Specific Shape Research Articles

Bite force transmission and mandible shape in grasshoppers, crickets, and allies is not driven by dietary niches.

Although species evolve in response to many intrinsic and extrinsic factors, frequently one factor has a dominating influence on a given organ system. In this context, mouthpart shape and function are thought to correlate strongly with dietary niche and this was advocated for decades, e.g., for insects. Orthoptera (grasshoppers, crickets, and allies) are a prominent case in this respect because mandible shape has been even used to predict feeding preferences. Here, we analysed mandible shape, force transmission efficiency, and their potential correlation with dietary categories in a phylogenetic framework for 153 extant Orthoptera. The mechanical advantage profile was used as a descriptor of gnathal edge shape and bite force transmission efficiency in order to understand how mandible shape is linked to biting efficiency and diet, and how these traits are influenced by phylogeny and allometry. Results show that mandible shape in fact is a poor predictor of feeding ecology and phylogenetic history has a strong influence on gnathal edge shape. Being ancestrally phytophagous, Orthoptera evolved in an environment with food sources being always abundant so that selective pressures leading to more specialized mouthpart shapes and force transmission efficiencies were low.

The Enduring Impact of Shape Following Perfect Coarctation of the Aorta Repair.

Objectives: Aortic arch appearances can be associated with worse cardiac function and chronic hypertension late after coarctation of the aorta (CoA) repair, even without residual obstruction. Statistical shape modeling (SSM) has identified specific 3D arch shapes linked to poorer cardiovascular outcomes. We sought a mechanistic explanation. Methods: From 53 asymptomatic patients late after CoA repair with no residual obstruction (age: 22.3 ± 5.6 years; 12-38 years after operation), eight aortic arch shapes associated with the four best and four worst cardiovascular parameters were obtained from 3D SSM. Four favorable shapes were affiliated with left ventricular (LV) ejection fraction +2 standard deviation (SD) values from the mean, and indexed LV end diastolic volume/indexed LV mass/resting systolic blood pressure that were -2SD. Four unfavorable shapes were defined by the reverse. Computational Fluid Dynamics modeling was carried out to assess differences in pressure gradient across the aortic arch and viscous energy loss (VEL) between favorable and unfavorable aortic arches. Results: In all aortic arches, the pressure gradients were clinically insignificant (<8 mm Hg). However, in the four unfavorable aortic arches, VEL were uniformly higher than those in the favorable shapes (VEL difference: 15%-32%). There was increased turbulence and more complex propagation of VEL along with the unfavorable aortic arches. Conclusions: This study reveals the variable flow dynamics that underpin the association of aortic arch shapes with worse cardiovascular outcomes late after successful CoA repair. Higher VEL persists in the unfavorable aortic arch shapes. Further understanding of the mechanism of viscous energy loss in cardiovascular maladaptation may afford mitigating strategies to monitor and modify this unrelenting liability.

A multi-criteria districting approach with a lexicographic compactness metric: An application to the Chilean postal service

Recent trends in customer habits have greatly affected last-mile logistics, increasing the pressure to effectively serve an increasing demand. For traditional postal mail companies, this change is an opportunity to alleviate the decreasing role of conventional mail within society and to focus on new products and services. Unfortunately, these changes also affect the efficiency of their supply chains, which were focused on delivering letters. In this work we consider the last-mile reorganization problem as faced by Correos de Chile, the Chilean public postal service. While this work is mostly focused on the particular needs of the company, the approach applies to other scenarios where the work allocation can be modeled as a districting problem with multiple simultaneous objectives and special shape conditions on the districts. To solve the proposed model, a multi-criteria heuristic procedure based on a combination of different neighborhood structures, each geared towards specific characteristics of the problem, is put forward. The applicability of the approach on large-size real-life conditions is tested on instances derived from real life operations showing the applicability of the proposed method.

Effect of Cutting Conditions on the Size of Dust Particles Generated during Milling of Carbon Fibre-Reinforced Composite Materials.

