Squamous Odontogenic Tumor Research Articles

Squamous odontogenic tumor of the mandible: A case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1

Squamous odontogenic tumor of the mandible: A case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1

Squamous odontogenic tumour: a case report

Squamous odontogenic tumour: a case report

Molecular profiling of odontogenic tumors: Pilot study

Background/Aim: In the pathogenesis of odontogenic tumors which arise from the rests of the dental apparatus in the jaw, several molecular pathways have been shown to play critical roles such as genetic alterations in the hedgehog, BRAF/Ras/MAPK, epidermal growth factor receptor. Next generation genomic sequencing has identified gene mutations in many different tumors. Materials and Methods: Here we report four types of odontogenic tumor including six cases in which five had mutation according to next generation sequencing analysis from archival paraffin blocks that diagnosed previously as ameloblastoma (solid), amloblastoma (unicystic-mural), ameloblastic fibroma, squamous odontogenic tumor, and adenomatoid odontogenic tumor. Results: All ameloblastomatic tumors were shown BRAF mutation and adenomatoid odontogenic tumors were KRAS mutation. Conclusion: This evidence may highlight the poorly understood pathogenesis of odontogenic tumors. Further comparisons need to be made with other benign and malignant odontogenic tumors so that unique odontogenic features may be found.

A RARE VARIANT OF SQUAMOUS ODONTOGENIC TUMOR WITH CORTICAL PERFORATION AND HIGH PROLIFERATION INDEX

Squamous odontogenic tumor is a benign and rare tumor of the jaws, with only about 50 cases reported since 1975. The majority are slow growing, rarely symptomatic. Although expansion may be present, cortical perforation and involvement of soft tissue are rare.

Mandibular intraosseous pseudocarcinomatous hyperplasia: a case report.

BackgroundMandibular pseudocarcinomatous hyperplasia is a rare and generally benign pathology. We report on one of these rare cases.Case presentationThe case history of a 73-year-old white man stated that he had a carcinoma of the oropharynx, which was primarily treated with radiotherapy and chemotherapy 4 years prior. As a result of radiotherapy he developed an osteoradionecrosis of his mandible and a consecutive pathological fracture of his left mandibular angle. Subsequent osteosynthesis was performed with a reconstruction plate. When we first saw him, his reconstruction plate was partially exposed with intraoral and extraoral fistulation. The resected bone of his defect-bordering jaw showed the typical pathohistological findings of an intraosseous mandibular pseudocarcinomatous hyperplasia. After a first reconstruction attempt with an iliac crest graft failed, definitive reconstruction of his mandible with a microvascular anastomosed fibula graft was achieved.ConclusionsIntraosseous pseudocarcinomatous hyperplasia of the mandible is a rare differential diagnosis in maxillofacial surgery. Besides other benign epithelial neoplasms, such as calcifying epithelial odontogenic tumor, squamous odontogenic tumor, or different forms of ameloblastoma, the far more frequent invasive squamous cell carcinoma needs to be excluded. A misinterpretation of pseudocarcinomatous hyperplasia as squamous cell carcinoma must be avoided because it can lead to a massive overtreatment.

Multicentric Squamous Odontogenic Tumor: A Case Report and Review of the Literature

Squamous odontogenic tumor (SOT) is a rare benign epithelial odontogenic neoplasm of the jaws. Both intraosseous and peripheral SOTs have been described in the English language literature. While most intraosseous SOTs occur as solitary lesions, a multicentric variant has also been previously described. Although the radiographic and microscopic features are identical for both solitary and multicentric clinical presentations, there are three significant differences between them. More specifically, multicentric SOT presents at an earlier age (third decade of life), has a slightly higher male to female ratio than the solitary type and has a marked predilection for African-Americans. Here we document the eighth reported case of multicentric SOT, which was diagnosed in a 43-year-old African-American male. In addition, we feature focal sebaceous metaplasia, a heretofore unknown microscopic feature of SOT. Clinical, radiological, and histopathological findings are discussed. The differential diagnosis, biological behavior and management modalities for SOT are also addressed.

