There is a growing concern about the increased global prevalence of children with autism spectrum disorder (ASD). A report published in autism research revealed that about 100 in 10,000 children around the world are diagnosed with autism spectrum disorder (ASD). The significant rise in ASD raises massive concerns among healthcare professionals. In the nursing profession, caring for autistic children is a challenging role. Nurses must especially address their needs. Implementing the nursing process requires an in-depth understanding of the behaviors demonstrated by children with ASD. In other words, to become more effective among these vulnerable groups, special training is needed to respond to their needs holistically. Nurses should recognize that children with ASD require individual assessment and treatment. The nursing assessment must note developmental delays and behavioral issues including speech and language abilities. Through detailed assessment, nurses can address the nursing problem and plan care appropriately. Nurses must work closely with the family in the implementation of care. The activity of daily living, health priority needs, and safety among children with ASD are evaluation measures that must be given with utmost importance. Caring for children with ASD requires appropriate nursing interventions. Nurses can become an agent of change, an educator, and an advocator. This present article highlighted nursing roles in the care of children with autism. It emphasized the nursing imperative in recognizing patients' health needs and identification of concerns with children's families. In particular, nurses must demonstrate responsibility in achieving desirable outcomes for children with ASD. Keywords: Autism Spectrum Disorder (ASD), Nursing Imperative for ASD