Conventional dry machining (without process media) of carbon fibre composite materials (CFRP) produces tiny chips/dust particles that float in the air and cause health hazards to the machining operator. The present study investigates the effect of cutting conditions (cutting speed, feed per tooth and depth of cut) during CFRP milling on the size, shape and amount of harmful dust particles. For the present study, one type of cutting tool (CVD diamond-coated carbide) was used directly for machining CFRP. The analysis of harmful dust particles was carried out on a Tescan Mira 3 (Tescan, Brno, Czech Republic) scanning electron microscope and a Keyence VK-X 1000 (Keyence, Itasca, IL, USA) confocal microscope. The results show that with the combination of higher feed per tooth (mm) and lower cutting speed, for specific CFRP materials, the size and shape of harmful dust particles is reduced. Particles ranging in size from 2.2 to 99 μm were deposited on the filters. Smaller particles were retained on the tool body (1.7 to 40 μm). Similar particle sizes were deposited on the machine and in the work area.

Controlling the Helical Pitch of Foldamers Through Terminal Functionality: A Solid State Study.

Developing new methods to control the size and shape of the helical structures adopted by foldamers is highly important as the secondary structure displayed by these supramolecular scaffolds often dictates their activity and function. Herein, we report on a systematic study demonstrating that the helical pitch of ortho-azobenzene/2,6-pyridyldicarboamide foldamers can be readily controlled through the nature of the terminal functionality. Remarkably, simply through varying the end group of the foldamer, and without modifying any other structural features of the scaffold, the helical pitch can be over doubled in magnitude (from 3.4 Å to 7.3 Å). Additionally, crystallographic analysis of a library ten foldamers has identified general trends in the influence of a range of terminal functionalities, including carboxylbenzyl (Cbz), diphenylcarbamyl (N(Ph)2), ferrocene (Fc) and tert-butyloxycarbonyl (Boc), in controlling the folding behaviour of these supramolecular scaffolds. These studies could prove useful in the future development of functional foldamers which adopt specific sizes and shapes.

A-Star (A*) with Map Processing for the Global Path Planning of Autonomous Underwater and Surface Vehicles Operating in Large Areas

The global path planning system is one of the basic systems ensuring the autonomous operation of unmanned underwater vehicles (UUVs) and unmanned surface vehicles (USVs) in a complex aquatic environment. The A* path planning algorithm is one of the most well-known algorithms used to obtain an almost optimal path, avoiding obstacles even in a complex environment containing objects with specific shapes and non-uniform arrangements. The main disadvantage of this algorithm is the computational cost of path calculation. This article presents a new approach based on the image processing of the map before determining the path using A*. The results of numerical research based on a large-sized map expressing the port area confirm the proposed method’s effectiveness, which reduces the calculation time by over 500 times with a slight increase in the path length compared to the basic version of the A* algorithm. Based on the obtained results, the proposed approach also increases the path’s safety by designating narrow and risky areas as closed to vehicle movement. For this reason, the method seems suitable for use in global path planning for autonomous underwater vehicles (AUVs) and autonomous surface vehicles (ASVs) operating in large areas.

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells.

Acquisition of specific cell shapes and morphologies is a central component of cell fate transitions. Although signaling circuits and gene regulatory networks that regulate pluripotent stem cell differentiation have been intensely studied, how these networks are integrated in space and time with morphological transitions and mechanical deformations to control state transitions remains a fundamental open question. Here, we focus on two distinct models of pluripotency, primed pluripotent stem cells and pre-implantation inner cell mass cells of human embryos to discover that cell fate transitions associate with rapid changes in nuclear shape and volume which collectively alter the nuclear mechanophenotype. Mechanistic studies in human induced pluripotent stem cells further reveal that these phenotypical changes and the associated active fluctuations of the nuclear envelope arise from growth factor signaling-controlled changes in chromatin mechanics and cytoskeletal confinement. These collective mechano-osmotic changes trigger global transcriptional repression and a condensation-prone environment that primes chromatin for a cell fate transition by attenuating repression of differentiation genes. However, while this mechano-osmotic chromatin priming has the potential to accelerate fate transitions and differentiation, sustained biochemical signals are required for robust induction of specific lineages. Our findings uncover a critical mechanochemical feedback mechanism that integrates nuclear mechanics, shape and volume with biochemical signaling and chromatin state to control cell fate transition dynamics.

