembly of the exocytosis/trans-SNARE complex through sequential interactions of synaptobrevins, syntaxins, and SNAP-25. Despite SNARE-mediated release being fundamental for intercellular communication in all excitable tissues, the role of auxiliary proteins modulating the import of reserve vesicles to the active zone, and thus, scaling repetitive exocytosis remains less explored. Secretagogin is a Ca2+-sensor protein with SNAP-25 being its only known interacting partner. SNAP-25 anchors readily releasable vesicles within the active zone, thus being instrumental for 1st phase release. However, genetic deletion of secretagogin impedes 2nd phase release instead, calling for the existence of alternative protein-protein interactions. Here, we screened the secretagogin interactome in the brain and pancreas, and found syntaxin-4 grossly overrepresented. Ca2+-loaded secretagogin interacted with syntaxin-4 at nanomolar affinity and 1:1 stoichiometry. Crystal structures of the protein complexes revealed a hydrophobic groove in secretagogin for the binding of syntaxin-4. This groove was also used to bind SNAP-25. In mixtures of equimolar recombinant proteins, SNAP-25 was sequestered by secretagogin in competition with syntaxin-4. Kd differences suggested that secretagogin could shape unidirectional vesicle movement by sequential interactions, a hypothesis supported by in vitro biological data. This mechanism could facilitate the movement of transport vesicles toward release sites, particularly in the endocrine pancreas where secretagogin, SNAP-25, and syntaxin-4 coexist in both α- and β-cells. Thus, secretagogin could modulate the pace and fidelity of vesicular hormone release by differential protein interactions.

Unveiling the upsides of low-skilled physical gig work: insights from the gig workers’ perspective in Malaysia

ABSTRACT The gig economy has proliferated recently, fuelled by digital platforms and the global pandemic. This shift has transformed the standard employment relationship between employer and employee, making it crucial to understand the gig workers’ performance in this setting. A sequential mixed-methods approach was used to investigate the underlying phenomena. The study commenced with 1st phase of qualitative study through semi-structured interviews to uncover the major themes spurring gig workers’ psychometric dimensions. Six major themes were identified in 1st phase of the qualitative study, two of which were unique to gig work (joy of gig work, work–life balance) while the 2nd phase of the quantitative study revealed that job autonomy, joy of gig work, and work–life balance positively affect work performance. The findings suggest the requisite refinement of gig worker classification, and gig work measurement tools within the context of organisational strategies and policy development considerations.

Quadriceps and Hamstrings Activation Peaks Earlier as Athletes Repeatedly Hop, but There are Differences Depending on ACL Reconstruction Technique.

After Anterior Cruciate Ligament Reconstruction (ACLR) athletes face the challenge of regaining their previous competitive level while avoiding re-injury and early knee joint cartilage degeneration. Quadriceps and hamstrings strength reductions and neuromuscular alterations potentially related to risk of re-injury are present after ACLR and relate to deficits in muscle activation. Cross-sectional laboratory study. To examine quadriceps and hamstrings muscle activation during repeated hops in healthy pivoting-sport athletes and those who had undergone ACLR (bone-tendon-bone and semitendinosus graft) who had met functional criteria allowing return to training. Surface electromyography (SEMG) was recorded from vastus medialis and lateralis and medial and lateral hamstrings bilaterally during 30 seconds' repeated hopping in male athletes on average eight months after ACLR surgery (5-12 months). All patients underwent hamstring (HS) (n=24) or bone-tendon-bone (BTB) reconstruction (n=20) and were compared to healthy controls (n=31). The SEMG signals were normalized to those obtained during maximal voluntary isometric contraction. A significant time shift in peak muscle activation (earlier) was seen for: vastus medialis and vastus lateralis activation in the control group, in the BTB group's healthy (but not injured) leg and both legs of the HS group. A significant time shift in peak muscle activation was seen for lateral hamstrings (earlier) in all but the BTB group's injured leg and the medial hamstrings in the control group only. Lower peak activation levels of the vastus lateralis (p\<0.001) and vastus medialis (p\<0.001) were observed in the injured compared to healthy legs and lower peak lateral hamstrings activity (p\<0.009) in the injured leg compared to control leg. Decline in medial hamstring peak activation (p\<0.022) was observed between 1st and 3rd phase of the hop cycle in all groups. Repeated hop testing revealed quadriceps and hamstring activation differences within ACLR athletes, and compared to healthy controls, that would be missed with single hop tests. 3.

