This article represents a study of the dynamics of the development of the number of small and medium-sized enterprises (SMEs) actively involved in the sphere of innovations and innovative technologies in the Russian Federation over the past decade from 2013 to 2023. Using comprehensive analysis of available data, through econometric modeling in the Gretl software environment, including governmental statistical reports, industry reviews, and scientific research, this study focuses on the evolution and dynamics of SMEs' development in this key sector, as well as on the factors influencing changes in their numbers. The results of the study will help better understand the trends and prospects of the development of small and medium-sized enterprises in the innovation sphere in Russia, as well as identify key factors shaping their competitiveness and contribution to the innovation development of the economy. This work is important for specialists and researchers interested in the development of business in the innovation sector in Russia, as well as for decision-makers at the level of government policy aimed at supporting SMEs and stimulating the further development of their innovation activity.