Being a predominantly agricultural nation, Nepal is dominated by this sector of the economy, which employs thousands of people. When the pandemic hit Nepal, a developing country, there was a concern on a nationwide level since the government was compelled to announce a lockdown that lasted for 4 months employing a variety of tactics, including lockdown, social isolation, quarantine, contact tracking, etc. Because of the lockdown condition, many encountered mental health concerns. When obliged to maintain a specific distance between members of their own family, neuromuscular issues were profound among the people. Therefore, in order to assess the impact of COVID-19 pandemic on Nepal’s way of life the case study was carried out. WHO, MoHP, and other organizations’ publications, as well as other secondary sources of information, served as the sole data foundation for this review. Hence, the worst conditions in Nepalese society were reflected in the 25% income reduction and the 5% job loss rate, both of which have an impact on peoples’ capacity to support themselves. In addition, there was a severe dearth of food, especially seed and fertilizer, which contributed to a food crisis and black marketing. By limiting tourism to Nepal, COVID-19 transformed the educational environment and had a negative impact on the country’s economy. Other diverse effects were observed on remittance and local institutions that COVID-19 has exhibited. Benefits for the environment were also obvious.