Specific Action Research Articles

Resveratrol targeting NRF2 disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage in mice pulmonary infection

Ethnopharmacological relevanceThe root of Polygonum cuspidatum Sieb. et Zucc (PC), known as 'Huzhang' in the Chinese Pharmacopoeia, has been traditionally employed for its anti-inflammatory, antiviral, antimicrobial, and other biological activities. Polydatin (PD) and its aglycone, resveratrol (RES), are key pharmacologically active components responsible for exerting anti-inflammatory and antioxidant effects. However, its specific targets and action mechanisms remain unclear. Aim of the studyThe equilibrium of the KEAP1-NRF2 system serves as the primary protective response to oxidative and electrophilic stresses within the body, particularly in cases of acute lung injury caused by pathogenic microbial infection. In this study, the precise mechanisms by which RES alleviates oxidative stress damage in conjunction with NRF2 activators are discussed. Materials and methodsThe active components from PC were screened to evaluate their potential to inhibit reactive oxygen species (ROS) and activate antioxidant activity dependent on antioxidant response elements (ARE). RES was evaluated for its potential to alleviate the oxidative stress caused by pathogenic microbial infection. Functional probes were designed to study the RES distribution and identify its targets. A lipopolysaccharide (LPS)-induced oxidative injury model was used to evaluate the effects of RES on the KEAP1-NRF2/ARE pathway in RAW 264.7 cells. The interaction between RES and NRF2 was elucidated using drug-affinity responsive target stability (DARTS), cellular thermal shift assays (CETSA), co-immunoprecipitation (Co-IP), and microscale thermophoresis (MST) techniques. The key binding sites were predicted using molecular docking and validated in NRF2-knockdownand reconstructed cells. Finally, protective effects against pulmonary stress were verified in a mouse model of pathogenic infection. ResultsThe accumulation of RES in lung macrophages disrupted the binding between KEAP1 and NRF2, thereby preventing the ubiquitination degradation of NRF2 through its interaction with Ile28 on the NRF2-DLG motif. The activation of NRF2 resulted in the upregulation of nuclear transcription, enhances the expression of antioxidant genes dependent on ARE, suppresses ROS generation, and ameliorates oxidative damage both in vivo and in vitro. ConclusionThese findings shed light on the potential of RES to mitigate oxidative stress damage caused by pathogenic microorganism-induced lung infections and facilitate the discovery of novel small molecule modulators targeting the KEAP1-NRF2 DLG motif interaction.

Not feeling the heat? Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature

Dietary protein modulates food intake (FI) via unclear mechanism(s). One possibility is that higher protein leads to greater post-ingestive heat production (Specific dynamic action: SDA) leading to earlier meal termination (increased satiation), and inhibition of further intake (increased satiety). The influence of dietary protein on feeding behaviour in C57BL/6J mice was tested using an automated FI monitoring system (BioDAQ), simultaneous to body temperature (Tb). Total FI, inter meal intervals (IMI, satiety) and meal size (MS, satiation) were related to changes in Tb after consuming low (5%, LP), moderate (15%, MP) and high (30%, HP) protein diets. Diets were tested over three conditions: 1) room temperature (RT, 21 ± 1 °C), 2) room temperature and running wheels (RTRW) and 3) low temperature (10 °C) and running wheels (LTRW). The differences between diets and conditions were also compared using mixed models. Mice housed at RT fed HP diet, reduced total FI compared with LP and MP due to earlier meal termination (satiation effect). FI was lowered in RTRW conditions with no differences between diets. FI significantly increased under LTRW conditions for all diets, with protein content leading to earlier meal termination (satiation) but not the intervals between feeding bouts (satiety). Tb fell immediately after feeding in all conditions. Despite a reduction in total FI in mice fed HP, mediated via increased satiation, this effect was not linked to increased Tb during meals. We conclude effects of dietary protein on intake are not mediated via SDA and Tb.

Proposal of Simplified Standardization of the Cell-Growth-Promoting Activity of Human Adipose Tissue Mesenchymal Stromal Cell Culture Supernatants.

