Relations Specialists Research Articles

Аналіз ендокринного статусу пацієнтів з ішемічною хворобою серця в кардіохірургічній практиці

The aim – to analyze the endocrine status of high-risk patients with coronary artery disease in cardiac surgery. Materials and methods. Retrospective analysis of data from random 354 high-risk patients who were operated on and discharged from M.M. Amosov National Institute of Cardiovascular Surgery of NAMS of Ukraine in the period from 2009 to 2019. The mean age of patients was 61.9±9.7 years. All patients underwent ECG, ECHO, coronary angiography and surgical myocardial revascularization with correction of concomitant cardiac pathology, if necessary. In the perioperative period all patients underwent general clinical and biochemical blood tests. Stratifying the risk according to the EuroSCORE II scale, patients belonged to the high risk group and had > 5 % probability of mortality. Results and discussion. All patients had hemodynamically significant stenosis of the coronary arteries that required surgical revascularization of the myocardium. The analysis showed that 287 (81.07 %) patients were overweight, 281 (79.3 %) – had metabolic syndrome, 90 (25.4 %) – type 2 diabetes mellitus (type 2 DM), 161 (45.45 %) – impaired glucose tolerance. Thyroid disease was diagnosed in 37 (10.4 %) patients, 11 (3.1 %) patients had hypothyroidism. In the postoperative period, paroxysms of atrial fibrillation occurred in 83 (23.4 %) patients, of whom 70 (84.3 %) had type 2 DM and impaired glucose tolerance. Deep sternal infection occurred in 4 (4.4 %) patients with type 2 DM, for 3 (3.3 %) of them sternoplasty performed. Neurological complications – stroke and transient ischemic attack had 10 (2.8 %) patients among which 9 (90 %) had glucose metabolism disturbance. Acute renal failure occurred in 10 (2.8 %) patients, of whom 8 (80 %) had type 2 DM and pre-DM. Conclusions. Despite the high predicted mortality on the EuroSCORE II scale – 8.82 %, the operative mortality in the study group was 0 %, which indicates a coordinated highly skilled Heart-team work, timely verification of comorbid conditions and the involvement of related specialists.

Influence of Connective Tissue Dysplasia Syndrome on Male Reproductive Function

The work demonstrates the influence of undifferentiated connective tissue dysplasia on male reproductive function, shows which dysplastic-dependent pathology of the male genital area affects the spermogram indices in men. Shown are local problems of deep pathophysiological and histological prerequisites in their development of the male factor of infertility in a married couple. The paper demonstrates the importance of the principles of joint work of related specialists at various stages of diagnosis, treatment and subsequent dispensary observation of patients with DSTS, taking into account the polyetiology and multifactorial nature of the pathologies of the genitourinary system caused by DSTS.
 The main diagnostic criteria for collagenopathies are minor anatomical anomalies of development, namely, the presence of three or more minor anatomical anomalies of development indicates a high probability of morphogenesis disorders in the form of congenital malformations of the male genital area. The role of the unfavorable course of the early prenatal period, during which the influence of an unfavorable factor can lead to one or another anomaly, for many organs, including the reproductive organs in men, has been revealed, since they are associated with DSTS pathology and are caused by a wide representation of connective tissue. It also demonstrated a great role in the development of non-hereditary forms of exposure to environmental factors, which makes it possible to make a correction with the help of appropriate recommendations. The data presented in the robot can be considered as a certain stage in the study of DSTS problems and its impact on the male reproductive system.

Особливості застосування примусових заходів медичного характеру до психічно хворих, які вчинили кримінальні правопорушення на сексуальному підґрунті