Abdominal vacuum therapy is a component of DAMAGE CONTROL SURGERY tactics for combat trauma to the abdomen

The goal of the study was to improve the outcomes of surgical care and treatment for patients with combat-related abdominal injuries at different levels of medical support during combat operations by using abdominal vacuum therapy as a component of Damage Control Surgery tactics. At the II level of combat medical support within the Damage Control Surgery tactics, abdominal vacuum therapy was applied to 75 wounded male combatants with a combat abdominal injury, aged 37.4±8.3 years (main group). The comparison group consisted of 87 wounded patients aged 37.5±10.2 years, operated on using Damage Control Surgery tactics with drainage of the abdominal cavity and suturing of the skin only. 40.0% of the wounded in the main group and 46.0% of the comparison group were admitted with signs of traumatic shock of various degrees. According to the AdTS scale, 78.7% of the wounded in the main group were admitted in a serious condition, 21.3% – in an extremely serious condition; in the comparison group, 74.7% were in severe condition, 25.3% were in extremely severe condition. In 57.3% of the wounded of the main group, abdominal vacuum therapy was carried out in the irrigation-flow mode. 24.0% used standard bandages for abdominal vacuum therapy, 76.0% used partially improvised ones. The level of negative pressure was set in the range of 40-125 mm Hg in constant mode. Intra-abdominal pressure was measured by a standard method (through the bladder) at admission and after surgery. The assessment of the state of the abdominal cavity in the I and III phases of Damage Control Surgery was carried out according to the Abdominal Cavity Index scale – an integral assessment expressed in points based on factors that can be assessed visually during surgery. The volume of surgical interventions in the 1st phase of the Damage Control Surgery tactic depended on the nature of the damage to the abdominal organs and the condition of the wounded. After the completion of Phase I of Damage Control Surgery tactics, all wounded were evacuated by road medical transport and medical helicopters to the next level of medical support, with abdominal vacuum therapy during evacuation in the main group and Damage Control Resuscitation measures. Under the effect of abdominal vacuum therapy, the reduction of intra-abdominal pressure in the main group was pronounced (Δ=9.2; p&lt;0.01) than in the comparison group (Δ=6.1; p&lt;0.01). Abdominal vacuum therapy during the II phase of the Damage Control Surgery tactic made it possible to clean the abdominal cavity better (p&lt;0.0001) than in the comparison group and provided better preparation for the implementation of the III phase of this tactic. As a result, reliable protection from external factors, active prevention of intra-abdominal pressure and rehabilitation of the abdominal cavity during the application of abdominal vacuum therapy during the II phase of Damage Control Surgery tactics in the main group of wounded after obstructive resections of the small intestine in the I phase made it possible to completely abandon terminal stomas in the III phase (in the comparison group – 5) in favor of the formation of small bowel intestinal anastomoses, and during obstructive colon resections, the number of terminal colostomas in the main group was reduced to 50.0% (in the comparison group -90.9%, р=0.004), also in favor of the formation anastomoses, which significantly improved the functional results of providing assistance to the wounded with a combat abdominal injury. The use of abdominal vacuum therapy during phases I-II of the Damage Control Surgery (DCS) tactics allows for the optimization of the scope of surgical interventions in phase III of Damage Control Surgery and significantly improves the functional outcomes of surgical care and treatment for patients with combat abdominal injuries at various levels of medical support during combat operations.

Context-relevant strategies for ICT integration in teaching and learning science subjects in Tanzania secondary schools

Information and Communication Technology (ICT) can improve science teaching and learning. However, understanding the contexts in which ICT is intended to be integrated for its effectiveness is limited. Therefore, the current study explored context-relevant strategies and challenges for ICT integration in the teaching and learning science subjects in secondary schools in Tanzania. Exploratory sequential design under mixed methods guided the study's conduct. 52 participants (45 science teachers, six heads of schools and one municipal education officer) were purposefully and conveniently involved. Data were collected in two phases: 1st phase was qualitative data through in-depth interviews, 2nd phase was quantitative data through a questionnaire. Thematic analysis guided qualitative data analysis where MS Excel in the form of pivotal charts were used to present the frequency of the responses. SPSS version 27 guided the quantitative data analysis, presenting the output descriptively. Participants presented various context-relevant strategies, including capacity building for teachers, building and equipping computer labs with ICT facilities, maintaining and repairing defective computers, deploying educational technology experts, and making ICT compulsory at all levels of education. On the other hand, participants identified a lack of ICT facilities, limited ICT training opportunities, and digital content as context-relevant challenges for ICT integration in science teaching and learning. The study recommends rigorous pre-service and in-service teacher training programmes on ICT pedagogical integration for science teaching and learning based on these findings. Again, we recommend the improvement of ICT infrastructure in schools to enhance the availability, access, and use of science teaching and learning. The study concludes that if sufficient infrastructures are available and science teachers are equipped with ICT knowledge, teaching and learning of science subjects will be effective.

