Abstract

In recent years, there is a great demand for the plant-based products because of broad biological activities, low impact on environment and safety to non-target organisms. Hence, many plant species have been screened and plants with high bioactive compounds have been identified. Spilanthes acmella Linn. is one such important medicinal plant with rich source of therapeutic constituents. S.acmella (FamilyAsteraceae) commonly known as Akarkara or toothache plant is an annual, spreading type with bicoloured, red/gold flower buds. The roots, flower heads and whole aerial part yield a compound known as spilanthol amides, which is a powerful stimulant, sialogogue and local anesthetic [1-3].

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