The conditioned medium (CM) obtained from mesenchymal stromal cell (MSC) culture has excellent cell growth-promoting activity and is used for cosmetics and healthcare products. Unlike pharmaceuticals, strict efficacy verification is not legally required for these products. However, their efficacy must be substantiated as commercial products. We attempted to simplify CM production and to standardize the evaluation of the growth-promoting activity of CM. CM was obtained through the culturing of two lines of commercially available human adipose tissue-derived MSCs using MEMα with or without 10% fetal bovine serum (FBS) for 24 h. Non-CM control media were produced by the same protocol without MSCs. Growth-promoting activities of the CM were estimated by [3H]-thymidine pulse. CM were subjected to molecular weight fractionation with ultrafiltration using 10 k-, 30 k-, 50 k-, and 100 k-membranes. The FBS-free CMs showed 1.34- to 1.85-fold increases and FBS-containing CMs showed 1.45- to 1.67-fold increases in proliferation-promoting activity compared with non-CM controls, regardless of the source of the cell. The thymidine incorporation levels were approximately three times higher in FBS-containing CMs. Aged cells also showed 1.67- to 2.48-fold increases in the activity due to FBS-containing CM, but not to FBS-free CM. The CM activities were sustained even after 1 year at 4 °C. Molecular weight fractionation showed that the activity was recovered in the fraction above 100 k. Clear and stable cell-growth-promoting activity was confirmed with CMs of commercially available adipose tissue MSCs. The activity was detected in the fraction over 100 k. We propose here the importance of standardizing the production and evaluation of CMs to indicate their specific action.

New targeted therapies in liposarcoma: state of art and future perspectives.

Liposarcomas (LPSs) represent the most common soft tissue sarcoma (STS) subtype, and exhibit distinct clinical molecular features according to histological subgroup. Chemotherapy (ChT), and in particular anthracycline-based schedules, still remains the standard of treatment for all LPS forms. However, given the increasing knowledge gained throughout last years about LPS molecular biology and their genomic profiling, new therapeutic alternatives with targeted drugs are now to be considered. In this review, we will highlight most promising ongoing and published clinical trials regarding targeted therapies in LPSs and provide some insights about future approaches and possible new treatment options for this rare disease. Among all the explored targets, mouse double minute 2 homolog amplification and CKD4-Rb axis inhibition seem to be the most promising target in well differentiated/dedifferentiated LPS subtype. On the other hand, myxoid LPS is known to have a particular sensitivity for trabectedin, which acts like a targeted drug due to its specific action on cellular DNA. In addition to these, multiple other strategies are now being evaluated in LPSs, including the administration of immune-checkpoint inhibitors (ICIs) and 'new-old' cytotoxic agents, such as cabazitaxel, in a continuously growing scenario. Although preliminary, results of recently published and ongoing examined clinical trials will hopefully be translated in clinical practice in the next future, leading the way to future research in this rare disease.

Abordaje y manejo médico-quirúrgico del paciente herido por traumatismo taurino

IntroductionBullfighting festivals are attributed to the cultural idiosyncrasies of the Ibero-American people, posing an extreme risk to the physical integrity of the participants. Spain is considered the country with the highest number of bull-related celebrations worldwide and, therefore, with the highest number of patients injured by bullfighting trauma treated, thus justifying a public health problem. The generalities associated with this type of trauma define the people injured as polytraumatised patients. In addition, it is important to know the kinematics of the injuries and their specific characteristics, in order to implement quality medical-surgical care. Methodsscientific review of the literature to promote a comprehensive guide for the medical-surgical management of patients injured by bullfighting trauma. ResultsWe described the guidelines to standardise protocols for in-hospital approach of patients injured by bullfighting trauma. ConclusionsBullfighting trauma is considered a real health problem in the emergency departments of the ibero-Americans countries, especially in Spain, where bullfighting is part of the national culture. The inherent characteristics of these animals cause injuries with special aspects, so it is important to know the generalities of bullfighting trauma. Because of the multidisciplinary approach, this guidelines are adressed to all healthcare providers involved in the management of these patients. It is essential to establish particular initial care for this type of injury, specific therapeutic action and follow-up based on the medical-surgical management of the trauma patient in order to reduce the associated morbidity and mortality.

