Previous studies have made great efforts to expand the instruction set in steady-state visual evoked potential (SSVEP)-based brain-computer interfaces. However, most systems are limited to single persons and expand the instruction set by increasing the flicker stimulation frequency range or via multiple frequencies sequential coding or joint frequency/phase coding. In this article, we propose a multibrain coding SSVEP paradigm that encodes the SSVEP instructions generated by <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> independent subjects with <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</i> flicker stimuli, thus increasing the instruction set to <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M<sup>N</sup></i> instructions. A total of 40 subjects participated in online experiments in this article. The results show that there is no significant difference in accuracy ( <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</i> > 0.05, paired t test) between the multibrain and single-brain coding systems, while the information transfer rate (ITR) increases significantly ( <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</i> < 0.0001, paired t test), with the ITR increasing from 37.66 ± 3.60 bits/min for the single-brain coding system to 111.65 ± 10.84 bits/min for multibrain coding system when <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> = 3 and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</i> = 5. In summary, the proposed multibrain coding paradigm exponentially increases the number of instructions without increasing the output instruction time, which is of great significance to the application and promotion of BCIs.