Occupational burnout syndrome most often occurs among professionals of the at-risk occupations, i.e. those who work in close contact with people and have to communicate a lot and intensively with others. This group includes educational specialists (teachers, educators, psychologists), medical professionals, and sale representatives. Fatigue, weakness, lack of interest in their activities against the background of chronic stress, is well known to many people, especially workaholics, who strive to do as much as possible, resulting in emotional burnout. With the onset of the Covid-19 pandemic, burnout has taken on a different form due to isolation, fears for the lives and health of family members, and distance from workplaces and well-accustomed co-workers. Distance learning has created new challenges for teachers and students of HEIs. Study before quarantine was already complicated, given the heavy workload, the large volume of the curriculum, and the constant lack of free time. Working in such rhythm makes it difficult to maintain mental health and prevent emotional burnout. The professional activity of university educators is characterized by increased responsibility, a wide range of commitments and the need for continuous professional development. In addition to the educational process, the teacher is responsible for the implementation of methodological, organizational, educational and research work. The influence of stressors on a teacher’s health contributes to the emergence of the syndrome of occupational burnout. “Quarantine” factors influencing the development of occupational burnout can be assigned into two groups: organizational and psychological factors related to the novel special organization of work in quarantine; psychological factors associated with the new psychological features of the professional activity and their own subjective characteristics. To prevent the development of occupational burnout, psychologists recommend to take care of yourself; do not forget about rest; realistically estimate own capabilities and, accordingly, plan work and time; do not make unnecessary commitments; do not demand too much from yourself; work should bring joy.