The A dependence of charged-particle spectra in π+, K+, and p interactions with Al and Au targets at 250 GeV/c are presented and compared to predictions of the Quark-Gluon String Model (QGSM). It is shown that the A dependence of invariant inclusive charged-particle spectra on the Feynman variable x is very weak between Al and Au targets. The QGSM shows a larger difference between fast-particle spectra for both Al and Au targets and different beam particles. The QGSM prediction for the leading-particle spectrum over an energy range from 250 GeV to 10 TeV in pAu(Pb) reactions is in a reasonable agreement with the results of NA22 data and a cosmic-ray experiment.