Splitting Pattern Research Articles

Mode shift at bottleneck increasing transit dispatch in peak time

For attracting more auto commuters to shift to transit mode and mitigating congestion at a bottleneck in morning &rush hour, additional dispatches of transit are operated during peak time. Classical bottleneck model combining with Logit-based discrete choice formula is extended to investigate commuters’ mode choice behaviors between private car and public transit. The existence of bi-mode user equilibrium when tolling auto commuter is proofed, and waiting time and time delay costs are formulated in two modes when additional buses are dispatched. Numerical experiments are conducted to examine mode split patterns and aggregate travel cost when additional dispatching service interval varying. Our results show the system aggregate trip cost would reduce prominently when extra buses are added into runs in appropriate time. Especially when waiting time equals 0.65 hour for auto commuters, the system aggregate trip cost would reduce by 70% in theory.

Quantum tunnelling pathways of the water pentamer.

We apply the semiclassical instanton method to calculate all feasible tunnelling pathways in the water pentamer. Similarly to the water trimer, there are labile flip dynamics as well as a number of different bifurcation pathways coupled to flips. In contrast to the trimer, the puckering motion of the oxygen ring makes the ring-polymer instanton approach difficult to converge, a problem which is resolved by using a recently developed time-independent formalism of the method. We use the results to predict the complete ground-state tunnelling splitting pattern of 320 states, which should help in the continuing effort to assign the experimental spectrum. A comparison between the rearrangement pathways in the water trimer and pentamer sheds light on the many-body cooperative effects of hydrogen bonding which are important for a full understanding of the liquid state.

Relationship of Icelandic cattle with Northern and Western European cattle breeds, admixture and population structure

ABSTRACTIcelandic cattle is believed to have been brought from Norway during the settlement of Iceland around AD 870-930. Previous research on genetic relationships has indicated that Icelandic cattle is most related to northern Nordic indigenous breeds. Using single nucleotide polymorphism genotype data from Icelandic cattle and 29 Northern and Western European cattle breeds, we studied relationships and admixture among these breeds, and assessed population structure in Icelandic cattle. Population structure analysis through principal component analysis, estimation of ancestry, and analysis of patterns of population splitting and mixing revealed that Icelandic cattle are most related to three Finncattle breeds (Eastern, Northern and Western Finncattle), and Swedish Mountain cattle. Icelandic cattle has very low levels of admixture. We observed very limited population structure in Icelandic cattle. The observed structure was due to variable sire contributions. Over 1000 years of almost complete isolation has made Icelandic cattle highly genetically distinct from other cattle breeds.

Classifications in Brief: AO Thoracolumbar Classification System.

Classifications in Brief: AO Thoracolumbar Classification System.

Dispersion-driven conformational preference in the gas phase: Microwave spectroscopic and theoretical study of allyl isocyanate.

The conformations of allyl isocyanate (CH2=CHCH2N=C=O) were explored in the gas phase by combining theoretical calculations and Fourier transform microwave spectroscopy, including the chirped pulse and Balle-Flygare types. Three conformers (I, II, and III) were predicted using D3(BJ) dispersion-corrected B3LYP and MP2 methods; however, the lowest energy conformer (conf. I) was absent at the standard B3LYP level. The observed microwave spectra are consistent with the presence of both conf. I and III in the supersonic jet, and surprisingly, this is the first report of the global minimum conf. I both experimentally and theoretically. Rotational transitions from the parent species of both conformers as well as their minor isotopologues (13C, 15N, and 18O) in natural abundance were assigned allowing experimental geometries to be derived. For conf. I, in addition to the typical splitting pattern due to the 14N quadrupole nucleus, the transitions show a tunneling splitting which arises from the interconversion motion between its two mirror images. The experimental observation of conf. I and the absence of conf. II in the jet are rationalized using quantum-chemical calculations to explore the importance of electron correlation and in particular, demonstrate the necessity of including dispersion effects in density functional theory calculations even for seemingly small molecules.

