Splanchnic Oxygen Consumption Research Articles

Response of estimated hepatic blood flow to graded hemorrhage and the infusion of levarterenol.

Levarterenol did not significantly affect the estimated hepatic blood flow, arterial-hepatic venous oxygen difference, or splanchnic oxygen consumption of the dog during graded hemorrhage. During the later stage of hemorrhage hepatic blood flow tended to spontaneously increase so that the percentage reduction in hepatic blood flow was less than the percentage reduction in blood volume.

CLINICAL STUDIES ON THE CIRCULATORY HEMODYNAMICS OF THE LIVER

On' twenty-nine patients, fifteen with liver cirrhosis, seven with epidemic hepatitis and seven with carcinoma of the liver, the hepatic blood flow was estimated by the hepatic venous catheterization. In fourteen of them, the hepatic arterio-venous oxygen difference was determined and splanchnic oxygen consumption was calculated. (1) In the patients with liver cirrhosis, the EHBF was generally decreased (565cc/min./M2). However, in the cases with hepatic enlargement and slight fibrosis observed peritoneoscopically the EHBF was normal or slightly decreased (830-940cc/min./M2), on the other hand in the cases with distinguished liver atrophy the EHBF was highly decreased (155-500 cc/min./M2). In the former, the prognosis was relatively good. (2) In the patients with epidemic hepatitis, the EHBF was 745 (480-1310) cc/min./M2, and in those with carcinoma of the liver was 630 (310-955) cc/min./M2. (3) The hepatic arterio-venous oxygen difference was 5.38 (2.36-6.90) Vol.% in the patients with liver cirrhosis, and 5.02 (2.11-7.85) Vol.% in epidmic hepatitis. These difference was smaller than that of the healthy persons and the cases without liver disease. Calculated splanchnic oxygen consumption was 24.8 (10.0-45.2) cc/min./M2 in liver cirrhosis and 35.3 (18.1-60.5) cc/min./M2 in epidemic hepatits, both having been less than that in control persons. (4) On the basis of the studies described on first report and here, the effect of upright standing, diet, blood transfusion and various drugs on the EHBF was examined and discussed.

An Hyperglycemic-Glycogenolytic Response to Pituitary Growth Hormone in Man.

Summary1. A rapid 30 minute intravenous infusion of 100 mg of a sample of growth hormone derived from pork pituitary glands by the technic of Raben and Wester-meyer resulted in a prompt hyperglycemia in man, which lasted during the infusion and rapidly subsided thereafter. 2. The hyperglycemia was due to an augmented output of glucose by the liver and was not associated with any change in splanchnic blood flow, oxygen consumption, or amino and urea nitrogen or ketone balances. 3. The hyperglycemic response to the extract was not modified by boiling at pH 3.5, was decreased by boiling in 0.2 N HCl or when the hormone was made up at pH 9.5, and was destroyed by standing in 0.1 N NaOH for 18 hours. Growth and diabetogenic activities in the rat were likewise destroyed by alkali treatment and unmodified by boiling at pH 3.5. Ketogenic and adipo-kinetic activities were destroyed by acid boiling and unaffected by alkali treatment. 4. The significance of these findings is discussed in light of the evidence that g...

The effect of subfebrile doses of bacterial pyrogens on splanchnic metabolism and cardiac output.

Abstract Subfebrile doses of bacterial pyrogens have been found to produce striking alterations in splanchnic circulation and metabolism. These consisted of a mean decrease in Bromsulphalein clearance of 33 per cent, a mean elevation of hepatic blood flow of 47 per cent, and a rise in mean splanchnic oxygen consumption of 18 per cent. Splanchnic glucose production was unaffected. The elevation of hepatic blood flow was not accompanied by proportionate increase in cardiac output. Contamination of parenterally injected materials with small amounts of bacterial pyrogens is, therefore, suggested as a possible cause for erratic alterations of splanchnic metabolism.

The effect of hemorrhage on hepatic blood flow and splanchnic oxygen consumption of the dog.

Using the BSP extraction technic, the hepatic blood flow of the dog was found to be reduced markedly following a single massive hemorrhage. However, increase in the arterial hepatic venous-oxygen difference compensated for as much as 75% reduction in flow; hence, splanchnic oxygen consumption was maintained under these circumstances. Significant reduction of splanchnic oxygen consumption occurred only during sustained shock when hepatic blood flow was so seriously diminished that high oxygen extraction could not compensate for the lowered oxygen delivery to the liver.

The hepatic blood flow and splanchnic oxygen consumption in alcoholic fatty liver.

The hepatic blood flow and splanchnic oxygen consumption in alcoholic fatty liver.

Effect of acute hemorrhage on hepatic blood flow and splanchnic oxygen consumption of the dog

Effect of acute hemorrhage on hepatic blood flow and splanchnic oxygen consumption of the dog

An estimation of the hepatic blood flow and splanchnic oxygen consumption in heart failure: Myers, J. D., and Hickam, J. B.: J. Clin. Investigation 27:620 (Sept.), 1948

An estimation of the hepatic blood flow and splanchnic oxygen consumption in heart failure: Myers, J. D., and Hickam, J. B.: J. Clin. Investigation 27:620 (Sept.), 1948

20. Estimation of the hepatic blood flow and splanchnic oxygen consumption in heart failure

20. Estimation of the hepatic blood flow and splanchnic oxygen consumption in heart failure