In the present arena, the tools of artificial intelligence (AI) play a significant role in research across various fields by enabling advanced data analysis, pattern recognition and decision-making. This research work presents the numerical investigation of bioconvective micropolar nanofluidic model (BCMNFM) by employing the knacks of AI-based nonlinear autoregressive (NAR) approach with a combination of backpropagated Levenberg–Marquardt neural networks (BLMNNs) represented as NAR-BLMNNs. This research work investigates the flow design to highlight the attributes of mass and heat exchange. A dataset for BCMNFM is created by applying the Adam numerical procedure by variation of unsteadiness parameter ([Formula: see text], magnetic field parameter ([Formula: see text] thermophoresis parameter (Nt), Brownian motion parameter (Nb), bioconvection Peclet number (Pe) and spin gradient viscosity parameter ([Formula: see text] The skills of AI-based NAR-BLMNNs technique is then utilized on the dataset created for BCMNFM to investigate the approximate solutions. The achieved and impactful values of performance consistently range between [Formula: see text] and [Formula: see text] across all scenarios of BCMNFM. The precision and the validation of predicted approach NAR-BLMNNs is exceptionally established by the graphical demonstration for all scenarios of MSE, regression metrics, error histograms and time series graphs. The numerical calculations attained through AI-based NAR-BLMNNs technique further rationalize the precision of the proposed methodology for solving the BCMNFM effectively and efficiently.