Spinal Loading Research Articles

Current Clinical Concepts: Management of Common Lumbar Spine Posterior Column Disorders in Young, Active Individuals.

Although posterior column disorders, such as spondylolysis and spondylolisthesis, are not commonly encountered in the general population, athletic trainers frequently see these conditions in athletic and active individuals due to the repetitive spinal extension and rotational loads placed on the pars interarticularis while participating in sport. Athletic trainers can successfully evaluate patients with posterior column disorders by performing a complete and comprehensive clinical examination to identify the location of pain, test spinal stability, and recognize compensatory movement patterns. Conservative management typically leads to a successful outcome in this population, with rest, bracing, and the use of therapeutic exercise having the best supporting evidence. In this Current Clinical Concepts review, we outlined the etiology and risk factors frequently associated with disorders of the posterior column. Additionally, we synthesized the literature for common evaluation techniques and interventions associated with the posterior column and provided a proposed rehabilitation progression to use in a younger, athletic population.

Biomechanical analysis of the impact of increasing levels of body mass index on the ability of a bracing orthosis to alter the asymmetric compressive growth plate loading in a scoliotic spine

BackgroundThe impact of increasing body mass index (BMI) on the magnitude of alterations in the asymmetric compressive vertebral growth plate loading of a scoliotic spine following 50% in-brace correction is studied using the finite element method, and subsequent alteration of the longitudinal bone growth rate is quantified. MethodsUpper body weight loading corresponding to a single patient spine geometry representing 4 BMI classifications – overweight (BMI = 25 kg/m2), and class-1, -2, and -3 obesity (BMI – 30 kg/m2, 35 kg/m2, and 40 kg/m2, respectively) – is applied to a three-dimensional finite element model (FEM) of the human thoracolumbosacral spine. The FEM represents a Lenke 1AN scoliotic curve type with 30-degree Cobb angle and 10-degree apical vertebral rotation. Bracing simulation is performed until 50% in-brace correction is achieved. Changes in bending moment at each motion segment and on each growth plate after bracing is simulated and compared between each BMI level. FindingsAs BMI increases, the average magnitude of change in bending moment on each growth plate following bracing decreases. For BMIs 30 kg/m2, 35 kg/m2, and 40 kg/m2, the average change in bending moment on each vertebral growth plate following 50% in-brace correction is 31% smaller (P = .00006), 60% smaller (P = .00007), and 96% smaller (P = .00006), respectively, than for BMI 25 kg/m2. InterpretationsResults indicate that BMI significantly impacts the ability of a bracing orthosis to alter the asymmetric compressive growth plate loading in a scoliotic spine, which is the design function of bracing. This suggests that increasing BMI may significantly impact the ability of a bracing orthosis to halt curve progression in a scoliotic patient.

Biomechanical Properties of Paraspinal Muscles Influence Spinal Loading-A Musculoskeletal Simulation Study.

Paraspinal muscles are vital to the functioning of the spine. Changes in muscle physiological cross-sectional area significantly affect spinal loading, but the importance of other muscle biomechanical properties remains unclear. This study explored the changes in spinal loading due to variation in five muscle biomechanical properties: passive stiffness, slack sarcomere length (SSL), in situ sarcomere length, specific tension, and pennation angle. An enhanced version of a musculoskeletal simulation model of the thoracolumbar spine with 210 muscle fascicles was used for this study and its predictions were validated for several tasks and multiple postures. Ranges of physiologically realistic values were selected for all five muscle parameters and their influence on L4-L5 intradiscal pressure (IDP) was investigated in standing and 36° flexion. We observed large changes in IDP due to changes in passive stiffness, SSL, in situ sarcomere length, and specific tension, often with interesting interplays between the parameters. For example, for upright standing, a change in stiffness value from one tenth to 10 times the baseline value increased the IDP only by 91% for the baseline model but by 945% when SSL was 0.4 μm shorter. Shorter SSL values and higher stiffnesses led to the largest increases in IDP. More changes were evident in flexion, as sarcomere lengths were longer in that posture and thus the passive curve is more influential. Our results highlight the importance of the muscle force-length curve and the parameters associated with it and motivate further experimental studies on in vivo measurement of those properties.

