We study a class of spatial discretizations for the Vlasov-Poisson system written as an hyperbolic system using Hermite polynomials. In particular, we focus on spectral methods and discontinuous Galerkin approximations. To obtain L2 stability properties, we introduce a new L2 weighted space, with a time dependent weight. For the Hermite spectral form of the Vlasov-Poisson system, we prove conservation of mass, momentum and total energy, as well as global stability for the weighted L2 norm. These properties are then discussed for several spatial discretizations. Finally, numerical simulations are performed with the proposed DG/Hermite spectral method to highlight its stability and conservation features.