Epidemiological study of odontogenic tumours: An institutional experience.

Epidemiological studies on odontogenic tumours conducted in different parts of the world emphasised variation in incidence and distributional pattern. Such epidemiological studies are obscured in Southern state of Andhra Pradesh in India. Present study was conducted at an institutional setup in South Indian population to assess the demographic data of odontogenic tumours. The retrospective study, which included all the odontogenic tumours from the archives of department of oral pathology, Dental teaching and Research Institution in southern part of India. Cases were selected based on the classification of WHO 2005 histopathological typing for odontogenic tumours and the assessment year considered was from 2002 to 2014. Demographic data was analysed for these tumours. Results were analysed using Chi-Square Test. Incidence of the odontogenic tumours was found to be 2.17%. Peak age incidence was recorded highest in third and fourth decade of life. Males were commonly involved [59%] with the male to female ratio of 1.43:1. Posterior mandible [53.4%] was the chief anatomical location involved with the tumours. Considering the individual lesions, Ameloblastoma [49%] was found to be more frequent, followed by Keratinizing cystic odontogenic tumour [32%], Odontome [6.2%], Adenomatoid odontogenic tumour [5.5%], Odontogenic myxoma [2.4%], Ameloblastic fibroma [0.6%], Calcifying epithelial odontogenic tumour [1.8%] and Squamous odontogenic tumour [1.2%]. The total frequency of odontogenic tumours was 2.17%. Ameloblastoma and Keratinizing cystic odontogenic tumours were the predominant tumours, demonstrating significant regional and geographic variation.

Recurrent squamous odontogenic tumor: A case report and review of the literature.

Squamous odontogenic tumors (SOTs) are benign, locally infiltrative neoplasms that localize to the periodontium. In total, <50 cases have been reported since the first description of SOTs in 1975. Although the exact etiology of SOTs is unknown, the tumors are considered to derive from the epithelial cell rests of Malassez. SOTs are characterized by radiological and clinical signs and symptoms, including pain with increased sensitivity in the affected area, bone expansion and increased tooth mobility. The present study describes the case of a patient that experienced numerous SOT recurrences and also discusses recommendations for treatment. A locally invasive mandibular SOT was identified in a Caucasian 41-year-old female patient. The treatment involved recommended conservative surgery, including local curettage. In addition, 49 cases published in the literature were reviewed to assess the treatment strategies. The present patient experienced two recurrences of the tumor during the 6-year follow-up period. Ultimately, the vitality of the adjacent teeth was compromised. An apicoectomy with a small amount of resection of the marginal bone was necessary. In >50% of the reported cases of SOT in the literature the adjacent teeth were extracted. The present case of SOT and the associated literature were also discussed. It was concluded that the treatment of choice appears to be a conservative surgical removal, but the successful management of SOTs often requires the removal of the adjacent teeth.

Squamous Odontogenic Tumor: Literature Review Focusing on the Radiographic Features and Differential Diagnosis.

Since its first publication in 1975, the squamous odontogenic tumor remains the rarest odontogenic lesion, with around 50 cases in the English-language literature in which the microscopic characteristics are frequently very well demonstrated. However, articles which discuss the radiographic aspects are scarce, especially with emphasis on the differential diagnosis. The present treatise proposes an assessment of jaw lesions with the same radiographic characteristics of the squamous odontogenic tumor to clarify the main findings for dental clinicians during routine diagnosis.

Squamous odontogenic tumor: report of a case of unusual involvement

The squamous odontogenic tumor (SOT) is defined as a very rare benign neoplasm, locally infiltrative and can extend to neighboring structures. This study aimed to report a case of SOT unusual involvement. A female patient, 56-year-old, smoker showed mild swelling in the chin region in the portion between the left canine and right first premolar. Axial, coronal and sagittal images showed expansive hypodense lesion in the mandibular symphysis and parasymphysis. Partial removal of the lesion was performed, which led to the diagnosis of SOT. The patient presented no recurrence during 4 years and 2 months follow-up.