Response mechanisms of resistance in L-form bacteria to different target antibiotics: Implications from oxidative stress to metabolism

Due to the specific action on bacterial cell wall, β-lactam antibiotics have gained widespread usage as they exhibit a high degree of specificity in targeting bacteria, but causing minimal toxicity to host cells. Under antibiotic pressure, bacteria may opt to shed their cell walls and transform into L-form state as a means to evade the antibiotic effects. In this study, we explored and identified diverse optimal conditions for both Gram-negative bacteria (E. coli DH5α (CTX)) and Gram-positive bacteria (B. subtilis ATCC6633), which were induced to L-form bacteria using lysozyme (0.5 ppm) and meropenem (64 ppm). Notably, when bacteria transformed into L-form state, both bacterial strains showed varying degrees of increased resistance to antibiotics polymyxin E, meropenem, rifampicin, and tetracycline. E. coli DH5α (CTX) exhibited the most significant enhancement in resistance to tetracycline, with a 128-fold increase, while B. subtilis ATCC6633 showed a 32-fold increase in resistance to tetracycline and polymyxin E. Furthermore, L-form bacteria maintained their normal metabolic activity, combined with enhanced oxidative stress, served as an adaptive strategy promoting the sustained survival of L-form bacteria. This study provided a theoretical basis for comprehending antibiotic resistance mechanisms, developing innovative treatment strategies, and confronting global antibiotic resistance challenges.

SELF REALIZATION AND DEVELOPMENT OF THE FUTURE TEACHER’S MICROENVIRONMENT

Nowadays, almost all the main characteristics of personality education processes fall into the problematic field of educational problems of discussion: personality formation (socially significant properties and qualities); content of theoretical and practical training of students as future specialists; ways and means of motivating professional self-realization, etc.Personality always interacts with other people, groups, and social objects. An individual’s belonging to certain microenvironments and other social groups present in a given society is condition that largely outlines the possibilities of person's development as an individual, as a personality, as a subject of activity, determining the direction of this development. These approaches outline different sides of the problem: the first starts from the demands of society; the second starts from the properties of the individual; the third offers ways to reconcile one or the other. However, at the same time, they are all complementary.Common to all social groups is the joint activity of people aimed at achieving common goals, performing a specific action based on the exchange of information and the existence of special means of control over the performance of certain functions. Distinctive features of a social group are the conditionality of the objectively existing structure of social relations and their relative independence. The positive development of the microenvironment of the life of the future specialist is most effective in interaction with the development of his / her self-realization.It is important to note that the information received by the future teacher from personal experience may or may not coincide with the information received through public sources of education and mass communications. The coincidence of these information sources in terms of content ensures the unity of the consciousness of the personality of the future teacher and the consciousness of society. Thus, certain concepts that are spread officially may not find real support in the life experience of a specific individual.Social and psychological attitudes of direct and indirect experience are formed under the influence of external factors in the inner world of the individual. Studying the issue of the formation of the influence of the social environment on the personality, it can be argued that the microsociety is the carrier of the management potential of the formation of some personality elements. It is in the microenvironment that it is possible to create such conditions that will directly affect the individual in order to form higher levels of self-realization.

Triggerable biomaterials‐based osteomyelitis theranostics

AbstractThe emergence of multidrug‐resistant bacteria poses a significant challenge in the treatment of osteomyelitis, rendering traditional antibiotic treatment strategies inadequate in terms of achieving a complete cure. In recent years, triggerable biomaterial‐based, antibiotic‐free osteomyelitis treatment strategies have rapidly evolved, demonstrating excellent bactericidal effects. Triggerable biomaterials‐based osteomyelitis theranostics encompass physical signal response strategies and host immune modulation approaches. These strategies can be effective against drug‐resistant bacteria, circumventing the gradual acquisition of resistance that often accompanies traditional antibiotic treatment. Additionally, the inherent physical properties of the triggerable biomaterials facilitate the precise imaging of osteomyelitis. There is no doubt that triggerable biomaterial‐mediated, antibiotic‐free therapies are emerging as a trend, which is critically important in combating multidrug‐resistant bacteria‐induced osteomyelitis. In this review, we summarize the latest advances in osteomyelitis treatment strategies from both pathogen‐directed and host‐directed perspectives. The design regimens and specific action mechanisms of triggerable biomaterial‐based nanoplatforms are also clarified. Finally, we outline the challenges faced by various antibiotic‐free therapies and provide an outlook on the prospects for synergistic interactions.