Compensatory biomechanics and spinal loading during dynamic maneuvers in patients with chronic low back pain

PurposeThis study explores the biomechanics underlying the sit-to-stand (STS) functional maneuver in chronic LBP patients to understand how different spinal disorders and levels of pain severity relate to unique compensatory biomechanical behaviors. This work stands to further our understanding of the relationship between spinal loading and symptoms in LBP patients.MethodsWe collected in-clinic motion data from 44 non-specific LBP (NS-LBP) and 42 spinal deformity LBP (SD-LBP) patients during routine clinical visits. An RGB-depth camera tracked 3D joint positions from the frontal view during unassisted, repeated STS maneuvers. Patient-reported outcomes (PROs) for back pain (VAS) and low back disability (ODI) were collected during the same clinical visit.ResultsBetween patient groups, SD-LBP patients had 14.3% greater dynamic sagittal vertical alignment (dSVA) and 10.1% greater peak spine torque compared to NS-LBP patients (p < 0.001). SD-LBP patients also had 11.8% greater hip torque (p < 0.001) and 86.7% greater knee torque (p = 0.04) compared to NS-LBP patients. There were no significant differences between patient groups in regard to anterior or vertical torso velocities, but anterior and vertical torso velocities correlated with both VAS (r = − 0.38, p < 0.001) and ODI (r = − 0.29, p = 0.01). PROs did not correlate with other variables.ConclusionPatients with LBP differ in movement biomechanics during an STS transfer as severity of symptoms may relate to different compensatory strategies that affect spinal loading. Further research aims to establish relationships between movement and PROs and to inform targeted rehabilitation approaches.

Submaximal electromyography-driven musculoskeletal modeling of the human trunk during static tasks: Equilibrium and stability analyses

Conventional electromyography-driven (EMG) musculoskeletal models are calibrated during maximum voluntary contraction (MVC) tasks, but individuals with low back pain cannot perform unbiased MVCs. To address this issue, EMG-driven models can be calibrated in submaximal tasks. However, the effects of maximal (when data points include the maximum contraction) and submaximal calibration techniques on model outputs (e.g., muscle forces, spinal loads) remain yet unknown. We calibrated a subject-specific EMG-driven model, using maximal/submaximal isometric contractions, and simulated different independent tasks. Both approaches satisfactorily predicted external moments (Pearson’s correlation ∼ 0.75; relative error = 44%), and removing calibration tasks under axial torques markedly improved the model performance (Pearson’s correlation ∼ 0.92; relative error ∼ 28%). Unlike individual muscle forces, gross (aggregate) model outputs (i.e., spinal loads, stability index, and sum of abdominal/back muscle forces) estimated from maximal and submaximal calibration techniques were highly correlated (r > 0.78). Submaximal calibration method overestimated spinal loads (6% in average) and abdominal muscle forces (11% in average). Individual muscle forces estimated from maximal and submaximal approaches were substantially different; however, gross model outputs (especially internal loads and stability index) remained highly correlated with small to moderate relative differences; therefore, the submaximal calibration technique can be considered as an alternative to the conventional maximal calibration approach.

Motion sickness decreases low back function and changes gene expression in military aircrew

