In recent years, significant efforts have been devoted towards the fabrication and application of layered double hydroxides (LDHs) due to their tremendous features such as excellent biocompatibility with negligible toxicity, large surface area, high conductivity, excellent solubility, and ion exchange properties. Most impressive, LDHs offer a favorable environment to attach several substances such as quantum dots, fluorescein dyes, proteins, and enzymes, which leads to strengthening the catalytic properties or increasing the sensing selectivity and sensitivity of the resulted hybrids. With the extensive ongoing research on the application of nanomaterials, many studies have led to remarkable achievements in exploring LDHs as sensing nanoplatforms. In optical sensors, for instance, many sensing strategies were tailored based on the enzyme-mimicking properties of LDHs, including colorimetric and chemiluminescence procedures. Meanwhile, others were designed based on intercalating some fluorogenic substrates on the LDHs, whereby the sensing signal can be acquired by quenching or enhancing their fluorescence after the addition of analytes. In this review, we aim to summarize the recent advances in optical sensors that use layered double hydroxides as sensing platforms for the determination of various analytes. By outlining some representative examples, we accentuate the change of spectral absorbance, chemiluminescence, and photoluminescence phenomena triggered by the interaction of LDH or functionalized-LDH with the indicators and analytes in the system. And finally, current limitations and possible future orientation in designing further LDHs-based optical sensors are presented. It is hoped that this review will be helpful in assisting the establishment of more improved sensors based on LDHs features. Optical sensors based on layered double hydroxides (LDHs) nanoplatforms were reviewed. The sensing system and detection approaches were rationally reviewed. Possible future orientations were highlighted.