Methodological Approaches to Constructing Human Capital Index: Regional Dimension

The paper analyses available foreign and domestic expertise in the treatment and methods for measuring human capital. The authors identify weaknesses of a common approach to measuring human capital based on international statistical standards not adapted to national features of information and statistical support for regional analysis in the face of prominent interregional differences in socio-economic development.A methodological approach to assessing human capital is substantiated using an integral indicator that combines subindices that reflect the accumulation and reproduction of human capital. Guided by this approach and statistics on the demographic situation, upgrading knowledge, skills and strengthening the public health, including that of the working population, and based on actual data for the regions of Russia (for the year 2020), a unified summary indicator of human capital for the constituent entities of the Russian Federation was calculated and the regions were ranked by a level of human capital development.According to the authors, the developed methodological approaches to measuring the human capital index shall make it possible to take more specific action on implementing the Programme for Socio-economic Development as applied to individual Russian regions

A call to action: informing research and practice in suicide prevention among individuals with psychosis.

Although it is well established that individuals living with psychosis are at increased risk for suicidal ideation, attempts, and death by suicide, several gaps in the literature need to be addressed to advance research and improve clinical practice. This Call-to-Action highlights three major gaps in our understanding of the intersection of psychosis and suicide as determined by expert consensus. The three gaps include research methods, suicide risk screening and assessment tools used with persons with psychosis, and psychosocial interventions and therapies. Specific action steps to address these gaps are outlined to inform research and practice, and thus, improve care and prognoses among persons with psychosis at risk for suicide.

Building Resilient Cities: A Comprehensive Review of Climate Change Adaptation Indicators for Urban Design

Urban areas generate more than 70% of the world’s climate change emissions, mainly CO2, produced by the combustion of fossil fuels. Climate change is increasing cities’ exposure to climate hazards, such as heat waves or floods. Therefore, there is a need to improve risk management with the inclusion of climate resilience in urban policy design. Despite improved urban climate monitoring, there are still relatively few scientific publications on climate change adaptation in urban areas. Adaptation to climate change is not achieved through specific action, but rather through the adoption and continuous implementation of adaptation actions such as housing rehabilitation, green space management and protection measures for vulnerable groups. This variety of actions makes it difficult not only to identify different indicators, but also to use common benchmarks. Considering the role of municipalities in adapting to climate change, it is crucial to identify adaptation indicators that serve as a basis for decision making, as well as evaluation methods that allow the effectiveness of planned and implemented measures in municipalities. It can be used to determine which measures increase the level of adaptation or lead to poor adaptation. Therefore, monitoring indicators makes it possible to evaluate the effectiveness of the measures, in addition to formulating new ones. This paper includes a literature review of existing index designed to address climate hazards and mitigate their impacts in urban areas.

In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride.

The primary treatment method for eradicating Helicobacter pylori (H. pylori) infection involves the use of antibiotic-based therapies. Due to the growing antibiotic resistance of H. pylori, there has been a surge of interest in exploring alternative therapies. Cetylpyridinium chloride (CPC) is a water-soluble and nonvolatile quaternary ammonium compound with exceptional broad-spectrum antibacterial properties. To date, there is no documented or described specific antibacterial action of CPC against H. pylori. Therefore, this study aimed to explore the in vitro activity of CPC against H. pylori and its potential antibacterial mechanism. CPC exhibited significant in vitro activity against H. pylori, with MICs ranging from 0.16 to 0.62 μg/mL and MBCs ranging from 0.31 to 1.24 μg/mL. CPC could result in morphological and physiological modifications in H. pylori, leading to the suppression of virulence and adherence genes expression, including flaA, flaB, babB, alpA, alpB, ureE, and ureF, and inhibition of urease activity. CPC has demonstrated in vitro activity against H. pylori by inhibiting its growth, inducing damage to the bacterial structure, reducing virulence and adherence factors expression, and inhibiting urease activity.

Ways to increase population income in conditions of economic instability

The purpose of the research is to study the theoretical and methodological foundations for the formation of incomes of the population in the country, economic and statistical analysis for specific official data and determine ways to increase incomes.Methodology. The study used methods of economic and statistical analysis and comparative assessment.The originality / value of the research are conclusions and proposals for increasing incomes as a result of a comprehensive analysis of the sources of formation, composition and structure of monetary incomes of the population in conditions of economic instability.Findings. The research proposed recommendations for increasing income through economic growth and improving the management of inflationary processes, reducing the share of the population with incomes below the subsistence level, developing a specific action plan taking into account regional characteristics in order to reduce the poverty line, and eliminating the income gap in urban and rural areas.