BackgroundMotion sickness and low back disorders are prevalent and debilitating conditions that affect the health, performance, and operational effectiveness of military aircrews. This study explored the effects of a motion sickness stimulus on biomechanical and genetic factors that could potentially be involved in the causal pathways for both disorders. MethodsSubjects recruited from a military population were exposed to either a mild (n = 12) or aggressive (n = 16) motion sickness stimulus in a Neuro-Otologic Test Center. The independent variable of interest was the motion sickness stimulus exposure (before vs. after), though differences between mild and aggressive stimuli were also assessed. Dependent measures for the study included motion sickness exposure duration, biomechanical variables (postural stability, gait function, low back function, lumbar spine loading), and gene expression. FindingsSeven of twelve subjects experiencing the mild motion sickness stimulus endured the full 30 min in the NOTC, whereas subjects lasted an average of 13.2 (SD 5.0) minutes in the NOTC with the aggressive motion sickness stimulus. Mild motion sickness exposure led to a significant decrease in the postural stability measure of sway area, though the aggressive motion sickness exposure led to a statistically significant increase in sway area. Both stimuli led to decreases in low back function, though the decrease was only statistically significant for the mild protocol. Both stimuli also led to significant changes in gene expression. InterpretationMotion sickness may alter standing balance, decrease low back function, and lead to changes in the expression of genes with roles in osteogenesis, myogenesis, development of brain lymphatics, inflammation, neuropathic pain, and more. These results may provide preliminary evidence for a link between motion sickness and low back disorders.

How Does the Lumbopelvic Complex Cope with the Obstetrical Load during Standing? Ergonomic Aspects of Body Posture in Pregnant Women

Pregnancy induces numerous modifications in the musculoskeletal system of the female body. Since one of the essential roles of the lumbopelvic structure is to support mechanical loads in the upright position, this study was designed to simulate the response of this complex to the growing foetus in pregnant women. The authors hypothesized that posture (i.e., lordosis and muscle involvement) under pregnancy conditions might be adjusted to minimize the demands of the obstetrical load. The analysis of the load on the musculoskeletal system during gestation was made based on numerical simulations carried out in the AnyBody Modeling System. The pregnancy-related adjustments such as increased pelvic anteversion and increased lumbar lordosis enhance the reduction of muscle activation (e.g., erector spinae, transversus abdominis or iliopsoas), muscle fatigue and spinal load (reaction force). The results may help develop antenatal exercise programs targeting core strength and pelvic stability.

Unsupervised Machine Learning on Motion Capture Data Uncovers Movement Strategies in Low Back Pain

Chronic low back pain (LBP) is a leading cause of disability and opioid prescriptions worldwide, representing a significant medical and socioeconomic problem. Clinical heterogeneity of LBP limits accurate diagnosis and precise treatment planning, culminating in poor patient outcomes. A current priority of LBP research is the development of objective, multidimensional assessment tools that subgroup LBP patients based on neurobiological pain mechanisms, to facilitate matching patients with the optimal therapies. Using unsupervised machine learning on full body biomechanics, including kinematics, dynamics, and muscle forces, captured with a marker-less depth camera, this study identified a forward-leaning sit-to-stand strategy (STS) as a discriminating movement biomarker for LBP subjects. A forward-leaning STS strategy, as opposed to a vertical rise strategy seen in the control participants, is less efficient and results in increased spinal loads. Inefficient STS with the subsequent higher spinal loading may be a biomarker of poor motor control in LBP patients as well as a potential source of the ongoing symptomology.

Axial Loading during MRI Induces Lumbar Foraminal Area Changes and Has the Potential to Improve Diagnostics of Nerve Root Compromise.

Lumbar foraminal stenosis is a common cause of lumbar radiculopathy and conventionally assessed with magnetic resonance imaging (MRI) in supine-positioned patients. An MRI acquired during spine loading may unmask pathology not otherwise revealed in a relaxed position. Therefore, we investigated how spine loading during MRI affects lumbar foramina. In 89 low-back pain patients’ lumbar, MRIs were performed in a relaxed supine position and during axial loading using a Dynawell® compression device. The smallest area of all intervertebral foramina at levels L3/L4–L5/S1 (534 foramina) was determined using a freehand polygonal tool in parasagittal T2-weighted sequences. The grading system described by Lee et al. was also used to qualitatively assess foraminal stenosis. Overall, a mean reduction of 2.2% (mean −0.89 cm2 and −0.87 cm2, respectively) was observed (p = 0.002), however for individual foramina large variations, with up to about 50% increase or decrease, were seen. Stratified for lumbar level, an area reduction was found for L3/L4 and L4/L5 foramina (mean change −0.03 cm2; p = 0.036; and −0.03 cm2; p = 0.004, respectively) but not for L5/S1. When comparing the measured area changes to qualitative foraminal grading, 22% of the foramina with a measured area decrease were evaluated with a higher grading. Thus, detailed information on foraminal appearance and nerve root affection can be obtained using this method.