Background. The question of the treatment of persons who accomplished sexual crimes continues to be discussed by researches around the world. Mark certain insufficiency of preparation of specialists in relation to an estimation and treatment of sexual disorders in medical and psychiatric establishments, and even in judicial psychiatric associations, that understanding, that treatment of sexual criminals is accessible and can be successful and effective needs a subsequent ground. Current criteria of the force usage of medical care are developed not enough. Aim. To find out the criteria of application of the forced measures of medical character This research is devoted to solving scientific and practical problems, which is to develop a forensic-psychiatric expert evaluation of persons who have committed sexual criminal offences. Materials and methods. The paper presents the results of a scientific study conducted as part of the dissertation “Forensіc psychіatrіc evaluatіon of persons who have sexual offences”. To achieve the goal of the study, the author analyzed 287 sub-experts who committed sexual offences and were on forensic psychiatric examination (FPE) at the Kyiv City FPE Center from 2000 to 2015 (16 years). In order to determine the relationship between the degree of violation of the ability to understand their actions, manage them and resolve expert issues, all observations were divided into 2 groups of comparison: 1 – 200 observations (sub-experts, considered “sane”); 2 – 14 (sub-experts, recognized as “insane”); 3 – 73 (“limited sanity”), this group was formed artificially from the group of “sane”, based on the concept of “limited sanity”. Research methods used in the work: information-analytical, socio-demographic, clinical-psychopathological, experimental-psychological, expert, situational analysis, statistical. Results. The criterion for the application of coercive measures of a medical nature (CMMN) in the form of a referral to a specialized psychiatric institution is the recognition of a person as “insane”, the provision of compulsory outpatient care. Conclusions. The identification of criteria for choosing the right forced medical health care type, i.e., validity and sufficiency of the recommended forced measure of a medical character, is needed to increase a quality upgrading prophylactic measures in the conditions of the forced treatment.

The Velocity of Crisis: How the Pandemic Creates Opportunities for Change.

The Velocity of Crisis: How the Pandemic Creates Opportunities for Change.

Features of polymorbid pathology in patients with autoimmune bullous dermatosis

Autoimmune bullous dermatosis (ABD) is a group of inherited and acquired skin diseases, the main morphological elements of which are the bullas, developed as a result of autoantibody production directed against protein structures of the epidermis and dermo-epidermal junction, leading to epidermal detachment and blistering on the skin and mucous membranes. The aim of the research is to analyze the detection rate and structure of polymorbid pathology in patients with autoimmune bullous dermatoses and to determine the Charlson index and 10-year viability in patients before and after prescription of glucocorticosteroid therapy. Materials and methods. The research included retrospective and prospective stages. At the first stage, the analysis of primary medical records was carried out, and histories of 70 patients over 18 years old, before the onset of autoimmune bullous dermatosis were analyzed. Clinical and epidemiological data were taken into account, the main and concomitant diagnoses were determined in accordance with ICD X. The Charlson index was calculated for all patients, the 10-year viability rate of patients with autoimmune bullous dermatoses was determined. Results. Polymorbid pathology was recorded in 81.4% of patients, before the onset of autoimmune bullous dermatosis. 48.6% of patients had two or more concomitant diseases. Among patients with diseases of internal organs, those with cardiovascular pathology (52.8%) occupied the first place, patients with gastroenteric pathology (41.4%) occupied the second place, patients with endocrinopathy held the third place (20.0%). The Charlson index median in patients of this group was 2.5 (1–3), the risk of fatal outcome over a 10-year period was 16.5%. Subsequently, after the onset of autoimmune bullous dermatosis, 65.7% of patients required the prescription of glucocorticosteroid therapy. Decompensation of concomitant pathology was diagnosed in 39.1% of patients, therefore they needed consultation of related specialists. The median polymorbidity index increased to 3.5 (2–5), the risk of a death increased to 34.5% ( p < 0.05). Conclusion . Polymorbid pathology worsens the course of autoimmune bullous dermatoses, increases the risk of disability and mortality, especially in patients receiving systemic glucocorticosteroid therapy, and therefore these patients should be under regular medical check-up not only of a dermatovenereologist, but also of related specialists.

Differences in the views of obstetricians-gynecologists and intensivists based on the survey “Provision of medical care to patients with stillbirth”. Original article

Introduction. The Russian Federation’s stillbirth rate is almost twice that of the United States and Europe, while domestic treatment protocols are still lacking. Objectives. To analyze the results of a survey of obstetricians-gynecologists and intensivists on the problems of providing medical care to patients with stillbirth. Materials and methods. We have developed a questionnaire, which consisted of 23 questions in Russian. A total of 369 Russian-speaking doctors, intensivists and obstetricians-gynecologists took part in the survey. Results. The need to turn off the mother’s consciousness at the time of giving birth to a dead fetus caused great disagreement between the related specialists (p = 0.0001). 56 % of intensivists and 35 % of obstetricians-gynecologists were in favor of turning off the mother’s consciousness. According to 23 % of obstetricians-gynecologists and only 9 % of intensivists, visual and tactile contact of a mother and her dead fetus has a positive impact on the psychoemotional state of the woman (p = 0.002). Respondents from both specialties preferred epidural analgesia in more than half of the cases. Conclusions. A list of issues for which the greatest differences in ratings were obtained has been identified, which will further help to identify priority issues for discussion and points of application for creating agreed documents on the best management of pregnant women with stillbirth.