Students Perceptions of Cigarette, Graphic Health Warnings, Fast Food Consumption, and Gadget Use On Physical Activity (Evidence-Based For Health Promoting University Program Recommendations)

Based on BPS data, consumption of cigarettes and e-cigarettes by teenagers over 15 years old decreased by 2.62% from the previous year, but it still has the potential to be dangerous. Adolescent health is quite worrying considering that teenagers are the main figures who can carry forward the vision for the future. The aim of this research is to obtain empirical evidence and appropriate strategies for implementing the HPU program. The method used is quantitative, through a survey with Franken-wallen incidental sampling, respondents are students pursuing higher education in 3 districts/cities, namely Banjar Regency, Banjarmasin City and Banjarbaru City. The survey was conducted from September to October (2 weeks) online. The results of this study show that cigarette and e-cigarette consumption is quite low, but respondents' perceptions regarding are still comprehensive (71%), including regarding graphic health warnings on cigarette packaging (80.1%). Interest in consuming fast food tends to be high (64.2%), who regularly consume fruit and vegetables (37.5% and 33.5%). The use of gadgets among students is very high (58%) and complaints regarding CVS also appear (45.5%). To support HPU, a specific action plan is needed, especially to strengthen understanding of the impact of consumption of cigarettes and so on.

Activating values intervention: an integrative pathway to well-being.

The present study expands the existing knowledge base regarding positive psychology interventions (PPIs), by employing an integrative approach to explore the potential benefits of translating values into action. Participants (n = 476) were randomly assigned to the Activating Values intervention, the affirmation-only, or the control (no treatment) group. The intervention involved participants choosing a life area they valued, affirming its importance, identifying a specific action related to that valued area, and then planning and carrying out that chosen action within the following week. Data was collected at baseline and three follow-up points: one, two, and three weeks after the intervention. Results suggest that the intervention contributes to the participants' well-being, including increased self-insight, sense of coherence, and prioritizing meaning, and decreased symptoms of psychopathology. Exploratory content analyses provide a deeper understanding of the content and frequency of activities chosen and the enabling conditions. The discussion explores the findings within this intersection as well as ramifications for brief, scalable interventions to support and promote well-being.

Long-term care needs and hospitalization costs with long-term care insurance: a mixed-sectional study.

With the rapid aging of the population, the health needs of the older adult have increased significantly, resulting in the frequent occurrence of the "social hospitalization" problem, which has led to a rapid increase in hospitalization costs. This study investigates whether the "social hospitalization problem" arising from the long-term care needs can be solved through the implementation of long-term care insurance, thereby improving the overall health of the older adults and controlling the unreasonable increase in hospitalization costs. The entropy theory was used as a conceptual model, based on data from the China Health and Retirement Longitudinal Study (CHARLS) in 2015 and 2018. The least-squares method was used to examine the relationship between long-term care needs and hospitalization costs, and the role that long-term care insurance implementation plays in its path of influence. The results of this study indicated that long-term care needs would increase hospitalization cost, which remained stable after a series of tests, such as replacing the core explanatory variables and introducing fixed effects. Through the intermediary effect test and mediated adjustment effect test, we found the action path of long-term care needs on hospitalization costs. Long-term care needs increases hospitalization costs through more hospitalizations. Long-term care insurance reduces hospitalization costs. Its specific action path makes long-term care insurance reduce hospitalization costs through a negative adjustment of the number of hospitalizations. To achieve fair and sustainable development of long-term care insurance, the following points should be achieved: First, long-term care insurance should consider the prevention in advance and expand the scope of participation and coverage; Second, long-term care insurance should consider the control in the event and set moderate levels of treatment payments; Third, long-term care insurance should consider post-supervision and explore appropriate payment methods.

Higher education actors’ responses to the Ukraine-Russia conflict: an analysis of geopolitical spatial imaginaries

ABSTRACT The Russian invasion of Ukraine, on 24th February 2022, was met with widespread condemnation across Europe, with many universities and higher education-focussed national and regional organisations issuing their own public statements about the invasion and subsequent conflict and, in some cases, taking specific action in relation to one or both of the countries. This article draws on an analysis of 55 such statements to examine what they reveal about how higher education organisations conceptualise the European higher education space, and the position of Russia and Ukraine within it. Specifically, the article considers what spatial imaginaries – pertaining to higher education – are evident in the statements about the Ukraine conflict issued by higher education organisations across Europe, and the extent to which the statements provide evidence about the role of these organisations as normative policy actors.