Effects of backrest and seat-pan inclination of tractor seat on biomechanical characteristics of lumbar, abdomen, leg and spine

Seat is a direct human-machine interaction component between the tractor and driver, and thus its reasonable parameter design is of great significance for preventing occupational diseases and improving driving comfort, safety and operation efficiency. In this study, a biomechanical model of seat-driver system was established with the AnyBody biomechanical software. The activities of the lumbar, abdominal and leg muscles and the load of the spine of the driver were used as indicators for quantitative simulation analysis of the inclination of backrest and seat-pan. The results reveal that the optimal range of backrest inclination angle is 3–15°, which contributes to the lowest muscle activity and spinal load of the driver. As for the seat-pan inclination, the activities of lumbar and abdominal muscles and the spinal load generally show slight fluctuations with increasing inclination angle, but there are complex changes in the activities of leg muscles, and the seat-pan inclination angle of 5–16° was determined as the optimal range for better overall driving comfort.

Choice of Spinal Interbody Fusion Cage Material and Design Influences Subsidence and Osseointegration Performance

The objective of the study was to quantify the effect of cage material (titanium-alloy vs. polyetheretherketone or PEEK) and design (porous vs. solid) on subsidence and osseointegration. Three lateral cages (solid PEEK, solid titanium, and 3-dimension-printed porous titanium cages) were evaluated for cage stiffness, subsidence compression stiffness, and dynamic subsidence displacement under simulated postoperative spine loading. Dowel-shaped implants made of grit-blasted solid titanium alloy (solid titanium) and porous titanium were fabricated using commercially available processes. Samples were processed for mechanical push-out testing and polymethylmethacrylate histology following an established ovine bone implantation model. The solid titanium cage exhibited the greatest stiffness (57.1±0.6kN/mm), followed by the porous titanium cage (40.4±0.3kN/mm) and the solid PEEK cage (37.1±1.2kN/mm). In the clinically relevant dynamic subsidence, the porous titanium cage showed the least amount of subsidence displacement (0.195±0.012mm), significantly less than that of the solid PEEK cage (0.328±0.020mm) and the solid titanium cage (0.538±0.027mm). Bony on-growth was noted histologically on all implant materials; however, only the porous titanium supported bony ingrowth with marked quantities of bone formed within the interconnected pores through 12weeks. Functional differences in osseointegration were noted between groups during push-out testing. The porous titanium showed the highest maximum shear stress at 12weeks and was the only group that demonstrated significant improvement (4-12weeks). The choice of material and design is critical to cage mechanical and biological performances. A porous titanium cage can reduce subsidence risk and generate biological stability through bone on-growth and ingrowth.

Static and Dynamic Postural Characteristics in Patients with Chronic Obstructive Pulmonary Disease: The Relationship with Dyspnea and Pulmonary Functions

