Special Line Research Articles

В.А. СУХОМЛИНСКИЙ О ВОЗРАСТНОМ СТАНОВЛЕНИИ ЦЕННОСТНЫХ ОРИЕНТИРОВ ШКОЛЬНИКОВ. ЛОГИКА, МЕХАНИЗМЫ, ТЕХНОЛОГИИ

The rich pedagogical heritage of V.A. Sukhomlinsky by virtue of its depth and uniqueness makes it possible to identify the axiological constants of pedagogy, relevant at each stage of society development. The purpose of this article is to reveal the logic of formation of value orientations of schoolchildren in the age aspect on the basis of V.A. Sukhomlinsky’s work experience as a teacher and director of Pavlyshskaya secondary school. To achieve this goal, the article addresses the following tasks: an attempt is made to identify those parts of V.A. Sukhomlinsky’s heritage that reflect the regularities of age and value development of schoolchildren; synthesis on their basis of the age logic of the formation of value orientations; filling the values realized in the pedagogical process by V.A. Sukhomlinsky with the content relevant for modern schoolchildren. In V.A. Sukhomlinsky’s pedagogical system it is possible to distinguish a special line of development of a schoolchild’s personality — age-specific features of the formation of his value orientations, which determine the subsequent life of a person: his future choices, successes and failures. The strength of V.A. Sukhomlinsky’s axiological ideas lies in building a system of school work on basic universal values, including the universal triad: Truth — Goodness — Beauty. Having proclaimed and realized first in the experience of his school and then in the pedagogical theory the cult of Book, Knowledge, Beauty, — he actually created a basic classification of values-objectives in pedagogy. According to the authors, this hierarchy of values of an adult can be relevant today, if we fill these values with actual content within the pedagogical process. The changed realities of the first third of the XXI century require the rejection of formal analysis of Sukhomlinsky’s heritage, since extrapolation of the great pedagogue’s ideas to the realities of the modern school in an unchanged form has become impossible. Gamification, neural networks and avalanche-like flow of information, which modern schoolchildren face, require adaptation of the great teacher’s ideas and change of approach to education, departure from value neutrality.

СОЗДАНИЕ И ПРОДУКТИВНОСТЬ МЕЖЛИНЕЙНОГО КРОССА ГУСЕЙ «МАКУЛИНСКИЙ»

Creation of specialized lines at the base of Lind geese breed has become the result of long selection work in “Vurnarets” LRS. This lines has been included in the State Register of selection achievements: the male MC line (the patent No. 12759 from 23.05.2023) and the female YAC line (the patent No. 12758 from 23.05.2023). “Mackulinsky” geese cross (the patent 12757 from 23.05.2023) has been received by these lines crossing. New cross poultry comparative tests have confirmed the new line usage effectiveness. Young day goslings cost is lower by 24.9% and gosling mass gain being reared for meat is higher by 7.7%.

COMPARATIVE STUDY OF PRODUCTION PERFORMANCE AMONG LOCAL QUAILS

This research was carried out to compare the productivity performance of three lines of local quail. The results showed a significant superiority in the daily gain weight (3.76 g/day/quail) and marketing weight (167.2 g/quail) for brown quail over other colors. Also, significant differences were found in the dressing ratio between males (67.8%) and females (65.76%). As for the egg production of quail, it was found a significant superiority of the desert quail over the other colors in the number of eggs produced, the average egg weight (9.73 g/ egg) and the HDEP (78.6 %) with the best feed conversation (2.15 g / g of egg). The results also show that the white-colored quail was average between the other two colors for the characteristics of the productive performance of body weight and egg production. It could be concluding from these results the possibility of directing the different colors of a particular trait and developing it into specialized lines for the production of eggs or meat through the selection process.

Functional Characterization of Sugar Beet M14 Antioxidant Enzymes in Plant Salt Stress Tolerance.