Understanding the Role of Solvent on the Growth of Zinc Oxide: Insight from Experiment and Molecular Dynamics Simulations.

The controlled synthesis of nanoparticles with tailored shapes and morphologies has garnered significant attention, driven by the ever-growing demand for advanced materials with defined properties. In nanoparticle formation, various parameters influence the final product, and among these, the solvent plays a pivotal role, as it constitutes the major component of the reaction medium. In this work, the critical role of solvents in controlling the growth of zinc oxide (ZnO) nanoparticles was investigated, with a focus on simple primary alcoholic solvents as the reaction medium. A model reaction based on the direct solvolysis of anhydrous zinc acetylacetonate was employed to probe the influence of different primary alcohols, specifically methanol, ethanol, and their mixture. A substantial difference in the preferential growth direction of the ZnO nanocrystals in methanol and ethanol was observed through XRD and was further proven through TEM. Thereby, in ethanol, a preferential growth in the [001] direction was observed, resulting in short nanorods as primary particles, while this growth was inhibited in methanol, leading to platelet- or sheet-like primary particles. To unravel the underlying mechanisms responsible for the observed solvent-dependent variations, molecular dynamics (MD) simulations were employed using an optimized interface force field to model the ZnO-alcohol interaction. These simulations provide valuable insights into the preferential adsorption of the solvent molecules onto the polar (0001) and (0001̅) and nonpolar (101̅0) ZnO surfaces, shedding light on the fundamental interactions driving the shape control phenomenon. Essentially, the experimental observations on primary particle morphology could be explained well by the adsorption behavior determined by the MD simulations. Furthermore, this report provides an extensive comparison with various similar reaction systems for ZnO synthesis, deriving correlations with the findings from the model system. These insights contribute to a deeper understanding of the intricate interplay between solvent properties and nanoparticle growth, offering a valuable toolkit for designing and optimizing the synthesis of ZnO nanoparticles with specific shapes and functionalities.

A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.

Three major types of GABAergic interneurons, parvalbumin-, somatostatin-, and vasoactive intestinal peptide-expressing (PV, SOM, VIP) cells, play critical but distinct roles in the cortical microcircuitry. Their specific electrophysiology and connectivity shape their inhibitory functions. To study the network dynamics and signal processing specific to these cell types in the cerebral cortex, we developed a multi-layer model incorporating biologically realistic interneuron parameters from rodent somatosensory cortex. The model is fitted to in vivo data on cell-type-specific population firing rates. With a protocol of cell-type-specific stimulation, network responses when activating different neuron types are examined. The model reproduces the experimentally observed inhibitory effects of PV and SOM cells and disinhibitory effect of VIP cells on excitatory cells. We further create a version of the model incorporating cell-type-specific short-term synaptic plasticity (STP). While the ongoing activity with and without STP is similar, STP modulates the responses of Exc, SOM, and VIP cells to cell-type-specific stimulation, presumably by changing the dominant inhibitory pathways. With slight adjustments, the model also reproduces sensory responses of specific interneuron types recorded in vivo. Our model provides predictions on network dynamics involving cell-type-specific short-term plasticity and can serve to explore the computational roles of inhibitory interneurons in sensory functions.

Covariation of Skull and Brain Morphology in Domestic Dogs.