Immunohistochemical expression of keratins 8 and 19 in odontogenic cysts and tumors

Objective: Cytokeratins (CKs) are integral components in the formation of enamel, dentin and/or cemental matrix and their subsequent mineralization. K8 and K19 are known to be chemically homologous during the formation of tooth structures. This feature is rather unique and is expressed across the milieu of odontogenic tissues in the physiological and pathological states. The present study was designed to evaluate the expressions of K8 and K19 in odontogenic lesions immunohistochemically and to test the hypothesis that they can be used to identify the odontogenic epithelium. Study Design: K8 and K19 were assessed in 60 cases of odontogenic lesions retrieved from the archival files, which included ameloblastoma (18), ameloblastic carcinoma (2), adenomatoid odontogenic tumor (AOT) (9), squamous odontogenic tumor (SOT) (1), odontogenic keratocyst (OKC) (10), dentigerous cyst (10), and radicular cyst (10), including two cases of normal gingiva and follicular tissue. Results: K8 was expressed in 53/60 (88.3%) and K19 in 56/60 (93.3%) odontogenic lesions. The labeling for K19 was found to be more intense compared to that for K8. Further, K8 and K19 were found to be positive in all the gingival and follicular tissues. Conclusions: Positive expressions of K8 and K19 in all the odontogenic lesions studied suggest that these can be used as definitive markers for identifying the odontogenic epithelium. However, the intense and consistent expression of K19 suggests that this CK is extremely sensitive in identifying the odontogenic epithelium.

Miles to Discover in Histological Grading of Odontogenic Tumours.

Odontogenic tumours (OTs) are lesions of great interest and importance to oral pathologists and maxillofacial surgeons alike, who for several decades have studied, catalogued these lesions and developed modalities for adequate treatment [1]. Ameloblastoma is the most common and most intriguing of all odontogenic tumours. Although benign it is highly polymorphic, due to its ability to undergo various forms of metaplasia. This has given rise to variants of ameloblastoma in which the stimulus for metaplastic change is poorly understood and has been attributed to the multipotentiality of odontogenic epithelium [2]. In the indexed case, 12-year-old boy presented with the complaint of gradually increasing painless growth in lower front teeth region since 8 months. No evident extraoral swelling or asymmetry was noticed. Regional lymph nodes were not clinically palpable and there was no history of trauma to the same site. Intraoral examination revealed approximately a 2.5x4cm, non tender mucosal sessile mass on lingual aspect of anterior mandible extending from central incisor to second premolar on left side obliterating the lower labial vestibule [Table/Fig-1]. [Table/Fig-1]: Intraoral picture reveals a sessile mass on lingual aspect of anterior mandible There was a faintly palpable anterior lingual expansion. The mandibular incisors, canine and premolar of left side were found to be non vital on thermal testing. Orthopantomograph (OPG) revealed a well circumscribed unilocular radiolucency in the anterior mandible extending from 44 to 35 without cortication. Thinning of lower border of mandible was seen. Root resorption of associated teeth due to pressure was evident [Table/Fig-2]. Considering the benign nature of the lesion, its site of occurrence i.e. anterior to first molars and unilocular appearance, central giant cell granuloma was considered as provisional diagnosis and excisional biopsy was done. [Table/Fig-2]: OPG showing a well circumscribed unilocular radiolucency in the anterior mandible with thinning of lower border Histopathological sections of this case showed well encapsulated tumour mass with extensive areas of squamous differentiation and features of plexiform ameloblastoma [Table/Fig-3]. [Table/Fig-3]: Photomicrograph reveals a well encapsulated tumour mass with extensive areas of squamous differentiation mixed with plexiform pattern (H&E, 10X) Few areas showed material secretion in the tumour matrix which were suggestive of calcifying epithelial odontogenic tumour but when stained with Congo red, came out to be negative [3]. Calcifications or even multinucleated giant cells were not evident in the submitted tissue. Keratin pearl formation was not seen but individual cell keratinization and squamous differentiation were evident throughout the stroma. The tumour appeared to be in biphasic pattern where at one end the tumour cells appeared to be stretched out making the intercellular ridges prominent whereas at the other end, tumour showed squamous differentiation, loss of intercellular bridges and cohesive tumour cells arranged in thick sheets [Table/Fig-4]. Tumour cells were positive for cytokeratin whereas surrounding material was negative [Table/Fig-5]. [Table/Fig-4]: Photomicrograph reveals area of cohesive tumour cells with squamous differentiation & loss of intercellular bridges (H&E, 10X) [Table/Fig-5]: Photomicrograph shows cytokeratin positivity in tumour cells (H&E, 10X) After extensive search in literature only three odontogenic tumours which show keratinization or squamous metaplasia were found. Acanthomatous ameloblstoma exhibit squamous metaplasia of stellate reticulum with or without keratin pearl formation [4]. However, in the present case frank keratin or squamous metaplasia was not seen but only squamous differentiation and individual cell keratinization were seen. Squamous odontogenic tumour also shows squamous metaplasia [5] but in the present case tumour was not arranged in follicles as well as material secretion by tumour cells did not appear to be keratin and tumour cells were not flattened squamous or cuboidal arranged in follicles. Keratoameloblastoma is a heterogenous group of odontogenic neoplasms which exhibit keratin formation in the connective tissue stroma [6]. Such frank keratin formation was absent in the present case. The index case is not of intraosseous squamous cell carcinoma as there was no dysplasia and few areas showed frank stellate reticulum like cells. Moreover, the present case is well encapsulated tumour supporting benign nature which is in contradiction to malignancy i.e. squamous cell carcinoma.