Administration Effect of Lemon Aroma Therapy on Pain Reduction with Women in the 1st Active Phase

Pain during labor is a natural process caused by cervical dilatation, hypoxia of the uterine muscles during contractions, ischemia of the uterine corpus, stretching of the lower uterine segment, and compression of the cervical nerves. If labor pain occurs pathologically, it can trigger complications in pregnancy, one of which is prolonged labor. Data from the World Health Organization (WHO) in 2020 show that the maternal mortality rate is still high, with 295,000 women dying due to complications during pregnancy and childbirth. Prolonged labor is one of the fifth causes of maternal death in the world, accounting for 8.5% of cases. Pain can be relieved pharmacologically and non-pharmacologically, with one non-pharmacological method being lemon aromatherapy. This study aims to determine the effect of lemon aromatherapy on reducing pain intensity in the active phase of the first stage of labor at Painan Hospital in 2023.This research used a quasi-experimental design with a non-equivalent control group pretest-posttest. The study was conducted in July 2023, using both primary and secondary data. The sample consisted of 30 respondents selected through total sampling techniques. Data analysis was performed using Wilcoxon and Mann-Whitney non-parametric statistical analysis techniques.The results of the study showed that most participants in the intervention group experienced controlled severe pain before and after the intervention, while the control group mostly experienced moderate pain before the intervention and uncontrolled severe pain after the intervention. The Mann-Whitney test indicated a significant difference in pain intensity between the intervention and control groups, with a p-value of 0.000 &lt; α (0.05), leading to the rejection of the null hypothesis.The researchers recommend that health services provide support to mothers experiencing pain during labor to ensure a comfortable birthing process.

Nuclear Modification Factor of Inclusive Charged Particles in Au+Au Collisions at sNN = 27 GeV with the STAR Experiment

The Beam Energy Scan (BES) program at RHIC aims to explore the QCD phase diagram, including the search for the evidence of the 1st order phase transition from hadronic matter to Quark-Gluon Plasma (QGP) and the location of the QCD critical point. One of the features previously observed in the study of QGP is the effect of suppression of particle production with high transverse momenta pT (&gt;2 GeV/c) at energies sNN = 62.4–200 GeV, which was deduced from the charged-particle nuclear modification factor (RCP) measured using the data from Beam Energy Scan Program Phase I (BES-I) of STAR experiment. In 2018, STAR has collected over 500 million events from Au+Au collisions at sNN = 27 GeV as a part of the STAR BES-II program, which is about a factor of 10 higher than BES-I 27 GeV data size. In this report, we present new measurements of charged particle production and the nuclear modification factor RCP, from this new 27 GeV data set and compare them with the BES-I results. The new measurements extend the previous BES-I results to higher transverse momentum range, which allows better exploration of the jet quenching effects at low RHIC energies, and may help to understand the effects of the formation and properties of QGP at these energies.

Colloid and nanoparticle-driven phase behavior in weakly perturbed nematic liquid crystals

We study theoretically weakly colloidal particle or nano-particle perturbed nematic liquid crystal (LC) order. We consider cases where the particles are essentially homogeneously dispersed in LC matrix. A mesoscopic Landau-de Gennes approach is used where we focus on the temperature variations in the amplitude order parameter field for different particle volume concentrations ϕ. In the dilute regime, we describe the nematic order in terms of interface and volume amplitude order fields. This modeling suggests that the temperature-driven order-disorder crossover exhibits a two-step transformation. In the case that particles locally support LC order, on decreasing temperature firstly the interface order is established, followed by the build-up of volume order. The latter appears via the 1st order phase transition. On the other hand, the interface order growth is formed either gradually or via the 1st order interfacial transition. In the regime of relatively high values of ϕ the system can be effectively described in terms of a single amplitude order parameter field. In this case, the temperature-driven phase behaviour is qualitatively similar to the interface order temperature response in the diluted regime. We analytically express phase transition temperatures and determine critical points in the temperature-interface interaction phase space. Key novelties of the paper are the determination of conditions for particle-LC interface-driven discontinuous change of nematic ordering and nanoparticle-enabled critical point condition in pressure-driven order-disorder phase transformations. Experimental evidences supporting the predicted phase behavior are presented.