Despite their distinct embryonic origins, the skull and brain are highly integrated. Understanding the covariation between the skull and brain can shed light on anatomical, cognitive, and behavioral traits in extant and extinct species. Domestic dogs offer a unique opportunity to investigate skull-brain covariation due to their diverse skull morphologies and neural anatomy. To assess this question, we examined T2-weighted MRI studies of 62 dogs from 33 breeds, plus an additional 17 dogs of mixed or unknown breeds. Scans were opportunistically collected from a veterinary teaching hospital of dogs that were referred for neurological examination but did not have grossly observable structural brain abnormalities. As the neurocrania of dogs become broader and shorter, there is a significant decrease in the gray matter volume of the right olfactory bulb, frontal cortex, marginal gyrus, and cerebellum. On the other hand, as the neurocrania of dogs become narrower and longer, there is a significant decrease in the gray matter volume of the olfactory bulb, frontal cortex, temporal cortex, amygdala, hypothalamus, hippocampus, periaqueductal gray, cerebellum, and brainstem. Selective breeding for specific skull shapes may impact canine brain anatomy and function.

Selective Cleavage and Structural Stability of Double Crosslinked Aromatic Polyamide Porous Materials

AbstractA porous, crosslinked aromatic polyamide having COCl and COOH groups (referred to as PA herein) prepared had a mesoporous structure and comprised agglomerates of particles with average diameters of approximately 30 nm. The PA was found to swell with significant deformation in response to water vapor, but was almost unchanged after exposure to toluene vapor. The polymeric structure returned to its original porous morphology after removal of the solvents, demonstrating that the PA possessed affinity for specific solvents and shape memory. The chemical composition and porous structure of the PA were also not affected by heating to 330 °C. The COCl groups in the PA could be modified by reaction with 2,4,6‐triaminopyrimidine (TAP), resulting in a doubly crosslinked structure based on the reaction with the TAP as well as the existing amide moieties in the polymer. The degree of modification was highly dependent on the reaction solvent used. The porous structure of the PA was essentially unchanged after this modification. The TAP‐based crosslinks in the modified PA could be selectively cleaved along with vaporization of the TAP by heating at 330 °C, which no change to the porous structure. Thus, the PA showed excellent heat resistance and structural stability.

Evaluation of two household decontamination methods on protective mask materials and disinfection effects

Abstract In order to find affective disinfection methods for general public to reuse protective mask, which could address supply shortages in the period of epidemic, household ovens and household ultraviolet disinfection cabinets were used as decontamination tools, and the influence of decontamination process on the protective performance of masks including PFE and TIL, as well as virus (PV I and MHV) inactivation effect were completely evaluated. It was found that the dry heat and UVGI decontamination with household devices had a little impact on PFE or TIL of masks, which indicated that two process had little effect on mask material and face seal fit. The virus inactivation results showed that dry heat decontamination could effectively inactivate the virus on the masks, and UVGI decontamination could not completely inactivate the virus caused by the special shape of masks, which could be concluded that dry heat decontamination with household oven was a feasible method to reuse the mask, and UVGI decontamination was not recommended. This study had guiding significance for the decontamination and reuse of masks by the general public.

The Determination of Criticality for Ice Shapes Based on CCAR-25

Determining the criticality of ice shapes is a necessary condition for verifying compliance with icing airworthiness regulations. However, the clear, concise, and applicable criterion based on the geometric characteristics of ice shapes has not been clearly given out by current advisory circulars. To address this problem, this paper summarizes aerodynamic performance items and recommended ice shapes the latest version of CCAR-25 and corresponding advisory circulars for a variety of flight phases, including takeoff, holding, en route, DTO, etc., instead of the single phase of holding in the previous research. Based on the geometric classification of the ice shapes, the dominant parameters of various ice shapes are clarified by the correlation between the geometric parameters and aerodynamic effects. The geometric parameters to determine the criticality of specific ice shapes are defined as the roughness height and range for the roughness ice and the total projection height in the direction of lift for the horn ice. On this basis, the detailed determination criterion of critical ice shape geometries corresponding to different flight phases and aircraft components is formulated, which will provide an operational selection methodology for determining the geometries of critical ice shapes at the airworthiness certification stage.

SAD: semi-supervised automatic detection of BOLD activations in high temporal resolution fMRI data.