Localized Anisotropic Domains Beneath Eastern North America

AbstractSeismic anisotropy beneath eastern North America likely reflects both the remnant lithospheric fabrics and the present‐day deformation of the asthenosphere. We report new observations of splitting in core‐refracted shear phases observed over 3–5 years at 33 sites in New Jersey, New York, and states in the New England region and also include data from eight previously studied locations. Our data set emphasizes back azimuthal coverage necessary to capture the directional variation of splitting parameters expected from vertically varying anisotropy. We report single‐phase splitting parameters as well as station‐averaged values based on splitting intensity technique that incorporates all observed records regardless of whether they showed evidence of splitting or not. Trends of averaged fast shear wave polarizations appear coherent and are approximately aligned with absolute plate motion direction. The general disparity between the fast axes and the trend of surface tectonic features suggests a dominant asthenosphere contribution for the observed seismic anisotropy. Averaged delay values systematically increase from ~0.5 s in New Jersey to ~1.4 s in Maine. Splitting parameters vary at all sites, and neighboring stations often show similar patterns of directional variation. We developed criteria to group stations based on their splitting patterns and identified four domains with distinct anisotropic properties. Splitting patterns of three domains suggest a layered anisotropic structure that is geographically variable, outlining distinct regions in the continental mantle, for example, the Proterozoic lithosphere of the Adirondack Mountains. A domain coincident with the North Appalachian Anomaly displays virtually no splitting, implying that the lithospheric fabric was locally erased.

Effect of Nonmagnetic Ion Deficiency on Magnetic Structure: Density Functional Study of Sr2MnO2Cu2-xTe2, Sr2MO2Cu2Te2 (M = Co, Mn), and the Oxide-Hydrides Sr2VO3H, Sr3V2O5H2, and SrVO2H.

Two seemingly puzzling observations on two magnetic systems were analyzed. For the oxide-hydrides Sr2VO3H, Sr3V2O5H2, and SrVO2H, made up of VO4H2 octahedra, the spin orientations of the V3+ (d2, S = 1) ions were reported to be different, namely, perpendicular to the H-V-H bond in Sr2VO3H but parallel to the H-V-H bond in Sr3V2O5H2 and SrVO2H, despite that the d-state split patterns of the VO4H2 octahedra are similar in the three oxide-hydrides. Another puzzling observation is the contrasting magnetic structures of Sr2CoO2Cu2Te2 and Sr2MnO2Cu1.58Te2, consisting of the layers made up of corner-sharing MO4Te2 (M = Co, Mn) octahedra. The Co2+ spins in each CoO2Te2 layer are antiferromagnetically coupled with spins perpendicular to the Te-Co-Te bond, whereas the Mn3+/Mn2+ ions of each MnO2Te2 layer are ferromagnetically coupled with spins parallel to the Te-Mn-Te bonds. We investigated the cause for these observations by performing first-principles density functional theory (DFT) calculations for stoichiometric phases Sr2VO3H, Sr3V2O5H2, SrVO2H, Sr2CoO2Cu2Te2, and Sr2MnO2Cu2Te2, as well as nonstoichiometric phase Sr2MnO2Cu1.5Te2. Our study reveals that the V3+ ions in all three oxide-hydrides should have the spin orientation parallel to the H-V-H bond. The unusual magnetic structure of the MnO2Te2 layers of Sr2MnO2Cu1.52Te2 arises from the preference of a Mn3+ spin to be parallel to the Te-Mn-Te bond, the ferromagnetic spin exchange between adjacent Mn3+ and Mn2+ ions, and the nearly equal numbers of Mn3+ and Mn2+ ions in each MnO2Te2 layer. We show that the spin orientation of the magnetic ions in an antiferromagnetically coupled perovskite layer, expected in the absence of nonmagnetic ion vacancies, cannot be altered by the magnetic ions of higher oxidation that result from trace vacancies at the nonmagnetic ion sites.

Internal Motions and Sulfur Hydrogen Bonding in Methyl 3-Mercaptopropionate.

The effect of sulfur hydrogen bonding on the conformational equilibrium of methyl 3-mercaptopropionate was investigated using microwave spectroscopy in a supersonic jet expansion. The two most stable conformers (I and II) were assigned in the rotational spectra, and complex splitting patterns owing to the methyl internal rotation and SH tunneling motion were resolved and analyzed in detail. For both conformers, the experimental torsional barriers for the methyl top are similar and about 5.1 kJ mol-1, revealing that their geometrical differences do not affect the methyl internal rotation. The experimentally derived rotational and centrifugal distortion constants, along with the methyl internal rotation barriers, are discussed and compared with results from density functional theory and ab initio calculations. Quantum theory of atoms in molecules, noncovalent interactions, and natural bond orbital analyses show that the global minimum geometry (I), which has the thiol hydrogen oriented toward the carbonyl of the ester, is stabilized by an SH···O=C hydrogen bond. The presence of a hydrogen bond is confirmed by the derivation of an accurate experimental geometry that reveals a hydrogen bond distance and S-H-O angle of 2.515(4) Å and 117.4(1)°, respectively. These results are key benchmarks to expand the current knowledge of sulfur hydrogen bonds and the relationship between internal motions and conformational preferences in esters.