Investigation of the liquid water content in composite saline soil containing chloride and sulfate ions

Different salt types have different effects on the liquid water content of saline soil, resulting in differences in the physico-mechanical properties and water/salt migration process of saline soil. In order to investigate the phase transition process and the change of the liquid water content in composite saline soil, saline soils with the same total salt content and different ratios of sodium chloride and sodium sulfate were taken as the objects. The results indicated that two phase transitions occur in the saline soil with single salt type, while three phase transitions can be found in the composite saline soil with two salt types. Mirabilite crystallization contributes to the 1st phase transition, mirabilite and ice precipitate together in the 2nd phase transition process, and mirabilite, ice, and hydrohalite precipitate simultaneously in the 3rd phase transition process. The liquid water is reduced in the phase transition process during cooling, and the pore characteristic has been changed significantly. The change of the liquid water content reflects the processes of salt crystallization and ice formation in saline soil, then the amounts of ice and hydrated salt were calculated at different temperatures, and the mechanism of inhibiting the deformation of sulfate saline soil was examined by adding sodium chloride. The results have reference value for those seeking understanding of the deformation in natural composite saline soil, and these findings can provide theoretical basis for the phase transition mechanism of saline soil in cold regions.

Mesocrystalline SrTiO3/CaTiO3 nanocomposites with 3D heteroepitaxial interfaces, superior piezoresponse and high Curie temperature

Ferroelectric mesocrystalline nanocomposites are promising piezoelectric nanomaterials due to the presence of three-dimensional (3-D) heteroepitaxial interfaces, rendering superior piezoelectric and dielectric responses due to lattice strain at the interface. Herein, we describe the synthesis of mesocrystalline SrTiO3/CaTiO3 (ST/CT) nanocomposites via a two-step topochemical process by using layered titanate H1.07Ti1.73O4·nH2O (HTO), as a precursor, and demonstrate the influence of synthesis parameters on nanostructure, morphology, piezoelectric response and dielectric behavior. The mesocrystalline ST/CT nanocomposites are formed by in-situ topotactic structural transformation, consisting of [110]-oriented ST nanocrystals and [001]-oriented CT nanocrystals with high-density 3-D heteroepitaxial interfaces. The presence of 3-D heteroepitaxial interfaces introduces lattice strain at the interface, leading to an enormously enhanced piezoelectric response with a d33* value of 301 p.m./V. Moreover, the Curie temperature of ST phase is significantly increased from −250 °C to 300 °C by introducing lattice strain. It is demonstrated that the piezoresponse depends on lattice mismatch at heteroepitaxial interfaces and optimal lattice mismatch is found to be ∼3.3%, where the largest lattice strain effect and an expected d33* value of about 450 p.m./V could be achieved. These results demonstrate the potential of lattice strain engineering for high-performance lead-free piezoelectric materials.

Alternatives to Carbon Dioxide in Two Phases for the Improvement of Broiler Chickens’ Welfare during Stunning