Сифилис как междисциплинарная проблема: от полиморфизма клинической картины висцеральных поражений к основным причинам и последствиям прогрессирования заболевания

Syphilis is a significant infection that can affect not only the mucous membranes and skin, but also internal organs. Visceral changes in patients with syphilis often cause nonspecific clinical manifestations and develop without any skin symptoms, which makes this disease an interdisciplinary problem. Untimely therapy, insufficient control of cure, late diagnosis of syphilitic lesions of internal organs may result in irreversible dystrophic changes and even permanent disability. Given that these patients might seek medical assistance in any healthcare institutions, it is important that not only dermatovenerologists, but also related specialists should be well aware of syphilis. In this article, we report cases of syphilitic lesions to the nervous and cardiovascular systems. Case series focus the attention of specialists on the negative consequences of improper clinical and serological control and late treatment of syphilis, which resulted in disease progression and organic lesions. Some of the patients with syphilisrelated visceral pathology described in this article had late diagnosis of syphilis primarily due to a narrow approach to symptom evaluation. Our study aims to raise doctors' awareness about current characteristics of syphilis and possible diagnostic errors. Key words: cardiovascular syphilis, neurosyphilis, ocular syphilis, diagnostic errors

Presurgical orthodontic treatment of newborns with deficiency of body weight

The study discusses the importance of interdisciplinary approach of pediatricians, surgeons, orthodontists, anesthesiologists and otorhinolaryngologists in the complex rehabilitation of newborns with bilateral cleft lip and palate. The aim of the study was to increase the effectiveness of treatment of newborns with bilateral cleft lip and palate through preliminary orthodontic preparation. This study clearly emphasizes that the conduction of early pre-surgical orthodontic treatment with the use of individual obturators contributes to the high-quality implementation of further surgical intervention and allows to normalize the act of breastfeeding in newborns. It has been proven that the interdisciplinary approach of doctors of related specialties helps to carry out a comprehensive diagnosis, counseling and subsequent treatment of newborns with bilateral cleft lip and palate. Thus, the integrated approach developed by related specialists in the neonatal period makes it possible to implement a highly qualified and step-by-step treatment from birth up to 18 years of age. Key words: bilateral cleft lip and palate, newborns, individual obturator, pediatrics, feeding, cheiloplasty, orthodontics

COVID-19 and its impact on the work of experts and public relations specialists in Poland

COVID-19 and its impact on the work of experts and public relations specialists in Poland

Профессиональное PR-сообщество на Дальнем Востоке: идентификация и самоорганизация

The article is devoted to the issues related to the study of the process of identification and professional self-organization of public relations specialists in the Far-Eastern region of Russia. This process is studied from the point of view of defining the group identity, group norms, and the activities of professional communities. The empirical basis of analysis was the results of an expert survey of public relations specialists in the Far-Eastern federal district. The authors identify the current professional PR communities of the Russian Far East, identify the motives of their members for more active participation in the communities life. There is an independent association of representatives of professional group due to the grassroots activity «spontaneous self-organization» and the presence of experience in consolidating PR specialists in a specific field (state) with an external actor. It is concluded that today there is a willingness of the self-organized PR community to participate in solving the socially significant issues for the region, the development of inter-sector partnership, as a result of formation of trusting attitude of population to the decisions taken in the region.

Professional experiences of on-call specialists in the field of violations of children’s rights

The article analyses the content of the activity of child rights protection on-call specialists, their experiences related to the representation of the child and his/her interests. In Lithuania, this position is new and it emerged after the reform of the child rights protection system, which was caused by the increase in cases of violence against children, which resulted in their death several times. The activity of on-call specialists is focused on making quick decisions in response to reports of violations of children’s rights in the family and society.
 Qualitative research revealed the experience of on-call specialists in relation to the assessments of violations of children’s rights in daily activities and the reactions of parents/ guardians to the assistance provided by on-call specialists.