Salt stress can cause cellular dehydration, which induces oxidative stress by increasing the production of reactive oxygen species (ROS) in plants. They may play signaling roles and cause structural damages to the cells. To overcome the negative impacts, the plant ROS scavenging system plays a vital role in maintaining the cellular redox homeostasis. The special sugar beet apomictic monosomic additional M14 line (BvM14) showed strong salt stress tolerance. Comparative proteomics revealed that six antioxidant enzymes (glycolate oxidase (GOX), peroxiredoxin (PrxR), thioredoxin (Trx), ascorbate peroxidase (APX), monodehydroascorbate reductase (MDHAR), and dehydroascorbate reductase3 (DHAR3)) in BvM14 were responsive to salt stress. In this work, the full-length cDNAs of genes encoding these enzymes in the redox system were cloned from the BvM14. Ectopic expression of the six genes reduced the oxidative damage of transgenic plants by regulating the contents of hydrogen peroxide (H2O2), malondialdehyde (MDA), ascorbic acid (AsA), and glutathione (GSH), and thus enhanced the tolerance of transgenic plants to salt stress. This work has charecterized the roles that the antioxidant enzymes play in the BvM14 response to salt stress and provided useful genetic resources for engineering and marker-based breeding of crops that are sensitive to salt stress.

Vector bundles on flag varieties

AbstractWe study vector bundles on flag varieties over an algebraically closed field k. In the first part, we suppose to be the Grassmannian parameterizing linear subspaces of dimension d in , where k is an algebraically closed field of characteristic . Let E be a uniform vector bundle over G of rank . We show that E is either a direct sum of line bundles or a twist of the pullback of the universal subbundle or its dual by a series of absolute Frobenius maps. In the second part, splitting properties of vector bundles on general flag varieties in characteristic zero are considered. We prove a structure theorem for bundles over flag varieties which are uniform with respect to the ith component of the manifold of lines in . Furthermore, we generalize the Grauert–Mlich–Barth theorem to flag varieties. As a corollary, we show that any strongly uniform i‐semistable bundle over the complete flag variety splits as a direct sum of special line bundles.

MODL-16. SOMATICALLY ENGINEERED MOUSE MODELS RECAPITULATING CELLULAR AND MOLECULAR FEATURES OF HUMAN GBM

Abstract INTRODUCTION Mouse models are instrumental in advancing our understanding of glioblastoma (GBM), however many commonly used models have features that limit their practicality or applicability. These limitations can include an incomplete immune context, a requirement for complex breeding strategies, high cost of specialized lines, and unpredictability in where tumors arise. We sought to develop and validate a mouse modeling system for some of the major human GBM subtypes that overcame these practical challenges. METHODS In vivo electroporation was used to introduce genetic alterations into periventricular cells of early postnatal C57Bl6/j mice. PiggyBac transposon/transposase and CRISPR-Cas9 systems were used to overexpress (OE) or knock out (KO) genes associated with mesenchymal (Nf1-KO/Pten-KO/p53-KO), classical (EGFRvIII-OE/Cdkn2a-KO/Pten-KO), and proneural (Pdgfra-OE/Cdk4-OE/p53-KO) IDH-WT GBM subtypes. KO or OE was confirmed by Indel Detection by Amplicon Analysis and immunofluorescent staining (IF). Tumours were analyzed for histologic, immunohistochemical, and transcriptional (RNAseq) features. RESULTS Tumors arose with near complete penetrance and median survivals of 36 to 116 days amongst models. All tumors were GFAP-expressing high-grade gliomas, with distinct phenotypes associated with different genetic combinations. Nf1-KO/Pten-KO/p53-KO tumors were composed of spindle cells. EGFRvIII-OE/Cdkn2a-KO/Pten-KO and Pdgfra-OE/Cdk4-OE/p53-KO tumors showed prevalence of small, round cells. Molecularly, Nf1-KO/Pten-KO/p53-KO tumors were enriched for human mesenchymal signature and displayed more differentiated phenotype. The Nf1-KO/Pten-KO/p53-KO model also showed increased stromal cells and macrophages. The other models had mixed proneural and classical profiles and were enriched for OPC- and NPC-like gene signatures found in human GBM. Once tumors formed, cells from each model were transplantable into C57Bl6/j mice to generate subsequent tumors. CONCLUSION We developed and validated a rapid, versatile, and reproducible system to model GBMs. These models allow for controlled study of GBM pathogenesis, progression, and treatment response, and allow for robust generation of syngeneic implantable mouse models that can serve as valuable tools for preclinical testing.

