To assess corneal asphericity (Q) and evaluate potential factors influencing the shape of the anterior corneal surface. Medical Optics Research Group, Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany. In this cross-sectional consecutive study, 3 topographic measurements were taken. Eyes were grouped by age in years (A: <or=29; B: 30 to 39; C: 40 to 49; D: 50 to 59; E: 60 to 69; F: >or=70), sex, and refraction. The study comprised 487 eyes (205 men, 288 women; age 17 to 81 years). The mean Q of the anterior corneal surface was -0.22 +/- 0.14 (SD) overall, -0.21 +/- 0.12 in Group A, -0.25 +/- 0.11 in Group B, -0.21 +/- 0.15 in Group C, -0.23 +/- 0.14 in Group D, -0.19 +/- 0.17 in Group E, -0.20 +/- 0.15 in Group F, -0.23 +/- 0.13 in men, -0.21 +/- 0.14 in women, -0.19 +/- 0.14 in hyperopes (n = 166; >+0.50 to +6.50 diopters [D]), -0.23 +/- 0.13 in emmetropes (n = 162; -0.50 to +0.50 D), and -0.23 +/- 0.15 in myopes (n = 165; <-0.50 to -8.00 D). There was no significant correlation between Q and age; Q differed significantly between men and women (P = .005), hyperopes and emmetropes (P<.0001), and hyperopes and myopes (P = .001). There were high interindividual variations in the Q value. Thus, proper correction of spherical aberration with intraocular lenses (IOLs) requires sophisticated selection of the asphericity of IOL surfaces based on biometric data and individual corneal Q values.