Squamous odontogenic tumor of the maxilla: a case report and review of the literature

Squamous odontogenic tumors are rare neoplasms of the jaw that are benign and locally infiltrative. The tumor originates in the gingival rests of Malassez, remnants of dental lamina or gingival surface epithelium. This type of tumor was first described by Pullon et al. (Oral Surg Oral Med Oral Pathol 40:616–630, 1975). The clinical presentation is mostly asymptomatic, though pain and tooth mobility may also occur. Radiographically, the tumor presents as a triangular radiolucent lesion found mostly in the maxilla and present between the roots of the teeth. Histologically, it may appear similar to acanthomatous and desmoplastic ameloblastoma; hence, it can present problems in differential diagnosis. Here, we describe a case of squamous odontogenic tumor of the anterior maxilla in a middle-aged Indian man.

PP118: Squamous odontogenic tumour: Report of a rare case and review of the literature

Squamous odontogenic tumour (SOT) was first described in 1975, by Pullon et al. as a rare, benign odontogenic tumor arising in close physical relationship to the dentition from the epithelial rests of Malassez in the periodontal ligament or gingival epithelium. To date, less than 50 cases have been described in the literature. We describe a case of SOT which was histologically misdiagnosed as a metastatic carcinoma of unknown origin. In the discussion and review of the literature that follows, the features of SOT, the differential diagnosis and the appropriate treatment are described.

Squamous odontogenic tumor-like proliferation in a radicular cyst: A case report

The squamous odontogenic tumour is a rare benign neoplasm whose aetiology remains unknown. It usually appears in the jaw and its origin could be related to the ephitelial remnants of Malassez. Histologically comprises numerous islets of squamous, non-keratinized, well-differentiated and rounded epithelial cells a fibrous stroma without signs of atypical cells. There is a non-neoplastic lesion with the same histological pattern than the squamous odontogenic tumour. This entity is characterized by squamous odontogenic tumour proliferations isolated into the cyst wall of an odontogenic cyst. It is rare and has a benign behavior. It has been suggested that these epithelial proliferations could be the former expression of the neoplastic form. It is very important to carry out clinical and radiological controls periodically. So far it has not been documented any change towards a squamous odontogenic tumour nor toward malignancy in a squamous odontogenic tumour like proliferation. Key words:Radicular cyst, squamous odontogenic tumour.