THE EFFECTIVENESS OF THE ACTIVITIES OF THE DEPARTMENT OF PUBLIC RELATIONS IN HOSPITALS IN IMPROVING THE CONDITION OF PATIENTS PSYCHOLOGICALLY” - A FIELD STUDY IN AIN SHAMS SPECIALIZED HOSPITAL

This research aims to shed light on the effectiveness of public relations department activities in hospitals to improve the condition of mentally ill patients by reaching proposals on the roles that public relations management should play within hospitals and thus improving patients 'condition psychologically. The research sample consisted of (100) individuals, (80) individual patients, at a rate of (80.0%), and they are detainees in the internal departments and frequenting the outpatient clinics of the hospital, which is the highest percentage, while the number of workers was (20) individuals at a rate of (20.0%) of Hospital workers The research belongs to the descriptive research where the method of social survey in the sample was used based on the questionnaire as a basic tool for data collection. The questionnaire forms were applied by (100) questionnaires to find out opinions about the effectiveness of the activities of the public relations department in the hospital in improving the condition of patients psychologically, and the study reached many results. Among the most important of them are the many psychological effects that patients suffer, as some patients feel psychosomatics (physical/ psychiatric diseases). The research recommended the interest of the hospital administration in providing an integrated therapeutic team of doctors, public relations specialists and psychologists to provide support and social support to patients through the effectiveness of relationship activities, which are to reduce the psychological effects.

Reasons of the high rate of the population incidence of micosis of feet: role of doctor and patient

BACKGROUND: Mycoses of the feet is a significant interdisciplinary health problem.
 AIM: To analyze and systematize the causes contributing to the high incidence of foot mycoses in Russia.
 MATERIALS AND METHODS: With the use of an anonymous questionnaire survey, the attitude of patients toward their health and the opinions of dermatologists and related specialists about the causes contributing to the high incidence of foot mycoses in the Russian population were analyzed.
 RESULTS: The reasons contributing to the high incidence of foot mycoses in Russia are ranked into four groups: (1) depend on the activities of the dermatological service; (2) are related to the level of professional training of doctors of related specialties; (3) objective organizational reasons for doctors of related specialties; (4) depend on the patients attitude to their health.
 CONCLUSION: The data obtained can be used to develop a complex of therapeutic and prophylactic measures to improve medical care for this contingent of patients.

Optimization of the choice of laparoscopic and open alloplastic surgery of postoperative ventral hernias

Background. Postoperative ventral hernias (PVH) account for 20.4-22 % of all abdominal hernias. The recurrence rate after alloplastic surgery of large and giant PVH is 10-25 %. Adequate selection of alloplastic surgery method in PVH may help to improve treatment outcomes and reduce the frequency of relapses.
 Objective. To describe the features of laparoscopic and open alloplastic surgery of PVH.
 Materials and methods. Analysis of literature sources on this topic.
 Results and discussion. According to the classification, PVH are divided into medial (subxiphoid, epigastric, umbilical, subumbilical, suprapubic) and lateral (subcostal, flank, iliac, lumbar). Autoplastic surgery (according to Sapezhko, Mayo) is used only for small-sized PVH in young and middle-aged people in the absence of diastasis recti and obesity (up to 3.5 %). In 96.5 % of cases alloplastic surgery is used (open – 81.1 %; laparoscopic – 15.4 %). There are about a dozen types of alloplastic interventions. When choosing the optimal intervention, it is necessary to take into account the width of the defect, the width of diastasis or contracture of the rectus abdominis muscles, the level of intra-abdominal pressure. When performing laparoscopic alloplastic intervention, prevention of trocar wound infection is performed using Dekasan solution (“Yuria-Pharm”) by rinsing before suturing. Alloplastic surgeries of giant PVH should be performed in combination with techniques for separating the anatomical components of the anterior abdominal wall and mandatory monitoring of intra-abdominal pressure, as intra-abdominal hypertension is a frequent complication of such procedures. Preoperative preparation and examination of patients before PVH surgery includes laboratory tests (general and biochemical blood tests, coagulation analysis), electro- and echocardiography, ultrasound or computed tomography of the required areas, spirography, consultations with related specialists, slag-free nutrition and 10-12 days of laxatives (in the outpatient settings), correction of comorbidities, maximum bowel cleansing before surgery, control of intra-abdominal pressure, prevention of infectious complications of the wound and prevention of thromboembolic complications. Contraindications to elective surgery include ineffective preoperative preparation, impaired cardiopulmonary activity, increased intra-abdominal pressure >12 mm H2O using bandage compression, reduction of breathing function <60 % of normal. To prevent postoperative wound infection during surgery at the stages of separation of the anatomical components of the anterior abdominal wall, fixation of the mesh and before drainage and suturing the wound, Decasan washing is used (400-800 ml depending on the wound surface area). Postoperative treatment includes analgesia (paracetamol – Infulgan, “Yuria-Pharm”), oxygen therapy, abdominal bandaging, monitoring of intra-abdominal pressure, stimulation of intestinal function (metoclopramide – Reosorbilact, “Yuria-Pharm”), antibacterial treatment, correction of electrolyte balance, nonsteroidal anti-inflammatory drugs. Removal of drainages from the mesh implant is performed in 3-4 days, from the subcutaneous wound – in 5-6 days.
 Conclusions. 1. The choice of PVH alloplastic surgery type should be made taking into account the size of the defects, the width of the diastasis recti and intra-abdominal pressure. 2. Optimization of the choice of treatment procedure for giant PVH can be achieved by determining the intra-abdominal pressure during surgery during contact of the rectus abdominis muscles. 3. Decasan lavage is used to prevent infection of trocar and surgical wounds.

