AbstractThe present investigation deals with the flow dynamics and heat transport of the nanofluid flow over a rotating disk. The flow is considered to be laminar and steady. Active–passive controls of tiny nanoparticles influenced by the Brownian motion and thermophoretic migration are included to reveal the variations in the hydrothermal behaviour. Thermal radiation, velocity slip, and thermal slip are also introduced to model the flow. The foremost governing equations are converted into its dimensionless form after applying the requisite similarity transformation. The spectral quasi-linearization method (SQLM) has been employed to extract the numeric outcomes of the flow. Effects of the underlying parameters on the flow and heat-mass transport are revealed through graphs and tables. Several three-dimensional (3D) and streamlines plots are depicted to enrich the Result and Discussion section. Results assured that the velocities in every direction reduce for velocity slip parameter and magnetic parameter. Temperature increases for thermophoresis and Brownian motion, but reduces for velocity and thermal slip parameter. Active flow reveals high temperature than passive flow. The Brownian motion and thermophoresis provide dual scenario for concentration profile. Heat and mass transport always sustain high magnitude for passive flow.