A semiclassical approach to the torsional tunneling splitting patterns in G6(EM), G12, G18, and G36(EM) molecules

A semiclassical method to predict the torsional splitting patterns in internally rotating molecules of G6(EM), G12, G18, and G36(EM) symmetries is described. To this purpose use is made of rotating axis systems denoted “Corioless”, in which the contribution to the torsional angular momentum from specific vibrational motions of the molecule, or part of it, vanishes. It is confirmed that the actual torsional splitting patterns in degenerate or perpendicular vibrational states can be predicted analytically and are determined by torsional Coriolis coupling. Rules stating the conditions required to generate limit splitting patterns (regular and inverted) are formulated in a quite general way and derived for the first time in the case of G18 molecules.

P2.14-14 Comparison of Molecular Testing Modalities for Detection of NRG1 Rearrangements in Invasive Mucinous Adenocarcinoma

The NRG1 (Neureguline-1) fusion gene has been recently described as a new molecular feature of non small cell lung cancer (NSCLC), strictly related to invasive mucinous adenocarcinoma (IMA) subtype. Despite of NRG1 fusion partners, all Nrg1 chimeric ligands were predicted to retain the EGF-like domain of the wild-type NRG1 III-β3 isoform that produces oncogenic signals through ErbB2-ErbB3 heterodimers and leads to phosphorylation of ErbB3. To date, the NRG1 fusions were quite exclusively identified by RNA sequencing and only in few cases confirmed by fluorescent in situ hybridization (FISH) analysis, mainly due to the cellular features of IMA subtypes that produce interference in fluorescent signals detection. An accurate detection of NRG1 rearrangement/fusions in clinical tumor samples is actually demanded. In this study we compared the performance of two molecular testing approaches to detect NRG1 breaks in paraffin embedded formalin fixed (FFPE) IMA lung tissues. A total of 19 lung FFPE IMAs were screened by immunohistochemistry (IHC) to evaluate the expression of phosphorylated-ErbB3 (pErbB3) receptor. Samples positive for pErbB3 staining were tested by using by break-apart FISH to detect putative NRG1 rearrangements and RNA-targeted next generation sequencing (NGS) to identify fusion variants. Eleven cases showed an increased expression of pErbB3 in cancer cells compared to the adjacent non-involving bronchial epithelium which demonstrated a basal level staining of the protein. pErbB3 positive cases were investigated by FISH and showed <15% of rearranged nuclei (range 17-47%, mean 29%). In addition to the canonical signal split pattern, the FISH NRG1 assay reveals that cells also showed rearrangement patterns in form of isolated 3’ signals, thus indicating a strength analogy with ALK and ROS1 fusions, where a 5’ gene deletion was frequently observed. CD74-NRG1 fusion variant was identified by NGS analysis in four cases, whereas in three cases a 3’/5’ NRG1 imbalance was detected. For both approaches, we identified assay characteristics that likely contributed to false-negative results. Our investigations confirm the usefulness of IHC/FISH combined approach for NRG1 broken tumors identification, but also highlight the crucial role of NGS to identify NRG1 functional chimeric transcripts. Such combined molecular testing should enhance the selection of NRG1-positive patients to include in clinical trials with specific compounds designed to inhibit the RTK downstream signal.

Loanword Syllable Adaptation in Persian: An Optimality-Theoretic Account

The present paper examines the process of loanword syllable adaptation in tetrasyllabic words in Persian, within an Optimality-theoretic framework. In Persian, consonant clusters are avoided in onset position. As a result, the loanwords borrowed from other languages which have complex onsets, when introduced into Persian, are adapted to fit the syllable structure of the target language. When placed word-initially, the onset cluster is generally resolved by the insertion of an epenthetic vowel. However, this vowel epenthesis occurs in a split pattern, as it does in many other languages. In this study, following Gouskova’s (2001) proposal, we argue that this split pattern in loanword syllabic adaptation can best be explained to be an effect of the Syllable Contact Law (SCL). That is, when the two segments in the onset cluster have a rising sonority sequence, the cluster is broken up by the process of anaptyxis; while in sequences of falling sonority, the cluster is resolved through the process of prothesis. It is argued that, this pattern uniformly holds true at least as far as the dictionary-derived data in the present study are concerned. For the exceptional cases of /SN/ and /SL/ clusters—not attested in our data set, but still present and frequently referred to in the literature—we propose the addition of two positional faithfulness constraints of the DEP-V/X_Y family (Fleischhacker 2001) to our set of universal constraints to account for all the possible cases of loanword syllabic adaptation in Persian.