ЛІНГВІСТИЧНИЙ СУПРОВІД МІЖНАРОДНОЇ ДІЯЛЬНОСТІ

International processes and phenomena transformation, political processes modernization, globalization of all public life, the priority of foreign policy activities to promote both Ukraine and other countries’ interests in the world, and the innovativeness of the international interaction tools determine the actualization of the study of the international specialists’ of skills and knowledge of foreign language communication and translation importance, aimed at ensuring international interaction and the formation of long-term formal and informal ties between government institutions, international actors, diplomatic institutions and political leaders in order to implement political, economic, security, cultural, social and humanitarian initiatives and projects, as well as to improve the management processes of institutions, both internal and external coordination, improving the state’s image in the international arena. The purpose of the article is to study the role of foreign language communication and translation skills and their importance in implementing foreign policy. The research methodology is complex. It is determined by the specifics of the subject of research, its purpose and objectives, as well as an interdisciplinary approach to the research problem. The study concluded that the professional activities of international relations specialists, diplomats, and international actors are a field of international communication, including policies, problems and events of public and state life, and languages spoken in different countries require solutions to bridge the linguistic gap, arising in the implementation of external international relations.

The Implications of Using Stereotypes

Abstract The term stereotype was first used around a century ago, but its meaning and implications are relevant today due to an increase in group diversity and interactions. Stereotypes are simplistic and generalized beliefs about group members that can have negative consequences. This article reviews some of the evidence relating to two of the most common implications of stereotypes; discrimination and changes in cognitive and physical performance related with stereotype threat. The findings from this article may be helpful for human resource (HR) specialists, professors, health related specialists and those engaged in evaluation activities.

The art of mass communication: image management as the main competence of a public relations specialist

Mass communications influence people's opinions, assessments, and behavior by using certain images. The ability to create images is an indicator of mass communication culture. The world around is presented by images of space organization, images of the life and history of the nation, images of the nation itself, embodied in its character and archetype, images of people, images of economic and social life, the socio-political structure of society, the economic and political development, and images of globalization, involving countries and peoples. The article shows what technologies are used in mass communications for public relations. The material of the article may be of interest in the framework of the program track "Advertising and Public Relations".