BackgroundThere is little evidence about posture influence and its relationship with pulmonary functions in chronic obstructive pulmonary diseases(COPD) patients. ObjectivesTo compare spinal curvature, mobility, and postural competency in participants with and without COPD and investigate the relationship of postural characteristics with dyspnea and pulmonary functions in COPD patients. MethodsWe included 47 COPD patients and 47 age and gender-matched controls in our cross-sectional study. Participants underwent the following evaluations: modified Medical Research Council Dyspnea Scale, respiratory function test, and postural measurements in the sagittal plane in a standing position using a non-invasive, computer-assisted electromechanical device. Postural variables were compared between groups, and the relationship between postural variables with dyspnea and pulmonary functions was analyzed by multivariate regression analysis. ResultsThoracic and lumbar curvature were higher (p<0.05), thoracic mobility and spinal inclination were lower (p=0.011, p=0.030, respectively) in patients with COPD. Thoracic angle and spinal inclination increased in COPD patients (p=0.040, p=0.011, respectively) while only spinal tilt increased in the control group (p=0.010) under spinal loading. Thoracic angle and mobility were related with dyspnea (r2=0.25, p<0.001), forced expiratory volume in the first second (r2=0.56, p<0.001), forced vital capacity (r2=0.41, p<0.001), and RV (r2 = 0.42, p<0.001). ConclusionCOPD patients had greater thoracic and lumbar angles in the static upright posture and lower thoracic mobility and spinal inclination in the sagittal plane. It was observed that patients increase their thoracic angles to maintain postural stability in dynamic conditions. Thoracic angle and mobility were related to dyspnea and pulmonary functions.

Quantitative cervical spine injury responses in whiplash loading with a numerical method of natural neural reflex consideration

Background and objectiveNeural reflex is hypothesized as a regulating step in spine stabilizing system. However, neural reflex control is still in its infancy to consider in the previous finite element analysis of head-neck system for various applications. The purpose of this study is to investigate the influences of neural reflex control on neck biomechanical responses, then provide a new way to achieve an accurate biomechanical analysis for head-neck system with a finite element model. MethodsA new FE head-neck model with detailed active muscles and spinal cord modeling was established and globally validated at multi-levels. Then, it was coupled with our previously developed neuromuscular head-neck model to analyze the effects of vestibular and proprioceptive reflexes on biomechanical responses of head-neck system in a typical spinal injury loading condition (whiplash). The obtained effects were further analyzed by comparing a review of epidemiologic data on cervical spine injury situations. ResultThe results showed that the active model (AM) with neural reflex control obviously presented both rational head-neck kinematics and tissue injury risk referring to the previous experimental and epidemiologic studies, when compared with the passive model (PM) without it. Tissue load concentration locations as well as stress/strain levels were both changed due to the muscle activation forces caused by neural reflex control during the whole loading process. For the bony structures, the AM showed a peak stress level accounting for only about 25% of the PM. For the discs, the stress concentrated location was transferred from C2-C6 in the PM to C4-C6 in the AM. For the spinal cord, the strain concentrated locations were transferred from C1 segment to around C4 segment when the effects of neural reflex control were implemented, while the gray matter and white matter peak strains were reduced to 1/3 and 1/2 of the PM, respectively. All these were well correlated with epidemiological studies on clinical cervical spine injuries. ConclusionIn summary, the present work demonstrated necessity of considering neural reflex in FE analysis of a head-neck system as well as our model biofidelity. Overall results also verified the previous hypothesis and further quantitatively indicated that the muscle activation caused by neural reflex is providing a protection for the neck in impact loading by decreasing the strain level and changing the possible injury to lower spinal cord level to reduce injury severity.

Trunk muscle forces and spinal loads while walking in persons with lower limb amputation: Influences of chronic low back pain