Effects of height/diameter ratio on failure and damage properties of granite under coupled bending and splitting deformation

In underground mining, rock roofs with different thicknesses have distinct failure patterns under the complex stress. To understand the height/diameter ratio (H/D) on failure properties and damage characteristics under the coupled bending and splitting deformation, a series of point-bending tests were conducted on granite disc samples with the same diameter but different heights. The micro-crack evolution during the test was measured and recorded by acoustic emission experiments. Test results indicated that the height/diameter ratio determines the failure mode of granite samples. The sample with the H/D less than 0.4 is primarily fractured in the bending mode. Once the H/D exceeds 0.4, the failure pattern transforms into the splitting pattern. According to analysis of the ringing count rate in the acoustic emission signals, more than 60% of the damage accumulates rapidly in the yield stage, while the damage in other stages increases steadily. In addition, the damage evolution curves calculated from the plastic region are consistent with those calculated by the ringing count rate, so that the damage properties of the granite disc samples are obtained under the complicated stress. The rapid accumulation of the damage indicates the sharp change of the stress inside the rock sample, which is the precursor information of the failure of rock samples.

C-shaped split ring resonator terahertz toroidal dipole metasurfaces

We designed and fabricated terahertz toroidal dipole metasurfaces based on a C-shaped split ring resonator metallic pattern fabricated on a flexible dielectric material (mylar). The toroidal dipole moment (Ty) was demonstrated as the dominant contribution to two different resonances at low frequency (ω1) and at high frequency (ω2). Simulation and LC circuit model analysis offered a quantitative explanation to the blue shift of the resonant frequencies at ω1 and ω2 as the increase of the opening angle(θ). The resonant frequencies showed a red shift at ω1 and ω2 as the increase of the outer ring radius (QR). Furthermore, the enhancement of the Q factor was attributed to the increase of Ty and the decrease of radiative loss. It was further proven that the model provided a new scheme for designing the toroidal dipole metasurfaces under a terahertz band, which was expected to be used as terahertz functional devices.

Family Communication Patterns of Abuser and Victim in Sexual Abuse Case Resolutions towards Children in Medan City Resort Police

This study aims to analyze the family communication patterns of abuser and victim in sexual abuse case resolutions towards children, the application of the principles of Islamic communication in resolving sexual abuse cases towards children and to know the obstacles in solving sexual abuse cases for underage children in the law area of Medan City Resort Police. The research method used in this study is a descriptive qualitative approach. This method describes the current state of the subject or object of study based on facts that appear or as they are. The results of the study shows that the family communication patterns of abuser and victim in sexual abuse case resolutions towards children in Medan City Resort Police are the Equality Pattern, Balance Split Pattern, Unbalanced Split Pattern and Monopoly Patterns.

SKS Splitting Beneath Mount St. Helens: Constraints on Subslab Mantle Entrainment

AbstractObservations of seismic anisotropy can provide direct constraints on the character of mantle flow in subduction zones, critical for our broader understanding of subduction dynamics. Here we present over 750 new SKS splitting measurements in the vicinity of Mount St. Helens in the Cascadia subduction zone using a combination of stations from the iMUSH broadband array and Cascades Volcano Observatory network. This provides the highest density of splitting measurements yet available in Cascadia, acting as a focused “telescope” for seismic anisotropy in the subduction zone. We retrieve spatially consistent splitting parameters (mean fast direction Φ: 74°, mean delay time ∂t: 1.0 s) with the azimuthal occurrence of nulls in agreement with the fast direction of splitting. When averaged across the array, a 90° periodicity in splitting parameters as a function of back azimuth is revealed, which has not been recovered previously with single‐station observations. The periodicity is characterized by a sawtooth pattern in Φ with a clearly defined 45° trend. We present new equations that reproduce this behavior based upon known systematic errors when calculating shear wave splitting from data with realistic seismic noise. The corrected results suggest a single layer of anisotropy with an ENE‐WSW fast axis parallel to the motion of the subducting Juan de Fuca plate; in agreement with predictions for entrained subslab mantle flow. The splitting pattern is consistent with that seen throughout Cascadia, suggesting that entrainment of the underlying asthenosphere with the subducting slab is coherent and widespread.

Optimizing mandibular sagittal split of large maxillomandibular advancements for obstructive sleep apnea: patient and surgical factors.