Pest risk assessment of African Leucinodes species for the European Union.

Following a request from the European Commission, the EFSA Panel on Plant Health performed a quantitative risk assessment for the EU of African Leucinodes species (Lepidoptera: Crambidae), which are fruit and shoot borers, especially of eggplant type fruit. The assessment focused on (i) potential pathways for entry, (ii) distribution of infested imports within EU, (iii) climatic conditions favouring establishment, (iv) spread and (v) impact. Options for risk reduction are discussed, but their effectiveness was not quantified. Leucinodes spp. are widely distributed across sub-Saharan Africa but are little studied and they could be much more widespread in Africa than reported. Much African literature erroneously reports them as Leucinodes orbonalis which is restricted to Asia. The import of eggplant type fruit from sub-Saharan Africa consists of special fruit types and caters mostly to niche markets in the EU. The main pathway for entry is fruit of Solanum aethiopicum and exotic varieties of eggplant (S. melongena). CLIMEX modelling was used with two possible thresholds of ecoclimatic index (EI) to assess establishment potential. Climates favouring establishment occur mostly in southern Europe, where, based on human population, 14% of the imported produce is distributed across NUTS2 regions where EI ≥ 30; or where 23% of the produce is distributed where EI ≥ 15. Over the next 5 years, an annual median estimate of ~ 8600 fruits, originating from Africa, and infested with African Leucinodes spp. are expected to enter EU NUTS2 regions where EI ≥ 15 (90% CR ~ 570-52,700); this drops to ~ 5200 (90% CR ~ 350-32,100) in NUTS2 regions where EI ≥ 30. Escape of adult moths occurs mostly from consumer waste; considering uncertainties in pathway transfer, such as adult emergence, mate finding and survival of progeny, the annual median probability of a mated female establishing a founder population in NUTS regions where EI ≥ 15 was estimated to be 0.0078 (90% CR 0.00023-0.12125). This equates to a median estimate of one founder population ~ every 128 years (90% CR approximately one every 8-4280 years). Using an EI ≥ 30, the median number of founder populations establishing in the EU annually is 0.0048 (90% CR 0.0001-0.0739), equating to a median estimate of one founder population approximately every 210 years (90% CR approximately one every 14-7020 years). Under climate change for the period 2040-2059, the percent of infested produce going to suitable areas would be increased to 33% for EI ≥ 15 and to 21% for EI ≥ 30. Accordingly, the waiting time until the next founder population would be reduced to median estimates of 89 years for EI ≥ 15 (90% CR ~ 6-2980 years) and 139 years for EI ≥ 30 (90% CR 9-4655 years). If a founder population were to establish, it is estimated to spread at a rate of 0.65-7.0 km per year after a lag phase of 5-92 years. Leucinodes spp. are estimated to reduce eggplant yield by a median value of 4.5% (90% CR 0.67%-13%) if growers take no specific action, or 0.54% (90% CR between 0.13% and 1.9%) if they do take targeted action, matching previous estimates made during a risk assessment of L. orbonalis from Asia.

Next steps for the psychological professions workforce in England – Delivering the NHS Long Term Workforce Plan

The NHS Long Term Workforce Plan (2023a) has set a trajectory to approximately double the size of the psychological professions workforce in England. If this is achieved, it can deliver a step change in provision of effective psychological healthcare. To deliver on the plan, we will need to embed dedicated professional leadership, and to continue a joined-up approach to expanding and developing the workforce across the psychological professions, designed around the needs of the public. Specific further action will be needed to develop a diverse and representative workforce, support retention, develop a variety of career paths, to diversify how we train, and crucially, to demonstrate the impact of our growth on patient outcomes and experience.

How Additive Manufacturing Empowers Commerce through Effective Data Management

Abstract This article summarizes the outcomes from a NIST-sponsored workshop that examined the additive manufacturing (AM) data management pain points experienced by small- and medium-sized enterprises in interacting with larger organizations and government procurement agencies. Three prominent themes emerged: cost of compliance, technology gaps associated with uncertainty and AM process qualification, and a desire for government leadership to address these issues. The article includes lists of specific action items proposed at the workshop to address these challenges.