Facile and cost-effective technique to control europium oxidation states in glassy fluorophosphate matrices with tunable photoluminescence

Inorganic fluorophosphate glasses doped with Eu^{2+}/Eu^{3+} are potential candidates for phosphors for commercial white LEDs. This report presents a fast, inexpensive and effective method of controlling the relative concentrations of Eu^{2+}/Eu^{3+} photoluminescent centers in these glasses. The technique consists of a fast quenching of the melt of initial reagents under appropriate conditions. Eu^{2+}/Eu^{3+} ratio was controlled by carrying out the melting under a reducing atmosphere at a temperature between 1000 and 1200 ^circC for periods of 5 to 15 minutes. The reducing atmosphere was provided by a ’double crucible’ technique and did not require special gas lines during the synthesis. The samples were studied by several complementary experimental methods (X-ray diffractometry—XRD, X-ray photoelectron spectroscopy—XPS, photoluminescence—PL—and photoluminescence excitation—PLE—spectroscopies as well as optical transmission spectroscopy). It was shown that the syntheses resulted in amorphous materials with different relative Eu^{2+}/Eu^{3+} concentration ratios, strongly dependent on the preparation conditions: the temperature and the time of melting in a reducing atmosphere. Moreover, changes in these ratios strongly affected the materials’ PL and PLE spectra. Demonstration of reproducible smooth transition from amaranth to blue luminescence color, with white in between, was the most spectacular result of this work.

Theoretical study of the line defect in χ3-borophene: structures, electronic properties, direct-current and alternating-current transport properties

Two-dimensional material χ3-borophene is a stable borophene allotrope and has been synthesized in experiment. Combining density functional theory with non-equilibrium Green’s function method, in the present study we theoretically investigated the structures, stabilities, electronic properties, and the direct-current (DC) and alternating-current (AC) transport properties of its line defects. The obtained results suggest that along the zigzag direction there exist some special line defects that can enhance the stability of χ3-borophene and the six-coordination B atoms play a key role for the enhanced stability. The line defects may change the atomic orbital components of the Dirac cone of χ3-borophene and have profound influences on the electronic properties. For the DC transport, under high bias voltages along a given transport direction the line defects may lead to constant current phenomena. For the AC transport, under different frequency ranges the line defects have different AC responses with respect to the external time-dependent field, exhibiting complicated AC transport behaviors. Furthermore, for the low-frequency range, the equivalent circuits of χ3-borophene and its line defects were suggested, which will be beneficial for designing borophene-based functional nanodevices.

Special lines on contact manifolds

In a series of two articles Kebekus studied deformation theory of minimal rational curves on contact Fano manifolds. Such curves are called contact lines. Kebekus proved that a contact line through a general point is necessarily smooth and has a fixed standard splitting type of the restricted tangent bundle. In this paper we study singular contact lines and those with special splitting type. We provide restrictions on the families of such lines, and on contact Fano varieties which have reducible varieties of minimal rational tangents. We also show that the results about singular lines naturally generalise to complex contact manifolds, which are not necessarily Fano, for instance, quasiprojective contact manifolds or contact manifolds of Fujiki class C. In particular, in many cases the dimension of a family of singular lines is at most 2 less than the dimension of the contact manifold.

Exploration and practice of building tele-critical care system

To look for the problems faced in the construction of the tele-critical care system, explore the framework of construction of the tele-critical care system, and verify the application effects of the established tele-critical care system. Through literature review and on-site investigation and demonstration, the causes affecting the construction of the tele-critical care system were explored. Through on-site investigation of the actual situation of the critical care department in relevant hospitals, arguing and choosing intended intensive care unit (ICU) and cooperative third-party communication and equipment companies, and through the Internet of Things and 5G communication technology, a tele-critical care system with the core hospital of the group as the center and the member institutes within the group as the nodes was built. Via the established tele-critical care system, activities such as tele-monitoring, visual remote ward rounds, remote consultation, remote teaching were carried out to verify the functions of the system. The insufficient cognition of relevant personnel, tele-medicine practice certification requirements, information security issues and the barriers of equipment information integration were the main causes affecting the construction of tele-critical care system. There were five parts in the tele-critical care system architecture foundations, including bed unit equipment and audio and video information collection system, lossless and secure transmission of collected information, real-time display of information in the remote center, real-time staff interaction between the centre and the nodal hospitals, and information cloud storage. It has been verified that patients' diagnostic and treatment information can be transmitted safely, losslessly and in real-time by a special line through private 5G network. Through this system, real-time and stable upload of audio and video information of patients and application information of monitors, ventilators and infusion work stations can be achieved; combined with tele-conference connections to conduct two-way communication with local medical staff, real-time tele-monitoring, visual remote ward rounds, remote consultation, remote teaching and other functions can be achieved. The tele-critical care system we established is feasible to construct within the medical group and can safely and effectively realize the functions of real-time tele-monitoring, visual remote ward rounds, remote consultation, and remote teaching.