Maxillomandibular advancement (MMA) confers consistent and high rates of surgical success for obstructive sleep apnea (OSA). In the era of value-based medicine, identifying factors that affect the stability of rigid fixation and allow rapid return to function are important targets for improvement. The aim of this study was to identify patient and surgical factors associated with mandibular sagittal split outcomes associated with optimal postoperatively skeletal stability. Retrospective cohort study. Forty-six subjects (43 males and 3 females) with postoperative CT scans including three-dimensional reconstruction from which mandibular split patterns could be analyzed were enrolled. Patient factors (age and polysomnographic measures) and surgical factors (extent of osteotomy prior to controlled fracture) were assessed. Outcome measures include (1) bone thickness for rigid fixation and (2) area of passive bony overlap after advancement. Age and severity of disease did not contribute significantly to optimal mandibular split patterns. For optimal area for passive bony overlap and thickness of buccal and lingual plates for rigid fixation, the most important factors are related to surgical technique. Anterior osteotomy just to the midline of inferior border and horizontal osteotomy to the mandibular foramen are associated with split patterns that result in optimal rigid fixation and passive bony overlap for OSA patients undergoing MMA. Optimal surgical technique has the most significant influence in allowing rapid return to function after MMA in patients with OSA.

Water Docking Bias in [4]Helicene

AbstractWe report on the one‐ and two‐water clusters of [4]helicene, the smallest polycyclic aromatic hydrocarbon with a helical sense, which were captured in the gas phase using high‐resolution rotational spectroscopy. The structures of the complexes are unambiguously revealed using microwave spectra of isotopically enriched species. In the one‐water cluster, the apparent splitting pattern is consistent with a tunneling motion that encompasses an exchange of strongly and weakly bonded water hydrogens. This motion is “locked” in the two‐water cluster. The relevant intermolecular contacts, symmetry, and aromaticity effects are unveiled for the microsolvated chiral topologies. These observations entail the first glance at the structures and internal dynamics of the water binding motifs of a chiral polycyclic aromatic hydrocarbon.

Water Docking Bias in [4]Helicene.

We report on the one- and two-water clusters of [4]helicene, the smallest polycyclic aromatic hydrocarbon with a helical sense, which were captured in the gas phase using high-resolution rotational spectroscopy. The structures of the complexes are unambiguously revealed using microwave spectra of isotopically enriched species. In the one-water cluster, the apparent splitting pattern is consistent with a tunneling motion that encompasses an exchange of strongly and weakly bonded water hydrogens. This motion is "locked" in the two-water cluster. The relevant intermolecular contacts, symmetry, and aromaticity effects are unveiled for the microsolvated chiral topologies. These observations entail the first glance at the structures and internal dynamics of the water binding motifs of a chiral polycyclic aromatic hydrocarbon.

Structural Elucidation of Presilphiperfolane-7α,8α-diol, a Bioactive Sesquiterpenoid from Pulicaria vulgaris: A Combined Approach of Solvent-Induced Chemical Shifts, GIAO Calculation of Chemical Shifts, and Full Spin Analysis.

Structural elucidation of a new triquinane sesquiterpenoid, presilphiperfolane-7α,8α-diol, 1a, isolated from Pulicaria vulgaris, was accomplished by combining solvent-induced removal of chemical shift degeneracy and computational (DFT-GIAO) prediction of NMR spectra with the analysis of 1H NMR splitting patterns. In addition to extensive NMR experiments (in 10 different solvents), MS, and FTIR, the identity of 1a was also confirmed by chemical transformations. The applied approach can facilitate structural elucidation of organic molecules and decrease the probability of an erroneous identification, permitting an unambiguous stereochemical elucidation and full NMR assignment. The pharmacological/toxicological profile of 1a was evaluated in several different models.

How does bone thickness affect the split pattern of sagittal ramus osteotomy?

This study examined the influence of bone thickness on the split pattern of sagittal ramus osteotomy at 62 sites using Dolphin 3D software. Four measurements of thickness were obtained from the preoperative computed tomography scans: measurement A was made 1.5mm above the lingula, using the coronal and sagittal planes; measurement B was made at the same height as measurement A and 1mm from the anterior border of the ramus; measurement C was obtained 5mm distal to the last molar and 5mm below the upper border of the mandible; measurement D was made in the area between the first and second molars, 6mm above the mandibular border. Three-dimensional postoperative images were used to classify the split pattern into types, based on the classification of Plooij et al. The data were analyzed using the Kruskal–Wallis test, followed by Dunn post-hoc test. Thirty-five sagittal splits were type I, one was type II, 19 were type III, and seven were type IV. Type I presented the greatest thickness, whereas type IV presented the lowest. There was a statistically significant difference in thickness only for measurement A, when types I and IV were compared. The results indicate that thinner mandibular rami are more prone to bad splits.