Fifty-six hypothyroid children diagnosed on neonatal screening were examined at 6 years with appropriate school achievement tests, tests of neuropsychologic functions, and the WISC-R. Controls were 31 sibs of hypothyroid patients and 29 euthyroid children with deficient T4 binding. The 56 patients,as well as other younger patients, had been examined at ages 3-5 for gross neurologic abnormalities including ataxia, nystagmus, and strabismus, and tested with the Stanford-Binet Intelligence Test, the Vineland Social Maturity Scales, and the Beery-Buktenica Test of Visual-motor Integration. They did not differ in any of these examinations from suitable controls. At 6 years, the patients and controls did not differ in overall WISC scores nor in any of the WISC subtests. More importantly, they did not differ in results of tests of school achievement, of varying modalities of sensory perceotion, of spatial orientation, of concept formation or of accuracy of fine movements. The patients did not suffer from short attention span or hyperactivity. They did,however, lag behind the controls in developing speed of motor performance.The speed of motor performance in the patients did not correlate with their IQ. This was the only failure of correlation between any neuropsychologic test and IQ in either patients or controls. Determination of the practical significance of delayed development of motor speed as well as final evaluation of the patients' intellectual development awaits results of school achievement tests after completion of the second or third grades, but none of the studies to date suggests potential school problems.
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