Persons with lower limb amputation (LLA) are at high risk for developing chronic low back pain (LBP), often with biomechanical factors considered as likely contributors. Here, trunk and pelvis kinematics, muscle forces, and resultant spinal loads were characterized in persons with LLA, with and without chronic LBP. Thirty-five persons with unilateral LLA – 19 with chronic LBP (“LLA-cLBP”), 16 without LBP (“LLA-nLBP”) – and 15 (uninjured) persons without LBP (“CTR-nLBP”) walked overground (1.3 m/s) while thorax and pelvis kinematics were tracked (and ranges of motion [ROM] computed), and used as inputs for a non-linear finite element model of the spine to estimate global and local muscle forces, and resultant spinal loads. In the frontal and transverse planes, thorax ROM were up to 66.6% smaller in LLA-nLBP versus LLA-cLBP (P < 0.001) and CTR-nLBP (P < 0.001). In the sagittal plane, pelvis ROM was 50.4% smaller in LLA-nLBP versus LLA-cLBP (P = 0.014). LLA-cLBP exhibited 45.5% and 34.2% greater peak local and global muscle forces, respectively, versus CTR-nLBP (P < 0.011). Up to 48.1% greater spinal loads were observed in LLA-cLBP versus CTR-nLBP (P < 0.013); peak compression and local muscle forces were respectively 20.2% and 41.0% larger in LLA-nLBP versus CTR-nLBP (P < 0.005). Despite differences in trunk and pelvis kinematics between LLA-cLBP and LLA-nLBP, trunk muscle forces and spinal loads were similar (P > 0.101) between these groups. Similar loading parameters regardless of LBP presence, while highly dependent on trunk muscle activation strategies, may mitigate further accumulation of mechanical fatigue. It remains important to understand the temporality of loading with respect to LBP onset following LLA.

The Immediate Effects of Two Different Exercises on Clinical Outcomes and H-reflex in Patients With Acute Lumbosacral Radiculopathy

Introduction: The evidence has shown that specific exercises effectively treat acute low back pain. This study aimed to investigate the effects of lumbar spinal loading in both directions in the sagittal plane in patients with acute lumbosacral radiculopathy. Materials and Methods: A total of 20 patients with unilateral acute lumbosacral radiculopathy voluntarily participated in the study. The patients randomly performed flexion or extension back exercise ten times in three sets with 1-min rest between each set. Pain intensity, range of forward bending and straight leg raising (SLR), time of sit to stand, and soleus H-reflex were measured before and after the exercise. Results: This study showed that flexion compared to extension loading exercises significantly improved pain intensity, SLR degree of freedom, forward bending range of motion, time of sit to stand, and H-reflex latency (P˂0.05). There was no significant improvement in the H-reflex amplitude of the patients doing either of the exercises (P=0.07). Conclusion: Flexion loading exercises are recommended for reducing pain intensity and improving spinal mobility and neurophysiological function of the nerve root functional status in patients with acute lumbosacral radiculopathy. It seems that flexion exercises with the flatting of lumbar lordosis and opening intervertebral space reduce disk pressure and neural tissue tension.

Personalised gravitational loading of the cervical spine from biplanar X-rays for asymptomatic and clinical subjects in neutral standing position

BackgroundAs a leading cause of disability with a high societal and economic cost, it is crucial to better understand risk factors of neck pain and surgical complications. Getting subject-specific external loading is essential for quantifying muscle forces and joint loads but it requires exertion trials and load cells which are uncommon in clinical settings. MethodsThis paper presents a method to compute the gravitational loading at four levels of the cervical spine (C3C4, C4C5, C5C6, C6C7) in neutral standing position from biplanar radiographs exclusively. The resulting load was decomposed in local disc frames and its components were used to compare different populations: 118 asymptomatic subjects and 46 patients before and after surgery (anterior cervical discectomy and fusion or total disc replacement). Comparisons were performed at C6C7 and the upper level adjacent to surgery. FindingsSignificant changes in gravitational loading were observed with age in healthy subjects as well as in patients after surgery and have been associated with changes in posture. InterpretationThis approach quantifies the influence of postural changes on gravitational loading on the cervical spine. It represents a simple way to obtain necessary input for muscle force quantification models in clinical routine and to use them for patient evaluation. The study of the subsequent subject-specific spinal loading could help further the understanding of cervical spine biomechanics, degeneration mechanisms and complications following surgery.

Recovering from Laboratory-Induced Slips and Trips Causes High Levels of Lumbar Muscle Activity and Spine Loading

Recovering from Laboratory-Induced Slips and Trips Causes High Levels of Lumbar Muscle Activity and Spine Loading

Newly Diagnosed Tumefactive Demyelinating Lesion and Multiple Sclerosis After COVID-19 Infection.