Ultrasonic testing of soldered joints in fuel manifolds of gas turbine engines

The X-ray technique used in the quality control of soldered joints of injectors with fuel manifold tubes of gas turbine engines (GTE) has a number of limitations and drawbacks. The detectability of flat flaws, e.g., dry solders, strongly depends on their orientation with respect to the direction of X-ray beam propagation. An ultrasonic method which provides increased efficiency of controlling soldered joints of modern gas turbine engines, the manifolds of which usually contain two rows of tubes is presented. A focused high-frequency pencil-type transducer has been used in the study. Samples with artificial reflectors in the form of flat-bottomed holes located in the soldering zone were analyzed. Special delay lines provided the transmission of ultrasonic waves at the angles close to the normal to the surface of the soldered joint. The results of the control obtained using the developed procedure were compared with the data of X-ray method. It is shown that ultrasonic technique provides detection of the flaws not detected by radiographic control. The sensitivity, minimal width of the flaw (dry solder) and possible completeness of the control were determined for the developed technique. The results obtained could be used to improve the method of control of soldered joints of GTE fuel manifolds.

Dynamic Responses Law of Subgrade of a Special Railway Line in Loess Region

Dynamic Responses Law of Subgrade of a Special Railway Line in Loess Region

ADOPTION OF TECHNOLOGY IN THE COLOMBIAN COMPETITIVENESS POLICY CONPES3527: BULB ONION CASE 2008-2016

The low productivity of the agricultural sector and the low levels of technology adoption are among the main obstacles for Colombia to be more competitive. To change this, the national competitiveness and productivity policy was in force between 2008 and 2016, through the document Conpes3527. The objective of this work was to show the successes and failures of the first strategic axis of Conpes, through the identification of the advance of competitiveness in the horticultural subsector, using the bulb onion in Cundinamarca as a case study, through a three-step methodology: first, the concept of systemic competitiveness was used to identify the level of analysis at which the work was carried out; second, five categories of analysis were defined: identification of technological problems; research funding; research; agricultural technical assistance and special credit lines and third, an index was built based on a survey applied to specialists to identify the progress of competitiveness. It was found that the tools designed in Conpes failed to improve competitiveness levels, due to five reasons: 1. The demands are written in an ambiguous way; 2. The expected levels of investment are not reached; 3. There is no research coordination instrument for the horticultural subsector; 4. The transfer model through Epsagro generated disorder and a disconnection between supply and demand for technical solutions and 5. The line of credit was not implemented.

The land degradation neutrality management enablers, challenges, and benefits for mobilizing private investments in Pakistan

