Spilanthes Research Articles

Molecular docking studies and formulation of value added product from Spilanthes Jacq. Triterpenoids as an inhibitor for Malaria causing Plasmodium sps.

Molecular docking studies and formulation of value added product from Spilanthes Jacq. Triterpenoids as an inhibitor for Malaria causing Plasmodium sps.

Diuretic activity of aqueous extract of Spilanthes paniculata flower in rats

Objectives: To evaluate the diuretic activity of aqueous extract of Spilanthes paniculata (SpE) flowers in rats. Materials and Methods: The three different doses of aqueous extract of SpE flowers (aqueous SpE) (100 mg/kg, 300 mg/kg, 500 mg/kg) and standard furosemide (10 mg/kg) were orally administered to rats. The various analytical parameters like urine volume, pH, density, conductivity, Na+ and K+ content were measured in the urine of saline loaded rats. Results: Treatment with three different doses of aqueous extract of SpE flowers (100 mg/kg, 300 mg/kg, 500 mg/kg p.o.) and standard furosemide (10 mg/kg) has significantly increased the urine volume, conductivity, Na+ and K+ content as compared to control group. The pH of urine was found to be increased by aqueous extract at 500 mg/kg, whereas decreased by aqueous extract at 100 mg/kg, 300 mg/kg, and standard furosemide. The density of urine shows significant similarity in the treated group compared to control group. Conclusion: The results suggest that the aqueous extract of SpE flowers presents a notable diuretic effect at different doses of (100 mg/kg, 300 mg/kg, and 500 mg/kg, p.o.) which is associated with marked increase in both urinary Na+ and K+ levels. The aqueous extract (500 mg/kg) has shown the most pronounced diuretic effect and may act as loop diuretic. Key words: Asteraceae, diuretic activity, Spilanthes paniculata

Detection of bioactive compounds from Spilanthes acmella (L.) plants and its various in vitro culture products

In this study, we analyzed the active chemical compounds of in vitro plantlets of Spilanthes acmella. With 19 samples, GC-MS (Gas Chromatography-Mass Spectrometry) analysis revealed that the naturally occurring insecticide, N-isobutyl-2E, 6Z, 8E-decatrienamide (spilanthol) was present in mother plant, flower heads and in vitro plantlets of S. acmellawith similar retention time (43.18 to 43.21 min). N-isobutyl-2E, 4Z, 8Z, 10E- dodecatetraenamide (an isomer of N-isobutyl-2E, 4E, 8E, 10E- dodecatetraenamide, a potent mosquito larvicide) was only detected in the in vitro plantlets of S. acmella.Antioxidant, butylated hydroxytoluene (BHT) and fatty acids (n-Hexadecanoic acid and tetradecanoic acid) could be obtained from all the sample extracts of mother plant, flower heads, in vitro plantlets, callus, air-dried cells, freeze-dried cells and fresh cells. Key words: Chemical analysis, spilanthol, micropropagation, Spilanthes acmella.

Evaluation of Antimicrobial activity of Spilanthes acmella flower head extract

In recent years, there is a great demand for the plant-based products because of broad biological activities, low impact on environment and safety to non-target organisms. Hence, many plant species have been screened and plants with high bioactive compounds have been identified. Spilanthes acmella Linn. is one such important medicinal plant with rich source of therapeutic constituents. S.acmella (FamilyAsteraceae) commonly known as Akarkara or toothache plant is an annual, spreading type with bicoloured, red/gold flower buds. The roots, flower heads and whole aerial part yield a compound known as spilanthol amides, which is a powerful stimulant, sialogogue and local anesthetic [1-3].

Revision of the Genus Spilanthes

Revision of the Genus Spilanthes