This study evaluated the exposure to gas mixtures of carbon dioxide (CO2) associated with nitrogen (N2) as alternatives to CO2 in two phases to improve the welfare of broiler chickens at slaughter. Broilers were exposed to one of three treatments: 40C90C (1st phase: &lt;40% CO2 for 2 min; 2nd phase: &gt;90% CO2 and &lt;2% O2 for 2 min, n = 92), 40C60N (40% CO2, 60% N2, and &lt;2% O2 for 4 min, n = 79), or 20C80N (20% CO2, 80% N2, and &lt;2% O2 for 4 min, n = 72). Brain activity (EEG) was assessed to determine the onset of loss of consciousness (LOC) and death. Behavioural assessment allowed for characterisation of an aversive response to the treatments and confirmed loss of posture (LOP) and motionlessness as behavioural proxies of LOC and brain death in 40C60N and 20N80C. However, the lack of quality of the EEG traces obtained in 40C90C did not allow us to determine the onset of LOC and brain death for this treatment. The onset of LOC in 40C60N was found at 19 s [14–30 s] and in 20C80N at 21 s [16–37 s], whereas a LOP was seen at 53 s [26–156 s] in 40C90C. Birds showed brain death in 40C60N at 64 s [43–108 s] and in 20C80N at 70 s [45–88 s]), while they became motionless in 40C90C at 177 s [89–212 s]. The 40C90C birds not only experienced more events of aversive behaviours related to mucosal irritation, dyspnoea, and breathlessness during induction to unconsciousness but were at risk of remaining conscious when the CO2 concentration was increased in the 2nd phase (known to cause severe pain). From an animal welfare point of view, 40C60N proved to be the least aversive of the three treatments tested, followed by 20C80N and 40C90C.

Pengaruh Pemberian Akupresur terhadap Nyeri Persalinan Fase Aktif

Contraction pain is main problem for patients in the 1st stage of labor in active phase. Labor pain in first stage of the active phase can be treated with acupressure at points L14 and SP6. The L14 and SP6 acupressure points can stimulate release of hormone oxytocin from pituitary, which will stimulate uterine contractions, thereby helping the labor process to be better and reducing pain during labor. The aim of this study was to determine how acupressure impacts labor pain during active phase of the first stage. Design of this research is one group pre-post test. This study involved 30 women giving birth normally, in 1st stage of the active phase, who had no abnormalities or injuries at L14 and SP6 locations. Ttool used is Wong Baker Pain Scale. The results showed that maternal patients in 1st active phase had an average pain scale of 8.03 before being given acupressure, and pain scale dropped to 3.26 after being given acupressure. There was a significant difference between the groups before and after acupressure with a p value of 0.000. There is an effect of giving acupressure on the intensity of pain in mothers giving birth during the first active phase

Nyatygran intrusive suite, Bureya massif: Petrography, geochemistry, and age

The proposed review and analytical article provides updated information on the geology, petrography, mineralogy, and chemical composition of rocks of the Precambrian Nyatygran intrusive suite. The article provides a geochemical interpretation of the chemical and trace element compositions and presents the most actual data on the uranium-lead isotopic age of the rocks. The igneous formations of the Nyatygran gabbro-granodiorite-granite complex make up small intrusive massifs of gabbroids and granitoids, located near the ore-bearing Mel’gin trough, in the basins of the Verkhny Mel’gin, Chepkan, and Bureya rivers and their tributaries. In the gabbroids, the main rock-forming minerals are labradorite, andesine, bluish-green hornblende, and biotite. The gneissic granitoids are dominated by cataclastic quartz and feldspars (andesine, oligoclase, microcline) and contain abundant micas (biotite, sericite). The subalkaline leucogranites are dominated by oligoclase, quartz, orthoclase, and microcline; they also contain significant amounts of biotite and aegirine and rare amphibole (hornblende). The gabbro and gabbrodiorites of normal and elevated alkalinity are assigned to the high-aluminous high-magnesian rocks. The gabbroids represent I-type igneous rocks. The gneissic granitoids of normal and elevated alkalinity are predominantly high-aluminous, more ferroan than magnesian rocks, and are represented by S- and I-type granitoids. The determined isotopic ages of the Nyatygran suite formations are confined to the three main ranges: 933 ± 12–916,3 ± 7,2 Ma (1st magmatic phase: gabbro, gabbrodiorites, amphibole-biotite granites), 909,0 ± 6,6–907,3 ± 5,5 Ma (2nd phase: granodiorites and granites), and 806,8 ± 6,6–789 ± 4,0 Ma (3rd phase: biotite granites and granite-porphyry dikes). The Nyatygran suite age is established as Neoproterozoic and corresponds to the early Neoproterozoic, or Tonian (1000–720 Ma), according to the International Chronostratigraphic Scale, 2018. On the 3rd generation 1:1 000 000-scale State geological maps of the Russian Federation, it is presented as Early Proterozoic.