Limited investments in land degradation neutrality (LDN) are causing environmental degradation and are the main barriers to socioeconomic development worldwide. Therefore, it is crucial to meet the target 15.3 of the Sustainable Development Goals to achieve soil neutrality by 2030 at the national level. Therefore, the primary purpose of this study is to find critical enablers, challenges, and benefits of LDN and develop a new administrative management framework for mobilizing private investments according to local financial market conditions. To achieve this research objective, the authors selected 14 degraded districts in four provinces of Pakistan. The data for this study were collected from 63 institutions that were directly or indirectly involved in land degradation risk prevention and management. The research evaluation process comprises a mixed-method approach to infer institutional survey data analysis. The interpretation of the results was based on two important dimensions, including 12 survey statements. From the perspective of LDN management (LDNM) enablers, the government’s long-term vision and strong commitment were validated as top-ranked measures among the six enablers for the implementation of LDN. The development of horizontal and vertical coordination mechanisms for the LDN is the second-most critical enabler. While developing public-private partnership (PPP) policies, procedures and services are perceived as the third most potent enabler. In terms of LDNM challenges and benefits, raising awareness of the LDN concept, capacity development, and LDN market risk assessment are identified as the main challenges. However, developing a green economy, securing social needs, and ensuring ecological sustainability are vital benefits. This study makes theoretical and practical contributions to the field of LDNM. Theoretically, this study contributes to the LDNM framework based on complexity theory by integrating transaction cost logic to execute win-win PPP agreements. Practically, to meet different market conditions, this study suggests three PPP models: special credit lines, risk-sharing facilities, and land protection performance contracts. These inputs will provide insight into what the government needs to develop for land use policy, promote LDN investments, and forge new partnerships between local financial institutions and landscape stakeholders.

Межлинейные кроссы в цигайском овцеводстве

Abstract. Domestic sheep breeds potential must be preserved in breeding farms, and the main method of improving the breed is working with breeding lines. The genetic variability of the breed is formed by specialized lines. Therefore, further improvement of the breed itself should be carried out along the way of improving its lines. Each of the lines is specialized according to certain characteristics. The presence of such breeding structures that are not related is one of the ways to improve the productive and biological characteristics of the breed. The method of interlinear crosses in sheep breeding in order to identify optimal combinations is used. The purpose of this work is to study the interlinear crosses of the bright Qigai breed on the basis of retrospective data. Statistical methods were used in the study. Scientific novelty. Tsigai breed young females interlinear crosses in order to improve economically useful traits were analyzed. Results research. The indicators of the live weight of the young females in the interlinear crosses is 53.0 ± 1.1 ... 47.0 ± 1.0 kg with a coefficient of variation of 6.4%. The wool fibers fineness 56th quality in 14.0% of crosses was noted. The interlinear crosses with the 54th quality of wool fibers fineness occupy the largest share by 65.1 %. The remaining crosses was with the 50th quality of wool fibers fineness. The distribution of wool fibers fineness by a positive level of correlation in comparison with the wool length fibers was characterized in the following way: this fact is confirmed by correlation coefficients with a positive level of conjugacy: r = 0.98 ..0.57. The wool fibers fineness in 36.1 % of the obtained interlinear crosses has a strong positive reliable correlation level, and in 47.2 % is weak and unreliable. In the interlinear crosses the wool fibers fineness were noted as follow: 65204 × 1128 in conjunction with the wool shearing, in the crosses 884 × 80077 and 884 × 20832 in conjunction with the live weight of young females.

Numerical Analysis on the RF Characteristics of the Gyromagnetic Nonlinear Transmission Lines

The gyromagnetic nonlinear transmission line (GNLTL) is a special transmission line loaded with ferrite cores, which can be used as a kind of wideband high-power microwave (HPM) source due to the pulse modulation mechanism. This article carried out a series of simulations and analyses focused on the RF characteristics of GNLTL. Based on the classic transmission line model (TLM) method, a numerical model linking the transmission line equations and the microscopic magnetization dynamics equations was established. The simulations systematically studied the effects of key parameters on the output characteristics especially the RF characteristics, including the effects of transmission line geometry, excitation pulse, magnetic material, and the biasing magnetic field. The simulation results and analyses revealed that almost each parameter has effects on the output, and the effects of different parameters are different. The research introduced in this article preliminarily reveals how the output microwave varies with the parameters and provides a method to find the appropriate parameter values of a GNLTL.

Critical Care Nurses' Knowledge of Correct Line Types for Administration of Common Intravenous Medications: Assessment and Intervention Study.

