FDG PET of Primary Spinal Glioblastoma Initially Mimicking a Transverse Myelitis on MRI

Abstract

Glioblastoma of the brain is well known for high FDG uptake and a poor prognosis. However, primary spinal glioblastoma is relatively rare and no other reports are available on its F-18 FDG PET findings. A 17-year-old girl presented with recurrent and progressive paraplegia and sensory change below the 10th thoracic dermatome. Cerebrospinal fluid cytology was negative for malignancy and showed only inflammation. Initial magnetic resonance imaging suggested transverse myelitis and steroid pulse therapy was administered, which caused a transient improvement in her symptoms. On reaggravation, F-18 FDG PET was performed and the findings were consistent with a malignant neoplasm. Surgical resection was undertaken and a primary spinal glioblastoma was confirmed based on pathologic findings.