Thesis The Effect Of Warm Compresses On The Intensity Of Pain During The 1st Active Phase At Syekh Yusuf Gowa Hospital In 2020

Childbirth is a physiological event in every woman's development into motherhood. This event can cause trauma because of the pain experienced, hot compresses are one method to overcome pain. The purpose of this study was to determine the effect of warm compresses on the intensity of labor pain during the 1st active phase at Syekh Yusuf Gowa Hospital.This type of research uses quantitative research with a quasi-experimental research design. The research design is one group pretest and postest design. Sampling technique with purposive sampling. The sample size was 30 respondents. Analysis using statistical test Mc Nemart test. The results showed that before the warm compress there were 8 people (26.7%) who experienced mild pain and 22 people (73.3%) who experienced severe pain. After being given warm compresses there were 8 (26.7%) who changed mild pain to severe and there were 22 (73.3%) people who changed from severe pain to mild pain. Based on the Mc Nemart test.then obtained the value of ρ = 0.000 &lt; 0.05, it can be concluded the effect of warm compresses on the intensity of labor pain when 1 phase is active. The conclusion of this study is that warm compresses are effective in reducing the intensity of labor pain during the active phase I at Syekh Yusuf Gowa Hospital. And it is hoped that health workers or midwives can apply warm water compresses to reduce pain in maternity mothers

Influence of Dietary Cation-Anion Differences (DCAD) on Nutrient Intake, Milk Yield and Metabolic Parameters of Transition Buffaloes

The study was divided into 2 phases. During 1st phase, 20 pre-partum buffaloes were divided into two groups, given -100 (high negative; HN) and -50 (low negative; LN) mEq/kg of dry matter (DM) diets. In the second phase, +200 (low positive; LP) and +400 (high positive; HP) mEq/kg of DM diets were formulated for postpartum buffaloes. Buffaloes that received LN DCAD were divided into 2 groups (LN-LP and LN-HP), and those that received HN DCAD were also divided into 2 groups (HN-LP and HN-HP). In the first phase, the group fed the HN DCAD diet had significantly lesser DM, nutrient intake, and urine pH (p&lt;0.05) but higher ME intake and ADF digestibility. Also, higher serum phosphorus levels (p&lt;0.05), fewer cases of hypocalcemia and ketosis, and a relatively smaller decrease in body weight were reported with the HN group. In the second phase, DM, organic matter, and NDF intakes were higher (p&lt;0.05) in HN-HP and LN-LP groups, whereas ME intake and nutrient digestibility were higher in HN-LP and LN-HP (p&lt;0.05). Daily milk, solid not fat (SNF), fat, protein, lactose yields, and plasma total protein, urea, and cholesterol concentrations were the highest in the HN-HP group (p&lt;0.05), but the highest fat content and fat yield were recorded in the HN-LP group (p&lt;0.05). Better efficiency of milk production and the lowest cases of hypocalcemia and ketosis were observed for both groups. In conclusion, for transition buffaloes, the HN and LN DCAD (-100 and +200 mEq/kg of DM, respectively) diets showed a beneficial impact.

Reduce the delivery time and relevant costs in a chaotic requests system via lean-Heijunka model to enhance the logistic Hamiltonian route

Online supply chain management (OSCM) is the smart way to deal with the vast amounts of data that come in from customers in a disorganized system to meet the quantities, volumes, and types of customer packages during both delivery and pick-up phases using a new design of vehicle boxes managed by IoT and to track their requests based on scheduling requests and sorting them to make a Hamiltonian route that guarantees the shortest travel distance. The OSCM framework consists of two sequential phases. 1st phase has four recruitment stages. The 1st stage discusses exploration resources (the relationship between the client and the vehicle) using IoT to receive customers' requests (Heijunka growth radius), then moves to exploration maturity to build a one-way Hamiltonian growth route direction. The 1st stage is based on tackling a Heijunka matrix fed through deep learning to classify the matrix into many conditional clusters according to customers' request forecasting and make the prediction value, which is the stop condition of cluster radius through next three stages. This study finds that XGboost outperforms Ada-boost by 14.352 % in the prediction stage. A heuristic rule based on NWBS enhances the FP-Growth algorithm over ECLAT by 7.648 % in the classification stage. Phase II is interested in reducing load and unloading activity time. This problem describes needing more than a different service at the same point (i.e., chaotic and unstable interaction leads to unstable delivery). Therefore, the online scheduling and tracking of the logistic routing using the IoT that Smart Lean Heijunka supports will enhance the SCM, increasing the visited points by 31.2 % and improving the profit by 41 %.

