In this special supplemental issue of Pediatric Blood and Cancer, we are delighted to present the first ever collaboration between the Children's Oncology Group (COG) and the International Society of Paediatric Oncology (SIOP) radiation oncology disciplines to jointly publish practice approaches and perspectives on the management of childhood cancers. Altogether, 109 authors have come together to contribute to this special supplement in tribute to Dr Giulio D'Angio, the father of pediatric radiation oncology. This combined international effort is dedicated to the memory of Dr D'Angio for his seminal contributions to the fields of pediatric radiation oncology and pediatric oncology. We are grateful to Drs Adamson, Perilongo, Vikram, and Buchsbaum for their thoughtful editorials. This supplemental issue has 21 papers covering the majority of pediatric cancers and touches on many other topics of interest to our discipline and to pediatric oncology in general. Among them, 13 are co-authored by both COG and SIOP Europe members from their respective disease committees. The remaining eight papers are authored by members of COG. The content of all of these articles represents recommended approaches by experts in the field, not the official positions of either COG or SIOP. We are especially delighted that the majority of these articles were written by young investigators with mentorship from senior members of COG and SIOP Europe. We hope that this will be the first of many future collaborations between COG and SIOP to improve the clinical outcomes of children treated with radiation therapy around the world. When asked by a reporter once what gave Dr D'Angio the most satisfaction in his professional career, his simple reply was “To get a letter from one of my patients saying that she's had a baby.” He always emphasized to all of us that “Cure is not enough.” As a discipline we will continue to pursue the important goal of providing the best quality cures for our patients. We conclude with a quote from Nelson Mandela “Children are the most vulnerable citizens of any society and our greatest treasures.” Children with cancer are even more so. This collaborative transatlantic effort is a testament to our commitment to their cause. We are greatly indebted to Dr Peter Newburger and the dedicated Pediatric Blood and Cancer journal staff without whose support and hard work throughout these last 2 years this collaboration would not have been possible.