Despite the prevalent use of the general linear model (GLM) in fMRI data analysis, assuming a pre-defined hemodynamic response function (HRF) for all voxels can lead to reduced reliability and may distort the inferences derived from it. To overcome the necessity of presuming a specific model for the hemodynamic response, we introduce a semi-supervised automatic detection (SAD) method. The proposedSADmethod employs a Bi-LSTM neural network to classify high temporal resolution fMRI data. Network training utilized an fMRI dataset with 75-ms temporal resolution in an iterative scheme. Classification performance was evaluated on a second fMRI dataset from the same participant, collected on a different day. Comparative analysis with the standard GLM approach was conducted to evaluate the cooperativeeffectiveness of the SAD method. The SAD method performed well based on the classification scores: true-positive rate = 0.961, area under the receiver operating curve = 0.998, true-negative rate = 0.99, F1-score = 0.979, False-negative rate = 0.038, false-discovery rate = 0.002, false-positive rate = 0.002 at 75-ms temporal resolution. SAD can detect hemodynamic responses at 75-ms temporal resolution without relying on a specific shape of an HRF. Future work could expand the use cases to include more participants and different fMRI paradigms.

Flat-topped optical spectrum as a specific marker of multi-pulse grouping in a soliton fiber laser.

We report the experimental observation of a stable generation regime in a soliton fiber laser, characterized by a distinct flat-topped optical spectrum. Notably, in multi-pulse generation, this specific spectrum shape prevents the harmonic mode-locking state, instead connecting the solitons into bound complexes or tight chaotic bunches. Physically, this suggests that in the observed regime, long-range attractive forces dominate over the inter-pulse repulsion across the entire laser cavity. Our experimental findings align with numerical simulations, which demonstrate that the predominance of a long-range inter-pulse attraction is due to a complex interaction mechanism. This mechanism combines the generation of dispersive waves with dissipative forces arising from gain depletion and recovery.

Single-pulse Gamma-Ray Bursts Have Prevalent Hard-to-soft Spectral Evolution

We analyze the spectral evolution of 62 bright Fermi gamma-ray bursts with large enough signal-to-noise to allow for time-resolved spectral analysis. We develop a new algorithm to test for single-pulse morphology that is insensitive to the specific shape of pulses. Instead, it only checks whether or not there are multiple, isolated, or statistical significant peaks in the light curve. In addition, we carry out a citizen science test to assess light-curve morphology and spectral evolution. We find that, no matter the adopted assessment method, bursts characterized by single-peaked prompt emission light curves have a greater tendency to also have a consistently decaying peak energy or hard-to-soft spectral evolution. This contrasts with the behavior of multipeaked bursts, for which the tendency is to have a peak frequency that is not monotonically decreasing. We discuss this finding in the theoretical framework of internal/external shocks and find it to be consistent with at least some single-pulse bursts associated with particularly high-density environments.

Laser microdissection system based on structured light modulation dual cutting mode and negative pressure adsorption collection.

Laser microdissection technology is favored by biomedical researchers for its ability to rapidly and accurately isolate target cells and tissues. However, the precision cutting capabilities of existing laser microdissection systems are hindered by limitations in overall mechanical movement accuracy, resulting in suboptimal cutting quality. Additionally, the use of current laser microdissection systems for target acquisition may lead to tissue burns and reduced acquisition rates due to inherent flaws in the capture methods. To address these challenges and achieve precise and efficient separation and capture of cellular tissues, we integrated a digital micromirror device (DMD) into the existing system optics to modulate spatial light. This allows the system to not only implement the traditional point scanning cutting method but also utilize the projection cutting method.We have successfully cut various patterns on commonly used laser microdissection materials such as PET films and mouse tissues. Under projection cutting mode, we were able to achieve precise cutting of special shapes with a diameter of 7.5 micrometers in a single pass, which improved cutting precision and efficiency. Furthermore, we employed a negative pressure adsorption method to efficiently collect target substances. This approach not only resulted in a single-pass capture rate exceeding 90% for targets of different sizes but also enabled simultaneous capture of multiple targets, overcoming the limitations of traditional single-target capture and enhancing target capture efficiency, and avoiding potential tissue damage from lasers.In summary, the integration of the digital micromirror device into laser microdissection systems significantly enhances cutting precision and efficiency, overcoming limitations of traditional systems. This advancement demonstrates the accuracy and effectiveness of laser microdissection systems in isolating and capturing biological tissues, highlighting their potential in medical applications.