To describe the parainfectious or postinfectious effects of COVID-19 infection on the first demyelinating presentation of Multiple Sclerosis and tumefactive demyelinating lesion (TDL) developing with Longitudinally Extensive Transverse Myelitis (LETM). We present six patients who presented with a first CNS demyelination event or whose demyelinating lesions had aggravated after COVID-19 infection between May and December 2020. Nasopharyngeal swab SARS-CoV-2 PCR positivity was detected in five cases and cerebrospinal fluid (CSF) PCR was positive in one. The symptoms, neurological signs, radiological and CSF findings of the cases were examined. A 24-year-old woman presented with LETM aggravated by COVID-19, accompanied by a newly developed open-ring enhanced TDL. Four patients were diagnosed with the first presentation of MS, and one presented with clinically isolated syndrome according to the McDonald 2017 criteria. The interval between SARS-CoV-2 infection and the onset of clinical symptoms ranged from 4-93 days. All of the cases present with pyramidal or brain stem findings and have high brain and/or spinal MRI load. This suggests the moderate activity of CNS demyelinating disease after COVID-19 infection. Based on this case series, all these first demyelinating events suggested that COVID-19 infection might trigger or exacerbate CNS demyelinating disease. SARS-CoV-2 plays a role in the clinical onset of Multiple Sclerosis. Active delayed demyelination developed within the first three months. This can be explained by COVID-triggered neuroimmune response that had been latent, and the initiation of the active disease process began with triggering or aggravation of the lesions in MRI. Multiple Sclerosis should be maintained during the COVID-19 pandemic.

A survey of physical and occupational therapists' views on lumbar loading movements.

[Purpose] To identify the lumbar loading movements necessary in clinical practice. [Participants and Methods] A questionnaire survey was conducted among physical and occupational therapists in Japan. There were no exclusion criteria regarding the number of years of experience, age, or field of employment. The participants were randomly selected and administered the questionnaire. They were asked to list and rank the lumbar loadings they considered necessary. [Results] A total of 739 respondents participated in the survey. The results of this nationwide survey indicated that the lifting movement of heavy objects in the trunk flexion position was the most common movement (for 354 participants). [Conclusion] The main loading movements of the lumbar spine were reported to be heavy lifting movements (in the trunk flexion position) and trunk rotation movements. As perspectives, we aim to conduct an analytical study of some of lumbar spine loading movements outlined in this study, using a musculoskeletal simulator and electromyography.

The effects of titanium mesh cage size on the biomechanical responses of cervical spine after anterior cervical corpectomy and fusion: A finite element study

BackgroundDue to the lack of sufficient studies focusing on titanium mesh cage size, there exists a puzzle among surgeons about how to determine the optimal size of cage to provide surgical segments an adequate distraction. MethodsThe biomechanical responses of cervical spine after the implantation of cages with different heights and trimmed angles were analyzed using the finite element method. Twenty Anterior Cervical Corpectomy and Fusion models, of which the surgical segment was C5, were developed corresponding to the combinations of 4-different-heights and 5-different-trimmed angle cages. Biomechanical parameters were calculated under simulated physiological load of cervical spine. A rating scale was designed to assess the biomechanical performances of titanium mesh cages with different heights and trimmed angles comprehensively, assisting to select the most appropriate combination of cage height and trimmed angle. FindingsIt was indicated that in the single-level Anterior Cervical Corpectomy and Fusion at C5 segment, a cage with a height fitting with the space between C4 and C6 as well as a trimmed angle 2° lower than the sagittal angle of C4 inferior endplate would provide adequate biomechanical environment for cervical spine to resist cage subsidence and reduce the impact to adjacent segments. InterpretationThe biomechanical responses of cervical spine are affected significantly by the height and trimmed angles of titanium mesh cage. The results of this study would provide quantitative guidance for surgeons to determine the optimal height and trimmed angle of titanium mesh cage for a specific patient in order to achieve favorable clinical outcomes.