Синдром Жубера як причина холестазу в дітей

Literature review and a case report of Joubert syndrome in a preschool child are presented. This syndrome is accompanied by chronic intrahepatic cholestasis, characteristic facial dysmorphia, congenital malformations of the urinary system, eyes pathology, confirmed by a molecular genetic test of TMEM67 gene mutations. Diagnostic aspects of this pathology have been reviewed. The clinical case description. Boy K was admitted to the pediatric hepatology department with respiratory and renal failure, decompensated acidosis. On admission, complaints included shortness of breath, severe itching, pale and dry skin, poor appetite and delayed physical development. On examination, dysembryogenic stigmas: large head circumference, elongated face, protruding forehead, high rounded eyebrows, deeply set eyes, hypertelorism, antimongoloid incision of the eyes, low auricles. The skin was pale, dry with the scratch marks on the arms and legs flexor surfaces. Ankles, wrists skin lichenification, bruising and hyperpigmentation was observed. Moderate palmar erythema, spider veins on the abdomen, watch-glass nails were present. The abdomen was enlarged due to hepatosplenomegaly. A clinical and paraclinical examination was conducted, the patient was consulted by related specialists. Based on the obtained data and molecular genetic examination, the diagnosis was made. Conclusion. Joubert's syndrome may have a clinical presentation similar to that in cholestatic liver disease with typical clinical and laboratory symptoms. The molecular genetic testing is an important workup component in children with liver pathology combined with damage to other organs and systems. Successful treatment is possible providing a multidisciplinary approach used. The study was conducted by the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the abovementioned institution. Informed consent of the child's parents was obtained for the research. The authors declare no conflict of interest. Keywords: Joubert syndrome, cholestasis, children.

Periodontal Status, Its Treatment Needs, and Its Relationship with Airflow Limitation and Quality of Life in COPD Patients.

Chronic obstructive pulmonary disease (COPD) is one of the most prevalent respiratory diseases in the world. There is an impressive relationship between periodontal status and airflow limitation in patients with COPD. Therefore, in this study, we aimed to investigate the periodontal status, its treatment needs, and its relationship with the severity of airway obstruction and quality of life in patients with COPD. In this case-control study, 36 healthy men (control group) and 35 men afflicted with COPD (case group) were investigated. On the basis of spirometry results and Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, patients with COPD were further divided into 4 groups. The participants' quality of life was evaluated using COPD Assessment Test (CAT) questionnaire. Thereafter, both groups of participants were referred to a dentistry clinic so that the related specialist could investigate their periodontal health status. The relationship between the periodontal indices and the variables under study including GOLD stage, CAT score, Forced Expiratory Volume in first second and Forced Vital Capacity (FEV1/FVC) ratio, Forced Expiratory Volume in first second (FEV1), and the exacerbation rate were statistically analyzed using independent t-test, one-way analysis of variance, Tukey's test, and Pearson correlation coefficient. The results revealed that probing pocket depth (PDD), bleeding on probing (BOP), and loss of attachment (LOA) are negatively correlated with FEV1% (r=-0.53, p=0.001), (r=-0.62, p=0.001), and (r=-0.72, p=0.001) as well as FEV1/FVC ratio (r=-0.45, p=0.007), (r=-0.47, p=0.004), and (r=-0.61, p=0.001), respectively. The results showed that PDD, BOP, and LOA are positively correlated with CAT score (r=0.51, p=0.002), (r=0.47, p=0.004), and (r=0.71, p=0.001), respectively. Periodontal problems are positively associated with COPD severity as determined by GOLD criteria and negatively associated with quality of life of patients with COPD.

Premenstrual syndrome: symptoms, diagnostics, phytotherapy (clinical lecture)

Premenstrual syndrome is a symptom complex characterized by repeated physical, psycho-emotional, behavioral symptoms that develop into the luteal phase of the cycle (2-14 days before menstruation) and disappear with its onset. The basis of the PMS diagnosis is the cyclical nature of pathological symptoms. The PMS diagnosis is established in accordance with ICD-10 criteria based on the analysis of frequency and severity of symptoms over two menstrual cycles. Differential diagnostics of PMS, and especially its most severe form - premenstrual dysphoric disorder, should be carried out first of all with various mental diseases, because in its clinical picture often it is psychoneurological symptomatology that prevails. It is necessary to exclude major depression, dysthymic conditions, generalized anxiety, panic disorder, bipolar diseases. Similar symptoms may have anaemia, autoimmune diseases, hypothyroidism, diabetes, convulsive conditions, endometriosis, chronic fatigue syndrome, and so on. The article notes the need for a comprehensive examination aimed at identifying gynecological and associated extragenital pathology with the involvement of related specialists. The existing recommendations for treatment of PMS, confirmed by randomized controlled studies, demonstrate the effectiveness of not only combined oral contraceptives, but also non-hormonal therapy, including phytopreparation containing the extract of Vitex sacred. Their application has yielded very positive results both in randomized controlled trials and in real clinical practice. At the same time, PMS therapy should take into account the state of general and reproductive health of women, concomitant diseases, tolerance of treatment, etc. These principles should be the basis for prevention, diagnosis and treatment of women with PMS.