Effects of stiffeners on anchor rod flexural strength in column base-plate connections

The present paper reports results of a numerical investigation of the mechanical behavior of a column base plate connection subjected to an axial compression force and a bending moment. A three-dimensional nonlinear model was developed, using the Cast3M software, and validated against experimental data. In addition, the material nonlinearity as well as contact conditions between the different components of the connection were thoughtfully considered. Based on the validated model, an extensive parametric analysis was conducted to investigate the effect of stiffeners on the forces in the anchor rods. The results clearly indicate that the design approaches that consider only the tensile strength of anchor rods while neglecting the bending moments can lead to a poor estimation of the forces applied to these rods. They also suggest that adding stiffeners provides additional strength and reduces the anchor rod bending in one direction. However, it is important to note that the stiffeners also induce an additional moment in the opposite direction. This could make the anchor rod more susceptible to biaxial bending with tension. Furthermore, this study proposes a new specific shape of stiffener is suggested (cbp5). It was concluded that the proposed shape of stiffeners allows a more uniform distribution of forces and avoids excessive stress concentrations, effectively prevents the biaxial bending in the anchor rod.

Nonreducing Sugar Scaffold Enables the Development of Immunomodulatory TLR4‐specific LPS Mimetics with Picomolar Potency

AbstractInnate immune defense mechanisms against infection and cancer encompass the modulation of pattern recognition receptor (PRR)‐mediated inflammation, including upregulation of various transcription factors and the activation of pro‐inflammatory pathways important for immune surveillance. Dysfunction of PRRs‐mediated signaling has been implicated in cancer and autoimmune diseases, while the overactivation of PRRs‐driven responses during infection can lead to devastating consequences such as acute lung injury or sepsis. We used crystal structure‐based design to develop immunomodulatory lipopolysaccharide (LPS) mimetics targeting one of the ubiquitous PRRs, Toll‐like Receptor 4 (TLR4). Taking advantage of an exo‐anomeric conformation and specific molecular shape of synthetic nonreducing β,β‐diglucosamine, which was investigated by NMR, we developed two sets of lipid A mimicking glycolipids capable of either potently activating innate immune responses or inhibiting pro‐inflammatory signaling. Stereoselective 1,1′‐glycosylation towards fully orthogonally protected nonreducing GlcNβ(1↔1′)βGlcN followed by stepwise assembly of differently functionalised phosphorylated glycolipids provided biologically active molecules that were evaluated for their ability to trigger or to inhibit cellular innate immune responses. Two LPS mimetics, identified as potent TLR4‐specific inducers of the intracellular signaling pathways, serve as vaccine adjuvant‐ and immunotherapy candidates, while anionic glycolipids with TLR4‐inhibitory potential hold therapeutic promise for the management of acute or chronic inflammation.

Temporary Road Marking Paint for Vehicle Perception Tests

In order to test camera- and LiDAR-based perception of road markings for automated driving, vehicle developers have started to utilize concepts for the agile alteration of road marking patterns on proving grounds. Road marking materials commonly used within this concept are different types of tape that can easily be applied and removed on asphalt and concrete. Due to the elasticity of tape, it cannot be used efficiently for small radii, symbols, lettering, and specific corner shapes (e.g., for parking slots). These road marking patterns are common in urban environments. With the growing capability of automated driving systems and more applications for urban environments, edgy road marking shapes gain importance for proving ground testing. This study examines the use of water-soluble road marking paint specifically designed for the use case of temporary applications on proving grounds for camera- and LiDAR-based perception testing. We found that white, water-soluble paint with 1.5% binder content and 2.25% coalescing agent content can provide realistic road markings for vehicle testing purposes. However, solubility affects the paint’s vulnerability to fading during rain. Hence, renewal activities over the course of longer test drives might be necessary. The paint could be removed using water pressure without significant residue or damaging of the asphalt.