Squamous odontogenic tumor: A case report

Squamous odontogenic tumor is a rare benign locally infiltrative odontogenic tumor of epithelial origin and only a few cases, less than 50, have been reported in literature. The challenge is in diagnosing the tumor is due to its close resemblance to acanthomatous ameloblastoma and well differentiated squamous cell carcinoma. Herein we report, not previously reported, characteristic case of squamous odontogenic tumor in the anterior maxilla in a teenager female. The diagnosis is predicated on recognition of the histopathologic features of squamous odontogenic tumor to obviate possible misdiagnosis of malignancy or ameloblastoma. The symptoms are modest. Squamous odontogenic tumor has a characteristic pathologic picture, which differs from ameloblastoma.

Squamous Odontogenic Tumor with Unusual Localization and Appearance: A Rare Case Report

Squamous odontogenic tumor is a rare benign neoplasm and may affect multiple sites in the mouth. SOT was first described by Pullon et al. (1975). Since then, there have been less than 50 reported cases. The tumor is often asymptomatic, although it can present with symptoms of pain and tooth mobility. We report a case of SOT occurring in a 26-year-old female in the anterior mandible with unusual localization and appearance.

Diagnosis and management of unicystic ameloblastomous lesion of the mandible. Does it influence the clinician- A report of a case and differential diagnosis

Ameloblastomas are an enigmatic group of tumours. Their name implies a resemblance to cells of enamel forming organ (dental hard tissues). Ameloblastoma is an odontogenic tumour which is an archetype of a neoplasm where the neoplastic component is epithelial only without contribution from the ectomesenchyme. Most common odontogenic neoplasm in Indian population. Ameloblastoma is locally aggressive, but often asymptomatic, showing a slow growth which is manifested as a facial swelling or radiographic incidental finding. Unicystic ameloblastoma refers to those cystic lesions that show clinical, radiographic, or gross features of a mandibular cyst, but on histological examination show a typical ameloblastomatous epithelium lining with or without luminal tumour growth. We present an unusual case of unicystic ameloblastoma appearing as an interdental radiolucent lesion of the mandible in a 26 years old male patient. In addition, an insight on the various pathologies such as radicular cyst, lateral periodontal cyst, collateral keratocystic odontogenic tumour, Squamous odontogenic tumour, central giant cell granuloma, extra follicular adenomatoid odontogenic tumour, central odontogenic myxoma, glandular odontogenic cyst, calcifying epithelial odontogenic tumour, with similar presentations were critically evaluated & discussed in differential diagnosis of such entities.

Squamous odontogenic tumor of mandible: Report of a case

Squamous odontogenic tumor of mandible: Report of a case

The diagnostic and surgical management of a multifocal calcifiyng epithelial odontogenic tumor in the mandible and maxilla associated with a squamous odontogenic tumor: first reported case in the literature

The calcifiyng epithelial odontogenic tumor (CEOT) and the squamous odontogenic tumor (SOT) are rare and benign odontogenic tumors that affect the jaw. This article describes the diagnostic and surgical management of a multifocal CEOT in the mandible and maxilla associated with an SOT. This case is the first to demonstrate that there may be a multifocal variant of CEOT associated with an SOT that has not been previously recognized. Clinical, radiographic, and histologic signs are reported. Treatment modality, oral rehabilitation, and long-term follow-up are shown. Because of the rarity of this kind of simultaneous pathologic association, it is of paramount, and indeed obvious, importance to prospective reviewers that published reports are produced meticulously, including all clinically, radiographically, and histologically relevant data.