Predictive Performance of Radiomic Features Extracted from Breast MR Imaging in Postoperative Upgrading of Ductal Carcinoma in Situ to Invasive Carcinoma.

To investigate the predictive performance of radiomic features extracted from breast MRI for upgrade of ductal carcinoma in situ (DCIS) to invasive carcinoma. This retrospective study included 71 women with DCIS lesions diagnosed preoperatively by biopsy. All women underwent breast dynamic contrast-enhanced (DCE) MRI of the breast, which included pre-contrast and five post-contrast phases continuously with a time resolution of 60s. Lesion segmentation was performed manually, and 144 radiomic features of the lesions were extracted from T2-weighted images (T2WI), pre-contrast T1-weighted images (T1WI), and post-contrast 1st, 2nd, and 5th phase subtraction images on DCE-MRI. Qualitative features of mammography, ultrasound, and MRI were also assessed. Clinicopathological features were evaluated using medical records. The least absolute shrinkage and selection operator (LASSO) algorithm was applied for features selection and model building. The predictive performance of postoperative upgrade to invasive carcinoma was assessed using the area under the receiver operating characteristic curve. Surgical specimens revealed 13 lesions (18.3%) that were upgraded to invasive carcinoma. Among clinicopathological and qualitative features, age was the only significant predictive variable. No significant radiomic features were observed on T2WI and post-contrast 2nd phase subtraction images on DCE-MRI. The area under the curves (AUCs) of the LASSO radiomics model integrated with age were 0.915 for pre-contrast T1WI, 0.862 for post-contrast 1st phase subtraction images, and 0.833 for post-contrast 5th phase subtraction images. The AUCs of the 200-times bootstrap internal validations were 0.885, 0.832, and 0.775. A radiomics approach using breast MRI may be a promising method for predicting the postoperative upgrade of DCIS. The present study showed that the radiomic features extracted from pre-contrast T1WI and post-contrast subtraction images in the very early phase of DCE-MRI were more predictable.

Poultry analysis and research on the preparation of crushed blue grass feed for poultry

Poultry is considered an important part of the biosystem. The demand for poultry meat in the world is increasing, and it is currently the second place among the meat products grown and consumed with 34 percent, and by 2030 it is expected to take the first place. The analysis of the state of poultry breeding in the world and in Uzbekistan was carried out. Currently, in Uzbekistan, great importance is attached to the development of poultry farming, and more chickens, quails, turkeys, geese and ducks are raised. If we take into account that these birds also eat blue grass and feeding them with blue grass is also beneficial for growth and development, it is reasonable to introduce chopped blue grass to the diet of the birds during the 1st phase: 18-45 weeks of age and the 2nd phase: 46-65 weeks of age. A device for crushing green grass has been developed. In this device, the crushed grass contains up to 5.9% of fractions larger than 20 mm, and when they are given to birds of the above age, they do not bend and come out, so it is necessary to separate them before feeding them to the birds.

Optimization of a hybrid multi-item fabricating-shipping integrated system considering scrap, adjustable-rate, and postponement

This study aims to optimize a hybrid multi-item fabricating-shipping integrated system incorporating scrap, adjustable rate, and postponement. In present-day competitive market environments, there is a clear client demand trend for various goods, shorter lead time, and expected quality. To satisfy the client’s needs, the management of manufacturing firms requires an effective and efficient plan to fabricate various high-quality goods in an expedited period, under limited capacity, and with minimal operating expenses. Inspired by facilitating production management to determine the best fabricating scheme/plan to achieve their operational goals, this work proposes an exploratory postponement model with quality assurance and uptime reduction strategies for their decision-making. By employing a two-phase making scheme, the required standard components are first made in the 1st phase, and multiple finished merchandise is fabricated in the 2nd phase. The study suggests strategies of contracting out a part of the common parts’ batch and adopting an adjusted/expedited making rate in the 2nd phase to considerably reduce both phases’ production uptimes. During both fabricating processes, the screening tasks identify/remove scrapped/faulty goods to ensure each finished batch’s quality. Equal-amount multiple shipments of end merchandise are transported to the clients in fixed time-interval. Optimization methodology and mathematical analyses support us in deriving the model’s expected annual operating cost and deciding the optimal production-transportation policy. A numerical illustration helps verify our model’s applicability and reveals important managerial insights into the studied problem to facilitate management in decision-making.