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Abstract
This paper describes a detailed study of spectral and time-resolved photoprocesses in human platelets and their complexes with platinum (Pt) nanoparticles (NPs). Fluorescence, quantum yield, and platelet amino acid lifetime changes in the presence and without femtosecond ablated platinum NPs have been studied. Fluorescence spectroscopy analysis of main fluorescent amino acids and their residues (tyrosine (Tyr), tryptophan (Trp), and phenylalanine (Phe)) belonging to the platelet membrane have been performed. The possibility of energy transfer between Pt NPs and the platelet membrane has been revealed. Förster Resonance Energy Transfer (FRET) model was used to perform the quantitative evaluation of energy transfer parameters. The prospects of Pt NPs usage deals with quenching-based sensing for pathology’s based on platelet conformations as cardiovascular diseases have been demonstrated.
Highlights
According to the World Health Organization (WHO) reports, cardiovascular deceases have been remaining the leading cause of death at the global level for the last two decades
The COVID-19 pandemic has resulted in cardiovascular decease (CVD) increase, which caused deaths in many countries [2,3,4]
Thrombus formation issues play an important role in the occurrence, diagnosis and treatment of cardiovascular diseases
Summary
According to the World Health Organization (WHO) reports, cardiovascular deceases have been remaining the leading cause of death at the global level for the last two decades. The COVID-19 pandemic has resulted in cardiovascular decease (CVD) increase, which caused deaths in many countries [2,3,4]. Thrombus formation issues play an important role in the occurrence, diagnosis and treatment of cardiovascular diseases. Platelets are responsible for thrombus formation processes and have been intensively studied worldwide. These blood elements are non-nuclear and their main physiological functions include prevention of blood loss, thrombus formation, secretion and participation in hemostasis. As the platelet activation is a key moment in the pathogenesis of cardiovascular complications, the inhibition of the platelet specific for antiplatelet
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