BackgroundThere is a paucity of information in the literature on core nursing staff knowledge on the requirements of specific intravenous administration lines for medications regularly given in critical care. There is also a lack of well-researched and appropriate information in the literature for intravenous administration line selection, and the need for filtration, protection from light, and other line-material selection precautions for many critical and noncritical medications used in these settings to maintain their potency and efficacy.ObjectiveWe aimed to assess the knowledge gap of clinicians with respect to intravenous administration line set material requirements for critical care medications.MethodsData were drawn from a clinician knowledge questionnaire, a region-wide database of administered infusions, and regional data on standard and special intravenous administration line consumption for 1 year (2019-2020) from an enterprise resource planning system log. The clinician knowledge questionnaire was validated with 3 groups (n=35) and then released for a general survey of critical care nurses (n=72) by assessing response dispersal and interrater reliability (Cronbach α=.889). Correct answers were determined by referencing available literature, with consensus between the team’s pharmacists. Percentage deviations from correct answers (which had multiple possible selections) were calculated for control and test groups. We reviewed all 3 sources of information to identify the gap between required usage and real usage, and the impact of knowledge deficits on this disparity.ResultsPercentage deviations from correct answers were substantial in the control groups and extensive in the test group for all medications tested (percentage deviation range –43% to 93%), with the exception of for total parenteral nutrition. Respondents scored poorly on questions about medications requiring light protection, and there was a difference of 2.75% between actual consumption of lines and expected consumption based on medication type requirement. Confusion over the requirements for low-sorbing lines, light protection of infusions, and the requirement for filtration of specific solutions was evident in all evidence sources. The consumption of low-sorbing lines (125,090/1,454,440, 8.60%) was larger than the regional data of medication usage data would suggest as being appropriate (15,063/592,392, 2.54%).ConclusionsThere is no single source of truth for clinicians on the interactions of critical care intravenous medications and administration line materials, protection from light, and filtration. Nursing staff showed limited knowledge of these requirements. To reduce clinical variability in this area, it is desirable to have succinct easy-to-access information available for clinicians to make decisions on which administration line type to use for each medication. The study’s results will be used to formulate solutions for bedside delivery of accurate information on special intravenous line requirements for critical care medications.

Computational Prediction of Graphdiyne-Supported Three-Atom Single-Cluster Catalysts

Computational Prediction of Graphdiyne-Supported Three-Atom Single-Cluster Catalysts

Proposing and Verifying Different Lines of Inquiry in the Investigation of Deliberate Destruction or Damage of Property

The authors summarize their research and present a system of general and special lines of inquiry put forward at the initial and subsequent stages of investigating deliberate destruction or damage of property, as well as typical portraits of the alleged offender as the basis for proposing these lines of inquiry. The investigation of the crime under Art. 167 of the Criminal Code of the Russian Federation is closely connected with the process of proposing and verifying general and special lines of inquiry. These general and special lines of inquiry into the deliberate destruction or damage of property are proposed on the basis of theoretical knowledge and factual data. Research of criminal cases allowed the authors to typify the personalities of alleged offenders in the crimes under consideration. The portrait of the typical offender acts as a theoretical basis for proposing theories regarding the personality of the alleged criminal (avenger, jealous person, envious person, repeat offender, arsonist, hooligan, bomber, member of a criminal gang, hypeman).

The Role of the 102 Service Department in the System of Operative Response of Police Bodies and Divisions

The relevance of the chosen topic is to determine the role and content of the structural unit “102” in the rapid response system, and the algorithm of their actions in providing the necessary assistance to people who called the special telephone line of the National Police of Ukraine. The purpose of the study is to determine the main function of the service department “102” as one of the structural units of organisational and analytical support and operational response of the National Police of Ukraine. The following methods for collecting and processing information were widely used in the research process: specific sociological (documentary, survey, observation) and some private scientific methods (system-structural, comparative-legal, historical-legal). The role of the service department “102” of organisational and analytical support and operational response of the National Police of Ukraine in the system of operational response of police bodies and units to statements and reports of criminal, administrative offenses or events. It is argued that the main function of the service department “102” units of organisational and analytical support and operational response of the National Police is to receive, process and register applications and notifications of offenses and events throughout the service area. It has also been proven that the necessary legislative initiative is to locate a person who has applied for real help on line 102. In addition, it was established that to properly perform the powers of officials of the service department “102” it is necessary to introduce the position of a psychologist to provide psychological assistance to victims. At the same time, it is argued that the service department “102” is a basic element in the operational response system of the National Police of Ukraine.