Spinal Glioblastoma Research Articles

CERVICAL INTRAMEDULLARY GLIOBLASTOMA WITH INTRACRANIAL DISSEMINATION: DESCRIPTION OF A RAPIDLY PROGRESSING CASE AND A LITERATURE REVIEW

We present a case of a 65-year-old female with glioblastoma of the spinal cord, which disseminated to an intracranial lesion. Magnetic resonance imaging revealed diffuse swelling at levels C1 to 4, which was pathologically consistent with glioblastoma, and right side pontine parenchyma mass. The patient died after seven weeks of hospitalization. The confirmed diagnosis of glioblastomas was obtained as a result of autopsy. Spinal glioblastomas are rare lesions of the central nervous system with a prognosis as poor as that of their intracranial counterpart. There have been only nine reports in English since 1990, including this case in Japan.

Long-term survival enhanced by cordectomy in a patient with a spinal glioblastoma multiforme and paraplegia

Spinal glioblastomas multiforme (GBMs) are rare lesions of the central nervous system with a prognosis as poor as that of their intracranial counterpart. The authors present a case of a 50-year-old man with a GBM of the spinal cord treated with surgical removal of the mass and cordectomy after the onset of paraplegia. Six years later, the patient developed hepatitis C and received interferon therapy. Six months after the start of interferon therapy, magnetic resonance imaging revealed a right cerebellar mass pathologically consistent with a GBM. Despite aggressive treatment, the patient died 1 month later. Although intracranial dissemination of spinal GBMs has been reported, this case illustrates the longest reported interval between the occurrence of a spinal GBM and its intracranial dissemination. Thus, cordectomy should be considered as a reasonable alternative in patients with complete loss of neurological function at and below the level where they harbor a malignant spinal cord astrocytoma.

Long-term survival enhanced by cordectomy in a patient with a spinal glioblastoma multiforme and paraplegia

✓Spinal glioblastomas multiforme (GBMs) are rare lesions of the central nervous system with a prognosis as poor as that of their intracranial counterpart. The authors present a case of a 50-year-old man with a GBM of the spinal cord treated with surgical removal of the mass and cordectomy after the onset of paraplegia. Six years later, the patient developed hepatitis C and received interferon therapy. Six months after the start of interferon therapy, magnetic resonance imaging revealed a right cerebellar mass pathologically consistent with a GBM. Despite aggressive treatment, the patient died 1 month later. Although intracranial dissemination of spinal GBMs has been reported, this case illustrates the longest reported interval between the occurrence of a spinal GBM and its intracranial dissemination. Thus, cordectomy should be considered as a reasonable alternative in patients with complete loss of neurological function at and below the level where they harbor a malignant spinal cord astrocytoma.

FDG PET of Primary Spinal Glioblastoma Initially Mimicking a Transverse Myelitis on MRI

Glioblastoma of the brain is well known for high FDG uptake and a poor prognosis. However, primary spinal glioblastoma is relatively rare and no other reports are available on its F-18 FDG PET findings. A 17-year-old girl presented with recurrent and progressive paraplegia and sensory change below the 10th thoracic dermatome. Cerebrospinal fluid cytology was negative for malignancy and showed only inflammation. Initial magnetic resonance imaging suggested transverse myelitis and steroid pulse therapy was administered, which caused a transient improvement in her symptoms. On reaggravation, F-18 FDG PET was performed and the findings were consistent with a malignant neoplasm. Surgical resection was undertaken and a primary spinal glioblastoma was confirmed based on pathologic findings.

Extremely rare glioblastoma multiforme of the conus medullaris with holocord and brain stem metastases, leading to cranial nerve deficit and respiratory failure: a case report and review of the literature

Background Spinal glioblastoma multiforme (GBM) is an uncommon entity and metastases are extremely rare. Glioblastoma multiforme of the conus medullaris is a rare and highly aggressive entity that can quickly progress to a dismal state. Proper diagnosis via histopathologic and immunochemical staining with close clinical and radiological follow-up is important for the management of this very aggressive tumor. Case Description The authors report the clinical features, histopathologic and immunochemical staining characteristics, as well as the radiographic evidence of a case of primary GBM of the conus medullaris with metastases to the whole spinal cord and brain in a 20-year-old man who presented with low back pain and bilateral lower extremity weakness and numbness. Review of the pathology slides using histopathologic and immunochemical staining showed GBM. Serial magnetic resonance scans, performed after the initial surgery, demonstrated enlargement of the primary GBM in the conus medullaris with metastases to the thoracic and cervical spinal cord as well as to the brain. Conclusions Glioblastoma multiforme of the conus medullaris with such clinical findings is extremely rare. We analyze similar cases in the literature and discuss the importance of monitoring the progression of such an entity as well as the need for aggressive management of the different complications as they arise to maintain a good quality of life.

胸髄初発と思われる巨大なＧｌｉｏｂｌａｓｔｏｍａ ｍｕｌｔｉｆｏｒｍｅの一例

Primary spinal glioblastoma is very rare. This document describes a case of a 44-year-old female who had a history of gait disturbance and low back pain at first admission. Though myelography, metorizamide CT, and MRI showed an intramedullary mass, the expansion of the mass was not identified. Laminectomy and dural decompression were performed at the level of Th1 to Th12, and a necrotic and invasive intramedullary tumor was found. The histological examination revealed glioblastome multiforma. The patient died 2 months after surgery due to respiratory arrest. The course was extraordinarily rapid.

Spinal Glioblastomas: Report of Seven Cases and Review of the Literature

Intramedullary glioblastomas are uncommon tumors. They occur chiefly in the cervicothoracic segments, have a slight tendency to occur in the early decades of life, and have a short clinical history before diagnosis. We report seven cases and discuss the salient features of these tumors, particularly the pathological features and treatment, in light of the relevant literature.

右肩挙上障害で発症した脊髄Ｇｌｉｏｂｌａｓｔｏｍａ Ｍｕｌｔｉｆｏｒｍｅの１例

Primary intramedullary spinal glioblastoma multiforme is very rare. Spinal dissemination from intracranial glioblastoma is also uncommon. We present a 13-year-old girl who had difficulty in elevating her right upper extremity and developed spinal symptoms. Metrizamide myelography, computed tomographic metrizamide myelography, and magnetic resonance imaging showed intramedullary mass expanding from medulla oblongata to C-7 vertebral body level. Laminectomy from C-2 to C-7 revealed intramedullary tumor infiltrating the right C-5 spinal nerves. Histopathologically, the surgical specimen showed the peculiar featuers of a glioblastoma multiforme.

Spinal Intramedullary Glioblastoma With Intracranial Seeding

Approximately one year after partial removal of an intramedullary glioblastoma at T12, a patient was admitted to Wadsworth Veterans Administration Hospital with signs and symptoms of an intracranial tumor. We describe the unusual occurrence of intracranial seeding from spinal glioblastoma and review this rare condition and the possible mechanism involved.